Pradeep D Uchil

Publications (40)

Electroporation.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Calcium Phosphate-Mediated Transfection of Cells with High-Molecular-Weight Genomic DNA.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Histochemical Staining of Cell Monolayers for β-Galactosidase.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Structural Basis and Mode of Action for Two Broadly Neutralizing Antibodies Against SARS-CoV-2 Emerging Variants of Concern.

bioRxiv : the preprint server for biology

Avec: Wenwei Li , Yaozong Chen , Jérémie Prévost , Irfan Ullah , Maolin Lu , Shang Yu Gong , Alexandra Tauzin , Romain Gasser , Dani Vézina , Sai Priya Anand , Guillaume Goyette , Debashree Chaterjee , Shilei Ding , William D Tolbert , Michael W Grunst , Yuxia Bo , Shijian Zhang , Jonathan Richard , Fei Zhou , Rick K Huang , Lothar Esser , Allison Zeher , Marceline Côté , Priti Kumar , Joseph Sodroski , Di Xia , Pradeep D Uchil , Marzena Pazgier , Andrés Finzi , Walther Mothes

HIV-1 Env trimers asymmetrically engage CD4 receptors in membranes.

Nature

Avec: Wenwei Li , Zhuan Qin , Elizabeth Nand , Michael W Grunst , Jonathan R Grover , Julian W Bess , Jeffrey D Lifson , Michael B Zwick , Hemant D Tagare , Pradeep D Uchil , Walther Mothes

Calcium Phosphate-Mediated Transfection of Eukaryotic Cells with Plasmid DNAs.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Transfection of Mammalian Cells with Calcium Phosphate-DNA Coprecipitates.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

VE607 stabilizes SARS-CoV-2 Spike in the "RBD-up" conformation and inhibits viral entry.

iScience

Avec: Shilei Ding , Irfan Ullah , Shang Yu Gong , Jonathan R Grover , Mohammadjavad Mohammadi , Yaozong Chen , Dani Vézina , Guillaume Beaudoin-Bussières , Vijay Tailor Verma , Guillaume Goyette , Fleur Gaudette , Jonathan Richard , Derek Yang , Amos B Smith , Marzena Pazgier , Marceline Côté , Cameron Abrams , Priti Kumar , Walther Mothes , Pradeep D Uchil , Andrés Finzi , Christian Baron

Fc effector cross-reactivity: A hidden arsenal against SARS-CoV-2's evasive maneuvering.

Cell reports. Medicine

Avec: Michael W Grunst , Pradeep D Uchil

Bioluminescence imaging reveals enhanced SARS-CoV-2 clearance in mice with combinatorial regimens.

iScience

Avec: Irfan Ullah , Fanny Escudie , Ivan Scandale , Zoela Gilani , Gabrielle Gendron-Lepage , Fleur Gaudette , Charles Mowbray , Laurent Fraisse , Renée Bazin , Andrés Finzi , Walther Mothes , Priti Kumar , Eric Chatelain , Pradeep D Uchil

Combinatorial Regimens Augment Drug Monotherapy for SARS-CoV-2 Clearance in Mice.

bioRxiv : the preprint server for biology

Longitudinal bioluminescent imaging of HIV-1 infection during antiretroviral therapy and treatment interruption in humanized mice.

PLoS pathogens

Avec: John D Ventura , Jagadish Beloor , Edward Allen , Tongyu Zhang , Kelsey A Haugh , Pradeep D Uchil , Christina Ochsenbauer , Collin Kieffer , Priti Kumar , Thomas J Hope , Walther Mothes

Introducing Genes into Cultured Mammalian Cells.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

DNA Transfection by Electroporation.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Lipofection.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

A Protective Role for the Lectin CD169/Siglec-1 against a Pathogenic Murine Retrovirus.

Cell host & microbe

Avec: Pradeep D Uchil , Ruoxi Pi , Kelsey A Haugh , Mark S Ladinsky , John D Ventura , Brad S Barrett , Mario L Santiago , Pamela J Bjorkman , George Kassiotis , Xaver Sewald , Walther Mothes

Structural basis and mode of action for two broadly neutralizing antibodies against SARS-CoV-2 emerging variants of concern.

