Xavier Declèves

Affiliations

Université Paris Cité, Inserm UMRS 1144, Optimisation Thérapeutique en Neuropsychopharmacologie, Paris, France.

Publications (36)

Mechanistic insights into P-glycoprotein ligand transport and inhibition revealed by enhanced molecular dynamics simulations.

Computational and structural biotechnology journal

Avec: Ahmad Elbahnsi , Balint Dudas , Salvatore Cisternino , Xavier Declèves , Maria A Miteva

LC-MS/MS method for simultaneous quantification of osilodrostat and metyrapone in human plasma from patients treated for Cushing's Syndrome.

Journal of pharmaceutical and biomedical analysis

Avec: David Balakirouchenane , Axelle Vasseur , Fidéline Bonnet-Serrano , Minna Choi , Nihel Khoudour , Alicja Puszkiel , Lionel Groussin , Michel Vidal , Xavier Declèves , Jérôme Bertherat , Benoit Blanchet

Phenotyping Indices of CYP450 and P-Glycoprotein in Human Volunteers and in Patients Treated with Painkillers or Psychotropic Drugs.

Pharmaceutics

Avec: Léa Darnaud , Clément Delage , Youssef Daali , Anne-Priscille Trouvin , Serge Perrot , Nihel Khoudour , Nadia Merise , Laurence Labat , Bruno Etain , Frank Bellivier , Célia Lloret-Linares , Vanessa Bloch , Emmanuel Curis , Xavier Declèves

Mechanistic Modeling of the Interplay Between Host Immune System, IL-7 and UCART19 Allogeneic CAR-T Cells in Adult B-cell Acute Lymphoblastic Leukemia.

Cancer research communications

Avec: Thibaud Derippe , Sylvain Fouliard , Ibtissam Marchiq , Sandra Dupouy , Maria Almena-Carrasco , Julia Geronimi , Xavier Declèves , Marylore Chenel , Donald E Mager

Molecular and Functional Study of Transient Receptor Potential Vanilloid 1-4 at the Rat and Human Blood-Brain Barrier Reveals Interspecies Differences.

Frontiers in cell and developmental biology

Avec: Huilong Luo , Bruno Saubamea , Stéphanie Chasseigneaux , Véronique Cochois , Maria Smirnova , Fabienne Glacial , Nicolas Perrière , Catarina Chaves , Salvatore Cisternino , Xavier Declèves

Transient Receptor Potential Vanilloid in the Brain Gliovascular Unit: Prospective Targets in Therapy.

Pharmaceutics

Avec: Huilong Luo , Xavier Declèves , Salvatore Cisternino

Pharmacokinetics of Baclofen in a Full-Term Newborn after Intrauterine Exposure: A Case Report.

Neonatology

Avec: David Balakirouchenane , Nihel Khoudour , Laurent Chouchana , Lucie Chevillard , Sophie Parat , Xavier Declèves

Megalencephalic leukoencephalopathy with subcortical cysts is a developmental disorder of the gliovascular unit.

eLife

Avec: Alice Gilbert , Xabier Elorza-Vidal , Armelle Rancillac , Audrey Chagnot , Mervé Yetim , Vincent Hingot , Thomas Deffieux , Anne-Cécile Boulay , Rodrigo Alvear-Perez , Salvatore Cisternino , Sabrina Martin , Sonia Taïb , Aontoinette Gelot , Virginie Mignon , Maryline Favier , Isabelle Brunet , Xavier Declèves , Mickael Tanter , Raul Estevez , Denis Vivien , Bruno Saubaméa , Martine Cohen-Salmon

Exposure of human cerebral microvascular endothelial cells hCMEC/D3 to laminar shear stress induces vascular protective responses.

Fluids and barriers of the CNS

Avec: Nina Choublier , Meryam Taghi , Marie-Claude Menet , Morgane Le Gall , Johanna Bruce , Philippe Chafey , François Guillonneau , Amélie Moreau , Claire Denizot , Yannick Parmentier , Samir Nakib , Didier Borderie , Haniaa Bouzinba-Segard , Pierre-Olivier Couraud , Sandrine Bourdoulous , Xavier Declèves

TSPO PET Imaging as a Potent Non-Invasive Biomarker for Diffuse Intrinsic Pontine Glioma in a Patient-Derived Orthotopic Rat Model.

