Pascal Furet

Affiliations

Novartis Institutes for Biomedical Research, Basel, Switzerland.

Publications (18)

p53 dynamics vary between tissues and are linked with radiation sensitivity.

Nature communications

Avec: Jacob Stewart-Ornstein , Yoshiko Iwamoto , Miles A Miller , Mark A Prytyskach , Stephane Ferretti , Philipp Holzer , Joerg Kallen , Pascal Furet , Ashwini Jambhekar , William C Forrester , Ralph Weissleder , Galit Lahav

Correction to "2-Formylpyridyl Ureas as Highly Selective Reversible-Covalent Inhibitors of Fibroblast Growth Factor Receptor 4".

ACS medicinal chemistry letters

Avec: Thomas Knoepfel , Pascal Furet , Robert Mah , Nicole Buschmann , Catherine Leblanc , Sebastien Ripoche , Diana Graus-Porta , Markus Wartmann , Inga Galuba , Robin A Fairhurst

Identification of NVP-CLR457 as an Orally Bioavailable Non-CNS-Penetrant pan-Class IA Phosphoinositol-3-Kinase Inhibitor.

Journal of medicinal chemistry

Avec: Robin A Fairhurst , Pascal Furet , Patricia Imbach-Weese , Frédéric Stauffer , Heinrich Rueeger , Clive McCarthy , Sebastien Ripoche , Susanne Oswald , Bertrand Arnaud , Aline Jary , Michel Maira , Christian Schnell , Daniel A Guthy , Markus Wartmann , Michael Kiffe , Sandrine Desrayaud , Francesca Blasco , Toni Widmer , Frank Seiler , Sascha Gutmann , Mark Knapp , Giorgio Caravatti

Leveraging Advanced In Silico Techniques in Early Drug Discovery: A Study of Potent Small-Molecule YAP-TEAD PPI Disruptors.

Journal of chemical information and modeling

Avec: Ernest Awoonor-Williams , Callum J Dickson , Pascal Furet , Andrei A Golosov , Viktor Hornak

Identification of Brain-Penetrant ATP-Competitive mTOR Inhibitors for CNS Syndromes.

Journal of medicinal chemistry

Avec: Simone Bonazzi , Audrey Gray , Noel M Thomsen , Jonathan Biag , Nancy Labbe-Giguere , Erin P Keaney , Hasnain A Malik , Yingchuan Sun , Jill Nunez , Rajeshri G Karki , Mark Knapp , Robert Elling , John Fuller , Gwynn Pardee , Lucas Craig , Ketthsy Capre , Sarah Salas , Aakruti Gorde , Guiqing Liang , Danuta Lubicka , Stephanie M McTighe , Carleton Goold , Shanming Liu , Lin Deng , Jin Hong , Alexander Fekete , Pascal Stadelmann , Wilfried Frieauff , Azeddine Elhajouji , Daniel Bauer , Andreas Lerchner , Branko Radetich , Pascal Furet , Grazia Piizzi , Doug Burdette , Christopher J Wilson , Stefan Peukert , Lawrence G Hamann , Leon O Murphy , Daniel Curtis

Structural States of Hdm2 and HdmX: X-ray Elucidation of Adaptations and Binding Interactions for Different Chemical Compound Classes.

ChemMedChem

Avec: Joerg Kallen , Aude Izaac , Suzanne Chau , Emmanuelle Wirth , Joseph Schoepfer , Robert Mah , Achim Schlapbach , Stefan Stutz , Andrea Vaupel , Vito Guagnano , Keiichi Masuya , Therese-Marie Stachyra , Bahaa Salem , Patrick Chene , Francois Gessier , Philipp Holzer , Pascal Furet

