Wendy A Bickmore

Affiliations

MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Crewe Road, Edinburgh, EH4 2XU, UK Wendy.Bickmore@igmm.ed.ac.uk Laura.Lettice@igmm.ed.ac.uk.

Publications (28)

Developmentally regulated

Development (Cambridge, England)

Avec: Iain Williamson , Lauren Kane , Paul S Devenney , Ilya M Flyamer , Eve Anderson , Fiona Kilanowski , Robert E Hill , Wendy A Bickmore , Laura A Lettice

Nuclear pore density controls heterochromatin reorganization during senescence.

Genes & development

Avec: Charlene Boumendil , Priya Hari , Karl C F Olsen , Juan Carlos Acosta , Wendy A Bickmore

DNA Methylation Directs Polycomb-Dependent 3D Genome Re-organization in Naive Pluripotency.

Cell reports

Avec: Katy McLaughlin , Ilya M Flyamer , John P Thomson , Heidi K Mjoseng , Ruchi Shukla , Iain Williamson , Graeme R Grimes , Robert S Illingworth , Ian R Adams , Sari Pennings , Richard R Meehan , Wendy A Bickmore

A central role for canonical PRC1 in shaping the 3D nuclear landscape.

Genes & development

Avec: Shelagh Boyle , Ilya M Flyamer , Iain Williamson , Dipta Sengupta , Wendy A Bickmore , Robert S Illingworth

Linking the

Science advances

Avec: Samantha Laber , Sara Forcisi , Liz Bentley , Julia Petzold , Franco Moritz , Kirill S Smirnov , Loubna Al Sadat , Iain Williamson , Sophie Strobel , Thomas Agnew , Shahana Sengupta , Tom Nicol , Harald Grallert , Margit Heier , Julius Honecker , Joffrey Mianne , Lydia Teboul , Rebecca Dumbell , Helen Long , Michelle Simon , Cecilia Lindgren , Wendy A Bickmore , Hans Hauner , Philippe Schmitt-Kopplin , Melina Claussnitzer , Roger D Cox

Transcription decouples estrogen-dependent changes in enhancer-promoter contact frequencies and spatial proximity.

PLoS genetics

Avec: Luciana I Gómez Acuña , Ilya Flyamer , Shelagh Boyle , Elias T Friman , Wendy A Bickmore

Oncogene expression from extrachromosomal DNA is driven by copy number amplification and does not require spatial clustering in glioblastoma stem cells.

eLife

Avec: Karin Purshouse , Elias T Friman , Shelagh Boyle , Pooran Singh Dewari , Vivien Grant , Alhafidz Hamdan , Gillian M Morrison , Paul M Brennan , Sjoerd V Beentjes , Steven M Pollard , Wendy A Bickmore

Decreased Enhancer-Promoter Proximity Accompanying Enhancer Activation.

Molecular cell

Avec: Nezha S Benabdallah , Iain Williamson , Robert S Illingworth , Lauren Kane , Shelagh Boyle , Dipta Sengupta , Graeme R Grimes , Pierre Therizols , Wendy A Bickmore

Fine-mapping and cell-specific enrichment at corneal resistance factor loci prioritize candidate causal regulatory variants.

Communications biology

Avec: Xinyi Jiang , Nefeli Dellepiane , Erola Pairo-Castineira , Thibaud Boutin , Yatendra Kumar , Wendy A Bickmore , Veronique Vitart

Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.

Nature communications

Avec: Stefano Gnan , Ilya M Flyamer , Kyle N Klein , Eleonora Castelli , Alexander Rapp , Andreas Maiser , Naiming Chen , Patrick Weber , Elin Enervald , M Cristina Cardoso , Wendy A Bickmore , David M Gilbert , Sara C B Buonomo

Cohesin is required for long-range enhancer action at the Shh locus.

Nature structural & molecular biology

Avec: Lauren Kane , Iain Williamson , Ilya M Flyamer , Yatendra Kumar , Robert E Hill , Laura A Lettice , Wendy A Bickmore

Dispersal of PRC1 condensates disrupts polycomb chromatin domains and loops.

Life science alliance

Avec: Iain Williamson , Shelagh Boyle , Graeme R Grimes , Elias T Friman , Wendy A Bickmore

Expansion of ventral foregut is linked to changes in the enhancer landscape for organ-specific differentiation.

