Titre : Test pharmacogénomique

Test pharmacogénomique : Questions médicales fréquentes

Termes MeSH sélectionnés :

Network Meta-Analysis
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"datePublished": "2025-05-11", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Test pharmacogénomique", "description": "Qu'est-ce qu'un test pharmacogénomique ?\nQuand est-il recommandé de faire un test ?\nQuels types de médicaments sont concernés ?\nComment se déroule un test ?\nLes tests sont-ils fiables ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Network+Meta-Analysis&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Test pharmacogénomique", "description": "Quels symptômes peuvent indiquer un besoin de test ?\nLes tests peuvent-ils prédire des symptômes ?\nPeut-on avoir des symptômes sans test ?\nLes symptômes varient-ils selon les gènes ?\nLes tests peuvent-ils aider à diagnostiquer des maladies ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Network+Meta-Analysis&page=2#section-symptômes" }, { "@type": 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"name": "Complications", "headline": "Complications sur Test pharmacogénomique", "description": "Quelles complications peuvent survenir sans test ?\nLes tests peuvent-ils prévenir des complications ?\nLes complications sont-elles toujours évitables ?\nComment gérer les complications liées aux médicaments ?\nLes complications peuvent-elles affecter le traitement futur ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Network+Meta-Analysis&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Test pharmacogénomique", "description": "Quels facteurs de risque influencent les tests ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes facteurs de risque sont-ils les mêmes pour tous ?\nComment évaluer les facteurs de risque ?\nLes facteurs de risque peuvent-ils changer ?", "url": "https://questionsmedicales.fr/mesh/D000071185?mesh_terms=Network+Meta-Analysis&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Qu'est-ce qu'un test pharmacogénomique ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "C'est un test qui analyse les gènes pour prédire la réponse aux médicaments." } }, { "@type": "Question", "name": "Quand est-il recommandé de faire un test ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Il est recommandé avant de commencer un traitement médicamenteux, surtout pour certains médicaments." } }, { "@type": "Question", "name": "Quels types de médicaments sont concernés ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Les médicaments pour le cancer, les antidépresseurs et les anticoagulants sont souvent testés." } }, { "@type": "Question", "name": "Comment se déroule un test ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Un échantillon de sang ou de salive est prélevé et analysé en laboratoire." } }, { "@type": "Question", "name": "Les tests sont-ils fiables ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, mais leur précision dépend de la qualité du laboratoire et des gènes analysés." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un besoin de test ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires graves ou une réponse inefficace au traitement peuvent le justifier." } }, { "@type": "Question", "name": "Les tests peuvent-ils prédire des symptômes ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent aider à anticiper des réactions indésirables à certains médicaments." } }, { "@type": "Question", "name": "Peut-on avoir des symptômes sans test ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains symptômes peuvent survenir sans lien avec la génétique ou les médicaments." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon les gènes ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les variations génétiques peuvent influencer la gravité et la nature des symptômes." } }, { "@type": "Question", "name": "Les tests peuvent-ils aider à diagnostiquer des maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Indirectement, en identifiant des prédispositions génétiques à certaines maladies." } }, { "@type": "Question", "name": "Les tests peuvent-ils prévenir des effets secondaires ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils aident à choisir des médicaments moins susceptibles de provoquer des effets indésirables." } }, { "@type": "Question", "name": "Comment intégrer les tests dans la prévention ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "En les utilisant lors de la prescription de médicaments pour anticiper les réactions." } }, { "@type": "Question", "name": "Les tests sont-ils recommandés pour tous ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils sont surtout recommandés pour les personnes avec des antécédents médicaux complexes." } }, { "@type": "Question", "name": "Peut-on se préparer à un test ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Il est conseillé de discuter de l'historique médical et des médicaments en cours avec le médecin." } }, { "@type": "Question", "name": "Les tests peuvent-ils réduire les coûts de santé ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en évitant des traitements inefficaces et des hospitalisations dues à des effets secondaires." } }, { "@type": "Question", "name": "Comment les tests influencent-ils les traitements ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Ils permettent de personnaliser les traitements en fonction de la réponse génétique." } }, { "@type": "Question", "name": "Peut-on éviter des traitements grâce aux tests ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en identifiant les médicaments susceptibles de provoquer des effets indésirables." } }, { "@type": "Question", "name": "Les tests sont-ils utilisés pour tous les médicaments ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils sont principalement utilisés pour certains médicaments à haut risque." } }, { "@type": "Question", "name": "Les résultats des tests sont-ils toujours clairs ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Pas toujours, certains résultats peuvent être ambigus et nécessiter une interprétation." } }, { "@type": "Question", "name": "Les tests peuvent-ils changer en cours de traitement ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des tests supplémentaires peuvent être nécessaires si le traitement échoue." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir sans test ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires graves ou des traitements inefficaces peuvent survenir." } }, { "@type": "Question", "name": "Les tests peuvent-ils prévenir des complications ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en identifiant les patients à risque de réactions indésirables aux médicaments." } }, { "@type": "Question", "name": "Les complications sont-elles toujours évitables ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Non, certaines complications peuvent survenir malgré un test pharmacogénomique." } }, { "@type": "Question", "name": "Comment gérer les complications liées aux médicaments ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "En ajustant le traitement selon les résultats des tests et en surveillant les effets." } }, { "@type": "Question", "name": "Les complications peuvent-elles affecter le traitement futur ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent influencer les choix de médicaments dans le futur." } }, { "@type": "Question", "name": "Quels facteurs de risque influencent les tests ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'hérédité, les antécédents médicaux et les traitements antérieurs sont des facteurs clés." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'environnement peut interagir avec la génétique et influencer la réponse aux médicaments." } }, { "@type": "Question", "name": "Les facteurs de risque sont-ils les mêmes pour tous ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Non, ils varient selon les individus et leurs antécédents médicaux." } }, { "@type": "Question", "name": "Comment évaluer les facteurs de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Par une évaluation médicale complète et des tests génétiques appropriés." } }, { "@type": "Question", "name": "Les facteurs de risque peuvent-ils changer ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent évoluer avec le temps et les traitements reçus." } } ] } ] }

