Ruud Delwel

Affiliations

Department of Hematology.
Oncode Institute, and.

Publications (21)

Atypical 3q26/MECOM rearrangements genocopy inv(3)/t(3;3) in acute myeloid leukemia.

Blood

Avec: Sophie Ottema , Roger Mulet-Lazaro , H Berna Beverloo , Claudia Erpelinck , Stanley van Herk , Robert van der Helm , Marije Havermans , Tim Grob , Peter J M Valk , Eric Bindels , Torsten Haferlach , Claudia Haferlach , Leonie Smeenk , Ruud Delwel

RUNX1-ETO Depletion in t(8;21) AML Leads to C/EBPα- and AP-1-Mediated Alterations in Enhancer-Promoter Interaction.

Cell reports

Avec: Anetta Ptasinska , Anna Pickin , Salam A Assi , Paulynn Suyin Chin , Luke Ames , Roberto Avellino , Stefan Gröschel , Ruud Delwel , Peter N Cockerill , Cameron S Osborne , Constanze Bonifer

Therapeutic Targeting of RNA Splicing Catalysis through Inhibition of Protein Arginine Methylation.

Cancer cell

Avec: Jia Yi Fong , Luca Pignata , Pierre-Alexis Goy , Kimihito Cojin Kawabata , Stanley Chun-Wei Lee , Cheryl M Koh , Daniele Musiani , Enrico Massignani , Andriana G Kotini , Alex Penson , Cheng Mun Wun , Yudao Shen , Megan Schwarz , Diana Hp Low , Alexander Rialdi , Michelle Ki , Heike Wollmann , Slim Mzoughi , Florence Gay , Christine Thompson , Timothy Hart , Olena Barbash , Genna M Luciani , Magdalena M Szewczyk , Bas J Wouters , Ruud Delwel , Eirini P Papapetrou , Dalia Barsyte-Lovejoy , Cheryl H Arrowsmith , Mark D Minden , Jian Jin , Ari Melnick , Tiziana Bonaldi , Omar Abdel-Wahab , Ernesto Guccione

Aberrant EVI1 splicing contributes to EVI1-rearranged leukemia.

Blood

Avec: Atsushi Tanaka , Taizo A Nakano , Masaki Nomura , Hiromi Yamazaki , Jan P Bewersdorf , Roger Mulet-Lazaro , Simon Hogg , Bo Liu , Alex Penson , Akihiko Yokoyama , Weijia Zang , Marije Havermans , Miho Koizumi , Yasutaka Hayashi , Hana Cho , Akinori Kanai , Stanley C Lee , Muran Xiao , Yui Koike , Yifan Zhang , Miki Fukumoto , Yumi Aoyama , Tsuyoshi Konuma , Hiroyoshi Kunimoto , Toshiya Inaba , Hideaki Nakajima , Hiroaki Honda , Hiroshi Kawamoto , Ruud Delwel , Omar Abdel-Wahab , Daichi Inoue

Subtype-specific regulatory network rewiring in acute myeloid leukemia.

Nature genetics

Avec: Salam A Assi , Maria Rosaria Imperato , Daniel J L Coleman , Anna Pickin , Sandeep Potluri , Anetta Ptasinska , Paulynn Suyin Chin , Helen Blair , Pierre Cauchy , Sally R James , Joaquin Zacarias-Cabeza , L Niall Gilding , Andrew Beggs , Sam Clokie , Justin C Loke , Phil Jenkin , Ash Uddin , Ruud Delwel , Stephen J Richards , Manoj Raghavan , Michael J Griffiths , Olaf Heidenreich , Peter N Cockerill , Constanze Bonifer

Induced cell-autonomous neutropenia systemically perturbs hematopoiesis in Cebpa enhancer-null mice.

Blood advances

Avec: Roberto Avellino , Roger Mulet-Lazaro , Marije Havermans , Remco Hoogenboezem , Leonie Smeenk , Nathan Salomonis , Rebekka K Schneider , Elwin Rombouts , Eric Bindels , Lee Grimes , Ruud Delwel

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML.

Blood

Avec: Roger Mulet-Lazaro , Stanley van Herk , Claudia Erpelinck , Eric Bindels , Mathijs A Sanders , Carlo Vermeulen , Ivo Renkens , Peter Valk , Ari M Melnick , Jeroen de Ridder , Michael Rehli , Claudia Gebhard , Ruud Delwel , Bas J Wouters

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells.