Discovery and

Journal of medicinal chemistry

Avec: Juraj Velcicky , Matthias R Bauer , Achim Schlapbach , Guillaume Lapointe , Arndt Meyer , Markus Vögtle , Ernst Blum , Estelle Ngo , Catherine Rolando , Pierre Nimsgern , Sylvie Teixeira-Fouchard , Hansjoerg Lehmann , Pascal Furet , Frédéric Berst , Jens Schümann , Rowan Stringer , Patrice Larger , Cindy Schmid , Catriona T Prendergast , Simone Riek , Patrick Schmutz , Sylvie Lehmann , Jörg Berghausen , Clemens Scheufler , Jean-Michel Rondeau , Christoph Burkhart , Thomas Knoepfel , Nina Gommermann

Capmatinib (INC280) Is Active Against Models of Non-Small Cell Lung Cancer and Other Cancer Types with Defined Mechanisms of MET Activation.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Sabrina Baltschukat , Barbara Schacher Engstler , Alan Huang , Huai-Xiang Hao , Angela Tam , Hui Qin Wang , Jinsheng Liang , Matthew T DiMare , Hyo-Eun Carrie Bhang , Youzhen Wang , Pascal Furet , William R Sellers , Francesco Hofmann , Joseph Schoepfer , Ralph Tiedt

FGF401, A First-In-Class Highly Selective and Potent FGFR4 Inhibitor for the Treatment of FGF19-Driven Hepatocellular Cancer.

Molecular cancer therapeutics

Avec: Andreas Weiss , Flavia Adler , Alexandra Buhles , Christelle Stamm , Robin A Fairhurst , Michael Kiffe , Dario Sterker , Mario Centeleghe , Markus Wartmann , Jacqueline Kinyamu-Akunda , Heiko S Schadt , Philippe Couttet , Armin Wolf , Youzhen Wang , Patrizia Barzaghi-Rinaudo , Masato Murakami , Audrey Kauffmann , Thomas Knoepfel , Nicole Buschmann , Catherine Leblanc , Robert Mah , Pascal Furet , Jutta Blank , Francesco Hofmann , William R Sellers , Diana Graus Porta

A new perspective on the interaction between the Vg/VGLL1-3 proteins and the TEAD transcription factors.

Scientific reports

Avec: Yannick Mesrouze , Gustavo Aguilar , Fedir Bokhovchuk , Typhaine Martin , Clara Delaunay , Frédéric Villard , Marco Meyerhofer , Catherine Zimmermann , Patrizia Fontana , Roman Wille , Thomas Vorherr , Dirk Erdmann , Pascal Furet , Clemens Scheufler , Tobias Schmelzle , Markus Affolter , Patrick Chène

Discovery of Roblitinib (FGF401) as a Reversible-Covalent Inhibitor of the Kinase Activity of Fibroblast Growth Factor Receptor 4.

Journal of medicinal chemistry

Avec: Robin A Fairhurst , Thomas Knoepfel , Nicole Buschmann , Catherine Leblanc , Robert Mah , Milen Todorov , Pierre Nimsgern , Sebastien Ripoche , Michel Niklaus , Nicolas Warin , Van Huy Luu , Mario Madoerin , Jasmin Wirth , Diana Graus-Porta , Andreas Weiss , Michael Kiffe , Markus Wartmann , Jacqueline Kinyamu-Akunda , Dario Sterker , Christelle Stamm , Flavia Adler , Alexandra Buhles , Heiko Schadt , Philippe Couttet , Jutta Blank , Inga Galuba , Jörg Trappe , Johannes Voshol , Nils Ostermann , Chao Zou , Jörg Berghausen , Alberto Del Rio Espinola , Wolfgang Jahnke , Pascal Furet

The First Class of Small Molecules Potently Disrupting the YAP-TEAD Interaction by Direct Competition.

ChemMedChem

Avec: Pascal Furet , Vincent Bordas , Mickaël Le Douget , Bahaa Salem , Yannick Mesrouze , Patricia Imbach-Weese , Holger Sellner , Markus Voegtle , Nicolas Soldermann , Emilie Chapeau , Markus Wartmann , Clemens Scheufler , Cesar Fernandez , Joerg Kallen , Vito Guagnano , Patrick Chène , Tobias Schmelzle

Identification of FAM181A and FAM181B as new interactors with the TEAD transcription factors.

