Thomas M Polasek

Affiliations

, Certara, Princeton, NJ, USA.
Centre for Medicine Use and Safety, Monash University, Melbourne, Australia.

ORCID: http://orcid.org/0000-0003-1008-5223

Publications (28)

The PRESIDE (PhaRmacogEnomicS In DEpression) Trial: a double-blind randomised controlled trial of pharmacogenomic-informed prescribing of antidepressants on depression outcomes in patients with major depressive disorder in primary care.

Trials

Avec: Sibel Saya , Patty Chondros , Anastasia Abela , Cathrine Mihalopolous , Mary Lou Chatterton , Jane Gunn , Timothy F Chen , Thomas M Polasek , Elise Dettmann , Rachel Brooks , Michelle King , Luke Spencer , Pavithran Alphonse , Shakira Milton , Georgia Ramsay , Zoe Siviour , Jamie Liew , Philip Ly , Matthew Thoenig , Raushaan Seychell , Floriana La Rocca , Luke B Hesson , Nydia Mejias , Terri Sivertsen , Melanie Anne Galea , Chad Bousman , Jon Emery

Drug-drug interactions that alter the exposure of glucuronidated drugs: Scope, UDP-glucuronosyltransferase (UGT) enzyme selectivity, mechanisms (inhibition and induction), and clinical significance.

Pharmacology & therapeutics

Avec: John O Miners , Thomas M Polasek , Julie-Ann Hulin , Andrew Rowland , Robyn Meech

Virtual twin for healthcare management.

Frontiers in digital health

Avec: Thomas M Polasek

Impact of Food on the Oral Absorption of N-Acetyl-D-Mannosamine in Healthy Men and Women.

Clinical pharmacology in drug development

Avec: Allan M Evans , Gianfranco Fornasini , Tahlia R Meola , William A Gahl , Marjan Huizing , Thomas M Polasek , Stephanie E Reuter

Liquid Biopsy for Patient Characterization in Cardiovascular Disease: Verification against Markers of Cytochrome P450 and P-Glycoprotein Activities.

Clinical pharmacology and therapeutics

Avec: Brahim Achour , Pauline Gosselin , Jean Terrier , Yvonne Gloor , Zubida M Al-Majdoub , Thomas M Polasek , Youssef Daali , Amin Rostami-Hodjegan , Jean-Luc Reny

Virtual twins for model-informed precision dosing of clozapine in patients with treatment-resistant schizophrenia.

CPT: pharmacometrics & systems pharmacology

Avec: Sam Mostafa , Reza Rafizadeh , Thomas M Polasek , Chad A Bousman , Amin Rostami-Hodjegan , Robert Stowe , Prescilla Carrion , Leslie J Sheffield , Carl M J Kirkpatrick

Beyond Population-Level Targets for Drug Concentrations: Precision Dosing Needs Individual-Level Targets that Include Superior Biomarkers of Drug Responses.

Clinical pharmacology and therapeutics

Avec: Thomas M Polasek , Richard W Peck

Phase 1 study of the iodine absorption, safety, and tolerability of a 0.5% povidone-iodine nasal spray (Nasodine).

International forum of allergy & rhinology

Avec: Peter L Friedland , Thomas M Polasek , Duncan Topliss

Pharmacogenomics - a minor rather than major force in clinical medicine.

Expert review of clinical pharmacology

Avec: Thomas M Polasek

Pharmacogenomics in general practice: The time has come.

Australian journal of general practice

Avec: Thomas M Polasek , Kym Mina , Graeme Suthers

Toward Dynamic Prescribing Information: Codevelopment of Companion Model-Informed Precision Dosing Tools in Drug Development.

Clinical pharmacology in drug development

Avec: Thomas M Polasek , Craig R Rayner , Richard W Peck , Andrew Rowland , Holly Kimko , Amin Rostami-Hodjegan

Precision dosing to avoid adverse drug reactions.

