Therapeutic targeting of Lyn kinase to treat chorea-acanthocytosis.
Animals
Dasatinib
/ administration & dosage
Drug Delivery Systems
/ methods
Female
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Neuroacanthocytosis
/ drug therapy
Protein Kinase Inhibitors
/ administration & dosage
Pyrimidines
/ administration & dosage
Vesicular Transport Proteins
/ genetics
src-Family Kinases
/ antagonists & inhibitors
Basal ganglia
Cell signaling
Chorein
Lyn
Neurodegeneration
Journal
Acta neuropathologica communications
ISSN: 2051-5960
Titre abrégé: Acta Neuropathol Commun
Pays: England
ID NLM: 101610673
Informations de publication
Date de publication:
03 05 2021
03 05 2021
Historique:
received:
14
02
2021
accepted:
14
04
2021
entrez:
4
5
2021
pubmed:
5
5
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Chorea-Acanthocytosis (ChAc) is a devastating, little understood, and currently untreatable neurodegenerative disease caused by VPS13A mutations. Based on our recent demonstration that accumulation of activated Lyn tyrosine kinase is a key pathophysiological event in human ChAc cells, we took advantage of Vps13a
Identifiants
pubmed: 33941276
doi: 10.1186/s40478-021-01181-y
pii: 10.1186/s40478-021-01181-y
pmc: PMC8091687
doi:
Substances chimiques
Protein Kinase Inhibitors
0
Pyrimidines
0
Vesicular Transport Proteins
0
Vps13a protein, mouse
0
lyn protein-tyrosine kinase
EC 2.7.10.2
src-Family Kinases
EC 2.7.10.2
nilotinib
F41401512X
Dasatinib
RBZ1571X5H
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
81Références
J Biomed Biotechnol. 2010;2010:840518
pubmed: 19911078
J Biol Chem. 2006 May 19;281(20):14474-85
pubmed: 16522639
Free Radic Biol Med. 2010 Aug 1;49(3):457-66
pubmed: 20488244
EMBO Mol Med. 2013 Aug;5(8):1247-62
pubmed: 23737459
Nat Rev Neurosci. 2004 Apr;5(4):317-28
pubmed: 15034556
Genes Cancer. 2010 Jan;1(1):40-9
pubmed: 20811583
Am J Hum Genet. 2016 Mar 3;98(3):500-513
pubmed: 26942284
Oncogene. 2005 Jan 13;24(3):336-43
pubmed: 15516974
JAMA Neurol. 2021 Mar 1;78(3):312-320
pubmed: 33315105
Nat Genet. 2001 Jun;28(2):119-20
pubmed: 11381253
J Med Chem. 2016 Nov 23;59(22):10030-10066
pubmed: 27414067
Free Radic Biol Med. 2018 Jan;114:40-51
pubmed: 28988799
JCI Insight. 2019 Nov 14;4(22):
pubmed: 31593554
Lancet Neurol. 2009 Apr;8(4):382-97
pubmed: 19296921
Blood. 2016 Dec 22;128(25):2976-2987
pubmed: 27742708
Cell Res. 2014 Jan;24(1):42-57
pubmed: 24343578
Anat Rec (Hoboken). 2014 Oct;297(10):1839-64
pubmed: 24890845
BMC Neurosci. 2010 Aug 09;11:92
pubmed: 20691122
J Neurosci. 2011 Feb 9;31(6):2180-7
pubmed: 21307254
FASEB J. 2019 Mar;33(3):4300-4313
pubmed: 30540497
Neurochem Int. 2018 Oct;119:35-41
pubmed: 28697973
J Lab Clin Med. 1989 Apr;113(4):469-81
pubmed: 2703759
J Neurochem. 2005 Feb;92(4):759-66
pubmed: 15686477
Tremor Other Hyperkinet Mov (N Y). 2015 Oct 19;5:346
