Siegfried Labeit

Affiliations

Department of Anesthesiology, Medical Faculty Mannheim, University of Heidelberg, 68169 Mannheim, Germany.
Myomedix GmbH, 69151 Neckargemünd, Germany.

Publications (32)

Regulation of Glucose Metabolism by MuRF1 and Treatment of Myopathy in Diabetic Mice with Small Molecules Targeting MuRF1.

International journal of molecular sciences

Avec: Siegfried Labeit , Stephanie Hirner , Julijus Bogomolovas , André Cruz , Moldir Myrzabekova , Anselmo Moriscot , Thomas Scott Bowen , Volker Adams

Muscle ankyrin repeat protein 1 (MARP1) locks titin to the sarcomeric thin filament and is a passive force regulator.

The Journal of general physiology

Avec: Robbert J van der Pijl , Marloes van den Berg , Martijn van de Locht , Shengyi Shen , Sylvia J P Bogaards , Stefan Conijn , Paul Langlais , Pleuni E Hooijman , Siegfried Labeit , Leo M A Heunks , Henk Granzier , Coen A C Ottenheijm

Empagliflozin Preserves Skeletal Muscle Function in a HFpEF Rat Model.

International journal of molecular sciences

Avec: Ephraim B Winzer , Antje Schauer , Erik Langner , Antje Augstein , Keita Goto , Anita Männel , Peggy Barthel , Anett Jannasch , Siegfried Labeit , Norman Mangner , Axel Linke , Volker Adams

Modulation of Titin and Contraction-Regulating Proteins in a Rat Model of Heart Failure with Preserved Ejection Fraction: Limb vs. Diaphragmatic Muscle.

International journal of molecular sciences

Avec: Beatrice Vahle , Leonard Heilmann , Antje Schauer , Antje Augstein , Maria-Elisa Prieto Jarabo , Peggy Barthel , Norman Mangner , Siegfried Labeit , T Scott Bowen , Axel Linke , Volker Adams

Removal of MuRF1 Increases Muscle Mass in Nemaline Myopathy Models, but Does Not Provide Functional Benefits.

International journal of molecular sciences

Avec: Johan Lindqvist , Justin Kolb , Josine de Winter , Paola Tonino , Zaynab Hourani , Siegfried Labeit , Coen Ottenheijm , Henk Granzier

The Effect of Heat Shock on Myogenic Differentiation of Human Skeletal-Muscle-Derived Mesenchymal Stem/Stromal Cells.

Cells

Avec: Rokas Mikšiūnas , Siegfried Labeit , Daiva Bironaitė

miR-29c Increases Protein Synthesis in Skeletal Muscle Independently of AKT/mTOR.

International journal of molecular sciences

Avec: Paula Ketilly Nascimento Alves , André Cruz , William J Silva , Siegfried Labeit , Anselmo Sigari Moriscot

Truncated titin is structurally integrated into the human dilated cardiomyopathic sarcomere.

The Journal of clinical investigation

Avec: Dalma Kellermayer , Hedvig Tordai , Balázs Kiss , György Török , Dániel M Péter , Alex Ali Sayour , Miklós Pólos , István Hartyánszky , Bálint Szilveszter , Siegfried Labeit , Ambrus Gángó , Gábor Bedics , Csaba Bödör , Tamás Radovits , Bela Merkely , Miklós Sz Kellermayer

Small-molecule mediated MuRF1 Inhibition protects from Doxorubicin-induced Cardiac Atrophy and Contractile Dysfunction.

European journal of pharmacology

Avec: Paula Alves , André Cruz , Volker Adams , Anselmo S Moriscot , Siegfried Labeit

Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid Improves Energetic Status and Cardiomyogenic Differentiation of Human Dilated Myocardium-Derived Primary Mesenchymal Cells.

International journal of molecular sciences

Avec: Rokas Miksiunas , Kestutis Rucinskas , Vilius Janusauskas , Siegfried Labeit , Daiva Bironaite

Emerging Strategies Targeting Catabolic Muscle Stress Relief.