Cell reports

A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection.

Cell reports

Avec: Guillaume Beaudoin-Bussières , Yaozong Chen , Irfan Ullah , Jérémie Prévost , William D Tolbert , Kelly Symmes , Shilei Ding , Mehdi Benlarbi , Shang Yu Gong , Alexandra Tauzin , Romain Gasser , Debashree Chatterjee , Dani Vézina , Guillaume Goyette , Jonathan Richard , Fei Zhou , Leonidas Stamatatos , Andrew T McGuire , Hughes Charest , Michel Roger , Edwin Pozharski , Priti Kumar , Walther Mothes , Pradeep D Uchil , Marzena Pazgier , Andrés Finzi

The Fc-effector function of COVID-19 convalescent plasma contributes to SARS-CoV-2 treatment efficacy in mice.

Cell reports. Medicine

Avec: Irfan Ullah , Guillaume Beaudoin-Bussières , Kelly Symmes , Marc Cloutier , Eric Ducas , Alexandra Tauzin , Annemarie Laumaea , Michael W Grunst , Katrina Dionne , Jonathan Richard , Philippe Bégin , Walther Mothes , Priti Kumar , Renée Bazin , Andrés Finzi , Pradeep D Uchil

Proof-of-concept studies with a computationally designed M

Proceedings of the National Academy of Sciences of the United States of America

Avec: Christina Papini , Irfan Ullah , Amalendu P Ranjan , Shuo Zhang , Qihao Wu , Krasimir A Spasov , Chunhui Zhang , Walther Mothes , Jason M Crawford , Brett D Lindenbach , Pradeep D Uchil , Priti Kumar , William L Jorgensen , Karen S Anderson

Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues.

bioRxiv : the preprint server for biology

Avec: Mark S Ladinsky , Li Zhu , Irfan Ullah , Pradeep D Uchil , Priti Kumar , Michael S Kay , Pamela J Bjorkman

Electron tomography visualization of HIV-1 virions trapped by fusion inhibitors to host cells in infected tissues.

Journal of virology

Avec: Mark S Ladinsky , Li Zhu , Irfan Ullah , Pradeep D Uchil , Priti Kumar , Michael S Kay , Pamela J Bjorkman

Calcium Phosphate-Mediated Transfection of Adherent Cells or Cells Growing in Suspension: Variations on the Basic Method.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

DNA Transfection Mediated by Cationic Lipid Reagents.

Cold Spring Harbor protocols

Avec: Priti Kumar , Arvindhan Nagarajan , Pradeep D Uchil

Live Imaging of SARS-CoV-2 Infection in Mice Reveals Neutralizing Antibodies Require Fc Function for Optimal Efficacy.

bioRxiv : the preprint server for biology

Avec: Irfan Ullah , Jérémie Prévost , Mark S Ladinsky , Helen Stone , Maolin Lu , Sai Priya Anand , Guillaume Beaudoin-Bussières , Kelly Symmes , Mehdi Benlarbi , Shilei Ding , Romain Gasser , Corby Fink , Yaozong Chen , Alexandra Tauzin , Guillaume Goyette , Catherine Bourassa , Halima Medjahed , Matthias Mack , Kunho Chung , Craig B Wilen , Gregory A Dekaban , Jimmy D Dikeakos , Emily A Bruce , Daniel E Kaufmann , Leonidas Stamatatos , Andrew T McGuire , Jonathan Richard , Marzena Pazgier , Pamela J Bjorkman , Walther Mothes , Andrés Finzi , Priti Kumar , Pradeep D Uchil

Real-time conformational dynamics of SARS-CoV-2 spikes on virus particles.