International journal of molecular sciences

Avec: Céline Chevaleyre , Dimitri Kereselidze , Fabien Caillé , Nicolas Tournier , Nagore G Olaciregui , Alexandra Winkeler , Xavier Declèves , Benoit Jego , Salvatore Cisternino , Sylvain Auvity , Charles Truillet

Cytochromes P450 and P-Glycoprotein Phenotypic Assessment to Optimize Psychotropic Pharmacotherapy: A Retrospective Analysis of Four Years of Practice in Psychiatry.

Journal of personalized medicine

Avec: Clément Delage , Léa Darnaud , Bruno Etain , Marina Vignes , Tu-Ky Ly , Alexia Frapsauce , Marc Veyrier , Marine Delavest , Emeline Marlinge , Vincent Hennion , Manon Meyrel , Aude Jacob , Margot Chouchana , Julie Smati , Guillaume Pataud , Nihel Khoudour , Jean-Eudes Fontan , Laurence Labat , Frank Bellivier , Célia Lloret-Linares , Xavier Declèves , Vanessa Bloch

A Minimal PBPK Model for Plasma and Cerebrospinal Fluid Pharmacokinetics of Trastuzumab after Intracerebroventricular Administration in Patients with HER2-Positive Brain Metastatic Localizations.

Pharmaceutical research

Avec: Alicja Puszkiel , Guilhem Bousquet , Françoise Stanke-Labesque , Jeanick Stocco , Philippe Decq , Lucie Chevillard , Stéphane Goutagny , Xavier Declèves

Extending the dosing intervals of nivolumab: model-based simulations in unselected cancer patients.

British journal of cancer

Avec: Alicja Puszkiel , Guillaume Bianconi , Blaise Pasquiers , David Balakirouchenane , Jennifer Arrondeau , Pascaline Boudou-Rouquette , Marie-Claire Bretagne , Joe-Elie Salem , Xavier Declèves , Michel Vidal , Nora Kramkimel , Sarah Guegan , Selim Aractingi , Olivier Huillard , Jérôme Alexandre , Marie Wislez , François Goldwasser , Benoit Blanchet

Characterization of the Blood-Brain Barrier Integrity and the Brain Transport of SN-38 in an Orthotopic Xenograft Rat Model of Diffuse Intrinsic Pontine Glioma.

Pharmaceutics

Avec: Catarina Chaves , Xavier Declèves , Meryam Taghi , Marie-Claude Menet , Joelle Lacombe , Pascale Varlet , Nagore G Olaciregui , Angel M Carcaboso , Salvatore Cisternino

Glucocorticoids dosing in obese subjects: A systematic review.

Therapie

Avec: Jérémie Delaleu , Alexandre Destere , Lorry Hachon , Xavier Declèves , Célia Lloret-Linares

Population pharmacokinetic modeling of sustained release lithium in the serum, erythrocytes and urine of patients with bipolar disorder.

European journal of clinical pharmacology

Avec: C Couffignal , J Bertrand , S Sportiche , Marine Jarroir , S El Balkhi , N Djebrani-Oussedik , J Poupon , X Declèves , F Mentré , F Bellivier

Modifications of physical and functional integrity of the blood-brain barrier in an inducible mouse model of neurodegeneration.

Neuropharmacology

Avec: Camille Taccola , Pascal Barneoud , Sylvaine Cartot-Cotton , Delphine Valente , Nathalie Schussler , Bruno Saubaméa , Stéphanie Chasseigneaux , Véronique Cochois , Virginie Mignon , Emmanuel Curis , Murielle Lochus , Sophie Nicolic , Agnès Dodacki , Salvatore Cisternino , Xavier Declèves , Fanchon Bourasset

Massive tramadol ingestion resulting in fatal brain injury - a pharmacokinetic study with discussion on the involved mechanisms of toxicity.

Clinical toxicology (Philadelphia, Pa.)