Protein science : a publication of the Protein Society

Avec: Fedir Bokhovchuk , Yannick Mesrouze , Clara Delaunay , Typhaine Martin , Frédéric Villard , Marco Meyerhofer , Patrizia Fontana , Catherine Zimmermann , Dirk Erdmann , Pascal Furet , Clemens Scheufler , Tobias Schmelzle , Patrick Chène

Structure-based design of potent linear peptide inhibitors of the YAP-TEAD protein-protein interaction derived from the YAP omega-loop sequence.

Bioorganic & medicinal chemistry letters

Avec: Pascal Furet , Bahaa Salem , Yannick Mesrouze , Tobias Schmelzle , Ian Lewis , Joerg Kallen , Patrick Chène

Molecular and structural characterization of a TEAD mutation at the origin of Sveinsson's chorioretinal atrophy.

The FEBS journal

Avec: Fedir Bokhovchuk , Yannick Mesrouze , Aude Izaac , Marco Meyerhofer , Catherine Zimmermann , Patrizia Fontana , Tobias Schmelzle , Dirk Erdmann , Pascal Furet , Joerg Kallen , Patrick Chène

Dissecting the Interaction Fingerprints and Binding Affinity of BYL719 Analogs Targeting PI3Kα.

The journal of physical chemistry. B

Avec: Sepehr Dehghani-Ghahnaviyeh , Cihan Soylu , Pascal Furet , Camilo Velez-Vega

Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.

Nature cancer

Avec: Emilie A Chapeau , Laurent Sansregret , Giorgio G Galli , Patrick Chène , Markus Wartmann , Thanos P Mourikis , Patricia Jaaks , Sabrina Baltschukat , Ines A M Barbosa , Daniel Bauer , Saskia M Brachmann , Clara Delaunay , Claire Estadieu , Jason E Faris , Pascal Furet , Stefanie Harlfinger , Andreas Hueber , Eloísa Jiménez Núñez , David P Kodack , Emeline Mandon , Typhaine Martin , Yannick Mesrouze , Vincent Romanet , Clemens Scheufler , Holger Sellner , Christelle Stamm , Dario Sterker , Luca Tordella , Francesco Hofmann , Nicolas Soldermann , Tobias Schmelzle

Optimization of a Class of Dihydrobenzofurane Analogs toward Orally Efficacious YAP-TEAD Protein-Protein Interaction Inhibitors.

ChemMedChem

Avec: Holger Sellner , Emilie Chapeau , Pascal Furet , Markus Voegtle , Bahaa Salem , Mickaël Le Douget , Vincent Bordas , Jean-Marc Groell , Anne-Laure Le Goff , Christine Rouzet , Thomas Wietlisbach , Thomas Zimmermann , Joseph McKenna , Cara E Brocklehurst , Patrick Chène , Markus Wartmann , Clemens Scheufler , Joerg Kallen , Gareth Williams , Stephanie Harlfinger , Martin Traebert , Bérengère M Dumotier , Tobias Schmelzle , Nicolas Soldermann

