Seth L Alper

Affiliations

Division of Nephrology, Department of Medicine, and.
Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts.

Publications (23)

FSGS-Causing INF2 Mutation Impairs Cleaved INF2 N-Fragment Functions in Podocytes.

Journal of the American Society of Nephrology : JASN

Avec: Balajikarthick Subramanian , Justin Chun , Chandra Perez-Gill , Paul Yan , Isaac E Stillman , Henry N Higgs , Seth L Alper , Johannes S Schlöndorff , Martin R Pollak

Genetic disruption of KCC cotransporters in a mouse model of thalassemia intermedia.

Blood cells, molecules & diseases

Avec: Boris E Shmukler , Alicia Rivera , Parul Bhargava , Katherine Nishimura , Edward H Kim , Ann Hsu , Jay G Wohlgemuth , James Morton , L Michael Snyder , Lucia De Franceschi , Marco B Rust , Christian A Hubner , Carlo Brugnara , Seth L Alper

Whole exome sequencing identified ATP6V1C2 as a novel candidate gene for recessive distal renal tubular acidosis.

Kidney international

Avec: Tilman Jobst-Schwan , Verena Klämbt , Maureen Tarsio , John F Heneghan , Amar J Majmundar , Shirlee Shril , Florian Buerger , Isabel Ottlewski , Boris E Shmukler , Rezan Topaloglu , Seema Hashmi , Farkhanda Hafeez , Francesco Emma , Marcella Greco , Guido F Laube , Hanan M Fathy , Martin Pohl , Jutta Gellermann , Danko Milosevic , Michelle A Baum , Shrikant Mane , Richard P Lifton , Patricia M Kane , Seth L Alper , Friedhelm Hildebrandt

Apolipoprotein L1 (APOL1) risk variant toxicity depends on the haplotype background.

Kidney international

Avec: Herbert Lannon , Shrijal S Shah , Leny Dias , Daniel Blackler , Seth L Alper , Martin R Pollak , David J Friedman

Combined genetic disruption of K-Cl cotransporters and Gardos channel KCNN4 rescues erythrocyte dehydration in the SAD mouse model of sickle cell disease.

Blood cells, molecules & diseases

Avec: Boris E Shmukler , Alicia Rivera , Parul Bhargava , Katherine Nishimura , Ann Hsu , Edward H Kim , Marie Trudel , Marco B Rust , Christian A Hubner , Carlo Brugnara , Seth L Alper

Transmembrane insertases and

The Journal of biological chemistry

Avec: Brianna E Talbot , David H Vandorpe , Brian R Stotter , Seth L Alper , Johannes S Schlondorff

The Peritoneal Surface Proteome in a Model of Chronic Peritoneal Dialysis Reveals Mechanisms of Membrane Damage and Preservation.

Frontiers in physiology

Avec: Michael Boehm , Rebecca Herzog , Florian Klinglmüller , Anton M Lichtenauer , Anja Wagner , Markus Unterwurzacher , Robert H J Beelen , Seth L Alper , Christoph Aufricht , Klaus Kratochwill

PTEN mutations in autism spectrum disorder and congenital hydrocephalus: developmental pleiotropy and therapeutic targets.

Trends in neurosciences

Avec: Tyrone DeSpenza , Marina Carlson , Shreyas Panchagnula , Stephanie Robert , Phan Q Duy , Nell Mermin-Bunnell , Benjamin C Reeves , Adam Kundishora , Aladine A Elsamadicy , Hannah Smith , Jack Ocken , Seth L Alper , Sheng Chih Jin , Ellen J Hoffman , Kristopher T Kahle

Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.