Avec: Alicja Puszkiel , Isabelle Malissin , Salvatore Cisternino , Nicolas Pallet , Xavier Declèves , Bruno Mégarbane

Marked and prolonged serotonin toxicity in a tramadol-poisoned patient with a pharmacokinetic study.

Clinical toxicology (Philadelphia, Pa.)

Avec: Guillaume Bianconi , Isabelle Malissin , Laurence Labat , Nihel Khoudour , Pascal Houzé , Nicolas Pallet , Bruno Mégarbane , Xavier Declèves

Exposure-Response Analysis of Osimertinib in Patients with Advanced Non-Small-Cell Lung Cancer.

Pharmaceutics

Avec: Thomas Rodier , Alicja Puszkiel , Evelina Cardoso , David Balakirouchenane , Céline Narjoz , Jennifer Arrondeau , Vincent Fallet , Nihel Khoudour , Monia Guidi , Michel Vidal , Xavier Declèves , Chantal Csajka , Jérôme Alexandre , Jacques Cadranel , Elizabeth Fabre , Marie Wislez , François Goldwasser , Benoit Blanchet

Relevance of red blood cell Lithium concentration in the management of Lithium-treated bipolar and unipolar disorders: a systematic narrative review.

International journal of bipolar disorders

Avec: Manon Coyac , Lynn Jalabert , Xavier Declèves , Bruno Etain , Frank Bellivier

Is the 3,4-methylendioxypyrovalerone/mephedrone combination responsible for enhanced stimulant effects? A rat study with investigation of the effect/concentration relationships.

Psychopharmacology

Avec: Nadia Benturquia , Lucie Chevillard , Christophe Poiré , Olivier Roussel , Camille Cohier , Xavier Declèves , Jean-Louis Laplanche , Mélanie Etheve-Quelquejeu , Huixiong Chen , Bruno Mégarbane

An Interspecies Molecular and Functional Study of Organic Cation Transporters at the Blood-Brain Barrier: From Rodents to Humans.

Pharmaceutics

Avec: Catarina Chaves , Federica Campanelli , Hélène Chapy , David Gomez-Zepeda , Fabienne Glacial , Maria Smirnova , Meryam Taghi , Johan Pallud , Nicolas Perrière , Xavier Declèves , Marie-Claude Menet , Salvatore Cisternino

[New formats for improving brain drug delivery of antibodies: the blood-brain barrier case].

Medecine sciences : M/S

Avec: Pierre Lafaye , Dominique Lesuisse , Xavier Declèves

The role of brain barriers in the neurokinetics and pharmacodynamics of lithium.

Pharmacological research

Avec: Huilong Luo , Lucie Chevillard , Frank Bellivier , Bruno Mégarbane , Bruno Etain , Salvatore Cisternino , Xavier Declèves

Review of the Existing Translational Pharmacokinetics Modeling Approaches Specific to Monoclonal Antibodies (mAbs) to Support the First-In-Human (FIH) Dose Selection.

International journal of molecular sciences

Avec: Blaise Pasquiers , Salih Benamara , Mathieu Felices , Laurent Nguyen , Xavier Declèves

Assessment of brain delivery of a model ABCB1/ABCG2 substrate in patients with non-contrast-enhancing brain tumors with positron emission tomography.

EJNMMI research

Avec: Beatrix Wulkersdorfer , Martin Bauer , Rudolf Karch , Harald Stefanits , Cécile Philippe , Maria Weber , Thomas Czech , Marie-Claude Menet , Xavier Declèves , Johannes A Hainfellner , Matthias Preusser , Marcus Hacker , Markus Zeitlinger , Markus Müller , Oliver Langer

Astroglial Connexin 43 Deficiency Protects against LPS-Induced Neuroinflammation: A TSPO Brain µPET Study with [

Cells

Avec: Nicolas Vignal , Anne-Cécile Boulay , Carine San , Martine Cohen-Salmon , Nathalie Rizzo-Padoin , Laure Sarda-Mantel , Xavier Declèves , Salvatore Cisternino , Benoît Hosten

CYP450 activities before and after Roux-en-Y gastric bypass: correlation with their intestinal and liver content.

Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Avec: Célia Lloret-Linares , Youssef Daali , Chadi Abbara , Claire Carette , Jean-Luc Bouillot , Eric Vicaut , Sebastien Czernichow , Xavier Declèves

Cannabidiol Increases Proliferation, Migration, Tubulogenesis, and Integrity of Human Brain Endothelial Cells through TRPV2 Activation.

Molecular pharmaceutics

Avec: Huilong Luo , Elisa Rossi , Bruno Saubamea , Stéphanie Chasseigneaux , Véronique Cochois , Nina Choublier , Maria Smirnova , Fabienne Glacial , Nicolas Perrière , Sandrine Bourdoulous , David M Smadja , Marie-Claude Menet , Pierre-Olivier Couraud , Salvatore Cisternino , Xavier Declèves

Pharmacophore-Based Discovery of Substrates of a Novel Drug/Proton-Antiporter in the Human Brain Endothelial hCMEC/D3 Cell Line.

Pharmaceutics

Avec: Maria Smirnova , Laura Goracci , Gabriele Cruciani , Laetitia Federici , Xavier Declèves , Hélène Chapy , Salvatore Cisternino

Solubility of lamotrigine in age-specific biorelevant media that simulated the fasted- and fed-conditions of the gastric and intestinal environments in pediatrics and adults: implications for traditional, re-formulated, modified, and new oral formulations.

BMC biotechnology

Avec: Ramzi Shawahna , Hala Saba'aneh , Amal Daraghmeh , Yara Qassarwi , Valentina Franco , Xavier Declèves

Accelerating robust plausible virtual patient cohort generation by substituting ODE simulations with parameter space mapping.

Journal of pharmacokinetics and pharmacodynamics

Avec: Thibaud Derippe , Sylvain Fouliard , Xavier Declèves , Donald E Mager

The Use of Levothyroxine Absorption Tests in Clinical Practice.

The Journal of clinical endocrinology and metabolism

Avec: Philippe Caron , Xavier Declèves

Translation of Monoclonal Antibodies Pharmacokinetics from Animal to Human Using Physiologically Based Modeling in Open Systems Pharmacology (OSP) Suite: A Retrospective Analysis of Bevacizumab.

Pharmaceutics

Avec: Blaise Pasquiers , Salih Benamara , Mathieu Felices , David Ternant , Xavier Declèves , Alicja Puszkiel

Fasting upregulates the monocarboxylate transporter MCT1 at the rat blood-brain barrier through PPAR δ activation.

Fluids and barriers of the CNS

Avec: Stéphanie Chasseigneaux , Véronique Cochois-Guégan , Lucas Lecorgne , Murielle Lochus , Sophie Nicolic , Corinne Blugeon , Laurent Jourdren , David Gomez-Zepeda , Stefan Tenzer , Sylvia Sanquer , Valérie Nivet-Antoine , Marie-Claude Menet , Jean-Louis Laplanche , Xavier Declèves , Salvatore Cisternino , Bruno Saubaméa