bioRxiv : the preprint server for biology

Avec: Maolin Lu , Pradeep D Uchil , Wenwei Li , Desheng Zheng , Daniel S Terry , Jason Gorman , Wei Shi , Baoshan Zhang , Tongqing Zhou , Shilei Ding , Romain Gasser , Jeremie Prevost , Guillaume Beaudoin-Bussieres , Sai Priya Anand , Annemarie Laumaea , Jonathan R Grover , Liu Lihong , David D Ho , John Mascola , Andres Finzi , Peter D Kwong , Scott C Blanchard , Walther Mothes

Molecular basis for antiviral activity of two pediatric neutralizing antibodies targeting SARS-CoV-2 Spike RBD.

iScience

Avec: Yaozong Chen , Jérémie Prévost , Irfan Ullah , Hugo Romero , Veronique Lisi , William D Tolbert , Jonathan R Grover , Shilei Ding , Shang Yu Gong , Guillaume Beaudoin-Bussières , Romain Gasser , Mehdi Benlarbi , Dani Vézina , Sai Priya Anand , Debashree Chatterjee , Guillaume Goyette , Michael W Grunst , Ziwei Yang , Yuxia Bo , Fei Zhou , Kathie Béland , Xiaoyun Bai , Allison R Zeher , Rick K Huang , Dung N Nguyen , Rebekah Sherburn , Di Wu , Grzegorz Piszczek , Bastien Paré , Doreen Matthies , Di Xia , Jonathan Richard , Priti Kumar , Walther Mothes , Marceline Côté , Pradeep D Uchil , Vincent-Philippe Lavallée , Martin A Smith , Marzena Pazgier , Elie Haddad , Andrés Finzi

Vaccinia Virus Strain MVA Expressing a Prefusion-Stabilized SARS-CoV-2 Spike Glycoprotein Induces Robust Protection and Prevents Brain Infection in Mouse and Hamster Models.

Vaccines

Avec: María M Lorenzo , Alejandro Marín-López , Kevin Chiem , Luis Jimenez-Cabello , Irfan Ullah , Sergio Utrilla-Trigo , Eva Calvo-Pinilla , Gema Lorenzo , Sandra Moreno , Chengjin Ye , Jun-Gyu Park , Alejandro Matía , Alejandro Brun , Juana M Sánchez-Puig , Aitor Nogales , Walther Mothes , Pradeep D Uchil , Priti Kumar , Javier Ortego , Erol Fikrig , Luis Martinez-Sobrido , Rafael Blasco

Immunogenicity and pre-clinical efficacy of an OMV-based SARS-CoV-2 vaccine.

Research square

Avec: Alberto Grandi , Michele Tomasi , Irfan Ullah , Cinzia Bertelli , Teresa Vanzo , Silvia Accordini , Assunta Gagliardi , Ilaria Zanella , Mattia Benedet , Riccardo Corbellari , Gabriele Di Lascio , Silvia Tamburini , Elena Caproni , Lorenzo Croia , Micol Ravà , Valeria Fumagalli , Pietro Di Lucia , Davide Marotta , Eleonora Sala , Matteo Iannacone , Priti Kumar , Walther Mothes , Pradeep D Uchil , Peter Cherepanov , Martino Bolognesi , Massimo Pizzato , Guido Grandi

Beta Spike-Presenting SARS-CoV-2 Virus-like Particle Vaccine Confers Broad Protection against Other VOCs in Mice.

Vaccines

Avec: Irfan Ullah , Kelly Symmes , Kadiatou Keita , Li Zhu , Michael W Grunst , Wenwei Li , Walther Mothes , Priti Kumar , Pradeep D Uchil

Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.

Journal of virology

Avec: Ruoxi Pi , Akiko Iwasaki , Xaver Sewald , Walther Mothes , Pradeep D Uchil

In Vivo Imaging-Driven Approaches to Study Virus Dissemination and Pathogenesis.