International journal of molecular sciences

Avec: Mattia Scalabrin , Volker Adams , Siegfried Labeit , T Scott Bowen

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients.

Disease models & mechanisms

Avec: Yuta Higashikuse , Nishant Mittal , Takuro Arimura , Sung Han Yoon , Mayumi Oda , Hirokazu Enomoto , Ruri Kaneda , Fumiyuki Hattori , Takeshi Suzuki , Atsushi Kawakami , Alexander Gasch , Tetsushi Furukawa , Siegfried Labeit , Keiichi Fukuda , Akinori Kimura , Shinji Makino

Cardiomyogenic Differentiation Potential of Human Dilated Myocardium-Derived Mesenchymal Stem/Stromal Cells: The Impact of HDAC Inhibitor SAHA and Biomimetic Matrices.

International journal of molecular sciences

Avec: Rokas Miksiunas , Ruta Aldonyte , Agne Vailionyte , Tadas Jelinskas , Romuald Eimont , Gintare Stankeviciene , Vytautas Cepla , Ramunas Valiokas , Kestutis Rucinskas , Vilius Janusauskas , Siegfried Labeit , Daiva Bironaite

Molecular Mechanisms behind Persistent Presence of Parvovirus B19 in Human Dilated Myocardium.

Advances in experimental medicine and biology

Avec: Daiva Bironaitė , Ieva Kažukauskienė , Julius Bogomolovas , Dainius Daunoravičius , Artūras Jakubauskas , Dalius Vitkus , Edvardas Žurauskas , Kęstutis Ručinskas , Siegfried Labeit , Virginija Grabauskiene

MuRF1 deficiency prevents age-related fat weight gain, possibly through accumulation of PDK4 in skeletal muscle mitochondria in older mice.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society

Avec: Kosuke Sugiura , Katsuya Hirasaka , Tasuku Maeda , Takayuki Uchida , Koji Kishimoto , Motoko Oarada , Siegfried Labeit , Anayt Ulla , Iori Sakakibara , Reiko Nakao , Koichi Sairyo , Takeshi Nikawa

The skeletal muscle circadian clock regulates titin splicing through RBM20.

eLife

Avec: Lance A Riley , Xiping Zhang , Collin M Douglas , Joseph M Mijares , David W Hammers , Christopher A Wolff , Neil B Wood , Hailey R Olafson , Ping Du , Siegfried Labeit , Michael J Previs , Eric T Wang , Karyn A Esser

Immunological and Structural Characterization of Titin Main Immunogenic Region; I110 Domain Is the Target of Titin Antibodies in Myasthenia Gravis.

Biomedicines

Avec: Christos Stergiou , Rhys Williams , Jennifer R Fleming , Vasiliki Zouvelou , Elpinickie Ninou , Francesca Andreetta , Elena Rinaldi , Ornella Simoncini , Renato Mantegazza , Julius Bogomolovas , John Tzartos , Siegfried Labeit , Olga Mayans , Socrates Tzartos

Titin kinase ubiquitination aligns autophagy receptors with mechanical signals in the sarcomere.

EMBO reports

Avec: Julius Bogomolovas , Jennifer R Fleming , Barbara Franke , Bruno Manso , Bernd Simon , Alexander Gasch , Marija Markovic , Thomas Brunner , Ralph Knöll , Ju Chen , Siegfried Labeit , Martin Scheffner , Christine Peter , Olga Mayans

ZSF1 rat as animal model for HFpEF: Development of reduced diastolic function and skeletal muscle dysfunction.

ESC heart failure

Avec: Antje Schauer , Runa Draskowski , Anett Jannasch , Virginia Kirchhoff , Keita Goto , Anita Männel , Peggy Barthel , Antje Augstein , Ephraim Winzer , Malte Tugtekin , Siegfried Labeit , Axel Linke , Volker Adams

Leucine Supplementation Decreases

Cells

Avec: Paula K N Alves , André Cruz , William J Silva , Siegfried Labeit , Anselmo S Moriscot

Frontiers in genetics

Avec: Dina Mukushkina , Dana Aisina , Anna Pyrkova , Alma Ryskulova , Siegfried Labeit , Anatoliy Ivashchenko

Targeting MuRF1 by small molecules in a HFpEF rat model improves myocardial diastolic function and skeletal muscle contractility.