Acta neuropathologica communications

Avec: Kevin Peikert , Enrica Federti , Alessandro Matte , Gabriela Constantin , Enrica Caterina Pietronigro , Paolo Francesco Fabene , Paola Defilippi , Emilia Turco , Federico Del Gallo , Pietro Pucci , Angela Amoresano , Anna Illiano , Flora Cozzolino , Maria Monti , Francesca Garello , Enzo Terreno , Seth Leo Alper , Hannes Glaß , Lisann Pelzl , Katja Akgün , Tjalf Ziemssen , Rainer Ordemann , Florian Lang , Anna Maria Brunati , Elena Tibaldi , Immacolata Andolfo , Achille Iolascon , Giuseppe Bertini , Mario Buffelli , Carlo Zancanaro , Erika Lorenzetto , Angela Siciliano , Massimiliano Bonifacio , Adrian Danek , Ruth Helen Walker , Andreas Hermann , Lucia De Franceschi

Peritoneal Dialysis Fluid Supplementation with Alanyl-Glutamine Attenuates Conventional Dialysis Fluid-Mediated Endothelial Cell Injury by Restoring Perturbed Cytoprotective Responses.

Biomolecules

Avec: Rebecca Herzog , Maria Bartosova , Silvia Tarantino , Anja Wagner , Markus Unterwurzacher , Juan Manuel Sacnun , Anton M Lichtenauer , Lilian Kuster , Betti Schaefer , Seth L Alper , Christoph Aufricht , Claus Peter Schmitt , Klaus Kratochwill

Challenges to dialysis treatment during the COVID-19 pandemic: a qualitative study of patients' and experts' perspectives.

Frontiers in psychology

Avec: Krystell Oviedo Flores , Tanja Stamm , Seth L Alper , Valentin Ritschl , Andreas Vychytil

Effect of Nitric Oxide Pathway Inhibition on the Evolution of Anaphylactic Shock in Animal Models: A Systematic Review.

Biology

Avec: Maryam Alfalasi , Sarah Alzaabi , Linda Östlundh , Rami H Al-Rifai , Suhail Al-Salam , Paul Michel Mertes , Seth L Alper , Elhadi H Aburawi , Abdelouahab Bellou

A neural stem cell paradigm of pediatric hydrocephalus.

Cerebral cortex (New York, N.Y. : 1991)

Avec: Phan Q Duy , Pasko Rakic , Seth L Alper , Stephanie M Robert , Adam J Kundishora , William E Butler , Christopher A Walsh , Nenad Sestan , Daniel H Geschwind , Sheng Chih Jin , Kristopher T Kahle

Apolipoprotein L1 (APOL1) cation current in HEK-293 cells and in human podocytes.

Pflugers Archiv : European journal of physiology

Avec: David H Vandorpe , John F Heneghan , Joshua S Waitzman , Gizelle M McCarthy , Angelo Blasio , Jose M Magraner , Olivia G Donovan , Lena B Schaller , Shrijal S Shah , Balajikarthick Subramanian , Cristian V Riella , David J Friedman , Martin R Pollak , Seth L Alper

Computational drug repositioning of clopidogrel as a novel therapeutic option for focal segmental glomerulosclerosis.

Translational research : the journal of laboratory and clinical medicine

Avec: Christoph A Gebeshuber , Lisa Daniel-Fischer , Heinz Regele , Helga Schachner , Christoph Aufricht , Christoph Kornauth , Matthias Ley , Seth L Alper , Rebecca Herzog , Klaus Kratochwill , Paul Perco

Exome sequencing implicates genetic disruption of prenatal neuro-gliogenesis in sporadic congenital hydrocephalus.

Nature medicine

Avec: Sheng Chih Jin , Weilai Dong , Adam J Kundishora , Shreyas Panchagnula , Andres Moreno-De-Luca , Charuta G Furey , August A Allocco , Rebecca L Walker , Carol Nelson-Williams , Hannah Smith , Ashley Dunbar , Sierra Conine , Qiongshi Lu , Xue Zeng , Michael C Sierant , James R Knight , William Sullivan , Phan Q Duy , Tyrone DeSpenza , Benjamin C Reeves , Jason K Karimy , Arnaud Marlier , Christopher Castaldi , Irina R Tikhonova , Boyang Li , Helena Perez Peña , James R Broach , Edith M Kabachelor , Peter Ssenyonga , Christine Hehnly , Li Ge , Boris Keren , Andrew T Timberlake , June Goto , Francesco T Mangano , James M Johnston , William E Butler , Benjamin C Warf , Edward R Smith , Steven J Schiff , David D Limbrick , Gregory Heuer , Eric M Jackson , Bermans J Iskandar , Shrikant Mane , Shozeb Haider , Bulent Guclu , Yasar Bayri , Yener Sahin , Charles C Duncan , Michael L J Apuzzo , Michael L DiLuna , Ellen J Hoffman , Nenad Sestan , Laura R Ment , Seth L Alper , Kaya Bilguvar , Daniel H Geschwind , Murat Günel , Richard P Lifton , Kristopher T Kahle

Cellular and Immunohistochemical Changes in Anaphylactic Shock Induced in the Ovalbumin-Sensitized Wistar Rat Model.