Nature cell biology

Avec: Yan Fung Wong , Yatendra Kumar , Martin Proks , Jose Alejandro Romero Herrera , Michaela Mrugala Rothová , Rita S Monteiro , Sara Pozzi , Rachel E Jennings , Neil A Hanley , Wendy A Bickmore , Joshua M Brickman

DNA-binding factor footprints and enhancer RNAs identify functional non-coding genetic variants.

Genome biology

Avec: Simon C Biddie , Giovanna Weykopf , Elizabeth F Hird , Elias T Friman , Wendy A Bickmore

Publisher Correction: BRD4 interacts with NIPBL and BRD4 is mutated in a Cornelia de Lange-like syndrome.

Nature genetics

Avec: Gabrielle Olley , Morad Ansari , Hemant Bengani , Graeme R Grimes , James Rhodes , Alex von Kriegsheim , Ana Blatnik , Fiona J Stewart , Emma Wakeling , Nicola Carroll , Alison Ross , Soo-Mi Park , Auteur inconnu , Wendy A Bickmore , Madapura M Pradeepa , David R FitzPatrick

Coolpup.py: versatile pile-up analysis of Hi-C data.

Bioinformatics (Oxford, England)

Avec: Ilya M Flyamer , Robert S Illingworth , Wendy A Bickmore

Patterns in the genome.

Heredity

Avec: Wendy A Bickmore

From bedside to bench: regulation of host factors in SARS-CoV-2 infection.

Experimental & molecular medicine

Avec: Samantha Y Q Ong , Ilya M Flyamer , Wendy A Bickmore , Simon C Biddie

Extensive pleiotropism and allelic heterogeneity mediate metabolic effects of

Science (New York, N.Y.)

Avec: Débora R Sobreira , Amelia C Joslin , Qi Zhang , Iain Williamson , Grace T Hansen , Kathryn M Farris , Noboru J Sakabe , Nasa Sinnott-Armstrong , Grazyna Bozek , Sharon O Jensen-Cody , Kyle H Flippo , Carole Ober , Wendy A Bickmore , Matthew Potthoff , Mengjie Chen , Melina Claussnitzer , Ivy Aneas , Marcelo A Nóbrega

Unique activities of two overlapping

Life science alliance

Avec: Kirsty Uttley , Andrew S Papanastasiou , Manuela Lahne , Jennifer M Brisbane , Ryan B MacDonald , Wendy A Bickmore , Shipra Bhatia

EvoChromo: towards a synthesis of chromatin biology and evolution.

Development (Cambridge, England)

Avec: Ines A Drinnenberg , Frédéric Berger , Simon J Elsässer , Peter R Andersen , Juan Ausió , Wendy A Bickmore , Alexander R Blackwell , Douglas H Erwin , James M Gahan , Brandon S Gaut , Zachary H Harvey , Steven Henikoff , Joyce Y Kao , Siavash K Kurdistani , Bernardo Lemos , Mia T Levine , Karolin Luger , Harmit S Malik , José M Martín-Durán , Catherine L Peichel , Marilyn B Renfree , Kinga Rutowicz , Peter Sarkies , Robert J Schmitz , Ulrich Technau , Joseph W Thornton , Tobias Warnecke , Kenneth H Wolfe

Bivalent promoter hypermethylation in cancer is linked to the H327me3/H3K4me3 ratio in embryonic stem cells.

BMC biology

Avec: Donnchadh S Dunican , Heidi K Mjoseng , Leanne Duthie , Ilya M Flyamer , Wendy A Bickmore , Richard R Meehan

Quantitative spatial and temporal assessment of regulatory element activity in zebrafish.

eLife

Avec: Shipra Bhatia , Dirk Jan Kleinjan , Kirsty Uttley , Anita Mann , Nefeli Dellepiane , Wendy A Bickmore

Cornelia de Lange syndrome-associated mutations cause a DNA damage signalling and repair defect.

Nature communications

Avec: Gabrielle Olley , Madapura M Pradeepa , Graeme R Grimes , Sandra Piquet , Sophie E Polo , David R FitzPatrick , Wendy A Bickmore , Charlene Boumendil

Imaging extrachromosomal DNA (ecDNA) in cancer.

