Patrick Pachl

Affiliations

JFB Institute of Zoology and Anthropology University of Göttingen Göttingen Germany.

Publications (16)

Metallacarborane Sulfamides: Unconventional, Specific, and Highly Selective Inhibitors of Carbonic Anhydrase IX.

Journal of medicinal chemistry

Avec: Bohumír Grüner , Jiří Brynda , Viswanath Das , Václav Šícha , Jana Štěpánková , Jan Nekvinda , Josef Holub , Klára Pospíšilová , Milan Fábry , Petr Pachl , Vlastimil Král , Michael Kugler , Vlastimil Mašek , Martina Medvedíková , Stanislava Matějková , Alice Nová , Barbora Lišková , Soňa Gurská , Petr Džubák , Marián Hajdúch , Pavlína Řezáčová

Crystal structure of the cold-adapted haloalkane dehalogenase DpcA from Psychrobacter cryohalolentis K5.

Acta crystallographica. Section F, Structural biology communications

Avec: Katsiaryna Tratsiak , Tatyana Prudnikova , Ivana Drienovska , Jiri Damborsky , Jiri Brynda , Petr Pachl , Michal Kuty , Radka Chaloupkova , Pavlina Rezacova , Ivana Kuta Smatanova

C1'-Branched acyclic nucleoside phosphonates mimicking adenosine monophosphate: Potent inhibitors of Trypanosoma brucei adenine phosphoribosyltransferase.

European journal of medicinal chemistry

Avec: Filip Kalčic , Jan Frydrych , Eva Doleželová , Martina Slapničková , Petr Pachl , Lenka Poštová Slavětínská , Martin Dračínský , Dana Hocková , Alena Zíková , Zlatko Janeba

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1.

Bioorganic & medicinal chemistry

Avec: Václav Zima , Carlos Berenguer Albiñana , Kateřina Rojíková , Jana Pokorná , Petr Pachl , Pavlína Řezáčová , Jason Hudlicky , Václav Navrátil , Pavel Majer , Jan Konvalinka , Milan Kožíšek , Aleš Machara

Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis.

The Journal of biological chemistry

Avec: Jodi L Brewster , Petr Pachl , James L O McKellar , Maria Selmer , Christopher J Squire , Wayne M Patrick

Rutinosidase from Aspergillus niger: crystal structure and insight into the enzymatic activity.

The FEBS journal

Avec: Petr Pachl , Jana Kapešová , Jiří Brynda , Lada Biedermannová , Helena Pelantová , Pavla Bojarová , Vladimír Křen , Pavlína Řezáčová , Michael Kotik

structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor.

Antiviral research

Avec: Jakub Hejdánek , Kateřina Radilová , Petr Pachl , Jan Hodek , Aleš Machara , Jan Weber , Pavlína Řezáčová , Jan Konvalinka , Milan Kožíšek

An evolutionary molecular adaptation of an unusual stefin from the liver fluke Fasciola hepatica redefines the cystatin superfamily.

The Journal of biological chemistry

Avec: Michal Buša , Zuzana Matoušková , Pavla Bartošová-Sojková , Petr Pachl , Pavlína Řezáčová , Ramon Marc Eichenberger , Peter Deplazes , Martin Horn , Saša Štefanić , Michael Mareš

3,5,7-Substituted Pyrazolo[4,3- d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models.

Journal of medicinal chemistry

Avec: Radek Jorda , Libor Havlíček , Antonín Šturc , Diana Tušková , Lenka Daumová , Mahmudul Alam , Jana Škerlová , Michaela Nekardová , Miroslav Peřina , Tomáš Pospíšil , Jitka Široká , Lubor Urbánek , Petr Pachl , Pavlína Řezáčová , Miroslav Strnad , Pavel Klener , Vladimír Kryštof

Imidazo[1,2-c]pyrimidin-5(6H)-one inhibitors of CDK2: Synthesis, kinase inhibition and co-crystal structure.