Biomolecules

Avec: Suhail Al-Salam , Elhadi H Aburawi , Suleiman Al-Hammadi , Sekhar Dhanasekaran , Mohamed Shafiuallah , Javed Yasin , Manjusha Sudhadevi , Aktham Awwad , Seth L Alper , Elsadig E Kazzam , Abdelouahab Bellou

Erythrocyte ion content and dehydration modulate maximal Gardos channel activity in KCNN4 V282M/+ hereditary xerocytosis red cells.

American journal of physiology. Cell physiology

Avec: Alicia Rivera , David H Vandorpe , Boris E Shmukler , Immacolata Andolfo , Achille Iolascon , Natasha M Archer , Estela Shabani , Michael Auerbach , Nelson Hamerschlak , James Morton , Jay G Wohlgemuth , Carlo Brugnara , L Michael Snyder , Seth L Alper

Mutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.

Neuron

Avec: Daniel Duran , Xue Zeng , Sheng Chih Jin , Jungmin Choi , Carol Nelson-Williams , Bogdan Yatsula , Jonathan Gaillard , Charuta Gavankar Furey , Qiongshi Lu , Andrew T Timberlake , Weilai Dong , Michelle A Sorscher , Erin Loring , Jennifer Klein , August Allocco , Ava Hunt , Sierra Conine , Jason K Karimy , Mark W Youngblood , Jinwei Zhang , Michael L DiLuna , Charles C Matouk , Shrikant Mane , Irina R Tikhonova , Christopher Castaldi , Francesc López-Giráldez , James Knight , Shozeb Haider , Mariya Soban , Seth L Alper , Masaki Komiyama , Andrew F Ducruet , Joseph M Zabramski , Alan Dardik , Brian P Walcott , Christopher J Stapleton , Beverly Aagaard-Kienitz , Georges Rodesch , Eric Jackson , Edward R Smith , Darren B Orbach , Alejandro Berenstein , Kaya Bilguvar , Miikka Vikkula , Murat Gunel , Richard P Lifton , Kristopher T Kahle

A High Content Screen for Mucin-1-Reducing Compounds Identifies Fostamatinib as a Candidate for Rapid Repurposing for Acute Lung Injury during the COVID-19 pandemic.

bioRxiv : the preprint server for biology

Avec: Maria Alimova , Eriene-Heidi Sidhom , Abhigyan Satyam , Moran Dvela-Levitt , Michelle Melanson , Brian T Chamberlain , Seth L Alper , Jean Santos , Juan Gutierrez , Ayshwarya Subramanian , Elizabeth Grinkevich , Estefania Reyes Bricio , Choah Kim , Abbe Clark , Andrew Watts , Rebecca Thompson , Jamie Marshall , Juan Lorenzo Pablo , Juliana Coraor , Julie Roignot , Katherine A Vernon , Keith Keller , Alissa Campbell , Maheswarareddy Emani , Matthew Racette , Silvana Bazua-Valenti , Valeria Padovano , Astrid Weins , Stephen P McAdoo , Frederick W K Tam , Lucienne Ronco , Florence Wagner , George C Tsokos , Jillian L Shaw , Anna Greka

Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology.

Nature communications

Avec: Huan Chen , David H Vandorpe , Xiang Xie , Seth L Alper , Mark L Zeidel , Weiqun Yu

Genomics of human congenital hydrocephalus.

Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery

Avec: Adam J Kundishora , Amrita K Singh , Garrett Allington , Phan Q Duy , Jian Ryou , Seth L Alper , Sheng Chih Jin , Kristopher T Kahle

Lithium preserves peritoneal membrane integrity by suppressing mesothelial cell αB-crystallin.