Réseau de co-auteurs

Salvatore Cisternino 14 collaborations

Nihel Khoudour 6 collaborations

Alicja Puszkiel 6 collaborations

Marie-Claude Menet 6 collaborations

David Balakirouchenane 4 collaborations

Bruno Etain 4 collaborations

Frank Bellivier 4 collaborations

Célia Lloret-Linares 4 collaborations

Huilong Luo 4 collaborations

Stéphanie Chasseigneaux 4 collaborations

Maria Smirnova 4 collaborations

Lucie Chevillard 4 collaborations

Bruno Mégarbane 4 collaborations

Michel Vidal 3 collaborations

Benoit Blanchet 3 collaborations

Laurence Labat 3 collaborations

Véronique Cochois 3 collaborations

Fabienne Glacial 3 collaborations

Nicolas Perrière 3 collaborations

Catarina Chaves 3 collaborations

Bruno Saubaméa 3 collaborations

Meryam Taghi 3 collaborations

Blaise Pasquiers 3 collaborations

Léa Darnaud 2 collaborations

Clément Delage 2 collaborations

Youssef Daali 2 collaborations

Vanessa Bloch 2 collaborations

Emmanuel Curis 2 collaborations

Thibaud Derippe 2 collaborations

Sylvain Fouliard 2 collaborations

Donald E Mager 2 collaborations

Bruno Saubamea 2 collaborations

Anne-Cécile Boulay 2 collaborations

Virginie Mignon 2 collaborations

Martine Cohen-Salmon 2 collaborations

Nina Choublier 2 collaborations

Pierre-Olivier Couraud 2 collaborations

Sandrine Bourdoulous 2 collaborations

Nagore G Olaciregui 2 collaborations

Guillaume Bianconi 2 collaborations

Jennifer Arrondeau 2 collaborations

Jérôme Alexandre 2 collaborations

Marie Wislez 2 collaborations

François Goldwasser 2 collaborations

Murielle Lochus 2 collaborations

Sophie Nicolic 2 collaborations

Isabelle Malissin 2 collaborations

Nicolas Pallet 2 collaborations

Jean-Louis Laplanche 2 collaborations

Hélène Chapy 2 collaborations

David Gomez-Zepeda 2 collaborations

Salih Benamara 2 collaborations

Mathieu Felices 2 collaborations

Ahmad Elbahnsi 1 collaboration

Balint Dudas 1 collaboration

Maria A Miteva 1 collaboration

Axelle Vasseur 1 collaboration

Fidéline Bonnet-Serrano 1 collaboration

Minna Choi 1 collaboration

Lionel Groussin 1 collaboration

Jérôme Bertherat 1 collaboration

Anne-Priscille Trouvin 1 collaboration

Serge Perrot 1 collaboration

Nadia Merise 1 collaboration

Ibtissam Marchiq 1 collaboration

Sandra Dupouy 1 collaboration

Maria Almena-Carrasco 1 collaboration

Julia Geronimi 1 collaboration

Marylore Chenel 1 collaboration

Laurent Chouchana 1 collaboration

Sophie Parat 1 collaboration

Alice Gilbert 1 collaboration

Xabier Elorza-Vidal 1 collaboration

Armelle Rancillac 1 collaboration

Audrey Chagnot 1 collaboration

Mervé Yetim 1 collaboration

Vincent Hingot 1 collaboration

Thomas Deffieux 1 collaboration

Rodrigo Alvear-Perez 1 collaboration

Sabrina Martin 1 collaboration

Sonia Taïb 1 collaboration

Aontoinette Gelot 1 collaboration

Maryline Favier 1 collaboration

Isabelle Brunet 1 collaboration

Mickael Tanter 1 collaboration

Raul Estevez 1 collaboration

Denis Vivien 1 collaboration

Morgane Le Gall 1 collaboration

Johanna Bruce 1 collaboration

Philippe Chafey 1 collaboration

François Guillonneau 1 collaboration

Amélie Moreau 1 collaboration

Claire Denizot 1 collaboration

Yannick Parmentier 1 collaboration

Samir Nakib 1 collaboration

Didier Borderie 1 collaboration

Haniaa Bouzinba-Segard 1 collaboration

Céline Chevaleyre 1 collaboration

Dimitri Kereselidze 1 collaboration

Fabien Caillé 1 collaboration

Nicolas Tournier 1 collaboration

Alexandra Winkeler 1 collaboration

Benoit Jego 1 collaboration

Sylvain Auvity 1 collaboration

Charles Truillet 1 collaboration

Marina Vignes 1 collaboration