Réseau de co-auteurs

Markus Wartmann 7 collaborations

Tobias Schmelzle 7 collaborations

Patrick Chène 7 collaborations

Joerg Kallen 6 collaborations

Clemens Scheufler 6 collaborations

Yannick Mesrouze 6 collaborations

Thomas Knoepfel 4 collaborations

Robert Mah 4 collaborations

Robin A Fairhurst 4 collaborations

Bahaa Salem 4 collaborations

Nicole Buschmann 3 collaborations

Catherine Leblanc 3 collaborations

Sebastien Ripoche 3 collaborations

Michael Kiffe 3 collaborations

Francesco Hofmann 3 collaborations

Christelle Stamm 3 collaborations

Dario Sterker 3 collaborations

Fedir Bokhovchuk 3 collaborations

Typhaine Martin 3 collaborations

Clara Delaunay 3 collaborations

Marco Meyerhofer 3 collaborations

Catherine Zimmermann 3 collaborations

Patrizia Fontana 3 collaborations

Dirk Erdmann 3 collaborations

Holger Sellner 3 collaborations

Nicolas Soldermann 3 collaborations

Philipp Holzer 2 collaborations

Diana Graus-Porta 2 collaborations

Inga Galuba 2 collaborations

Patricia Imbach-Weese 2 collaborations

Mark Knapp 2 collaborations

Daniel Bauer 2 collaborations

Aude Izaac 2 collaborations

Joseph Schoepfer 2 collaborations

Achim Schlapbach 2 collaborations

Vito Guagnano 2 collaborations

Pierre Nimsgern 2 collaborations

Jörg Berghausen 2 collaborations

Sabrina Baltschukat 2 collaborations

Youzhen Wang 2 collaborations

William R Sellers 2 collaborations

Andreas Weiss 2 collaborations

Flavia Adler 2 collaborations

Alexandra Buhles 2 collaborations

Jacqueline Kinyamu-Akunda 2 collaborations

Philippe Couttet 2 collaborations

Jutta Blank 2 collaborations

Frédéric Villard 2 collaborations

Vincent Bordas 2 collaborations

Mickaël Le Douget 2 collaborations

Markus Voegtle 2 collaborations

Emilie Chapeau 2 collaborations

Jacob Stewart-Ornstein 1 collaboration

Yoshiko Iwamoto 1 collaboration

Miles A Miller 1 collaboration

Mark A Prytyskach 1 collaboration

Stephane Ferretti 1 collaboration

Ashwini Jambhekar 1 collaboration

William C Forrester 1 collaboration

Ralph Weissleder 1 collaboration

Galit Lahav 1 collaboration

Frédéric Stauffer 1 collaboration

Heinrich Rueeger 1 collaboration

Clive McCarthy 1 collaboration

Susanne Oswald 1 collaboration

Bertrand Arnaud 1 collaboration

Aline Jary 1 collaboration

Michel Maira 1 collaboration

Christian Schnell 1 collaboration

Daniel A Guthy 1 collaboration

Sandrine Desrayaud 1 collaboration

Francesca Blasco 1 collaboration

Toni Widmer 1 collaboration

Frank Seiler 1 collaboration

Sascha Gutmann 1 collaboration

Giorgio Caravatti 1 collaboration

Ernest Awoonor-Williams 1 collaboration

Callum J Dickson 1 collaboration

Andrei A Golosov 1 collaboration

Viktor Hornak 1 collaboration

Simone Bonazzi 1 collaboration

Audrey Gray 1 collaboration

Noel M Thomsen 1 collaboration

Jonathan Biag 1 collaboration

Nancy Labbe-Giguere 1 collaboration

Erin P Keaney 1 collaboration

Hasnain A Malik 1 collaboration

Yingchuan Sun 1 collaboration

Jill Nunez 1 collaboration

Rajeshri G Karki 1 collaboration

Robert Elling 1 collaboration

John Fuller 1 collaboration

Gwynn Pardee 1 collaboration

Lucas Craig 1 collaboration

Ketthsy Capre 1 collaboration

Sarah Salas 1 collaboration

Aakruti Gorde 1 collaboration

Guiqing Liang 1 collaboration

Danuta Lubicka 1 collaboration

Stephanie M McTighe 1 collaboration

Carleton Goold 1 collaboration

Shanming Liu 1 collaboration

Lin Deng 1 collaboration

Jin Hong 1 collaboration

Alexander Fekete 1 collaboration

Pascal Stadelmann 1 collaboration

