Sam Watcham

Affiliations

Wellcome-MRC Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Department of Haematology, University of Cambridge, Cambridge, UK.

ORCID: 0000-0002-8399-7875

Publications (10)

The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production.

Science advances

Avec: Daniel Prins , Hyun Jung Park , Sam Watcham , Juan Li , Michele Vacca , Hugo P Bastos , Alexander Gerbaulet , Antonio Vidal-Puig , Berthold Göttgens , Anthony R Green

New insights into hematopoietic differentiation landscapes from single-cell RNA sequencing.

Blood

Avec: Sam Watcham , Iwo Kucinski , Berthold Gottgens

Manipulating niche composition limits damage to haematopoietic stem cells during Plasmodium infection.

Nature cell biology

Avec: Myriam L R Haltalli , Samuel Watcham , Nicola K Wilson , Kira Eilers , Alexander Lipien , Heather Ang , Flora Birch , Sara Gonzalez Anton , Chiara Pirillo , Nicola Ruivo , Maria L Vainieri , Constandina Pospori , Robert E Sinden , Tiago C Luis , Jean Langhorne , Ken R Duffy , Berthold Göttgens , Andrew M Blagborough , Cristina Lo Celso

Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin.

Journal of medicinal chemistry

Avec: Frank Narjes , Fredrik Edfeldt , Jens Petersen , Linda Öster , Corinne Hamblet , James Bird , Peter Bold , Rebecca Rae , Elisabeth Bäck , Stina Stomilovic , Pavol Zlatoidsky , Tor Svensson , Lotta Hidestål , Lavaniya Kunalingam , Igor Shamovsky , Leonardo De Maria , Euan Gordon , Richard J Lewis , Sophie Watcham , Katerine van Rietschoten , Gemma E Mudd , Helen Harrison , Liuhong Chen , Michael J Skynner

Identification and Optimization of EphA2-Selective Bicycles for the Delivery of Cytotoxic Payloads.

Journal of medicinal chemistry

Avec: Gemma E Mudd , Amy Brown , Liuhong Chen , Katerine van Rietschoten , Sophie Watcham , Daniel P Teufel , Silvia Pavan , Rachid Lani , Philip Huxley , Gavin S Bennett

MMAE Delivery Using the

Molecular cancer therapeutics

Avec: Gavin Bennett , Amy Brown , Gemma Mudd , Philip Huxley , Katerine Van Rietschoten , Silvia Pavan , Liuhong Chen , Sophie Watcham , Johanna Lahdenranta , Nicholas Keen

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Molecular cell

Avec: Felix A Dingler , Meng Wang , Anfeng Mu , Christopher L Millington , Nina Oberbeck , Sam Watcham , Lucas B Pontel , Ashley N Kamimae-Lanning , Frederic Langevin , Camille Nadler , Rebecca L Cordell , Paul S Monks , Rui Yu , Nicola K Wilson , Asuka Hira , Kenichi Yoshida , Minako Mori , Yusuke Okamoto , Yusuke Okuno , Hideki Muramatsu , Yuichi Shiraishi , Masayuki Kobayashi , Toshinori Moriguchi , Tomoo Osumi , Motohiro Kato , Satoru Miyano , Etsuro Ito , Seiji Kojima , Hiromasa Yabe , Miharu Yabe , Keitaro Matsuo , Seishi Ogawa , Berthold Göttgens , Michael R G Hodskinson , Minoru Takata , Ketan J Patel

Preleukemic single-cell landscapes reveal mutation-specific mechanisms and gene programs predictive of AML patient outcomes.

Cell genomics

Avec: Tomoya Isobe , Iwo Kucinski , Melania Barile , Xiaonan Wang , Rebecca Hannah , Hugo P Bastos , Shirom Chabra , M S Vijayabaskar , Katherine H M Sturgess , Matthew J Williams , George Giotopoulos , Ludovica Marando , Juan Li , Justyna Rak , Malgorzata Gozdecka , Daniel Prins , Mairi S Shepherd , Sam Watcham , Anthony R Green , David G Kent , George S Vassiliou , Brian J P Huntly , Nicola K Wilson , Berthold Göttgens

STAT1 is essential for HSC function and maintains MHCIIhi stem cells that resist myeloablation and neoplastic expansion.

Blood

Avec: Juan Li , Matthew J Williams , Hyun Jung Park , Hugo P Bastos , Xiaonan Wang , Daniel Prins , Nicola K Wilson , Carys Johnson , Kendig Sham , Michelle Wantoch , Sam Watcham , Sarah J Kinston , Dean C Pask , Tina L Hamilton , Rachel Sneade , Amie K Waller , Cedric Ghevaert , George S Vassiliou , Elisa Laurenti , David G Kent , Berthold Göttgens , Anthony R Green

Discovery of BT8009: A Nectin-4 Targeting Bicycle Toxin Conjugate for the Treatment of Cancer.