Blood

Avec: Kimihito C Kawabata , Hongliang Zong , Cem Meydan , Sarah Wyman , Bas J Wouters , Mayumi Sugita , Srinjoy Goswami , Michael Albert , Winnie Yip , Gail J Roboz , Zhengming Chen , Ruud Delwel , Martin Carroll , Christopher E Mason , Ari Melnick , Monica L Guzman

From Genotype to Phenotype: How Enhancers Control Gene Expression and Cell Identity in Hematopoiesis.

HemaSphere

Avec: Roger Mulet-Lazaro , Ruud Delwel

Oncogene

Science advances

Avec: Dorien Pastoors , Marije Havermans , Roger Mulet-Lazaro , Duncan Brian , Willy Noort , Julius Grasel , Remco Hoogenboezem , Leonie Smeenk , Jeroen A A Demmers , Michael D Milsom , Tariq Enver , Richard W J Groen , Eric Bindels , Ruud Delwel

Core-binding factor leukemia hijacks the T-cell-prone PU.1 antisense promoter.

Blood

Avec: E van der Kouwe , G Heller , A Czibere , J A Pulikkan , C Agreiter , L H Castilla , R Delwel , A Di Ruscio , A K Ebralidze , M Forte , F Grebien , E Heyes , L Kazianka , J Klinger , C Kornauth , T Le , K Lind , I A M Barbosa , T Pemovska , A Pichler , A-S Schmolke , C M Schweicker , H Sill , W R Sperr , A Spittler , S Surapally , B Q Trinh , P Valent , K Vanura , R S Welner , J Zuber , D G Tenen , P B Staber

Somatic Mutations Drive Specific, but Reversible, Epigenetic Heterogeneity States in AML.

Cancer discovery

Avec: Sheng Li , Xiaowen Chen , Jiahui Wang , Cem Meydan , Jacob L Glass , Alan H Shih , Ruud Delwel , Ross L Levine , Christopher E Mason , Ari M Melnick

EVI1 drives leukemogenesis through aberrant ERG activation.

Blood

Avec: Johannes Schmoellerl , Inês A M Barbosa , Martina Minnich , Florian Andersch , Leonie Smeenk , Marije Havermans , Thomas Eder , Tobias Neumann , Julian Jude , Michaela Fellner , Anja Ebert , Monika Steininger , Ruud Delwel , Florian Grebien , Johannes Zuber

Epigenetic alterations affecting hematopoietic regulatory networks as drivers of mixed myeloid/lymphoid leukemia.

Nature communications

Avec: Roger Mulet-Lazaro , Stanley van Herk , Margit Nuetzel , Aniko Sijs-Szabo , Noelia Díaz , Katherine Kelly , Claudia Erpelinck-Verschueren , Lucia Schwarzfischer-Pfeilschifter , Hanna Stanewsky , Ute Ackermann , Dagmar Glatz , Johanna Raithel , Alexander Fischer , Sandra Pohl , Anita Rijneveld , Juan M Vaquerizas , Christian Thiede , Christoph Plass , Bas J Wouters , Ruud Delwel , Michael Rehli , Claudia Gebhard

Modelling and drug targeting of a myeloid neoplasm with atypical 3q26/MECOM rearrangement using patient-specific iPSCs.

British journal of haematology

Avec: Momoko Nakamura , Kazuhisa Chonabayashi , Megumi Narita , Yasuko Matsumura , Misato Nishikawa , Yotaro Ochi , Yasuhito Nannya , Masakatsu Hishizawa , Daichi Inoue , Ruud Delwel , Seishi Ogawa , Akifumi Takaori-Kondo , Yoshinori Yoshida

Selective Requirement of MYB for Oncogenic Hyperactivation of a Translocated Enhancer in Leukemia.

Cancer discovery

Avec: Leonie Smeenk , Sophie Ottema , Roger Mulet-Lazaro , Anja Ebert , Marije Havermans , Andrea Arricibita Varea , Michaela Fellner , Dorien Pastoors , Stanley van Herk , Claudia Erpelinck-Verschueren , Tim Grob , Remco M Hoogenboezem , François G Kavelaars , Daniel R Matson , Emery H Bresnick , Eric M Bindels , Alex Kentsis , Johannes Zuber , Ruud Delwel

Correction to: EVI2B is a C/EBPα target gene required for granulocytic differentiation and functionality of hematopoietic progenitors.