Histochemistry and cell biology

Avec: Karin Purshouse , Steven M Pollard , Wendy A Bickmore

TADs do not stay in the loop.

Molecular cell

Avec: Davide Michieletto , Wendy A Bickmore

Mena regulates nesprin-2 to control actin-nuclear lamina associations, trans-nuclear membrane signalling and gene expression.

Nature communications

Avec: Frederic Li Mow Chee , Bruno Beernaert , Billie G C Griffith , Alexander E P Loftus , Yatendra Kumar , Jimi C Wills , Martin Lee , Jessica Valli , Ann P Wheeler , J Douglas Armstrong , Maddy Parsons , Irene M Leigh , Charlotte M Proby , Alex von Kriegsheim , Wendy A Bickmore , Margaret C Frame , Adam Byron

Ultra-long-range interactions between active regulatory elements.

Genome research

Avec: Elias T Friman , Ilya M Flyamer , Davide Marenduzzo , Shelagh Boyle , Wendy A Bickmore

Réseau de co-auteurs

Ilya M Flyamer 9 collaborations

Iain Williamson 8 collaborations

Shelagh Boyle 6 collaborations

Graeme R Grimes 5 collaborations

Elias T Friman 5 collaborations

Robert S Illingworth 4 collaborations

Yatendra Kumar 4 collaborations

Lauren Kane 3 collaborations

Robert E Hill 2 collaborations

Laura A Lettice 2 collaborations

Charlene Boumendil 2 collaborations

Heidi K Mjoseng 2 collaborations

Richard R Meehan 2 collaborations

Dipta Sengupta 2 collaborations

Melina Claussnitzer 2 collaborations

Karin Purshouse 2 collaborations

Steven M Pollard 2 collaborations

Nefeli Dellepiane 2 collaborations

Simon C Biddie 2 collaborations

Gabrielle Olley 2 collaborations

Alex von Kriegsheim 2 collaborations

Madapura M Pradeepa 2 collaborations

David R FitzPatrick 2 collaborations

Kirsty Uttley 2 collaborations

Shipra Bhatia 2 collaborations

Paul S Devenney 1 collaboration

Eve Anderson 1 collaboration

Fiona Kilanowski 1 collaboration

Priya Hari 1 collaboration

Karl C F Olsen 1 collaboration

Juan Carlos Acosta 1 collaboration

Katy McLaughlin 1 collaboration

John P Thomson 1 collaboration

Ruchi Shukla 1 collaboration

Ian R Adams 1 collaboration

Sari Pennings 1 collaboration

Samantha Laber 1 collaboration

Sara Forcisi 1 collaboration

Liz Bentley 1 collaboration

Julia Petzold 1 collaboration

Franco Moritz 1 collaboration

Kirill S Smirnov 1 collaboration

Loubna Al Sadat 1 collaboration

Sophie Strobel 1 collaboration

Thomas Agnew 1 collaboration

Shahana Sengupta 1 collaboration

Tom Nicol 1 collaboration

Harald Grallert 1 collaboration

Margit Heier 1 collaboration

Julius Honecker 1 collaboration

Joffrey Mianne 1 collaboration

Lydia Teboul 1 collaboration

Rebecca Dumbell 1 collaboration

Helen Long 1 collaboration

Michelle Simon 1 collaboration

Cecilia Lindgren 1 collaboration

Hans Hauner 1 collaboration

Philippe Schmitt-Kopplin 1 collaboration

Roger D Cox 1 collaboration

Luciana I Gómez Acuña 1 collaboration

Ilya Flyamer 1 collaboration

Pooran Singh Dewari 1 collaboration

Vivien Grant 1 collaboration

Alhafidz Hamdan 1 collaboration

Gillian M Morrison 1 collaboration

Paul M Brennan 1 collaboration

Sjoerd V Beentjes 1 collaboration

Nezha S Benabdallah 1 collaboration

Pierre Therizols 1 collaboration

Xinyi Jiang 1 collaboration

Erola Pairo-Castineira 1 collaboration

Thibaud Boutin 1 collaboration

Veronique Vitart 1 collaboration

Stefano Gnan 1 collaboration