Science translational medicine

Avec: Rebecca Herzog , Juan Manuel Sacnun , Guadalupe González-Mateo , Maria Bartosova , Katarzyna Bialas , Anja Wagner , Markus Unterwurzacher , Isabel J Sobieszek , Lisa Daniel-Fischer , Krisztina Rusai , Lucía Pascual-Antón , Klaus Kaczirek , Andreas Vychytil , Claus Peter Schmitt , Manuel López-Cabrera , Seth L Alper , Christoph Aufricht , Klaus Kratochwill

Réseau de co-auteurs

Sheng Chih Jin 5 collaborations

Kristopher T Kahle 5 collaborations

Boris E Shmukler 4 collaborations

David H Vandorpe 4 collaborations

Rebecca Herzog 4 collaborations

Christoph Aufricht 4 collaborations

Klaus Kratochwill 4 collaborations

Phan Q Duy 4 collaborations

Martin R Pollak 3 collaborations

Alicia Rivera 3 collaborations

Carlo Brugnara 3 collaborations

Shrikant Mane 3 collaborations

Richard P Lifton 3 collaborations

Anja Wagner 3 collaborations

Markus Unterwurzacher 3 collaborations

Adam J Kundishora 3 collaborations

Balajikarthick Subramanian 2 collaborations

Parul Bhargava 2 collaborations

Katherine Nishimura 2 collaborations

Edward H Kim 2 collaborations

Ann Hsu 2 collaborations

Jay G Wohlgemuth 2 collaborations

James Morton 2 collaborations

L Michael Snyder 2 collaborations

Lucia De Franceschi 2 collaborations

Marco B Rust 2 collaborations

Christian A Hubner 2 collaborations

John F Heneghan 2 collaborations

Shrijal S Shah 2 collaborations

David J Friedman 2 collaborations

Anton M Lichtenauer 2 collaborations

Tyrone DeSpenza 2 collaborations

Shreyas Panchagnula 2 collaborations

Benjamin C Reeves 2 collaborations

Hannah Smith 2 collaborations

Ellen J Hoffman 2 collaborations

Immacolata Andolfo 2 collaborations

Achille Iolascon 2 collaborations

Maria Bartosova 2 collaborations

Juan Manuel Sacnun 2 collaborations

Claus Peter Schmitt 2 collaborations

Andreas Vychytil 2 collaborations

Suhail Al-Salam 2 collaborations

Elhadi H Aburawi 2 collaborations

Abdelouahab Bellou 2 collaborations

William E Butler 2 collaborations

Nenad Sestan 2 collaborations

Daniel H Geschwind 2 collaborations

Lisa Daniel-Fischer 2 collaborations

Weilai Dong 2 collaborations

Carol Nelson-Williams 2 collaborations

Sierra Conine 2 collaborations

Qiongshi Lu 2 collaborations

Xue Zeng 2 collaborations

Jason K Karimy 2 collaborations

Christopher Castaldi 2 collaborations

Irina R Tikhonova 2 collaborations

Andrew T Timberlake 2 collaborations

Edward R Smith 2 collaborations

Shozeb Haider 2 collaborations

Michael L DiLuna 2 collaborations

Kaya Bilguvar 2 collaborations

Justin Chun 1 collaboration

Chandra Perez-Gill 1 collaboration

Paul Yan 1 collaboration

Isaac E Stillman 1 collaboration

Henry N Higgs 1 collaboration

Johannes S Schlöndorff 1 collaboration

Tilman Jobst-Schwan 1 collaboration

Verena Klämbt 1 collaboration

Maureen Tarsio 1 collaboration

Amar J Majmundar 1 collaboration

Shirlee Shril 1 collaboration

Florian Buerger 1 collaboration

Isabel Ottlewski 1 collaboration

Rezan Topaloglu 1 collaboration

Seema Hashmi 1 collaboration

Farkhanda Hafeez 1 collaboration

Francesco Emma 1 collaboration

Marcella Greco 1 collaboration

Guido F Laube 1 collaboration

Hanan M Fathy 1 collaboration

Martin Pohl 1 collaboration

Jutta Gellermann 1 collaboration

Danko Milosevic 1 collaboration

Michelle A Baum 1 collaboration