Annual review of virology

Avec: Pradeep D Uchil , Kelsey A Haugh , Ruoxi Pi , Walther Mothes

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.

bioRxiv : the preprint server for biology

Avec: Yaozong Chen , Lulu Sun , Irfan Ullah , Guillaume Beaudoin-Bussières , Sai Priya Anand , Andrew P Hederman , William D Tolbert , Rebekah Sherburn , Dung N Nguyen , Lorie Marchitto , Shilei Ding , Di Wu , Yuhong Luo , Suneetha Gottumukkala , Sean Moran , Priti Kumar , Grzegorz Piszczek , Walther Mothes , Margaret E Ackerman , Andrés Finzi , Pradeep D Uchil , Frank J Gonzalez , Marzena Pazgier

Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles.

Cell host & microbe

Avec: Maolin Lu , Pradeep D Uchil , Wenwei Li , Desheng Zheng , Daniel S Terry , Jason Gorman , Wei Shi , Baoshan Zhang , Tongqing Zhou , Shilei Ding , Romain Gasser , Jérémie Prévost , Guillaume Beaudoin-Bussières , Sai Priya Anand , Annemarie Laumaea , Jonathan R Grover , Lihong Liu , David D Ho , John R Mascola , Andrés Finzi , Peter D Kwong , Scott C Blanchard , Walther Mothes

Live imaging of SARS-CoV-2 infection in mice reveals that neutralizing antibodies require Fc function for optimal efficacy.

Immunity

In vivo imaging of retrovirus infection reveals a role for Siglec-1/CD169 in multiple routes of transmission.

eLife

Avec: Kelsey A Haugh , Mark S Ladinsky , Irfan Ullah , Helen M Stone , Ruoxi Pi , Alexandre Gilardet , Michael W Grunst , Priti Kumar , Pamela J Bjorkman , Walther Mothes , Pradeep D Uchil

Engineered ACE2-Fc counters murine lethal SARS-CoV-2 infection through direct neutralization and Fc-effector activities.

Science advances

PLSCR1 is a cell-autonomous defence factor against SARS-CoV-2 infection.

Nature

Avec: Dijin Xu , Weiqian Jiang , Lizhen Wu , Ryan G Gaudet , Eui-Soon Park , Maohan Su , Sudheer Kumar Cheppali , Nagarjuna R Cheemarla , Pradeep Kumar , Pradeep D Uchil , Jonathan R Grover , Ellen F Foxman , Chelsea M Brown , Phillip J Stansfeld , Joerg Bewersdorf , Walther Mothes , Erdem Karatekin , Craig B Wilen , John D MacMicking

Antiviral HIV-1 SERINC restriction factors disrupt virus membrane asymmetry.

Nature communications

Avec: Susan A Leonhardt , Michael D Purdy , Jonathan R Grover , Ziwei Yang , Sandra Poulos , William E McIntire , Elizabeth A Tatham , Satchal K Erramilli , Kamil Nosol , Kin Kui Lai , Shilei Ding , Maolin Lu , Pradeep D Uchil , Andrés Finzi , Alan Rein , Anthony A Kossiakoff , Walther Mothes , Mark Yeager

Immunogenicity and Pre-Clinical Efficacy of an OMV-Based SARS-CoV-2 Vaccine.