Journal of cachexia, sarcopenia and muscle

Avec: Volker Adams , Antje Schauer , Antje Augstein , Virginia Kirchhoff , Runa Draskowski , Anett Jannasch , Keita Goto , Gemma Lyall , Anita Männel , Peggy Barthel , Norman Mangner , Ephraim B Winzer , Axel Linke , Siegfried Labeit

Small-Molecule Inhibition of MuRF1 Prevents Early Disuse-Induced Diaphragmatic Dysfunction and Atrophy.

International journal of molecular sciences

Avec: Fernando Ribeiro , Paula K N Alves , Luiz R G Bechara , Julio C B Ferreira , Siegfried Labeit , Anselmo S Moriscot

Genetic Ablation of

Biomolecules

Avec: Ieva Rinkūnaitė , Egidijus Šimoliūnas , Milda Alksnė , Gabrielė Bartkutė , Siegfried Labeit , Virginija Bukelskienė , Julius Bogomolovas

Class I and II Histone Deacetylase Inhibitors as Therapeutic Modulators of Dilated Cardiac Tissue-Derived Mesenchymal Stem/Stromal Cells.

International journal of molecular sciences

Avec: Rokas Mikšiūnas , Siegfried Labeit , Daiva Bironaite

Skeletal Muscle Anti-Atrophic Effects of Leucine Involve Myostatin Inhibition.

DNA and cell biology

Avec: André Cruz , Andrea Ferian , Paula K N Alves , William Jose Silva , Mirella Ribeiro Bento , Alexander Gasch , Siegfried Labeit , Anselmo Sigari Moriscot

Small-molecule-mediated chemical knock-down of MuRF1/MuRF2 and attenuation of diaphragm dysfunction in chronic heart failure.

Journal of cachexia, sarcopenia and muscle

Avec: Volker Adams , T Scott Bowen , Sarah Werner , Peggy Barthel , Christina Amberger , Anne Konzer , Johannes Graumann , Peter Sehr , Joe Lewis , Jan Provaznik , Vladimir Benes , Petra Büttner , Alexander Gasch , Norman Mangner , Christian C Witt , Dittmar Labeit , Axel Linke , Siegfried Labeit

[The Interaction of miRNA-5p and miRNA-3p with the mRNAs of Orthologous Genes].

Molekuliarnaia biologiia

Avec: O Yu Yurikova , D E Aisina , R E Niyazova , Sh A Atambayeva , S Labeit , A T Ivashchenko

The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas

Avec: J G Silvestre , I L Baptista , W J Silva , A Cruz , M T Silva , E H Miyabara , S Labeit , A S Moriscot

miR-29c improves skeletal muscle mass and function throughout myocyte proliferation and differentiation and by repressing atrophy-related genes.

Acta physiologica (Oxford, England)

Avec: William José Silva , Flavia Aparecida Graça , André Cruz , João Guilherme Silvestre , Siegfried Labeit , Elen Haruka Miyabara , Chao Yun Irene Yan , Da Zhi Wang , Anselmo Sigari Moriscot

Expression of MuRF1 or MuRF2 is essential for the induction of skeletal muscle atrophy and dysfunction in a murine pulmonary hypertension model.

Skeletal muscle

Avec: Thanh Nguyen , T Scott Bowen , Antje Augstein , Antje Schauer , Alexander Gasch , Axel Linke , Siegfried Labeit , Volker Adams

Identification of Bovine miRNAs with the Potential to Affect Human Gene Expression.

