Thomas P Spargo

Affiliations

Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
NIHR Biomedical Research Centre, South London and Maudsley NHS Foundation Trust, King's College London, London, United Kingdom.

Publications (6)

A polymorphic transcriptional regulatory domain in the amyotrophic lateral sclerosis risk gene

Frontiers in molecular neuroscience

Avec: Jack N G Marshall , Alexander Fröhlich , Li Li , Abigail L Pfaff , Ben Middlehurst , Thomas P Spargo , Alfredo Iacoangeli , Bing Lang , Ammar Al-Chalabi , Sulev Koks , Vivien J Bubb , John P Quinn

Molecular dynamics analysis of superoxide dismutase 1 mutations suggests decoupling between mechanisms underlying ALS onset and progression.

Computational and structural biotechnology journal

Avec: Munishikha Kalia , Mattia Miotto , Deborah Ness , Sarah Opie-Martin , Thomas P Spargo , Lorenzo Di Rienzo , Tommaso Biagini , Francesco Petrizzelli , Ahmad Al Khleifat , Renata Kabiljo , Auteur inconnu , Auteur inconnu , Tommaso Mazza , Giancarlo Ruocco , Edoardo Milanetti , Richard Jb Dobson , Ammar Al-Chalabi , Alfredo Iacoangeli

The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration.

Nature communications

Avec: Sarah Opie-Martin , Alfredo Iacoangeli , Simon D Topp , Olubunmi Abel , Keith Mayl , Puja R Mehta , Aleksey Shatunov , Isabella Fogh , Harry Bowles , Naomi Limbachiya , Thomas P Spargo , Ahmad Al-Khleifat , Kelly L Williams , Jennifer Jockel-Balsarotti , Taha Bali , Wade Self , Lyndal Henden , Garth A Nicholson , Nicola Ticozzi , Diane McKenna-Yasek , Lu Tang , Pamela J Shaw , Adriano Chio , Albert Ludolph , Jochen H Weishaupt , John E Landers , Jonathan D Glass , Jesus S Mora , Wim Robberecht , Philip Van Damme , Russell McLaughlin , Orla Hardiman , Leonard van den Berg , Jan H Veldink , Phillippe Corcia , Zorica Stevic , Nailah Siddique , Vincenzo Silani , Ian P Blair , Dong-Sheng Fan , Florence Esselin , Elisa de la Cruz , William Camu , Nazli A Basak , Teepu Siddique , Timothy Miller , Robert H Brown , Ammar Al-Chalabi , Christopher E Shaw

Calculating variant penetrance from family history of disease and average family size in population-scale data.

Genome medicine

Avec: Thomas P Spargo , Sarah Opie-Martin , Harry Bowles , Cathryn M Lewis , Alfredo Iacoangeli , Ammar Al-Chalabi

GEOexplorer: a webserver for gene expression analysis and visualisation.

Nucleic acids research

Avec: Guy P Hunt , Luigi Grassi , Rafael Henkin , Fabrizio Smeraldi , Thomas P Spargo , Renata Kabiljo , Sulev Koks , Zina Ibrahim , Richard J B Dobson , Ammar Al-Chalabi , Michael R Barnes , Alfredo Iacoangeli

Mutations in the tail and rod domains of the neurofilament heavy-chain gene increase the risk of ALS.

Annals of clinical and translational neurology

Avec: Heather Marriott , Thomas P Spargo , Ahmad Al Khleifat , Peter M Andersen , Nazli A Başak , Johnathan Cooper-Knock , Philippe Corcia , Philippe Couratier , Mamede de Carvalho , Vivian Drory , Marc Gotkine , John E Landers , Russell McLaughlin , Jesús S Mora Pardina , Karen E Morrison , Susana Pinto , Christopher E Shaw , Pamela J Shaw , Vincenzo Silani , Nicola Ticozzi , Philip van Damme , Leonard H van den Berg , Patrick Vourc'h , Markus Weber , Jan H Veldink , Auteur inconnu , Richard J Dobson , Patrick Schwab , Ammar Al-Chalabi , Alfredo Iacoangeli