European journal of medicinal chemistry

Avec: Josef Jansa , Radek Jorda , Jana Škerlová , Petr Pachl , Miroslav Peřina , Eva Řezníčková , Tomáš Heger , Tomáš Gucký , Pavlína Řezáčová , Antonín Lyčka , Vladimír Kryštof

Azanitrile Inhibitors of the SmCB1 Protease Target Are Lethal to

ACS infectious diseases

Avec: Adéla Jílková , Martin Horn , Jindřich Fanfrlík , Jim Küppers , Petr Pachl , Pavlína Řezáčová , Martin Lepšík , Pavla Fajtová , Petra Rubešová , Marta Chanová , Conor R Caffrey , Michael Gütschow , Michael Mareš

A novel structurally characterized haloacid dehalogenase superfamily phosphatase from Thermococcus thioreducens with diverse substrate specificity.

Acta crystallographica. Section D, Structural biology

Avec: Petra Havlickova , Vitezslav Brinsa , Jiri Brynda , Petr Pachl , Tatyana Prudnikova , Jeroen R Mesters , Barbora Kascakova , Michal Kuty , Marc L Pusey , Joseph D Ng , Pavlina Rezacova , Ivana Kuta Smatanova

Repeated convergent evolution of parthenogenesis in Acariformes (Acari).

Ecology and evolution

Avec: Patrick Pachl , Matti Uusitalo , Stefan Scheu , Ina Schaefer , Mark Maraun

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome.

The Journal of biological chemistry

Avec: Jason K K Low , Karishma Patel , Natasha Jones , Paul Solomon , Alexander Norman , Joshua W C Maxwell , Petr Pachl , Jacqueline M Matthews , Richard J Payne , Toby Passioura , Hiroaki Suga , Louise J Walport , Joel P Mackay

Design, Synthesis, Biological Evaluation, and Crystallographic Study of Novel Purine Nucleoside Phosphorylase Inhibitors.

Journal of medicinal chemistry

Avec: Jan Skácel , Stefan Djukic , Ondřej Baszczyňski , Filip Kalčic , Tadeáš Bílek , Karel Chalupský , Jaroslav Kozák , Alexandra Dvořáková , Eva Tloušt'ová , Zuzana Král'ová , Markéta Šmídková , Jan Voldřich , Michaela Rumlová , Petr Pachl , Jiří Brynda , Tereza Vučková , Milan Fábry , Jan Snášel , Iva Pichová , Pavlína Řezáčová , Helena Mertlíková-Kaiserová , Zlatko Janeba

Structural characterization of two prototypical repressors of SorC family reveals tetrameric assemblies on DNA and mechanism of function.

Nucleic acids research

Avec: Markéta Šoltysová , Jana Škerlová , Petr Pachl , Karel Škubník , Milan Fábry , Irena Sieglová , Martina Farolfi , Irina Grishkovskaya , Michal Babiak , Jiří Nováček , Libor Krásný , Pavlína Řezáčová