Therapeutic advances in drug safety

Avec: Thomas M Polasek , Carl M J Kirkpatrick , Amin Rostami-Hodjegan

Model-Informed Precision Dosing: Background, Requirements, Validation, Implementation, and Forward Trajectory of Individualizing Drug Therapy.

Annual review of pharmacology and toxicology

Avec: Adam S Darwich , Thomas M Polasek , Jeffrey K Aronson , Kayode Ogungbenro , Daniel F B Wright , Brahim Achour , Jean-Luc Reny , Youssef Daali , Birgit Eiermann , Jack Cook , Lawrence Lesko , Andrew J McLachlan , Amin Rostami-Hodjegan

First-in-human single-dose study of nizubaglustat, a dual inhibitor of ceramide glucosyltransferase and non-lysosomal glucosylceramidase: Safety, tolerability, pharmacokinetics, and pharmacodynamics of single ascending and multiple doses in healthy adults.

Molecular genetics and metabolism

Avec: Cecile Paquet Luzy , Emilie Doppler , Thomas M Polasek , Ruben Giorgino

Calculation of the pharmacogenomics benefit score for patients with medication-related problems.

Frontiers in genetics

Avec: Thomas M Polasek

Letter to the editor: reply to Bousman

Pharmacogenomics

Avec: Graeme K Suthers , Tom M Polasek

What Does it Take to Make Model-Informed Precision Dosing Common Practice? Report from the 1st Asian Symposium on Precision Dosing.

The AAPS journal

Avec: Thomas M Polasek , Amin Rostami-Hodjegan , Dong-Seok Yim , Masoud Jamei , Howard Lee , Holly Kimko , Jae Kyoung Kim , Phuong Thi Thu Nguyen , Adam S Darwich , Jae-Gook Shin

Delineating gene-environment effects using virtual twins of patients treated with clozapine.

CPT: pharmacometrics & systems pharmacology

Avec: Sam Mostafa , Thomas M Polasek , Chad Bousman , Amin Rostami-Hodjegan , Leslie J Sheffield , Ian Everall , Christos Pantelis , Carl M J Kirkpatrick

A phase I trial of SON-1010, a tumor-targeted, interleukin-12-linked, albumin-binding cytokine, shows favorable pharmacokinetics, pharmacodynamics, and safety in healthy volunteers.

Frontiers in immunology

Avec: Richard T Kenney , John K Cini , Susan Dexter , Manuel DaFonseca , Justus Bingham , Isabelle Kuan , Sant P Chawla , Thomas M Polasek , Jason Lickliter , Philip J Ryan

Personality vulnerabilities and adverse event reporting in phase 1 clinical studies.

Trials

Avec: Joanna Skommer , Krish Gunesh , Thomas M Polasek

Efficacy and safety of pharmacogenomic-guided antidepressant prescribing in patients with depression: an umbrella review and updated meta-analysis.

Frontiers in psychiatry

Avec: Kiflu G Tesfamicael , Lijun Zhao , Rubén Fernández-Rodríguez , David L Adelson , Michael Musker , Thomas M Polasek , Martin David Lewis

Precision medicine technology hype or reality? The example of computer-guided dosing.

F1000Research

Avec: Thomas M Polasek , Sepehr Shakib , Amin Rostami-Hodjegan

Use of Physiologically Based Pharmacokinetic Modeling to Identify Physiological and Molecular Characteristics Driving Variability in Axitinib Exposure: A Fresh Approach to Precision Dosing in Oncology.

Journal of clinical pharmacology

Avec: Michael J Sorich , Fayzah Mutlib , Madelé van Dyk , Ashley M Hopkins , Thomas M Polasek , Jean-Claude Marshall , A David Rodrigues , Andrew Rowland

Artificial Intelligence and Machine Learning Applied at the Point of Care.

Frontiers in pharmacology

Avec: Zuzanna Angehrn , Liina Haldna , Anthe S Zandvliet , Eva Gil Berglund , Joost Zeeuw , Billy Amzal , S Y Amy Cheung , Thomas M Polasek , Marc Pfister , Thomas Kerbusch , Niedre M Heckman

Model-Informed Drug Development for Anti-Infectives: State of the Art and Future.