Kyle N Klein 1 collaboration

Eleonora Castelli 1 collaboration

Alexander Rapp 1 collaboration

Andreas Maiser 1 collaboration

Naiming Chen 1 collaboration

Patrick Weber 1 collaboration

Elin Enervald 1 collaboration

M Cristina Cardoso 1 collaboration

David M Gilbert 1 collaboration

Sara C B Buonomo 1 collaboration

Yan Fung Wong 1 collaboration

Martin Proks 1 collaboration

Jose Alejandro Romero Herrera 1 collaboration

Michaela Mrugala Rothová 1 collaboration

Rita S Monteiro 1 collaboration

Sara Pozzi 1 collaboration

Rachel E Jennings 1 collaboration

Neil A Hanley 1 collaboration

Joshua M Brickman 1 collaboration

Giovanna Weykopf 1 collaboration

Elizabeth F Hird 1 collaboration

Morad Ansari 1 collaboration

Hemant Bengani 1 collaboration

James Rhodes 1 collaboration

Ana Blatnik 1 collaboration

Fiona J Stewart 1 collaboration

Emma Wakeling 1 collaboration

Nicola Carroll 1 collaboration

Alison Ross 1 collaboration

Soo-Mi Park 1 collaboration

None None 1 collaboration

Samantha Y Q Ong 1 collaboration

Débora R Sobreira 1 collaboration

Amelia C Joslin 1 collaboration

Qi Zhang 1 collaboration

Grace T Hansen 1 collaboration

Kathryn M Farris 1 collaboration

Noboru J Sakabe 1 collaboration

Nasa Sinnott-Armstrong 1 collaboration

Grazyna Bozek 1 collaboration

Sharon O Jensen-Cody 1 collaboration

Kyle H Flippo 1 collaboration

Carole Ober 1 collaboration

Matthew Potthoff 1 collaboration

Mengjie Chen 1 collaboration

Ivy Aneas 1 collaboration

Marcelo A Nóbrega 1 collaboration

Andrew S Papanastasiou 1 collaboration

Manuela Lahne 1 collaboration

Jennifer M Brisbane 1 collaboration

Ryan B MacDonald 1 collaboration

Ines A Drinnenberg 1 collaboration

Frédéric Berger 1 collaboration

Simon J Elsässer 1 collaboration

Peter R Andersen 1 collaboration

Juan Ausió 1 collaboration

Alexander R Blackwell 1 collaboration

Douglas H Erwin 1 collaboration

James M Gahan 1 collaboration

Brandon S Gaut 1 collaboration

Zachary H Harvey 1 collaboration

Steven Henikoff 1 collaboration

Joyce Y Kao 1 collaboration

Siavash K Kurdistani 1 collaboration

Bernardo Lemos 1 collaboration

Mia T Levine 1 collaboration

Karolin Luger 1 collaboration

Harmit S Malik 1 collaboration

José M Martín-Durán 1 collaboration

Catherine L Peichel 1 collaboration

Marilyn B Renfree 1 collaboration

Kinga Rutowicz 1 collaboration

Peter Sarkies 1 collaboration

Robert J Schmitz 1 collaboration

Ulrich Technau 1 collaboration

Joseph W Thornton 1 collaboration

Tobias Warnecke 1 collaboration

Kenneth H Wolfe 1 collaboration

Donnchadh S Dunican 1 collaboration

Leanne Duthie 1 collaboration

Dirk Jan Kleinjan 1 collaboration

Anita Mann 1 collaboration

Sandra Piquet 1 collaboration

Sophie E Polo 1 collaboration

Davide Michieletto 1 collaboration

Frederic Li Mow Chee 1 collaboration

Bruno Beernaert 1 collaboration

Billie G C Griffith 1 collaboration

Alexander E P Loftus 1 collaboration

Jimi C Wills 1 collaboration

Martin Lee 1 collaboration

Jessica Valli 1 collaboration

Ann P Wheeler 1 collaboration

J Douglas Armstrong 1 collaboration

Maddy Parsons 1 collaboration

Irene M Leigh 1 collaboration

Charlotte M Proby 1 collaboration

Margaret C Frame 1 collaboration

Adam Byron 1 collaboration

Davide Marenduzzo 1 collaboration