Frontiers in genetics

Avec: Moldir Myrzabekova , Siegfried Labeit , Raigul Niyazova , Aigul Akimniyazova , Anatoliy Ivashchenko

Réseau de co-auteurs

Volker Adams 9 collaborations

André Cruz 6 collaborations

Axel Linke 6 collaborations

Antje Schauer 5 collaborations

Antje Augstein 5 collaborations

Peggy Barthel 5 collaborations

Alexander Gasch 5 collaborations

Norman Mangner 4 collaborations

T Scott Bowen 4 collaborations

Julius Bogomolovas 4 collaborations

Keita Goto 3 collaborations

Anita Männel 3 collaborations

Anett Jannasch 3 collaborations

Anselmo Sigari Moriscot 3 collaborations

Anselmo S Moriscot 3 collaborations

Daiva Bironaite 3 collaborations

Paula K N Alves 3 collaborations

Moldir Myrzabekova 2 collaborations

Henk Granzier 2 collaborations

Ephraim B Winzer 2 collaborations

Rokas Mikšiūnas 2 collaborations

Daiva Bironaitė 2 collaborations

William J Silva 2 collaborations

Rokas Miksiunas 2 collaborations

Kestutis Rucinskas 2 collaborations

Vilius Janusauskas 2 collaborations

Jennifer R Fleming 2 collaborations

Olga Mayans 2 collaborations

Runa Draskowski 2 collaborations

Virginia Kirchhoff 2 collaborations

Anatoliy Ivashchenko 2 collaborations

S Labeit 2 collaborations

Stephanie Hirner 1 collaboration

Julijus Bogomolovas 1 collaboration

Anselmo Moriscot 1 collaboration

Thomas Scott Bowen 1 collaboration

Robbert J van der Pijl 1 collaboration

Marloes van den Berg 1 collaboration

Martijn van de Locht 1 collaboration

Shengyi Shen 1 collaboration

Sylvia J P Bogaards 1 collaboration

Stefan Conijn 1 collaboration

Paul Langlais 1 collaboration

Pleuni E Hooijman 1 collaboration

Leo M A Heunks 1 collaboration

Coen A C Ottenheijm 1 collaboration

Erik Langner 1 collaboration

Beatrice Vahle 1 collaboration

Leonard Heilmann 1 collaboration

Maria-Elisa Prieto Jarabo 1 collaboration

Johan Lindqvist 1 collaboration

Justin Kolb 1 collaboration

Josine de Winter 1 collaboration

Paola Tonino 1 collaboration

Zaynab Hourani 1 collaboration

Coen Ottenheijm 1 collaboration

Paula Ketilly Nascimento Alves 1 collaboration

Dalma Kellermayer 1 collaboration

Hedvig Tordai 1 collaboration

Balázs Kiss 1 collaboration

György Török 1 collaboration

Dániel M Péter 1 collaboration

Alex Ali Sayour 1 collaboration

Miklós Pólos 1 collaboration

István Hartyánszky 1 collaboration

Bálint Szilveszter 1 collaboration

Ambrus Gángó 1 collaboration

Gábor Bedics 1 collaboration

Csaba Bödör 1 collaboration

Tamás Radovits 1 collaboration

Bela Merkely 1 collaboration

Miklós Sz Kellermayer 1 collaboration

Paula Alves 1 collaboration

Mattia Scalabrin 1 collaboration

Yuta Higashikuse 1 collaboration

Nishant Mittal 1 collaboration

Takuro Arimura 1 collaboration

Sung Han Yoon 1 collaboration

Mayumi Oda 1 collaboration

Hirokazu Enomoto 1 collaboration

Ruri Kaneda 1 collaboration

Fumiyuki Hattori 1 collaboration

Takeshi Suzuki 1 collaboration

Atsushi Kawakami 1 collaboration

Tetsushi Furukawa 1 collaboration

Keiichi Fukuda 1 collaboration

Akinori Kimura 1 collaboration

Shinji Makino 1 collaboration

Ruta Aldonyte 1 collaboration

Agne Vailionyte 1 collaboration

Tadas Jelinskas 1 collaboration

Romuald Eimont 1 collaboration

Gintare Stankeviciene 1 collaboration