Clinical pharmacology and therapeutics

Avec: Craig R Rayner , Patrick F Smith , David Andes , Kayla Andrews , Hartmut Derendorf , Lena E Friberg , Debra Hanna , Alex Lepak , Edward Mills , Thomas M Polasek , Jason A Roberts , Virna Schuck , Mark J Shelton , David Wesche , Karen Rowland-Yeo

Safety and immunogenicity of a plant-derived rotavirus-like particle vaccine in adults, toddlers and infants.

Vaccine

Avec: Natsuki Kurokawa , Michelle K Robinson , Catherine Bernard , Yutaka Kawaguchi , Yoshito Koujin , Anthonet Koen , Shabir Madhi , Thomas M Polasek , Monica McNeal , Michèle Dargis , Manon M-J Couture , Sonia Trépanier , Bruce D Forrest , Naohisa Tsutsui

Pharmacogenomics in psychiatry - the challenge of cytochrome P450 enzyme phenoconversion and solutions to assist precision dosing.

Pharmacogenomics

Avec: Sam Mostafa , Thomas M Polasek , Chad A Bousman , Daniel J Müeller , Leslie J Sheffield , Joel Rembach , Carl Mj Kirkpatrick

Safety, Tolerability, and Pharmacokinetics of IMU-935, a Novel Inverse Agonist of Retinoic Acid Receptor-Related Orphan Nuclear Receptor γt: Results From a Double-Blind, Placebo-Controlled, First-in-Human Phase 1 Study.

Clinical pharmacology in drug development

Avec: Thomas M Polasek , Indika Leelasena , Irina Betscheider , Marija Marolt , Hella Kohlhof , Daniel Vitt , Frank Fliegert , Andreas R Muehler