pubmed: 26504667
EMBO J. 2019 Feb 15;38(4):
pubmed: 30617086
Neuropathol Appl Neurobiol. 2019 Apr;45(3):230-243
pubmed: 29722054
Elife. 2019 Feb 11;8:
pubmed: 30741634
Arch Neurol. 1968 Oct;19(4):403-9
pubmed: 5677189
J Biol Chem. 2015 Sep 18;290(38):22945-54
pubmed: 26229100
Sci Rep. 2014 May 02;4:4874
pubmed: 24786396
J Cereb Blood Flow Metab. 2012 Jul;32(7):1152-66
pubmed: 22027938
Eur J Med Genet. 2018 Nov;61(11):699-705
pubmed: 29253590
PLoS Pathog. 2016 Jan 06;12(1):e1005363
pubmed: 26735693
J Neurosci. 2016 Nov 23;36(47):12027-12043
pubmed: 27881786
J Cell Biol. 2018 Oct 1;217(10):3625-3639
pubmed: 30093493
J Cell Sci. 2011 Mar 15;124(Pt 6):910-20
pubmed: 21378309
Prog Neurobiol. 2013 Jul-Aug;106-107:33-54
pubmed: 23827971
J Cell Biol. 2018 Oct 1;217(10):3322-3324
pubmed: 30181317
Proc Natl Acad Sci U S A. 2000 Mar 14;97(6):2875-80
pubmed: 10688892
Blood. 2011 Nov 17;118(20):5652-63
pubmed: 21951684
Orphanet J Rare Dis. 2011 Oct 25;6:68
pubmed: 22027213
Nat Genet. 2001 Jun;28(2):121-2
pubmed: 11381254
Haematologica. 2015 Jul;100(7):870-80
pubmed: 25934765
J Cell Sci. 2008 May 15;121(Pt 10):1649-60
pubmed: 18430781
Neural Regen Res. 2020 Aug;15(8):1388-1396
pubmed: 31997797
Brain. 2012 Sep;135(Pt 9):2750-65
pubmed: 22915735
Parkinsonism Relat Disord. 2018 Apr;49:17-21
pubmed: 29317187
Ann Neurol. 2020 Jul;88(1):183-194
pubmed: 32468646
Int J Biomed Imaging. 2016;2016:7462014
pubmed: 26880871
J Immunol Res. 2018 Apr 16;2018:4784268
pubmed: 29850629
J Mol Med (Berl). 2002 Aug;80(8):475-91
pubmed: 12185448
Hum Mol Genet. 2013 Aug 15;22(16):3315-28
pubmed: 23666528
Hum Mol Genet. 2009 May 15;18(10):1779-94
pubmed: 19246516
PLoS Genet. 2014 Oct 02;10(10):e1004626
pubmed: 25275521
Mol Cell Proteomics. 2016 Oct;15(10):3126-3138
pubmed: 27507836
JAMA Neurol. 2020 Mar 1;77(3):309-317
pubmed: 31841599
Nat Rev Mol Cell Biol. 2009 Aug;10(8):513-25
pubmed: 19603039
Curr Neurol Neurosci Rep. 2015;15(2):514
pubmed: 25620691
J Neurosci. 2009 Oct 28;29(43):13578-88
pubmed: 19864570
Nat Cell Biol. 2013 Jul;15(7):741-50
pubmed: 23685627
Arch Neurol. 1968 Feb;18(2):134-40
pubmed: 5636069
Ann Clin Transl Neurol. 2015 Jan;2(1):29-37
pubmed: 25642432
EMBO J. 2016 Nov 2;35(21):2350-2370
pubmed: 27621269
Nat Rev Cancer. 2004 Jun;4(6):470-80
pubmed: 15170449
Neuroimage Clin. 2017 Jun 09;15:581-586
pubmed: 28652970
Eur J Hum Genet. 2002 Nov;10(11):773-81
pubmed: 12404112
Blood. 2006 Sep 1;108(5):1524-32
pubmed: 16705093
Nat Rev Neurol. 2019 Apr;15(4):204-223
pubmed: 30867588
J Neural Transm (Vienna). 2004 Aug;111(8):1017-30
pubmed: 15254790
Acta Neuropathol. 2012 Jun;123(6):905-6
pubmed: 22476160
Parkinsonism Relat Disord. 2018 Apr;49:54-59
pubmed: 29402698
Neurobiol Aging. 2014 Jul;35(7):1660-8
pubmed: 24560998
PLoS One. 2011;6(6):e21521
pubmed: 21731772