Tu-Ky Ly 1 collaboration

Alexia Frapsauce 1 collaboration

Marc Veyrier 1 collaboration

Marine Delavest 1 collaboration

Emeline Marlinge 1 collaboration

Vincent Hennion 1 collaboration

Manon Meyrel 1 collaboration

Aude Jacob 1 collaboration

Margot Chouchana 1 collaboration

Julie Smati 1 collaboration

Guillaume Pataud 1 collaboration

Jean-Eudes Fontan 1 collaboration

Guilhem Bousquet 1 collaboration

Françoise Stanke-Labesque 1 collaboration

Jeanick Stocco 1 collaboration

Philippe Decq 1 collaboration

Stéphane Goutagny 1 collaboration

Pascaline Boudou-Rouquette 1 collaboration

Marie-Claire Bretagne 1 collaboration

Joe-Elie Salem 1 collaboration

Nora Kramkimel 1 collaboration

Sarah Guegan 1 collaboration

Selim Aractingi 1 collaboration

Olivier Huillard 1 collaboration

Joelle Lacombe 1 collaboration

Pascale Varlet 1 collaboration

Angel M Carcaboso 1 collaboration

Jérémie Delaleu 1 collaboration

Alexandre Destere 1 collaboration

Lorry Hachon 1 collaboration

C Couffignal 1 collaboration

J Bertrand 1 collaboration

S Sportiche 1 collaboration

Marine Jarroir 1 collaboration

S El Balkhi 1 collaboration

N Djebrani-Oussedik 1 collaboration

J Poupon 1 collaboration

X Declèves 1 collaboration

F Mentré 1 collaboration

F Bellivier 1 collaboration

Camille Taccola 1 collaboration

Pascal Barneoud 1 collaboration

Sylvaine Cartot-Cotton 1 collaboration

Delphine Valente 1 collaboration

Nathalie Schussler 1 collaboration

Agnès Dodacki 1 collaboration

Fanchon Bourasset 1 collaboration

Pascal Houzé 1 collaboration

Thomas Rodier 1 collaboration

Evelina Cardoso 1 collaboration

Céline Narjoz 1 collaboration

Vincent Fallet 1 collaboration

Monia Guidi 1 collaboration

Chantal Csajka 1 collaboration

Jacques Cadranel 1 collaboration

Elizabeth Fabre 1 collaboration

Manon Coyac 1 collaboration

Lynn Jalabert 1 collaboration

Nadia Benturquia 1 collaboration

Christophe Poiré 1 collaboration

Olivier Roussel 1 collaboration

Camille Cohier 1 collaboration

Mélanie Etheve-Quelquejeu 1 collaboration

Huixiong Chen 1 collaboration

Federica Campanelli 1 collaboration

Johan Pallud 1 collaboration

Pierre Lafaye 1 collaboration

Dominique Lesuisse 1 collaboration

Laurent Nguyen 1 collaboration

Beatrix Wulkersdorfer 1 collaboration

Martin Bauer 1 collaboration

Rudolf Karch 1 collaboration

Harald Stefanits 1 collaboration

Cécile Philippe 1 collaboration

Maria Weber 1 collaboration

Thomas Czech 1 collaboration

Johannes A Hainfellner 1 collaboration

Matthias Preusser 1 collaboration

Marcus Hacker 1 collaboration

Markus Zeitlinger 1 collaboration

Markus Müller 1 collaboration

Oliver Langer 1 collaboration

Nicolas Vignal 1 collaboration

Carine San 1 collaboration

Nathalie Rizzo-Padoin 1 collaboration

Laure Sarda-Mantel 1 collaboration

Benoît Hosten 1 collaboration

Chadi Abbara 1 collaboration

Claire Carette 1 collaboration

Jean-Luc Bouillot 1 collaboration

Eric Vicaut 1 collaboration

Sebastien Czernichow 1 collaboration

Elisa Rossi 1 collaboration

David M Smadja 1 collaboration

Laura Goracci 1 collaboration

Gabriele Cruciani 1 collaboration

Laetitia Federici 1 collaboration

Ramzi Shawahna 1 collaboration

Hala Saba'aneh 1 collaboration

Amal Daraghmeh 1 collaboration

Yara Qassarwi 1 collaboration

Valentina Franco 1 collaboration

Philippe Caron 1 collaboration

David Ternant 1 collaboration

Véronique Cochois-Guégan 1 collaboration

Lucas Lecorgne 1 collaboration

Corinne Blugeon 1 collaboration

Laurent Jourdren 1 collaboration

Stefan Tenzer 1 collaboration

Sylvia Sanquer 1 collaboration

Valérie Nivet-Antoine 1 collaboration