Pavel Bashtrykov

Affiliations

Department of Biochemistry, Institute of Biochemistry and Technical Biochemistry, University of Stuttgart, 70569, Stuttgart, Germany.

Publications (30)

Methylation of recombinant mononucleosomes by DNMT3A demonstrates efficient linker DNA methylation and a role of H3K36me3.

Communications biology

Avec: Alexander Bröhm , Tabea Schoch , Michael Dukatz , Nora Graf , Franziska Dorscht , Evelin Mantai , Sabrina Adam , Pavel Bashtrykov , Albert Jeltsch

Mutations of R882 change flanking sequence preferences of the DNA methyltransferase DNMT3A and cellular methylation patterns.

Nucleic acids research

Avec: Max Emperle , Sabrina Adam , Stefan Kunert , Michael Dukatz , Annika Baude , Christoph Plass , Philipp Rathert , Pavel Bashtrykov , Albert Jeltsch

Comprehensive structure-function characterization of DNMT3B and DNMT3A reveals distinctive de novo DNA methylation mechanisms.

Nature communications

Avec: Linfeng Gao , Max Emperle , Yiran Guo , Sara A Grimm , Wendan Ren , Sabrina Adam , Hidetaka Uryu , Zhi-Min Zhang , Dongliang Chen , Jiekai Yin , Michael Dukatz , Hiwot Anteneh , Renata Z Jurkowska , Jiuwei Lu , Yinsheng Wang , Pavel Bashtrykov , Paul A Wade , Gang Greg Wang , Albert Jeltsch , Jikui Song

Flanking sequences influence the activity of TET1 and TET2 methylcytosine dioxygenases and affect genomic 5hmC patterns.

Communications biology

Avec: Sabrina Adam , Julia Bräcker , Viviane Klingel , Bernd Osteresch , Nicole E Radde , Jens Brockmeyer , Pavel Bashtrykov , Albert Jeltsch

On the accuracy of the epigenetic copy machine: comprehensive specificity analysis of the DNMT1 DNA methyltransferase.

Nucleic acids research

Avec: Sabrina Adam , Viviane Klingel , Nicole E Radde , Pavel Bashtrykov , Albert Jeltsch

Targeting oncogenic TERT promoter variants by allele-specific epigenome editing.

Clinical epigenetics

Avec: Alexandra G Kouroukli , Nivethika Rajaram , Pavel Bashtrykov , Helene Kretzmer , Reiner Siebert , Albert Jeltsch , Susanne Bens

Molecular Processes Connecting DNA Methylation Patterns with DNA Methyltransferases and Histone Modifications in Mammalian Genomes.

Genes

Avec: Albert Jeltsch , Julian Broche , Pavel Bashtrykov

Genome-wide investigation of the dynamic changes of epigenome modifications after global DNA methylation editing.

Nucleic acids research

Avec: Julian Broche , Goran Kungulovski , Pavel Bashtrykov , Philipp Rathert , Albert Jeltsch

Preferential Self-interaction of DNA Methyltransferase DNMT3A Subunits Containing the R882H Cancer Mutation Leads to Dominant Changes of Flanking Sequence Preferences.

Journal of molecular biology

Avec: Alexandra Mack , Max Emperle , Philipp Schnee , Sabrina Adam , Jürgen Pleiss , Pavel Bashtrykov , Albert Jeltsch

DNA methyltransferase DNMT3A forms interaction networks with the CpG site and flanking sequence elements for efficient methylation.

The Journal of biological chemistry

Avec: Michael Dukatz , Marianna Dittrich , Elias Stahl , Sabrina Adam , Alex de Mendoza , Pavel Bashtrykov , Albert Jeltsch

Refined read-out: The hUHRF1 Tandem-Tudor domain prefers binding to histone H3 tails containing K4me1 in the context of H3K9me2/3.

Protein science : a publication of the Protein Society

Avec: Michel Choudalakis , Goran Kungulovski , Rebekka Mauser , Pavel Bashtrykov , Albert Jeltsch

Amplicon-Based Bisulfite Conversion-NGS DNA Methylation Analysis Protocol.

Methods in molecular biology (Clifton, N.J.)

Avec: Claudia Albrecht , Pavel Bashtrykov , Albert Jeltsch

Allele-specific DNA demethylation editing leads to stable upregulation of allele-specific gene expression.

iScience

Avec: Nivethika Rajaram , Katharina Benzler , Pavel Bashtrykov , Albert Jeltsch

Engineering of Effector Domains for Targeted DNA Methylation with Reduced Off-Target Effects.