Cell death and differentiation

Avec: Polina Zjablovskaja , Miroslava Kardosova , Petr Danek , Pavla Angelisova , Touati Benoukraf , Alexander A Wurm , Tomas Kalina , Stephanie Sian , Martin Balastik , Ruud Delwel , Tomas Brdicka , Daniel G Tenen , Gerhard Behre , Fréderic Fiore , Bernard Malissen , Vaclav Horejsi , Meritxell Alberich-Jorda

The leukemic oncogene EVI1 hijacks a MYC super-enhancer by CTCF-facilitated loops.

Nature communications

Avec: Sophie Ottema , Roger Mulet-Lazaro , Claudia Erpelinck-Verschueren , Stanley van Herk , Marije Havermans , Andrea Arricibita Varea , Michael Vermeulen , H Berna Beverloo , Stefan Gröschel , Torsten Haferlach , Claudia Haferlach , Bas J Wouters , Eric Bindels , Leonie Smeenk , Ruud Delwel

Oncogenic Enhancers in Leukemia.

Blood cancer discovery

Avec: Roger Mulet-Lazaro , Ruud Delwel

STAG2 mutations reshape the cohesin-structured spatial chromatin architecture to drive gene regulation in acute myeloid leukemia.

Cell reports

Avec: Alexander Fischer , Benjamín Hernández-Rodríguez , Roger Mulet-Lazaro , Margit Nuetzel , Fabian Hölzl , Stanley van Herk , François G Kavelaars , Hanna Stanewsky , Ute Ackermann , Amadou H Niang , Noelia Diaz , Edith Reuschel , Nicholas Strieder , Inmaculada Hernández-López , Peter J M Valk , Juan M Vaquerizas , Michael Rehli , Ruud Delwel , Claudia Gebhard

Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsufficiency.

Haematologica

Avec: Avigail Rein , Ifat Geron , Eitan Kugler , Hila Fishman , Eyal Gottlieb , Ifat Abramovich , Amir Giladi , Ido Amit , Roger Mulet-Lazaro , Ruud Delwel , Stefan Gröschel , Smadar Levin-Zaidman , Nili Dezorella , Vered Holdengreber , Tata Nageswara Rao , Joanne Yacobovich , Orna Steinberg-Shemer , Qiu-Hua Huang , Yun Tan , Sai-Juan Chen , Shai Izraeli , Yehudit Birger