Réseau de co-auteurs

Petr Pachl 15 collaborations

Pavlína Řezáčová 10 collaborations

Jiří Brynda 3 collaborations

Milan Fábry 3 collaborations

Jana Škerlová 3 collaborations

Tatyana Prudnikova 2 collaborations

Jiri Brynda 2 collaborations

Michal Kuty 2 collaborations

Pavlina Rezacova 2 collaborations

Ivana Kuta Smatanova 2 collaborations

Filip Kalčic 2 collaborations

Zlatko Janeba 2 collaborations

Jan Konvalinka 2 collaborations

Milan Kožíšek 2 collaborations

Aleš Machara 2 collaborations

Martin Horn 2 collaborations

Michael Mareš 2 collaborations

Radek Jorda 2 collaborations

Miroslav Peřina 2 collaborations

Vladimír Kryštof 2 collaborations

Bohumír Grüner 1 collaboration

Viswanath Das 1 collaboration

Václav Šícha 1 collaboration

Jana Štěpánková 1 collaboration

Jan Nekvinda 1 collaboration

Josef Holub 1 collaboration

Klára Pospíšilová 1 collaboration

Vlastimil Král 1 collaboration

Michael Kugler 1 collaboration

Vlastimil Mašek 1 collaboration

Martina Medvedíková 1 collaboration

Stanislava Matějková 1 collaboration

Alice Nová 1 collaboration

Barbora Lišková 1 collaboration

Soňa Gurská 1 collaboration

Petr Džubák 1 collaboration

Marián Hajdúch 1 collaboration

Katsiaryna Tratsiak 1 collaboration

Ivana Drienovska 1 collaboration

Jiri Damborsky 1 collaboration

Radka Chaloupkova 1 collaboration

Jan Frydrych 1 collaboration

Eva Doleželová 1 collaboration

Martina Slapničková 1 collaboration

Lenka Poštová Slavětínská 1 collaboration

Martin Dračínský 1 collaboration

Dana Hocková 1 collaboration

Alena Zíková 1 collaboration

Václav Zima 1 collaboration

Carlos Berenguer Albiñana 1 collaboration

Kateřina Rojíková 1 collaboration

Jana Pokorná 1 collaboration

Jason Hudlicky 1 collaboration

Václav Navrátil 1 collaboration

Pavel Majer 1 collaboration

Jodi L Brewster 1 collaboration

James L O McKellar 1 collaboration

Maria Selmer 1 collaboration

Christopher J Squire 1 collaboration

Wayne M Patrick 1 collaboration

Jana Kapešová 1 collaboration

Lada Biedermannová 1 collaboration

Helena Pelantová 1 collaboration

Pavla Bojarová 1 collaboration

Vladimír Křen 1 collaboration

Michael Kotik 1 collaboration

Jakub Hejdánek 1 collaboration

Kateřina Radilová 1 collaboration

Jan Hodek 1 collaboration

Jan Weber 1 collaboration

Michal Buša 1 collaboration

Zuzana Matoušková 1 collaboration

Pavla Bartošová-Sojková 1 collaboration

Ramon Marc Eichenberger 1 collaboration

Peter Deplazes 1 collaboration

Saša Štefanić 1 collaboration

Libor Havlíček 1 collaboration

Antonín Šturc 1 collaboration

Diana Tušková 1 collaboration

Lenka Daumová 1 collaboration

Mahmudul Alam 1 collaboration

Michaela Nekardová 1 collaboration

Tomáš Pospíšil 1 collaboration

Jitka Široká 1 collaboration

Lubor Urbánek 1 collaboration

Miroslav Strnad 1 collaboration

Pavel Klener 1 collaboration

Josef Jansa 1 collaboration

Eva Řezníčková 1 collaboration

Tomáš Heger 1 collaboration

Tomáš Gucký 1 collaboration

Antonín Lyčka 1 collaboration

Adéla Jílková 1 collaboration

Jindřich Fanfrlík 1 collaboration

Jim Küppers 1 collaboration

Martin Lepšík 1 collaboration

Pavla Fajtová 1 collaboration

Petra Rubešová 1 collaboration

Marta Chanová 1 collaboration

Conor R Caffrey 1 collaboration

Michael Gütschow 1 collaboration

Petra Havlickova 1 collaboration

Vitezslav Brinsa 1 collaboration

Jeroen R Mesters 1 collaboration

Barbora Kascakova 1 collaboration

Marc L Pusey 1 collaboration

Joseph D Ng 1 collaboration

Matti Uusitalo 1 collaboration

Stefan Scheu 1 collaboration

Ina Schaefer 1 collaboration

Mark Maraun 1 collaboration

Jason K K Low 1 collaboration

Karishma Patel 1 collaboration

Natasha Jones 1 collaboration

Paul Solomon 1 collaboration

Alexander Norman 1 collaboration

Joshua W C Maxwell 1 collaboration

Jacqueline M Matthews 1 collaboration

Richard J Payne 1 collaboration

Toby Passioura 1 collaboration

Hiroaki Suga 1 collaboration

Louise J Walport 1 collaboration

Joel P Mackay 1 collaboration

Jan Skácel 1 collaboration

Stefan Djukic 1 collaboration

Ondřej Baszczyňski 1 collaboration

Tadeáš Bílek 1 collaboration

Karel Chalupský 1 collaboration

Jaroslav Kozák 1 collaboration

Alexandra Dvořáková 1 collaboration

Eva Tloušt'ová 1 collaboration

Zuzana Král'ová 1 collaboration

Markéta Šmídková 1 collaboration

Jan Voldřich 1 collaboration

Michaela Rumlová 1 collaboration

Tereza Vučková 1 collaboration

Jan Snášel 1 collaboration

Iva Pichová 1 collaboration

Helena Mertlíková-Kaiserová 1 collaboration

Markéta Šoltysová 1 collaboration

Karel Škubník 1 collaboration

Irena Sieglová 1 collaboration

Martina Farolfi 1 collaboration

Irina Grishkovskaya 1 collaboration

Michal Babiak 1 collaboration

Jiří Nováček 1 collaboration

Libor Krásný 1 collaboration