Ruth M Kluck

Affiliations

Molecular Genetics of Cancer Division, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia. kluck@wehi.edu.au.
Department of Medical Biology, The University of Melbourne, Parkville, VIC, Australia. kluck@wehi.edu.au.

Publications (10)

Probing BAK and BAX Activation and Pore Assembly with Cytochrome c Release, Limited Proteolysis, and Oxidant-Induced Linkage.

Methods in molecular biology (Clifton, N.J.)

Avec: Sweta Iyer , Rachel T Uren , Ruth M Kluck

Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.

Blood

Avec: Rachel Thijssen , Sarah T Diepstraten , Donia Moujalled , Edward Chew , Christoffer Flensburg , Melissa X Shi , Michael A Dengler , Veronique Litalien , Sarah MacRaild , Maoshan Chen , Natasha S Anstee , Boris Reljić , Sarah S Gabriel , Tirta M Djajawi , Chris D Riffkin , Brandon J Aubrey , Catherine Chang , Lin Tai , Zhen Xu , Thomas Morley , Giovanna Pomilio , Claudia Bruedigam , Axel Kallies , David A Stroud , Ashish Bajel , Ruth M Kluck , Steven W Lane , Marie Schoumacher , Sébastien Banquet , Ian J Majewski , Andreas Strasser , Andrew W Roberts , David C S Huang , Fiona C Brown , Gemma L Kelly , Andrew H Wei

Structure of the BAK-activating antibody 7D10 bound to BAK reveals an unexpected role for the α1-α2 loop in BAK activation.

Cell death and differentiation

Avec: Adeline Y Robin , Michelle S Miller , Sweta Iyer , Melissa X Shi , Ahmad Z Wardak , Daisy Lio , Nicholas A Smith , Brian J Smith , Richard W Birkinshaw , Peter E Czabotar , Ruth M Kluck , Peter M Colman

Structure of detergent-activated BAK dimers derived from the inert monomer.

Molecular cell

Avec: Richard W Birkinshaw , Sweta Iyer , Daisy Lio , Cindy S Luo , Jason M Brouwer , Michelle S Miller , Adeline Y Robin , Rachel T Uren , Grant Dewson , Ruth M Kluck , Peter M Colman , Peter E Czabotar

The BCL-2 family member BID plays a role during embryonic development in addition to its BH3-only protein function by acting in parallel to BAX, BAK and BOK.

The EMBO journal

Avec: Francine S Ke , Steven Holloway , Rachel T Uren , Agnes W Wong , Melissa H Little , Ruth M Kluck , Anne K Voss , Andreas Strasser

Lymphoma cells lacking pro-apoptotic BAX are highly resistant to BH3-mimetics targeting pro-survival MCL-1 but retain sensitivity to conventional DNA-damaging drugs.

Cell death and differentiation

Avec: Sarah T Diepstraten , Savannah Young , John E La Marca , Zilu Wang , Ruth M Kluck , Andreas Strasser , Gemma L Kelly

A lipid signature of BAK-driven apoptotic pore formation.

bioRxiv : the preprint server for biology

Avec: Rachel T Uren , Matthew E Ritchie , Agnes W Wong , Justin P Ludeman , Etsuko Uno , Vinod K Narayana , David P De Souza , Dmitri Sviridov , Ruth M Kluck

Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.

Cell death & disease

Avec: Sweta Iyer , Rachel T Uren , Michael A Dengler , Melissa X Shi , Etsuko Uno , Jerry M Adams , Grant Dewson , Ruth M Kluck

BH3 mimetic drugs cooperate with Temozolomide, JQ1 and inducers of ferroptosis in killing glioblastoma multiforme cells.

Cell death and differentiation

Avec: Diane Moujalled , Adam G Southon , Eiman Saleh , Kerstin Brinkmann , Francine Ke , Melinda Iliopoulos , Ryan S Cross , Misty R Jenkins , Duong Nhu , Zilu Wang , Melissa X Shi , Ruth M Kluck , Guillaume Lessene , Stephanie Grabow , Ashley I Bush , Andreas Strasser

A novel inhibitory BAK antibody enables assessment of non-activated BAK in cancer cells.

Cell death and differentiation

Avec: Hema Preethi Subas Satish , Sweta Iyer , Melissa X Shi , Agnes W Wong , Karla C Fischer , Ahmad Z Wardak , Daisy Lio , Jason M Brouwer , Rachel T Uren , Peter E Czabotar , Michelle S Miller , Ruth M Kluck

Réseau de co-auteurs

Rachel T Uren 6 collaborations

Sweta Iyer 5 collaborations

Melissa X Shi 5 collaborations

Andreas Strasser 4 collaborations

Michelle S Miller 3 collaborations

Daisy Lio 3 collaborations

Peter E Czabotar 3 collaborations

Agnes W Wong 3 collaborations

Sarah T Diepstraten 2 collaborations

Michael A Dengler 2 collaborations

Gemma L Kelly 2 collaborations

Adeline Y Robin 2 collaborations

Ahmad Z Wardak 2 collaborations

Richard W Birkinshaw 2 collaborations

Peter M Colman 2 collaborations

Jason M Brouwer 2 collaborations

Grant Dewson 2 collaborations

Zilu Wang 2 collaborations

Etsuko Uno 2 collaborations

Rachel Thijssen 1 collaboration

Donia Moujalled 1 collaboration

Edward Chew 1 collaboration

Christoffer Flensburg 1 collaboration

Veronique Litalien 1 collaboration

Sarah MacRaild 1 collaboration

Maoshan Chen 1 collaboration

Natasha S Anstee 1 collaboration

Boris Reljić 1 collaboration

Sarah S Gabriel 1 collaboration

Tirta M Djajawi 1 collaboration

Chris D Riffkin 1 collaboration

Brandon J Aubrey 1 collaboration

Catherine Chang 1 collaboration

Lin Tai 1 collaboration

Zhen Xu 1 collaboration

Thomas Morley 1 collaboration

Giovanna Pomilio 1 collaboration

Claudia Bruedigam 1 collaboration

Axel Kallies 1 collaboration

David A Stroud 1 collaboration

Ashish Bajel 1 collaboration

Steven W Lane 1 collaboration

Marie Schoumacher 1 collaboration

Sébastien Banquet 1 collaboration

Ian J Majewski 1 collaboration

Andrew W Roberts 1 collaboration

David C S Huang 1 collaboration

Fiona C Brown 1 collaboration

Andrew H Wei 1 collaboration

Nicholas A Smith 1 collaboration

Brian J Smith 1 collaboration

Cindy S Luo 1 collaboration

Francine S Ke 1 collaboration

Steven Holloway 1 collaboration

Melissa H Little 1 collaboration

Anne K Voss 1 collaboration

Savannah Young 1 collaboration

John E La Marca 1 collaboration

Matthew E Ritchie 1 collaboration

Justin P Ludeman 1 collaboration

Vinod K Narayana 1 collaboration

David P De Souza 1 collaboration

Dmitri Sviridov 1 collaboration

Jerry M Adams 1 collaboration

Diane Moujalled 1 collaboration

Adam G Southon 1 collaboration

Eiman Saleh 1 collaboration

Kerstin Brinkmann 1 collaboration

Francine Ke 1 collaboration

Melinda Iliopoulos 1 collaboration

Ryan S Cross 1 collaboration

Misty R Jenkins 1 collaboration

Duong Nhu 1 collaboration

Guillaume Lessene 1 collaboration

Stephanie Grabow 1 collaboration

Ashley I Bush 1 collaboration

Hema Preethi Subas Satish 1 collaboration

Karla C Fischer 1 collaboration