Patricia M Kane 1 collaboration

Friedhelm Hildebrandt 1 collaboration

Herbert Lannon 1 collaboration

Leny Dias 1 collaboration

Daniel Blackler 1 collaboration

Marie Trudel 1 collaboration

Brianna E Talbot 1 collaboration

Brian R Stotter 1 collaboration

Johannes S Schlondorff 1 collaboration

Michael Boehm 1 collaboration

Florian Klinglmüller 1 collaboration

Robert H J Beelen 1 collaboration

Marina Carlson 1 collaboration

Stephanie Robert 1 collaboration

Nell Mermin-Bunnell 1 collaboration

Adam Kundishora 1 collaboration

Aladine A Elsamadicy 1 collaboration

Jack Ocken 1 collaboration

Kevin Peikert 1 collaboration

Enrica Federti 1 collaboration

Alessandro Matte 1 collaboration

Gabriela Constantin 1 collaboration

Enrica Caterina Pietronigro 1 collaboration

Paolo Francesco Fabene 1 collaboration

Paola Defilippi 1 collaboration

Emilia Turco 1 collaboration

Federico Del Gallo 1 collaboration

Pietro Pucci 1 collaboration

Angela Amoresano 1 collaboration

Anna Illiano 1 collaboration

Flora Cozzolino 1 collaboration

Maria Monti 1 collaboration

Francesca Garello 1 collaboration

Enzo Terreno 1 collaboration

Seth Leo Alper 1 collaboration

Hannes Glaß 1 collaboration

Lisann Pelzl 1 collaboration

Katja Akgün 1 collaboration

Tjalf Ziemssen 1 collaboration

Rainer Ordemann 1 collaboration

Florian Lang 1 collaboration

Anna Maria Brunati 1 collaboration

Elena Tibaldi 1 collaboration

Giuseppe Bertini 1 collaboration

Mario Buffelli 1 collaboration

Carlo Zancanaro 1 collaboration

Erika Lorenzetto 1 collaboration

Angela Siciliano 1 collaboration

Massimiliano Bonifacio 1 collaboration

Adrian Danek 1 collaboration

Ruth Helen Walker 1 collaboration

Andreas Hermann 1 collaboration

Silvia Tarantino 1 collaboration

Lilian Kuster 1 collaboration

Betti Schaefer 1 collaboration

Krystell Oviedo Flores 1 collaboration

Tanja Stamm 1 collaboration

Valentin Ritschl 1 collaboration

Maryam Alfalasi 1 collaboration

Sarah Alzaabi 1 collaboration

Linda Östlundh 1 collaboration

Rami H Al-Rifai 1 collaboration

Paul Michel Mertes 1 collaboration

Pasko Rakic 1 collaboration

Stephanie M Robert 1 collaboration

Christopher A Walsh 1 collaboration

Joshua S Waitzman 1 collaboration

Gizelle M McCarthy 1 collaboration

Angelo Blasio 1 collaboration

Jose M Magraner 1 collaboration

Olivia G Donovan 1 collaboration

Lena B Schaller 1 collaboration

Cristian V Riella 1 collaboration

Christoph A Gebeshuber 1 collaboration

Heinz Regele 1 collaboration

Helga Schachner 1 collaboration

Christoph Kornauth 1 collaboration

Matthias Ley 1 collaboration

Paul Perco 1 collaboration

Andres Moreno-De-Luca 1 collaboration

Charuta G Furey 1 collaboration

August A Allocco 1 collaboration

Rebecca L Walker 1 collaboration

Ashley Dunbar 1 collaboration

Michael C Sierant 1 collaboration

James R Knight 1 collaboration

William Sullivan 1 collaboration

Arnaud Marlier 1 collaboration

Boyang Li 1 collaboration

Helena Perez Peña 1 collaboration

James R Broach 1 collaboration

Edith M Kabachelor 1 collaboration

Peter Ssenyonga 1 collaboration

Christine Hehnly 1 collaboration

Li Ge 1 collaboration

Boris Keren 1 collaboration

June Goto 1 collaboration

Francesco T Mangano 1 collaboration

James M Johnston 1 collaboration

Benjamin C Warf 1 collaboration