Wilfried Frieauff 1 collaboration

Azeddine Elhajouji 1 collaboration

Andreas Lerchner 1 collaboration

Branko Radetich 1 collaboration

Grazia Piizzi 1 collaboration

Doug Burdette 1 collaboration

Christopher J Wilson 1 collaboration

Stefan Peukert 1 collaboration

Lawrence G Hamann 1 collaboration

Leon O Murphy 1 collaboration

Daniel Curtis 1 collaboration

Suzanne Chau 1 collaboration

Emmanuelle Wirth 1 collaboration

Stefan Stutz 1 collaboration

Andrea Vaupel 1 collaboration

Keiichi Masuya 1 collaboration

Therese-Marie Stachyra 1 collaboration

Patrick Chene 1 collaboration

Francois Gessier 1 collaboration

Juraj Velcicky 1 collaboration

Matthias R Bauer 1 collaboration

Guillaume Lapointe 1 collaboration

Arndt Meyer 1 collaboration

Markus Vögtle 1 collaboration

Ernst Blum 1 collaboration

Estelle Ngo 1 collaboration

Catherine Rolando 1 collaboration

Sylvie Teixeira-Fouchard 1 collaboration

Hansjoerg Lehmann 1 collaboration

Frédéric Berst 1 collaboration

Jens Schümann 1 collaboration

Rowan Stringer 1 collaboration

Patrice Larger 1 collaboration

Cindy Schmid 1 collaboration

Catriona T Prendergast 1 collaboration

Simone Riek 1 collaboration

Patrick Schmutz 1 collaboration

Sylvie Lehmann 1 collaboration

Jean-Michel Rondeau 1 collaboration

Christoph Burkhart 1 collaboration

Nina Gommermann 1 collaboration

Barbara Schacher Engstler 1 collaboration

Alan Huang 1 collaboration

Huai-Xiang Hao 1 collaboration

Angela Tam 1 collaboration

Hui Qin Wang 1 collaboration

Jinsheng Liang 1 collaboration

Matthew T DiMare 1 collaboration

Hyo-Eun Carrie Bhang 1 collaboration

Ralph Tiedt 1 collaboration

Mario Centeleghe 1 collaboration

Heiko S Schadt 1 collaboration

Armin Wolf 1 collaboration

Patrizia Barzaghi-Rinaudo 1 collaboration

Masato Murakami 1 collaboration

Audrey Kauffmann 1 collaboration

Diana Graus Porta 1 collaboration

Gustavo Aguilar 1 collaboration

Roman Wille 1 collaboration

Thomas Vorherr 1 collaboration

Markus Affolter 1 collaboration

Milen Todorov 1 collaboration

Michel Niklaus 1 collaboration

Nicolas Warin 1 collaboration

Van Huy Luu 1 collaboration

Mario Madoerin 1 collaboration

Jasmin Wirth 1 collaboration

Heiko Schadt 1 collaboration

Jörg Trappe 1 collaboration

Johannes Voshol 1 collaboration

Nils Ostermann 1 collaboration

Chao Zou 1 collaboration

Alberto Del Rio Espinola 1 collaboration

Wolfgang Jahnke 1 collaboration

Cesar Fernandez 1 collaboration

Ian Lewis 1 collaboration

Sepehr Dehghani-Ghahnaviyeh 1 collaboration

Cihan Soylu 1 collaboration

Camilo Velez-Vega 1 collaboration

Emilie A Chapeau 1 collaboration

Laurent Sansregret 1 collaboration

Giorgio G Galli 1 collaboration

Thanos P Mourikis 1 collaboration

Patricia Jaaks 1 collaboration

Ines A M Barbosa 1 collaboration

Saskia M Brachmann 1 collaboration

Claire Estadieu 1 collaboration

Jason E Faris 1 collaboration

Stefanie Harlfinger 1 collaboration

Andreas Hueber 1 collaboration

Eloísa Jiménez Núñez 1 collaboration

David P Kodack 1 collaboration

Emeline Mandon 1 collaboration

Vincent Romanet 1 collaboration

Luca Tordella 1 collaboration

Jean-Marc Groell 1 collaboration

Anne-Laure Le Goff 1 collaboration

Christine Rouzet 1 collaboration

Thomas Wietlisbach 1 collaboration

Thomas Zimmermann 1 collaboration

Joseph McKenna 1 collaboration

Cara E Brocklehurst 1 collaboration

Gareth Williams 1 collaboration

Stephanie Harlfinger 1 collaboration

Martin Traebert 1 collaboration

Bérengère M Dumotier 1 collaboration