Réseau de co-auteurs

Roger Mulet-Lazaro 12 collaborations

Marije Havermans 7 collaborations

Stanley van Herk 6 collaborations

Leonie Smeenk 6 collaborations

Eric Bindels 5 collaborations

Bas J Wouters 5 collaborations

Sophie Ottema 3 collaborations

Stefan Gröschel 3 collaborations

Michael Rehli 3 collaborations

Claudia Gebhard 3 collaborations

Claudia Erpelinck-Verschueren 3 collaborations

H Berna Beverloo 2 collaborations

Claudia Erpelinck 2 collaborations

Tim Grob 2 collaborations

Peter J M Valk 2 collaborations

Torsten Haferlach 2 collaborations

Claudia Haferlach 2 collaborations

Anetta Ptasinska 2 collaborations

Anna Pickin 2 collaborations

Salam A Assi 2 collaborations

Paulynn Suyin Chin 2 collaborations

Roberto Avellino 2 collaborations

Peter N Cockerill 2 collaborations

Constanze Bonifer 2 collaborations

Alex Penson 2 collaborations

Ari Melnick 2 collaborations

Omar Abdel-Wahab 2 collaborations

Daichi Inoue 2 collaborations

Remco Hoogenboezem 2 collaborations

Ari M Melnick 2 collaborations

Cem Meydan 2 collaborations

Christopher E Mason 2 collaborations

Dorien Pastoors 2 collaborations

Michaela Fellner 2 collaborations

Anja Ebert 2 collaborations

Johannes Zuber 2 collaborations

Margit Nuetzel 2 collaborations

Hanna Stanewsky 2 collaborations

Ute Ackermann 2 collaborations

Alexander Fischer 2 collaborations

Juan M Vaquerizas 2 collaborations

Andrea Arricibita Varea 2 collaborations

François G Kavelaars 2 collaborations

Robert van der Helm 1 collaboration

Luke Ames 1 collaboration

Cameron S Osborne 1 collaboration

Jia Yi Fong 1 collaboration

Luca Pignata 1 collaboration

Pierre-Alexis Goy 1 collaboration

Kimihito Cojin Kawabata 1 collaboration

Stanley Chun-Wei Lee 1 collaboration

Cheryl M Koh 1 collaboration

Daniele Musiani 1 collaboration

Enrico Massignani 1 collaboration

Andriana G Kotini 1 collaboration

Cheng Mun Wun 1 collaboration

Yudao Shen 1 collaboration

Megan Schwarz 1 collaboration

Diana Hp Low 1 collaboration

Alexander Rialdi 1 collaboration

Michelle Ki 1 collaboration

Heike Wollmann 1 collaboration

Slim Mzoughi 1 collaboration

Florence Gay 1 collaboration

Christine Thompson 1 collaboration

Timothy Hart 1 collaboration

Olena Barbash 1 collaboration

Genna M Luciani 1 collaboration

Magdalena M Szewczyk 1 collaboration

Eirini P Papapetrou 1 collaboration

Dalia Barsyte-Lovejoy 1 collaboration

Cheryl H Arrowsmith 1 collaboration

Mark D Minden 1 collaboration

Jian Jin 1 collaboration

Tiziana Bonaldi 1 collaboration

Ernesto Guccione 1 collaboration

Atsushi Tanaka 1 collaboration

Taizo A Nakano 1 collaboration

Masaki Nomura 1 collaboration

Hiromi Yamazaki 1 collaboration

Jan P Bewersdorf 1 collaboration

Simon Hogg 1 collaboration

Bo Liu 1 collaboration

Akihiko Yokoyama 1 collaboration

Weijia Zang 1 collaboration

Miho Koizumi 1 collaboration

Yasutaka Hayashi 1 collaboration

Hana Cho 1 collaboration

Akinori Kanai 1 collaboration

Stanley C Lee 1 collaboration

Muran Xiao 1 collaboration

Yui Koike 1 collaboration

Yifan Zhang 1 collaboration

Miki Fukumoto 1 collaboration

Yumi Aoyama 1 collaboration

Tsuyoshi Konuma 1 collaboration

Hiroyoshi Kunimoto 1 collaboration

Toshiya Inaba 1 collaboration

Hideaki Nakajima 1 collaboration

Hiroaki Honda 1 collaboration

Hiroshi Kawamoto 1 collaboration

Maria Rosaria Imperato 1 collaboration

Daniel J L Coleman 1 collaboration

Sandeep Potluri 1 collaboration

Helen Blair 1 collaboration

Pierre Cauchy 1 collaboration

Sally R James 1 collaboration

Joaquin Zacarias-Cabeza 1 collaboration

L Niall Gilding 1 collaboration

Andrew Beggs 1 collaboration

Sam Clokie 1 collaboration

Justin C Loke 1 collaboration

Phil Jenkin 1 collaboration

Ash Uddin 1 collaboration

Stephen J Richards 1 collaboration

Manoj Raghavan 1 collaboration

Michael J Griffiths 1 collaboration

Olaf Heidenreich 1 collaboration

Nathan Salomonis 1 collaboration

Rebekka K Schneider 1 collaboration

Elwin Rombouts 1 collaboration

Lee Grimes 1 collaboration

Mathijs A Sanders 1 collaboration

Carlo Vermeulen 1 collaboration

Ivo Renkens 1 collaboration

Peter Valk 1 collaboration

Jeroen de Ridder 1 collaboration

Kimihito C Kawabata 1 collaboration

