Murine Leukemia Virus Exploits Innate Sensing by Toll-Like Receptor 7 in B-1 Cells To Establish Infection and Locally Spread in Mice.


Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
01 11 2019
Historique:
received: 04 06 2019
accepted: 06 08 2019
pubmed: 23 8 2019
medline: 17 6 2020
entrez: 23 8 2019
Statut: epublish

Résumé

Lymph-borne Friend murine leukemia virus (FrMLV) exploits the sentinel macrophages in the draining popliteal lymph node (pLN) to infect highly permissive innate-like B-1 cells and establish infection in mice. The reason for FrMLV sensitivity of B-1 cells and their impact on viral spread is unknown. Here we demonstrate that Toll-like receptor 7 (TLR7) sensing and type I interferon (IFN-I) signaling in B-1 cells contribute to FrMLV susceptibility. FrMLV infection in B-1 cell-deficient mice (

Identifiants

pubmed: 31434732
pii: JVI.00930-19
doi: 10.1128/JVI.00930-19
pmc: PMC6803250
pii:
doi:

Substances chimiques

Interferon Type I 0
Membrane Glycoproteins 0
Tlr7 protein, mouse 0
Toll-Like Receptor 7 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIH HHS
ID : S10 OD020142
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI127429
Pays : United States
Organisme : Howard Hughes Medical Institute
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA098727
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA016359
Pays : United States
Organisme : NIAID NIH HHS
ID : P50 AI150464
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

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Auteurs

Ruoxi Pi (R)

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA.

Akiko Iwasaki (A)

Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut, USA.
Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, Connecticut, USA.
Howard Hughes Medical Institute, Chevy Chase, Maryland, USA.

Xaver Sewald (X)

Max von Pettenkofer Institute & Gene Center, Virology, National Reference Center for Retroviruses, Faculty of Medicine, LMU München, Munich, Germany.
German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany.

Walther Mothes (W)

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA walther.mothes@yale.edu pradeep.uchil@yale.edu.

Pradeep D Uchil (PD)

Department of Microbial Pathogenesis, Yale University School of Medicine, New Haven, Connecticut, USA walther.mothes@yale.edu pradeep.uchil@yale.edu.

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