Vytautas Cepla 1 collaboration

Ramunas Valiokas 1 collaboration

Ieva Kažukauskienė 1 collaboration

Dainius Daunoravičius 1 collaboration

Artūras Jakubauskas 1 collaboration

Dalius Vitkus 1 collaboration

Edvardas Žurauskas 1 collaboration

Kęstutis Ručinskas 1 collaboration

Virginija Grabauskiene 1 collaboration

Kosuke Sugiura 1 collaboration

Katsuya Hirasaka 1 collaboration

Tasuku Maeda 1 collaboration

Takayuki Uchida 1 collaboration

Koji Kishimoto 1 collaboration

Motoko Oarada 1 collaboration

Anayt Ulla 1 collaboration

Iori Sakakibara 1 collaboration

Reiko Nakao 1 collaboration

Koichi Sairyo 1 collaboration

Takeshi Nikawa 1 collaboration

Lance A Riley 1 collaboration

Xiping Zhang 1 collaboration

Collin M Douglas 1 collaboration

Joseph M Mijares 1 collaboration

David W Hammers 1 collaboration

Christopher A Wolff 1 collaboration

Neil B Wood 1 collaboration

Hailey R Olafson 1 collaboration

Ping Du 1 collaboration

Michael J Previs 1 collaboration

Eric T Wang 1 collaboration

Karyn A Esser 1 collaboration

Christos Stergiou 1 collaboration

Rhys Williams 1 collaboration

Vasiliki Zouvelou 1 collaboration

Elpinickie Ninou 1 collaboration

Francesca Andreetta 1 collaboration

Elena Rinaldi 1 collaboration

Ornella Simoncini 1 collaboration

Renato Mantegazza 1 collaboration

John Tzartos 1 collaboration

Socrates Tzartos 1 collaboration

Barbara Franke 1 collaboration

Bruno Manso 1 collaboration

Bernd Simon 1 collaboration

Marija Markovic 1 collaboration

Thomas Brunner 1 collaboration

Ralph Knöll 1 collaboration

Ju Chen 1 collaboration

Martin Scheffner 1 collaboration

Christine Peter 1 collaboration

Ephraim Winzer 1 collaboration

Malte Tugtekin 1 collaboration

Dina Mukushkina 1 collaboration

Dana Aisina 1 collaboration

Anna Pyrkova 1 collaboration

Alma Ryskulova 1 collaboration

Gemma Lyall 1 collaboration

Fernando Ribeiro 1 collaboration

Luiz R G Bechara 1 collaboration

Julio C B Ferreira 1 collaboration

Ieva Rinkūnaitė 1 collaboration

Egidijus Šimoliūnas 1 collaboration

Milda Alksnė 1 collaboration

Gabrielė Bartkutė 1 collaboration

Virginija Bukelskienė 1 collaboration

Andrea Ferian 1 collaboration

William Jose Silva 1 collaboration

Mirella Ribeiro Bento 1 collaboration

Sarah Werner 1 collaboration

Christina Amberger 1 collaboration

Anne Konzer 1 collaboration

Johannes Graumann 1 collaboration

Peter Sehr 1 collaboration

Joe Lewis 1 collaboration

Jan Provaznik 1 collaboration

Vladimir Benes 1 collaboration

Petra Büttner 1 collaboration

Christian C Witt 1 collaboration

Dittmar Labeit 1 collaboration

O Yu Yurikova 1 collaboration

D E Aisina 1 collaboration

R E Niyazova 1 collaboration

Sh A Atambayeva 1 collaboration

A T Ivashchenko 1 collaboration

J G Silvestre 1 collaboration

I L Baptista 1 collaboration

W J Silva 1 collaboration

A Cruz 1 collaboration

M T Silva 1 collaboration

E H Miyabara 1 collaboration

A S Moriscot 1 collaboration

William José Silva 1 collaboration

Flavia Aparecida Graça 1 collaboration

João Guilherme Silvestre 1 collaboration

Elen Haruka Miyabara 1 collaboration

Chao Yun Irene Yan 1 collaboration

Da Zhi Wang 1 collaboration

Thanh Nguyen 1 collaboration

Raigul Niyazova 1 collaboration

Aigul Akimniyazova 1 collaboration