Réseau de co-auteurs

Amin Rostami-Hodjegan 8 collaborations

Andrew Rowland 3 collaborations

Sam Mostafa 3 collaborations

Leslie J Sheffield 3 collaborations

Carl M J Kirkpatrick 3 collaborations

Chad Bousman 2 collaborations

Brahim Achour 2 collaborations

Youssef Daali 2 collaborations

Jean-Luc Reny 2 collaborations

Chad A Bousman 2 collaborations

Richard W Peck 2 collaborations

Craig R Rayner 2 collaborations

Holly Kimko 2 collaborations

Adam S Darwich 2 collaborations

Sibel Saya 1 collaboration

Patty Chondros 1 collaboration

Anastasia Abela 1 collaboration

Cathrine Mihalopolous 1 collaboration

Mary Lou Chatterton 1 collaboration

Jane Gunn 1 collaboration

Timothy F Chen 1 collaboration

Elise Dettmann 1 collaboration

Rachel Brooks 1 collaboration

Michelle King 1 collaboration

Luke Spencer 1 collaboration

Pavithran Alphonse 1 collaboration

Shakira Milton 1 collaboration

Georgia Ramsay 1 collaboration

Zoe Siviour 1 collaboration

Jamie Liew 1 collaboration

Philip Ly 1 collaboration

Matthew Thoenig 1 collaboration

Raushaan Seychell 1 collaboration

Floriana La Rocca 1 collaboration

Luke B Hesson 1 collaboration

Nydia Mejias 1 collaboration

Terri Sivertsen 1 collaboration

Melanie Anne Galea 1 collaboration

Jon Emery 1 collaboration

John O Miners 1 collaboration

Julie-Ann Hulin 1 collaboration

Robyn Meech 1 collaboration

Allan M Evans 1 collaboration

Gianfranco Fornasini 1 collaboration

Tahlia R Meola 1 collaboration

William A Gahl 1 collaboration

Marjan Huizing 1 collaboration

Stephanie E Reuter 1 collaboration

Pauline Gosselin 1 collaboration

Jean Terrier 1 collaboration

Yvonne Gloor 1 collaboration

Zubida M Al-Majdoub 1 collaboration

Reza Rafizadeh 1 collaboration

Robert Stowe 1 collaboration

Prescilla Carrion 1 collaboration

Peter L Friedland 1 collaboration

Duncan Topliss 1 collaboration

Kym Mina 1 collaboration

Graeme Suthers 1 collaboration

Jeffrey K Aronson 1 collaboration

Kayode Ogungbenro 1 collaboration

Daniel F B Wright 1 collaboration

Birgit Eiermann 1 collaboration

Jack Cook 1 collaboration

Lawrence Lesko 1 collaboration

Andrew J McLachlan 1 collaboration

Cecile Paquet Luzy 1 collaboration

Emilie Doppler 1 collaboration

Ruben Giorgino 1 collaboration

Graeme K Suthers 1 collaboration

Tom M Polasek 1 collaboration

Dong-Seok Yim 1 collaboration

Masoud Jamei 1 collaboration

Howard Lee 1 collaboration

Jae Kyoung Kim 1 collaboration

Phuong Thi Thu Nguyen 1 collaboration

Jae-Gook Shin 1 collaboration

Ian Everall 1 collaboration

Christos Pantelis 1 collaboration

Richard T Kenney 1 collaboration

John K Cini 1 collaboration

Susan Dexter 1 collaboration

Manuel DaFonseca 1 collaboration

Justus Bingham 1 collaboration

Isabelle Kuan 1 collaboration

Sant P Chawla 1 collaboration

Jason Lickliter 1 collaboration

Philip J Ryan 1 collaboration

Joanna Skommer 1 collaboration

Krish Gunesh 1 collaboration

Kiflu G Tesfamicael 1 collaboration

Lijun Zhao 1 collaboration

Rubén Fernández-Rodríguez 1 collaboration

David L Adelson 1 collaboration

Michael Musker 1 collaboration

Martin David Lewis 1 collaboration

Sepehr Shakib 1 collaboration

Michael J Sorich 1 collaboration

Fayzah Mutlib 1 collaboration

Madelé van Dyk 1 collaboration

Ashley M Hopkins 1 collaboration

Jean-Claude Marshall 1 collaboration

A David Rodrigues 1 collaboration

Zuzanna Angehrn 1 collaboration

Liina Haldna 1 collaboration

Anthe S Zandvliet 1 collaboration

Eva Gil Berglund 1 collaboration

Joost Zeeuw 1 collaboration

Billy Amzal 1 collaboration

S Y Amy Cheung 1 collaboration

Marc Pfister 1 collaboration

Thomas Kerbusch 1 collaboration

Niedre M Heckman 1 collaboration

Patrick F Smith 1 collaboration

David Andes 1 collaboration

Kayla Andrews 1 collaboration

Hartmut Derendorf 1 collaboration

Lena E Friberg 1 collaboration

Debra Hanna 1 collaboration

Alex Lepak 1 collaboration

Edward Mills 1 collaboration

Jason A Roberts 1 collaboration

Virna Schuck 1 collaboration

Mark J Shelton 1 collaboration

David Wesche 1 collaboration

Karen Rowland-Yeo 1 collaboration

Natsuki Kurokawa 1 collaboration

Michelle K Robinson 1 collaboration

Catherine Bernard 1 collaboration

Yutaka Kawaguchi 1 collaboration

Yoshito Koujin 1 collaboration

Anthonet Koen 1 collaboration

Shabir Madhi 1 collaboration

Monica McNeal 1 collaboration

Michèle Dargis 1 collaboration

Manon M-J Couture 1 collaboration

Sonia Trépanier 1 collaboration

Bruce D Forrest 1 collaboration

Naohisa Tsutsui 1 collaboration

Daniel J Müeller 1 collaboration

Joel Rembach 1 collaboration

Carl Mj Kirkpatrick 1 collaboration

Indika Leelasena 1 collaboration

Irina Betscheider 1 collaboration

Marija Marolt 1 collaboration

Hella Kohlhof 1 collaboration

Daniel Vitt 1 collaboration

Frank Fliegert 1 collaboration

Andreas R Muehler 1 collaboration