Réseau de co-auteurs

Alfredo Iacoangeli 6 collaborations

Ammar Al-Chalabi 6 collaborations

Sarah Opie-Martin 3 collaborations

None None 3 collaborations

Sulev Koks 2 collaborations

Ahmad Al Khleifat 2 collaborations

Renata Kabiljo 2 collaborations

Harry Bowles 2 collaborations

Nicola Ticozzi 2 collaborations

Pamela J Shaw 2 collaborations

John E Landers 2 collaborations

Russell McLaughlin 2 collaborations

Jan H Veldink 2 collaborations

Vincenzo Silani 2 collaborations

Christopher E Shaw 2 collaborations

Jack N G Marshall 1 collaboration

Alexander Fröhlich 1 collaboration

Li Li 1 collaboration

Abigail L Pfaff 1 collaboration

Ben Middlehurst 1 collaboration

Bing Lang 1 collaboration

Vivien J Bubb 1 collaboration

John P Quinn 1 collaboration

Munishikha Kalia 1 collaboration

Mattia Miotto 1 collaboration

Deborah Ness 1 collaboration

Lorenzo Di Rienzo 1 collaboration

Tommaso Biagini 1 collaboration

Francesco Petrizzelli 1 collaboration

Tommaso Mazza 1 collaboration

Giancarlo Ruocco 1 collaboration

Edoardo Milanetti 1 collaboration

Richard Jb Dobson 1 collaboration

Simon D Topp 1 collaboration

Olubunmi Abel 1 collaboration

Keith Mayl 1 collaboration

Puja R Mehta 1 collaboration

Aleksey Shatunov 1 collaboration

Isabella Fogh 1 collaboration

Naomi Limbachiya 1 collaboration

Ahmad Al-Khleifat 1 collaboration

Kelly L Williams 1 collaboration

Jennifer Jockel-Balsarotti 1 collaboration

Taha Bali 1 collaboration

Wade Self 1 collaboration

Lyndal Henden 1 collaboration

Garth A Nicholson 1 collaboration

Diane McKenna-Yasek 1 collaboration

Lu Tang 1 collaboration

Adriano Chio 1 collaboration

Albert Ludolph 1 collaboration

Jochen H Weishaupt 1 collaboration

Jonathan D Glass 1 collaboration

Jesus S Mora 1 collaboration

Wim Robberecht 1 collaboration

Philip Van Damme 1 collaboration

Orla Hardiman 1 collaboration

Leonard van den Berg 1 collaboration

Phillippe Corcia 1 collaboration

Zorica Stevic 1 collaboration

Nailah Siddique 1 collaboration

Ian P Blair 1 collaboration

Dong-Sheng Fan 1 collaboration

Florence Esselin 1 collaboration

Elisa de la Cruz 1 collaboration

William Camu 1 collaboration

Nazli A Basak 1 collaboration

Teepu Siddique 1 collaboration

Timothy Miller 1 collaboration

Robert H Brown 1 collaboration

Cathryn M Lewis 1 collaboration

Guy P Hunt 1 collaboration

Luigi Grassi 1 collaboration

Rafael Henkin 1 collaboration

Fabrizio Smeraldi 1 collaboration

Zina Ibrahim 1 collaboration

Richard J B Dobson 1 collaboration

Michael R Barnes 1 collaboration

Heather Marriott 1 collaboration

Peter M Andersen 1 collaboration

Nazli A Başak 1 collaboration

Johnathan Cooper-Knock 1 collaboration

Philippe Corcia 1 collaboration

Philippe Couratier 1 collaboration

Mamede de Carvalho 1 collaboration

Vivian Drory 1 collaboration

Marc Gotkine 1 collaboration

Jesús S Mora Pardina 1 collaboration

Karen E Morrison 1 collaboration

Susana Pinto 1 collaboration

Philip van Damme 1 collaboration

Leonard H van den Berg 1 collaboration

Patrick Vourc'h 1 collaboration

Markus Weber 1 collaboration

Richard J Dobson 1 collaboration

Patrick Schwab 1 collaboration