Vaccines

Réseau de co-auteurs

Priti Kumar 31 collaborations

Walther Mothes 27 collaborations

Irfan Ullah 20 collaborations

Andrés Finzi 14 collaborations

Shilei Ding 12 collaborations

Arvindhan Nagarajan 10 collaborations

Yaozong Chen 9 collaborations

Sai Priya Anand 9 collaborations

Marzena Pazgier 9 collaborations

Guillaume Beaudoin-Bussières 9 collaborations

Romain Gasser 8 collaborations

Michael W Grunst 8 collaborations

Jonathan Richard 8 collaborations

Jérémie Prévost 7 collaborations

Maolin Lu 7 collaborations

Guillaume Goyette 7 collaborations

Jonathan R Grover 7 collaborations

Wenwei Li 6 collaborations

Alexandra Tauzin 6 collaborations

William D Tolbert 6 collaborations

Mark S Ladinsky 6 collaborations

Pamela J Bjorkman 6 collaborations

Shang Yu Gong 5 collaborations

Dani Vézina 5 collaborations

Kelly Symmes 5 collaborations

Fei Zhou 4 collaborations

Marceline Côté 4 collaborations

Kelsey A Haugh 4 collaborations

Ruoxi Pi 4 collaborations

Mehdi Benlarbi 4 collaborations

Yuxia Bo 3 collaborations

Rick K Huang 3 collaborations

Di Xia 3 collaborations

Fleur Gaudette 3 collaborations

Renée Bazin 3 collaborations

Leonidas Stamatatos 3 collaborations

Andrew T McGuire 3 collaborations

Annemarie Laumaea 3 collaborations

Li Zhu 3 collaborations

Craig B Wilen 3 collaborations

Dung N Nguyen 3 collaborations

Rebekah Sherburn 3 collaborations

Di Wu 3 collaborations

Grzegorz Piszczek 3 collaborations

Debashree Chaterjee 2 collaborations

Shijian Zhang 2 collaborations

Lothar Esser 2 collaborations

Allison Zeher 2 collaborations

Joseph Sodroski 2 collaborations

Fanny Escudie 2 collaborations

Ivan Scandale 2 collaborations

Zoela Gilani 2 collaborations

Gabrielle Gendron-Lepage 2 collaborations

Charles Mowbray 2 collaborations

Laurent Fraisse 2 collaborations

Eric Chatelain 2 collaborations

John D Ventura 2 collaborations

Xaver Sewald 2 collaborations

Debashree Chatterjee 2 collaborations

Michael S Kay 2 collaborations

Helen Stone 2 collaborations

Corby Fink 2 collaborations

Catherine Bourassa 2 collaborations

Halima Medjahed 2 collaborations

Matthias Mack 2 collaborations

Kunho Chung 2 collaborations

Gregory A Dekaban 2 collaborations

Jimmy D Dikeakos 2 collaborations

Emily A Bruce 2 collaborations

Daniel E Kaufmann 2 collaborations

Desheng Zheng 2 collaborations

Daniel S Terry 2 collaborations

Jason Gorman 2 collaborations

Wei Shi 2 collaborations

Baoshan Zhang 2 collaborations

Tongqing Zhou 2 collaborations

David D Ho 2 collaborations

Peter D Kwong 2 collaborations

Scott C Blanchard 2 collaborations

Ziwei Yang 2 collaborations

Alberto Grandi 2 collaborations

Michele Tomasi 2 collaborations

Cinzia Bertelli 2 collaborations

Teresa Vanzo 2 collaborations

Silvia Accordini 2 collaborations

Assunta Gagliardi 2 collaborations

Ilaria Zanella 2 collaborations

Mattia Benedet 2 collaborations

Riccardo Corbellari 2 collaborations

Gabriele Di Lascio 2 collaborations

Silvia Tamburini 2 collaborations

Elena Caproni 2 collaborations

Lorenzo Croia 2 collaborations

Micol Ravà 2 collaborations

Valeria Fumagalli 2 collaborations

Pietro Di Lucia 2 collaborations

Davide Marotta 2 collaborations

Eleonora Sala 2 collaborations

Matteo Iannacone 2 collaborations

Peter Cherepanov 2 collaborations

Martino Bolognesi 2 collaborations

Massimo Pizzato 2 collaborations

Guido Grandi 2 collaborations

Lulu Sun 2 collaborations

Andrew P Hederman 2 collaborations

Lorie Marchitto 2 collaborations