International journal of molecular sciences

Avec: Daniel Hofacker , Julian Broche , Laura Laistner , Sabrina Adam , Pavel Bashtrykov , Albert Jeltsch

H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction.

Journal of molecular biology

Avec: Michael Dukatz , Katharina Holzer , Michel Choudalakis , Max Emperle , Cristiana Lungu , Pavel Bashtrykov , Albert Jeltsch

Biotechnological Applications of MBD Domain Proteins for DNA Methylation Analysis.

Journal of molecular biology

Avec: Albert Jeltsch , Julian Broche , Cristiana Lungu , Pavel Bashtrykov

The T1150A cancer mutant of the protein lysine dimethyltransferase NSD2 can introduce H3K36 trimethylation.

The Journal of biological chemistry

Avec: Mina S Khella , Philipp Schnee , Sara Weirich , Tan Bui , Alexander Bröhm , Pavel Bashtrykov , Jürgen Pleiss , Albert Jeltsch

Locus-Specific and Stable DNA Demethylation at the

Genes

Avec: Claudia Albrecht , Nivethika Rajaram , Julian Broche , Pavel Bashtrykov , Albert Jeltsch

Repeat DNA methylation is modulated by adherens junction signaling.

Communications biology

Avec: Lisa-Marie Brenner , Florian Meyer , Haiqian Yang , Anja R Köhler , Pavel Bashtrykov , Ming Guo , Albert Jeltsch , Cristiana Lungu , Monilola A Olayioye

RepEnTools: an automated repeat enrichment analysis package for ChIP-seq data reveals hUHRF1 Tandem-Tudor domain enrichment in young repeats.

Mobile DNA

Avec: Michel Choudalakis , Pavel Bashtrykov , Albert Jeltsch

Specific DNMT3C flanking sequence preferences facilitate methylation of young murine retrotransposons.

Communications biology

Avec: Leonie Dossmann , Max Emperle , Michael Dukatz , Alex de Mendoza , Pavel Bashtrykov , Albert Jeltsch

DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation.

Nature communications

Avec: Sabrina Adam , Hiwot Anteneh , Maximilian Hornisch , Vincent Wagner , Jiuwei Lu , Nicole E Radde , Pavel Bashtrykov , Jikui Song , Albert Jeltsch

Structural and biochemical insight into the mechanism of dual CpG site binding and methylation by the DNMT3A DNA methyltransferase.

Nucleic acids research

Avec: Max Emperle , Disha M Bangalore , Sabrina Adam , Stefan Kunert , Hannah S Heil , Katrin G Heinze , Pavel Bashtrykov , Ingrid Tessmer , Albert Jeltsch

Deep Enzymology Studies on DNA Methyltransferases Reveal Novel Connections between Flanking Sequences and Enzyme Activity.

Journal of molecular biology

Avec: Albert Jeltsch , Sabrina Adam , Michael Dukatz , Max Emperle , Pavel Bashtrykov

Complex DNA sequence readout mechanisms of the DNMT3B DNA methyltransferase.

Nucleic acids research

Avec: Michael Dukatz , Sabrina Adam , Mahamaya Biswal , Jikui Song , Pavel Bashtrykov , Albert Jeltsch

Modular dual-color BiAD sensors for locus-specific readout of epigenome modifications in single cells.

Cell reports methods

Avec: Anja R Köhler , Johannes Haußer , Annika Harsch , Steffen Bernhardt , Lilia Häußermann , Lisa-Marie Brenner , Cristiana Lungu , Monilola A Olayioye , Pavel Bashtrykov , Albert Jeltsch

Non-canonical functions of UHRF1 maintain DNA methylation homeostasis in cancer cells.

Nature communications

Avec: Kosuke Yamaguchi , Xiaoying Chen , Brianna Rodgers , Fumihito Miura , Pavel Bashtrykov , Frédéric Bonhomme , Catalina Salinas-Luypaert , Deis Haxholli , Nicole Gutekunst , Bihter Özdemir Aygenli , Laure Ferry , Olivier Kirsh , Marthe Laisné , Andrea Scelfo , Enes Ugur , Paola B Arimondo , Heinrich Leonhardt , Masato T Kanemaki , Till Bartke , Daniele Fachinetti , Albert Jeltsch , Takashi Ito , Pierre-Antoine Defossez

Efficient Targeted DNA Methylation with dCas9-Coupled DNMT3A-DNMT3L Methyltransferase.

Methods in molecular biology (Clifton, N.J.)