Sources (10000 au total)

Network Meta-analysis of Different Treatments for Vestibular Migraine.

Although one of the major presentations of vestibular migraine is dizziness with/without unsteady gait, it is still classified as one of the migraine categories. However, in contrast to ordinary migra... The objective of this current network meta-analysis (NMA) was to compare the efficacy and acceptability of individual treatment strategies in patients with vestibular migraine.... The PubMed, Embase, ScienceDirect, ProQuest, Web of Science, ClinicalKey, Cochrane Central, and ClinicalTrials.gov databases were systematically searched for randomized controlled trials (RCTs), with ... Seven randomized controlled trials (N = 828, mean age 37.6 years, 78.4% female) and seven active regimens were included. We determined that only valproic acid (standardized mean difference [SMD] -1.61... The current study provides evidence that only valproic acid, propranolol, and venlafaxine might be associated with beneficial efficacy in vestibular migraine treatment.... CRD42023388343....

Preventive Medications in Pediatric Migraine: A Network Meta-Analysis.

Pediatric migraine substantially impacts quality of life and academic performance among children and adolescents. Understanding the efficacy and safety of pharmacological interventions for migraine pr... To conduct a comprehensive network meta-analysis to evaluate the efficacy and safety associated with pharmacological treatments for pediatric migraine prophylaxis among pediatric patients with a migra... PubMed, Embase, and SCOPUS were searched for publications up to September 2023. Search terms and indexing were chosen to encompass relevant studies, focusing on randomized clinical trials in pediatric... Inclusion criteria targeted randomized clinical trials involving pediatric patients with migraine. Studies were selected based on their examination of oral pharmacological interventions. The search yi... Data extraction adhered to Preferred Reporting Items for Systematic Reviews and Meta-Analyses reporting guidelines. Five investigators independently extracted study data into a spreadsheet in duplicat... The primary outcome was migraine frequency (number of attacks per month). Secondary outcomes included a 50% or greater responder rate, headache duration, headache intensity, and disability (assessed b... The analysis incorporated 45 trials with 3771 participants. Compared with placebo, pregabalin (ratio of means [RoM], 0.38; 95% CI, 0.18-0.79) and topiramate with vitamin D3 (RoM, 0.44; 95% CI, 0.30-0.... In this network meta-analysis of randomized clinical trials, topiramate and pregabalin were associated with reduction in headache frequency and intensity. Although there were also other drugs that sho...

Efficacy of Laser in Hair Removal: A Network Meta-analysis.

Laser hair removal is an increasingly prevalent trend of cosmetic procedures. The purpose of this study was to assess the effectiveness of hair reduction among several types of laser interventions.... The selected studies searched in PubMed and EMBASE were assessed for quality of evidence, and extracted data on absolute hair count and hair reduction rate. Qualitative data were synthesized using sta... A total of 13 randomized controlled trials (RCTs) (... Eliminating unwanted hair with lasers or intense pulsed light is safe and effective; however, which type of intervention is more beneficial in the long-term process should be studied with a longer fol...

