Timothy Guzi

Affiliations

Blueprint Medicines Corporation, Cambridge, Massachusetts.

Publications (5)

Evaluation of Protein Kinase cAMP-Activated Catalytic Subunit Alpha as a Therapeutic Target for Fibrolamellar Carcinoma.

Gastro hep advances

Avec: Stefanie S Schalm , Erin O'Hearn , Kevin Wilson , Timothy P LaBranche , Grace Silva , Zhuo Zhang , Lucian DiPietro , Neil Bifulco , Richard Woessner , Nicolas Stransky , Darshan Sappal , Robert Campbell , Riadh Lobbardi , Michael Palmer , Joseph Kim , Chaoyang Ye , Marion Dorsch , Christoph Lengauer , Timothy Guzi , Vivek Kadambi , Andrew Garner , Klaus P Hoeflich

Structure Overhaul Affords a Potent Purine PI3Kδ Inhibitor with Improved Tolerability.

Journal of medicinal chemistry

Avec: Joey L Methot , Hua Zhou , Sam D Kattar , Meredeth A McGowan , Kevin Wilson , Yudith Garcia , Yongi Deng , Michael Altman , Xavier Fradera , Charles Lesburg , Thierry Fischmann , Chaomin Li , Steve Alves , Sanjiv Shah , Rafael Fernandez , Peter Goldenblatt , Armetta Hill , Lynsey Shaffer , Dapeng Chen , Vince Tong , Robbie L McLeod , Hongshi Yu , Alan Bass , Ray Kemper , Nicholas T Gatto , Lisa LaFranco-Scheuch , Benjamin Wesley Trotter , Timothy Guzi , Jason D Katz

Phe19 modification of HDM2-p53 PPI inhibitors to alleviate CYP3A4 metabolism/mechanism-based inhibition liability.

Bioorganic & medicinal chemistry letters

Avec: Yuan Tian , Brian R Lahue , Yao Ma , Latha G Nair , Weidong Pan , Ronald J Doll , Timothy Guzi , Yao Ma , Yaolin Wang , Stéphane L Bogen

Acquired On-Target Clinical Resistance Validates FGFR4 as a Driver of Hepatocellular Carcinoma.

Cancer discovery

Avec: Megan A Hatlen , Oleg Schmidt-Kittler , Cori Ann Sherwin , Emily Rozsahegyi , Nooreen Rubin , Michael P Sheets , Joseph L Kim , Chandrasekhar Miduturu , Neil Bifulco , Natasja Brooijmans , Hongliang Shi , Timothy Guzi , Andy Boral , Christoph Lengauer , Marion Dorsch , Richard D Kim , Yoon-Koo Kang , Beni B Wolf , Klaus P Hoeflich

Human polymerase theta helicase positions DNA microhomologies for double-strand break repair.

bioRxiv : the preprint server for biology

Avec: Christopher J Zerio , Yonghong Bai , Brian A Sosa-Alvarado , Timothy Guzi , Gabriel C Lander

Réseau de co-auteurs

Kevin Wilson 2 collaborations

Neil Bifulco 2 collaborations

Marion Dorsch 2 collaborations

Christoph Lengauer 2 collaborations

Klaus P Hoeflich 2 collaborations

Yao Ma 2 collaborations

Stefanie S Schalm 1 collaboration

Erin O'Hearn 1 collaboration

Timothy P LaBranche 1 collaboration

Grace Silva 1 collaboration

Zhuo Zhang 1 collaboration

Lucian DiPietro 1 collaboration

Richard Woessner 1 collaboration

Nicolas Stransky 1 collaboration

Darshan Sappal 1 collaboration

Robert Campbell 1 collaboration

Riadh Lobbardi 1 collaboration

Michael Palmer 1 collaboration

Joseph Kim 1 collaboration

Chaoyang Ye 1 collaboration

Vivek Kadambi 1 collaboration

Andrew Garner 1 collaboration

Joey L Methot 1 collaboration

Hua Zhou 1 collaboration

Sam D Kattar 1 collaboration

Meredeth A McGowan 1 collaboration

Yudith Garcia 1 collaboration

Yongi Deng 1 collaboration

Michael Altman 1 collaboration

Xavier Fradera 1 collaboration

Charles Lesburg 1 collaboration

Thierry Fischmann 1 collaboration

Chaomin Li 1 collaboration

Steve Alves 1 collaboration

Sanjiv Shah 1 collaboration

Rafael Fernandez 1 collaboration

Peter Goldenblatt 1 collaboration

Armetta Hill 1 collaboration

Lynsey Shaffer 1 collaboration

Dapeng Chen 1 collaboration

Vince Tong 1 collaboration

Robbie L McLeod 1 collaboration

Hongshi Yu 1 collaboration

Alan Bass 1 collaboration

Ray Kemper 1 collaboration

Nicholas T Gatto 1 collaboration

Lisa LaFranco-Scheuch 1 collaboration

Benjamin Wesley Trotter 1 collaboration

Jason D Katz 1 collaboration

Yuan Tian 1 collaboration

Brian R Lahue 1 collaboration

Latha G Nair 1 collaboration

Weidong Pan 1 collaboration

Ronald J Doll 1 collaboration

Yaolin Wang 1 collaboration

Stéphane L Bogen 1 collaboration

Megan A Hatlen 1 collaboration

Oleg Schmidt-Kittler 1 collaboration

Cori Ann Sherwin 1 collaboration

Emily Rozsahegyi 1 collaboration

Nooreen Rubin 1 collaboration

Michael P Sheets 1 collaboration

Joseph L Kim 1 collaboration

Chandrasekhar Miduturu 1 collaboration

Natasja Brooijmans 1 collaboration

Hongliang Shi 1 collaboration

Andy Boral 1 collaboration

Richard D Kim 1 collaboration

Yoon-Koo Kang 1 collaboration

Beni B Wolf 1 collaboration

Christopher J Zerio 1 collaboration

Yonghong Bai 1 collaboration

Brian A Sosa-Alvarado 1 collaboration

Gabriel C Lander 1 collaboration