Avec: Pavel Bashtrykov , Nivethika Rajaram , Albert Jeltsch

Development of super-specific epigenome editing by targeted allele-specific DNA methylation.

Epigenetics & chromatin

Avec: Nivethika Rajaram , Alexandra G Kouroukli , Susanne Bens , Pavel Bashtrykov , Albert Jeltsch

Protocol for Allele-Specific Epigenome Editing Using CRISPR/dCas9.

Methods in molecular biology (Clifton, N.J.)

Avec: Nivethika Rajaram , Pavel Bashtrykov , Albert Jeltsch

Réseau de co-auteurs

Albert Jeltsch 30 collaborations

Sabrina Adam 12 collaborations

Michael Dukatz 8 collaborations

Max Emperle 7 collaborations

Nivethika Rajaram 6 collaborations

Julian Broche 5 collaborations

Cristiana Lungu 4 collaborations

Jikui Song 3 collaborations

Nicole E Radde 3 collaborations

Michel Choudalakis 3 collaborations

Alexander Bröhm 2 collaborations

Stefan Kunert 2 collaborations

Philipp Rathert 2 collaborations

Hiwot Anteneh 2 collaborations

Jiuwei Lu 2 collaborations

Viviane Klingel 2 collaborations

Alexandra G Kouroukli 2 collaborations

Susanne Bens 2 collaborations

Goran Kungulovski 2 collaborations

Philipp Schnee 2 collaborations

Jürgen Pleiss 2 collaborations

Alex de Mendoza 2 collaborations

Claudia Albrecht 2 collaborations

Lisa-Marie Brenner 2 collaborations

Anja R Köhler 2 collaborations

Monilola A Olayioye 2 collaborations

Tabea Schoch 1 collaboration

Nora Graf 1 collaboration

Franziska Dorscht 1 collaboration

Evelin Mantai 1 collaboration

Annika Baude 1 collaboration

Christoph Plass 1 collaboration

Linfeng Gao 1 collaboration

Yiran Guo 1 collaboration

Sara A Grimm 1 collaboration

Wendan Ren 1 collaboration

Hidetaka Uryu 1 collaboration

Zhi-Min Zhang 1 collaboration

Dongliang Chen 1 collaboration

Jiekai Yin 1 collaboration

Renata Z Jurkowska 1 collaboration

Yinsheng Wang 1 collaboration

Paul A Wade 1 collaboration

Gang Greg Wang 1 collaboration

Julia Bräcker 1 collaboration

Bernd Osteresch 1 collaboration

Jens Brockmeyer 1 collaboration

Helene Kretzmer 1 collaboration

Reiner Siebert 1 collaboration

Alexandra Mack 1 collaboration

Marianna Dittrich 1 collaboration

Elias Stahl 1 collaboration

Rebekka Mauser 1 collaboration

Katharina Benzler 1 collaboration

Daniel Hofacker 1 collaboration

Laura Laistner 1 collaboration

Katharina Holzer 1 collaboration

Mina S Khella 1 collaboration

Sara Weirich 1 collaboration

Tan Bui 1 collaboration

Florian Meyer 1 collaboration

Haiqian Yang 1 collaboration

Ming Guo 1 collaboration

Leonie Dossmann 1 collaboration

Maximilian Hornisch 1 collaboration

Vincent Wagner 1 collaboration

Disha M Bangalore 1 collaboration

Hannah S Heil 1 collaboration

Katrin G Heinze 1 collaboration

Ingrid Tessmer 1 collaboration

Mahamaya Biswal 1 collaboration

Johannes Haußer 1 collaboration

Annika Harsch 1 collaboration

Steffen Bernhardt 1 collaboration

Lilia Häußermann 1 collaboration

Kosuke Yamaguchi 1 collaboration

Xiaoying Chen 1 collaboration

Brianna Rodgers 1 collaboration

Fumihito Miura 1 collaboration

Frédéric Bonhomme 1 collaboration

Catalina Salinas-Luypaert 1 collaboration

Deis Haxholli 1 collaboration

Nicole Gutekunst 1 collaboration

Bihter Özdemir Aygenli 1 collaboration

Laure Ferry 1 collaboration

Olivier Kirsh 1 collaboration

Marthe Laisné 1 collaboration

Andrea Scelfo 1 collaboration

Enes Ugur 1 collaboration

Paola B Arimondo 1 collaboration

Heinrich Leonhardt 1 collaboration

Masato T Kanemaki 1 collaboration

Till Bartke 1 collaboration

Daniele Fachinetti 1 collaboration

Takashi Ito 1 collaboration

Pierre-Antoine Defossez 1 collaboration