Journal of medicinal chemistry

Avec: Gemma E Mudd , Heather Scott , Liuhong Chen , Katerine van Rietschoten , Gabriela Ivanova-Berndt , Katarzyna Dzionek , Amy Brown , Sophie Watcham , Lewi White , Peter U Park , Phil Jeffrey , Mike Rigby , Paul Beswick

Réseau de co-auteurs

Berthold Göttgens 5 collaborations

Nicola K Wilson 4 collaborations

Sophie Watcham 4 collaborations

Liuhong Chen 4 collaborations

Daniel Prins 3 collaborations

Juan Li 3 collaborations

Hugo P Bastos 3 collaborations

Anthony R Green 3 collaborations

Katerine van Rietschoten 3 collaborations

Gemma E Mudd 3 collaborations

Amy Brown 3 collaborations

Hyun Jung Park 2 collaborations

Iwo Kucinski 2 collaborations

Silvia Pavan 2 collaborations

Philip Huxley 2 collaborations

Xiaonan Wang 2 collaborations

Matthew J Williams 2 collaborations

David G Kent 2 collaborations

George S Vassiliou 2 collaborations

Michele Vacca 1 collaboration

Alexander Gerbaulet 1 collaboration

Antonio Vidal-Puig 1 collaboration

Berthold Gottgens 1 collaboration

Myriam L R Haltalli 1 collaboration

Samuel Watcham 1 collaboration

Kira Eilers 1 collaboration

Alexander Lipien 1 collaboration

Heather Ang 1 collaboration

Flora Birch 1 collaboration

Sara Gonzalez Anton 1 collaboration

Chiara Pirillo 1 collaboration

Nicola Ruivo 1 collaboration

Maria L Vainieri 1 collaboration

Constandina Pospori 1 collaboration

Robert E Sinden 1 collaboration

Tiago C Luis 1 collaboration

Jean Langhorne 1 collaboration

Ken R Duffy 1 collaboration

Andrew M Blagborough 1 collaboration

Cristina Lo Celso 1 collaboration

Frank Narjes 1 collaboration

Fredrik Edfeldt 1 collaboration

Jens Petersen 1 collaboration

Linda Öster 1 collaboration

Corinne Hamblet 1 collaboration

James Bird 1 collaboration

Peter Bold 1 collaboration

Rebecca Rae 1 collaboration

Elisabeth Bäck 1 collaboration

Stina Stomilovic 1 collaboration

Pavol Zlatoidsky 1 collaboration

Tor Svensson 1 collaboration

Lotta Hidestål 1 collaboration

Lavaniya Kunalingam 1 collaboration

Igor Shamovsky 1 collaboration

Leonardo De Maria 1 collaboration

Euan Gordon 1 collaboration

Richard J Lewis 1 collaboration

Helen Harrison 1 collaboration

Michael J Skynner 1 collaboration

Daniel P Teufel 1 collaboration

Rachid Lani 1 collaboration

Gavin S Bennett 1 collaboration

Gavin Bennett 1 collaboration

Gemma Mudd 1 collaboration

Katerine Van Rietschoten 1 collaboration

Johanna Lahdenranta 1 collaboration

Nicholas Keen 1 collaboration

Felix A Dingler 1 collaboration

Meng Wang 1 collaboration

Anfeng Mu 1 collaboration

Christopher L Millington 1 collaboration

Nina Oberbeck 1 collaboration

Lucas B Pontel 1 collaboration

Ashley N Kamimae-Lanning 1 collaboration

Frederic Langevin 1 collaboration

Camille Nadler 1 collaboration

Rebecca L Cordell 1 collaboration

Paul S Monks 1 collaboration

Rui Yu 1 collaboration

Asuka Hira 1 collaboration

Kenichi Yoshida 1 collaboration

Minako Mori 1 collaboration

Yusuke Okamoto 1 collaboration

Yusuke Okuno 1 collaboration

Hideki Muramatsu 1 collaboration

Yuichi Shiraishi 1 collaboration

Masayuki Kobayashi 1 collaboration

Toshinori Moriguchi 1 collaboration

Tomoo Osumi 1 collaboration

Motohiro Kato 1 collaboration

Satoru Miyano 1 collaboration

Etsuro Ito 1 collaboration

Seiji Kojima 1 collaboration

Hiromasa Yabe 1 collaboration

Miharu Yabe 1 collaboration

Keitaro Matsuo 1 collaboration

Seishi Ogawa 1 collaboration

Michael R G Hodskinson 1 collaboration

Minoru Takata 1 collaboration

Ketan J Patel 1 collaboration

Tomoya Isobe 1 collaboration

Melania Barile 1 collaboration

Rebecca Hannah 1 collaboration

Shirom Chabra 1 collaboration

M S Vijayabaskar 1 collaboration

Katherine H M Sturgess 1 collaboration

George Giotopoulos 1 collaboration

Ludovica Marando 1 collaboration

Justyna Rak 1 collaboration

Malgorzata Gozdecka 1 collaboration

Mairi S Shepherd 1 collaboration

Brian J P Huntly 1 collaboration

Carys Johnson 1 collaboration

Kendig Sham 1 collaboration

Michelle Wantoch 1 collaboration

Sarah J Kinston 1 collaboration

Dean C Pask 1 collaboration

Tina L Hamilton 1 collaboration

Rachel Sneade 1 collaboration

Amie K Waller 1 collaboration

Cedric Ghevaert 1 collaboration

Elisa Laurenti 1 collaboration

Heather Scott 1 collaboration

Gabriela Ivanova-Berndt 1 collaboration

Katarzyna Dzionek 1 collaboration

Lewi White 1 collaboration

Peter U Park 1 collaboration

Phil Jeffrey 1 collaboration

Mike Rigby 1 collaboration

Paul Beswick 1 collaboration