Hongliang Zong 1 collaboration

Sarah Wyman 1 collaboration

Mayumi Sugita 1 collaboration

Srinjoy Goswami 1 collaboration

Michael Albert 1 collaboration

Winnie Yip 1 collaboration

Gail J Roboz 1 collaboration

Zhengming Chen 1 collaboration

Martin Carroll 1 collaboration

Monica L Guzman 1 collaboration

Duncan Brian 1 collaboration

Willy Noort 1 collaboration

Julius Grasel 1 collaboration

Jeroen A A Demmers 1 collaboration

Michael D Milsom 1 collaboration

Tariq Enver 1 collaboration

Richard W J Groen 1 collaboration

E van der Kouwe 1 collaboration

G Heller 1 collaboration

A Czibere 1 collaboration

J A Pulikkan 1 collaboration

C Agreiter 1 collaboration

L H Castilla 1 collaboration

R Delwel 1 collaboration

A Di Ruscio 1 collaboration

A K Ebralidze 1 collaboration

M Forte 1 collaboration

F Grebien 1 collaboration

E Heyes 1 collaboration

L Kazianka 1 collaboration

J Klinger 1 collaboration

C Kornauth 1 collaboration

T Le 1 collaboration

K Lind 1 collaboration

I A M Barbosa 1 collaboration

T Pemovska 1 collaboration

A Pichler 1 collaboration

A-S Schmolke 1 collaboration

C M Schweicker 1 collaboration

H Sill 1 collaboration

W R Sperr 1 collaboration

A Spittler 1 collaboration

S Surapally 1 collaboration

B Q Trinh 1 collaboration

P Valent 1 collaboration

K Vanura 1 collaboration

R S Welner 1 collaboration

J Zuber 1 collaboration

D G Tenen 1 collaboration

P B Staber 1 collaboration

Sheng Li 1 collaboration

Xiaowen Chen 1 collaboration

Jiahui Wang 1 collaboration

Jacob L Glass 1 collaboration

Alan H Shih 1 collaboration

Ross L Levine 1 collaboration

Johannes Schmoellerl 1 collaboration

Inês A M Barbosa 1 collaboration

Martina Minnich 1 collaboration

Florian Andersch 1 collaboration

Thomas Eder 1 collaboration

Tobias Neumann 1 collaboration

Julian Jude 1 collaboration

Monika Steininger 1 collaboration

Florian Grebien 1 collaboration

Aniko Sijs-Szabo 1 collaboration

Noelia Díaz 1 collaboration

Katherine Kelly 1 collaboration

Lucia Schwarzfischer-Pfeilschifter 1 collaboration

Dagmar Glatz 1 collaboration

Johanna Raithel 1 collaboration

Sandra Pohl 1 collaboration

Anita Rijneveld 1 collaboration

Christian Thiede 1 collaboration

Christoph Plass 1 collaboration

Momoko Nakamura 1 collaboration

Kazuhisa Chonabayashi 1 collaboration

Megumi Narita 1 collaboration

Yasuko Matsumura 1 collaboration

Misato Nishikawa 1 collaboration

Yotaro Ochi 1 collaboration

Yasuhito Nannya 1 collaboration

Masakatsu Hishizawa 1 collaboration

Seishi Ogawa 1 collaboration

Akifumi Takaori-Kondo 1 collaboration

Yoshinori Yoshida 1 collaboration

Remco M Hoogenboezem 1 collaboration

Daniel R Matson 1 collaboration

Emery H Bresnick 1 collaboration

Eric M Bindels 1 collaboration

Alex Kentsis 1 collaboration

Polina Zjablovskaja 1 collaboration

Miroslava Kardosova 1 collaboration

Petr Danek 1 collaboration

Pavla Angelisova 1 collaboration

Touati Benoukraf 1 collaboration

Alexander A Wurm 1 collaboration

Tomas Kalina 1 collaboration

Stephanie Sian 1 collaboration

Martin Balastik 1 collaboration

Tomas Brdicka 1 collaboration

Daniel G Tenen 1 collaboration

Gerhard Behre 1 collaboration

Fréderic Fiore 1 collaboration

Bernard Malissen 1 collaboration

Vaclav Horejsi 1 collaboration

Meritxell Alberich-Jorda 1 collaboration

Michael Vermeulen 1 collaboration

Benjamín Hernández-Rodríguez 1 collaboration

Fabian Hölzl 1 collaboration

Amadou H Niang 1 collaboration

Noelia Diaz 1 collaboration

Edith Reuschel 1 collaboration

Nicholas Strieder 1 collaboration

Inmaculada Hernández-López 1 collaboration

Avigail Rein 1 collaboration

Ifat Geron 1 collaboration

Eitan Kugler 1 collaboration

Hila Fishman 1 collaboration

Eyal Gottlieb 1 collaboration

Ifat Abramovich 1 collaboration

Amir Giladi 1 collaboration

Ido Amit 1 collaboration

Smadar Levin-Zaidman 1 collaboration

Nili Dezorella 1 collaboration

Vered Holdengreber 1 collaboration

Tata Nageswara Rao 1 collaboration

Joanne Yacobovich 1 collaboration

Orna Steinberg-Shemer 1 collaboration

Qiu-Hua Huang 1 collaboration

Yun Tan 1 collaboration

Sai-Juan Chen 1 collaboration

Shai Izraeli 1 collaboration

Yehudit Birger 1 collaboration