A network meta-analysis of arthroscopic rotator cuff repair.

Rotator cuff tear is a common shoulder injury that often leads to serious limitations in daily life. Herein, a network Meta-analysis using frequency theory was performed to evaluate the clinical outco... PubMed, EMbase, The Cochrane Library, and Web of Science were searched for randomized controlled trials and cohort studies comparing rotator cuff repair techniques published from inception to May 2022... A total of 51 articles were finally included, including 27 randomized controlled trials and 24 cohort studies. Results from the network Meta-analysis showed that: (1) In terms of the American Shoulder... Based on the results of network Meta-analysis and surface under the cumulative ranking, platelet-rich plasma therapy, bone marrow stimulation, and double-row repair have good overall rehabilitation ef...

Treatment of children with infantile spasms: A network meta-analysis.

We performed a systematic review and network meta-analysis (NMA) to obtain comparative effectiveness estimates and rankings of non-surgical interventions used to treat infantile spasms.... All randomized controlled trials (RCTs) including children 2 months to 3 years of age with infantile spasms (with hypsarrhythmia or hypsarrhythmia variants on electroencephalography) receiving appropr... Twenty-two RCTs comparing first-line treatments for infantile spasms were reviewed; of these, 17 were included in the NMA. Both frequentist and Bayesian network rankings for electroclinical remission ... Treatments including ACTH and high dose prednisolone are more effective in achieving electroclinical and clinical remissions for infantile spasms.... Adrenocorticotropic hormone and high dose prednisolone are more effective than other medications for infantile spasms. Symptomatic etiology decreases the likelihood of remission even after adjusting f...

Comparison of interventions for Barrett's esophagus: A network meta-analysis.

Barrett's esophagus (BE) is a precancerous condition that has the potential to develop into esophageal cancer (EC). Currently, there is a wide range of management options available for individuals at ... Data extracted from eligible randomized controlled trials were utilized in a Bayesian network meta-analysis to examine the relative effectiveness of BE's treatment regimens and determine their ranking... We identified twenty-three RCT studies with a total of 1675 participants, and ten different interventions. Regarding complete ablation of non-dysplastic BE, the comparative effectiveness ranking indic... Endoscopic surveillance alone or PPI/H2RA alone may not be sufficient for managing BE, even in cases of non-dysplastic BE. However, APC has shown excellent efficacy in treating non-dysplastic BE. For ...

Treatment of diabetic kidney disease. A network meta-analysis.

Diabetic kidney disease (DKD) is a health burden of rising importance. Slowing progression to end stage kidney disease is the main goal of drug treatment. The aim of this analysis is to compare drug t... We searched Medline, CENTRAL and clinicaltrials.gov for randomized, controlled studies including adults with DKD treated with the following drugs of interest: single angiotensin-converting-enzyme-inhi... Of initial 3489 publications, 38 clinical trials were found eligible, in total including 42346 patients. Concerning the primary endpoints overall mortality and end stage kidney disease, SGLT2i on top ... As the only drug class, SGLT2i showed in our analysis beneficial effects on top of ACEi/ARB treatment regarding mortality and end stage kidney disease and by that reconfirmed its position as treatment...

Pharmaceutical Therapies for the Treatment of Obesity: A Network Meta-analysis.

Despite the introduction of various pharmaceutical therapies for treating obesity, selecting the optimal treatment remains challenging for both patients and physicians. Therefore, in this network meta... International databases, including PubMed, Web of Science, Scopus, Cochrane Library, and Embase, were searched for studies published from database inception to April 2023. The consistency assumption w... Of 9519 retrieved references, 96 randomized controlled trials, including 68 with both men and women, 23 with women only, and 5 with men only, met the eligibility criteria for this study. There were 4 ... According to the results of this NMA, semaglutide seems to be an effective treatment option for both men and women, whereas beloranib appears to be particularly effective for women with obesity and ov...

Model selection for component network meta-analysis in connected and disconnected networks: a simulation study.

Network meta-analysis (NMA) allows estimating and ranking the effects of several interventions for a clinical condition. Component network meta-analysis (CNMA) is an extension of NMA which considers t... We evaluate a forward model selection strategy for component network meta-analysis to relax the additivity assumption that can be used in connected or disconnected networks. In addition, we describe a... CNMA models provide good performance for connected networks and can be an alternative to standard NMA if additivity holds. For disconnected networks, we recommend to use additive CNMA only if strong c... CNMA methods are feasible for connected networks but questionable for disconnected networks....