Yuhong Luo 2 collaborations

Suneetha Gottumukkala 2 collaborations

Sean Moran 2 collaborations

Margaret E Ackerman 2 collaborations

Frank J Gonzalez 2 collaborations

Zhuan Qin 1 collaboration

Elizabeth Nand 1 collaboration

Julian W Bess 1 collaboration

Jeffrey D Lifson 1 collaboration

Michael B Zwick 1 collaboration

Hemant D Tagare 1 collaboration

Mohammadjavad Mohammadi 1 collaboration

Vijay Tailor Verma 1 collaboration

Derek Yang 1 collaboration

Amos B Smith 1 collaboration

Cameron Abrams 1 collaboration

Christian Baron 1 collaboration

Jagadish Beloor 1 collaboration

Edward Allen 1 collaboration

Tongyu Zhang 1 collaboration

Christina Ochsenbauer 1 collaboration

Collin Kieffer 1 collaboration

Thomas J Hope 1 collaboration

Brad S Barrett 1 collaboration

Mario L Santiago 1 collaboration

George Kassiotis 1 collaboration

Hughes Charest 1 collaboration

Michel Roger 1 collaboration

Edwin Pozharski 1 collaboration

Marc Cloutier 1 collaboration

Eric Ducas 1 collaboration

Katrina Dionne 1 collaboration

Philippe Bégin 1 collaboration

Christina Papini 1 collaboration

Amalendu P Ranjan 1 collaboration

Shuo Zhang 1 collaboration

Qihao Wu 1 collaboration

Krasimir A Spasov 1 collaboration

Chunhui Zhang 1 collaboration

Jason M Crawford 1 collaboration

Brett D Lindenbach 1 collaboration

William L Jorgensen 1 collaboration

Karen S Anderson 1 collaboration

Jeremie Prevost 1 collaboration

Guillaume Beaudoin-Bussieres 1 collaboration

Liu Lihong 1 collaboration

John Mascola 1 collaboration

Andres Finzi 1 collaboration

Hugo Romero 1 collaboration

Veronique Lisi 1 collaboration

Kathie Béland 1 collaboration

Xiaoyun Bai 1 collaboration

Allison R Zeher 1 collaboration

Bastien Paré 1 collaboration

Doreen Matthies 1 collaboration

Vincent-Philippe Lavallée 1 collaboration

Martin A Smith 1 collaboration

Elie Haddad 1 collaboration

María M Lorenzo 1 collaboration

Alejandro Marín-López 1 collaboration

Kevin Chiem 1 collaboration

Luis Jimenez-Cabello 1 collaboration

Sergio Utrilla-Trigo 1 collaboration

Eva Calvo-Pinilla 1 collaboration

Gema Lorenzo 1 collaboration

Sandra Moreno 1 collaboration

Chengjin Ye 1 collaboration

Jun-Gyu Park 1 collaboration

Alejandro Matía 1 collaboration

Alejandro Brun 1 collaboration

Juana M Sánchez-Puig 1 collaboration

Aitor Nogales 1 collaboration

Javier Ortego 1 collaboration

Erol Fikrig 1 collaboration

Luis Martinez-Sobrido 1 collaboration

Rafael Blasco 1 collaboration

Kadiatou Keita 1 collaboration

Akiko Iwasaki 1 collaboration

Lihong Liu 1 collaboration

John R Mascola 1 collaboration

Helen M Stone 1 collaboration

Alexandre Gilardet 1 collaboration

Dijin Xu 1 collaboration

Weiqian Jiang 1 collaboration

Lizhen Wu 1 collaboration

Ryan G Gaudet 1 collaboration

Eui-Soon Park 1 collaboration

Maohan Su 1 collaboration

Sudheer Kumar Cheppali 1 collaboration

Nagarjuna R Cheemarla 1 collaboration

Pradeep Kumar 1 collaboration

Ellen F Foxman 1 collaboration

Chelsea M Brown 1 collaboration

Phillip J Stansfeld 1 collaboration

Joerg Bewersdorf 1 collaboration

Erdem Karatekin 1 collaboration

John D MacMicking 1 collaboration

Susan A Leonhardt 1 collaboration

Michael D Purdy 1 collaboration

Sandra Poulos 1 collaboration

William E McIntire 1 collaboration

Elizabeth A Tatham 1 collaboration

Satchal K Erramilli 1 collaboration

Kamil Nosol 1 collaboration

Kin Kui Lai 1 collaboration

Alan Rein 1 collaboration

Anthony A Kossiakoff 1 collaboration

Mark Yeager 1 collaboration