Steven J Schiff 1 collaboration

David D Limbrick 1 collaboration

Gregory Heuer 1 collaboration

Eric M Jackson 1 collaboration

Bermans J Iskandar 1 collaboration

Bulent Guclu 1 collaboration

Yasar Bayri 1 collaboration

Yener Sahin 1 collaboration

Charles C Duncan 1 collaboration

Michael L J Apuzzo 1 collaboration

Laura R Ment 1 collaboration

Murat Günel 1 collaboration

Suleiman Al-Hammadi 1 collaboration

Sekhar Dhanasekaran 1 collaboration

Mohamed Shafiuallah 1 collaboration

Javed Yasin 1 collaboration

Manjusha Sudhadevi 1 collaboration

Aktham Awwad 1 collaboration

Elsadig E Kazzam 1 collaboration

Natasha M Archer 1 collaboration

Estela Shabani 1 collaboration

Michael Auerbach 1 collaboration

Nelson Hamerschlak 1 collaboration

Daniel Duran 1 collaboration

Jungmin Choi 1 collaboration

Bogdan Yatsula 1 collaboration

Jonathan Gaillard 1 collaboration

Charuta Gavankar Furey 1 collaboration

Michelle A Sorscher 1 collaboration

Erin Loring 1 collaboration

Jennifer Klein 1 collaboration

August Allocco 1 collaboration

Ava Hunt 1 collaboration

Mark W Youngblood 1 collaboration

Jinwei Zhang 1 collaboration

Charles C Matouk 1 collaboration

Francesc López-Giráldez 1 collaboration

James Knight 1 collaboration

Mariya Soban 1 collaboration

Masaki Komiyama 1 collaboration

Andrew F Ducruet 1 collaboration

Joseph M Zabramski 1 collaboration

Alan Dardik 1 collaboration

Brian P Walcott 1 collaboration

Christopher J Stapleton 1 collaboration

Beverly Aagaard-Kienitz 1 collaboration

Georges Rodesch 1 collaboration

Eric Jackson 1 collaboration

Darren B Orbach 1 collaboration

Alejandro Berenstein 1 collaboration

Miikka Vikkula 1 collaboration

Murat Gunel 1 collaboration

Maria Alimova 1 collaboration

Eriene-Heidi Sidhom 1 collaboration

Abhigyan Satyam 1 collaboration

Moran Dvela-Levitt 1 collaboration

Michelle Melanson 1 collaboration

Brian T Chamberlain 1 collaboration

Jean Santos 1 collaboration

Juan Gutierrez 1 collaboration

Ayshwarya Subramanian 1 collaboration

Elizabeth Grinkevich 1 collaboration

Estefania Reyes Bricio 1 collaboration

Choah Kim 1 collaboration

Abbe Clark 1 collaboration

Andrew Watts 1 collaboration

Rebecca Thompson 1 collaboration

Jamie Marshall 1 collaboration

Juan Lorenzo Pablo 1 collaboration

Juliana Coraor 1 collaboration

Julie Roignot 1 collaboration

Katherine A Vernon 1 collaboration

Keith Keller 1 collaboration

Alissa Campbell 1 collaboration

Maheswarareddy Emani 1 collaboration

Matthew Racette 1 collaboration

Silvana Bazua-Valenti 1 collaboration

Valeria Padovano 1 collaboration

Astrid Weins 1 collaboration

Stephen P McAdoo 1 collaboration

Frederick W K Tam 1 collaboration

Lucienne Ronco 1 collaboration

Florence Wagner 1 collaboration

George C Tsokos 1 collaboration

Jillian L Shaw 1 collaboration

Anna Greka 1 collaboration

Huan Chen 1 collaboration

Xiang Xie 1 collaboration

Mark L Zeidel 1 collaboration

Weiqun Yu 1 collaboration

Amrita K Singh 1 collaboration

Garrett Allington 1 collaboration

Jian Ryou 1 collaboration

Guadalupe González-Mateo 1 collaboration

Katarzyna Bialas 1 collaboration

Isabel J Sobieszek 1 collaboration

Krisztina Rusai 1 collaboration

Lucía Pascual-Antón 1 collaboration

Klaus Kaczirek 1 collaboration

Manuel López-Cabrera 1 collaboration