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"@type": "Question",
"name": "Comment la protéogénomique aide-t-elle au diagnostic des maladies ?",
"position": 1,
"acceptedAnswer": {
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"text": "Elle permet d'identifier des biomarqueurs protéiques spécifiques pour un diagnostic plus précis."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés en protéogénomique ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques comme la spectrométrie de masse et l'électrophorèse sont couramment utilisées."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle détecter des cancers ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à identifier des protéines spécifiques associées à différents types de cancers."
}
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{
"@type": "Question",
"name": "Quels échantillons sont analysés en protéogénomique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des échantillons de tissus, de sang ou de fluides biologiques sont souvent analysés."
}
},
{
"@type": "Question",
"name": "La protéogénomique est-elle utilisée en médecine personnalisée ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet d'adapter les traitements en fonction du profil protéique du patient."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent être liés à des anomalies protéiques ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes variés comme la fatigue, la douleur ou des troubles neurologiques peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes sont-elles étudiées en protéogénomique ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la protéogénomique aide à comprendre les mécanismes sous-jacents des maladies auto-immunes."
}
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{
"@type": "Question",
"name": "Comment les protéines affectent-elles les symptômes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les protéines peuvent influencer des voies biologiques, entraînant divers symptômes cliniques."
}
},
{
"@type": "Question",
"name": "Les symptômes de maladies métaboliques sont-ils liés à la protéogénomique ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des déséquilibres protéiques peuvent contribuer à des symptômes de maladies métaboliques."
}
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{
"@type": "Question",
"name": "Peut-on prédire des symptômes grâce à la protéogénomique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des modèles prédictifs basés sur des profils protéiques peuvent anticiper certains symptômes."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle aider à la prévention des maladies ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet d'identifier des facteurs de risque protéiques pour des interventions précoces."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont identifiés par la protéogénomique ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme des niveaux anormaux de certaines protéines peuvent indiquer un risque accru."
}
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{
"@type": "Question",
"name": "Comment la protéogénomique influence-t-elle les programmes de dépistage ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet de cibler des populations à risque pour des dépistages plus efficaces."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir des maladies grâce à des interventions protéogénomiques ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interventions basées sur des profils protéiques peuvent réduire le risque de maladies."
}
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{
"@type": "Question",
"name": "La nutrition peut-elle être influencée par la protéogénomique ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à adapter les régimes alimentaires en fonction des besoins protéiques individuels."
}
},
{
"@type": "Question",
"name": "La protéogénomique influence-t-elle les traitements ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle permet de développer des thérapies ciblées basées sur le profil protéique des patients."
}
},
{
"@type": "Question",
"name": "Quels types de traitements sont développés grâce à la protéogénomique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements biologiques, comme les anticorps monoclonaux, sont souvent développés."
}
},
{
"@type": "Question",
"name": "La protéogénomique aide-t-elle à la résistance aux médicaments ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle identifie des mécanismes de résistance, permettant d'ajuster les traitements."
}
},
{
"@type": "Question",
"name": "Les traitements peuvent-ils être personnalisés grâce à la protéogénomique ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils protéiques individuels."
}
},
{
"@type": "Question",
"name": "Quels médicaments sont influencés par la protéogénomique ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments anticancéreux et des immunothérapies sont souvent influencés par cette approche."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir en cas d'anomalies protéiques ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des troubles métaboliques ou des maladies dégénératives peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées à la protéogénomique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des profils protéiques spécifiques peuvent être associés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Comment la protéogénomique aide-t-elle à comprendre les complications ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle permet d'analyser les interactions entre gènes et protéines, révélant des mécanismes de complications."
}
},
{
"@type": "Question",
"name": "Les complications liées à la protéogénomique sont-elles évitables ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être évitées par des interventions précoces basées sur des analyses protéiques."
}
},
{
"@type": "Question",
"name": "Peut-on prédire des complications grâce à la protéogénomique ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des modèles prédictifs basés sur des données protéomiques peuvent anticiper des complications."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque identifiés par la protéogénomique ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme l'âge, l'hérédité et des niveaux protéiques anormaux sont souvent identifiés."
}
},
{
"@type": "Question",
"name": "La protéogénomique peut-elle identifier des risques environnementaux ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut révéler comment des facteurs environnementaux influencent les profils protéiques."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie influencent-elles les facteurs de risque protéogénomiques ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme l'alimentation et l'exercice peuvent modifier les niveaux protéiques."
}
},
{
"@type": "Question",
"name": "Comment la génétique influence-t-elle les facteurs de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "La génétique détermine la production de certaines protéines, influençant ainsi le risque de maladies."
}
},
{
"@type": "Question",
"name": "Peut-on modifier les facteurs de risque grâce à la protéogénomique ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des interventions ciblées peuvent aider à modifier les niveaux protéiques et réduire les risques."
}
}
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This study assessed the feasibility of nursing handoff notes to identify underreported hospital-acquired pressure injury (HAPI) events....
We have established a natural language processing-assisted manual review process and workflow for data extraction from a corpus of nursing notes across all medical inpatient and intensive care units i...
Our initial corpus involved 70,981 notes during a 1-year period from 5484 unique admissions for 4220 patients. Our interrater human reviewer agreement on identifying HAPI was high ( κ = 0.67; 95% conf...
Natural language processing-based surveillance is proven to be feasible and high yield using nursing handoff notes....
Methods that can automate, support, and streamline the preanesthesia evaluation process may improve resource utilization and efficiency. Natural language processing (NLP) involves the extraction of re...
For each patient, we collected all pertinent notes from the institution's electronic medical record that were available no later than 1 day before their preoperative anesthesia clinic appointment. Per...
A total of 93 patients were included in the NLP pipeline input. Free-text notes were extracted from the electronic medical record of these patients for a total of 9765 notes. The NLP pipeline and anes...
In this proof-of-concept study, we demonstrated that utilization of NLP produced an output that identified medical conditions relevant to preanesthetic evaluation from unstructured free-text input. Au...
Medical lexicons enable the natural language processing (NLP) of health texts. Lexicons gather terms and concepts from thesauri and ontologies, and linguistic data for part-of-speech (PoS) tagging, le...
This article describes an unified medical lexicon for Medical Natural Language Processing in Spanish. MedLexSp includes terms and inflected word forms with PoS information and Unified Medical Language...
The lexicon is distributed in a delimiter-separated value file; an XML file with the Lexical Markup Framework; a lemmatizer module for the Spacy and Stanza libraries; and complementary Lexical Record ...
The electronic Medical Records and Genomics (eMERGE) Network assessed the feasibility of deploying portable phenotype rule-based algorithms with natural language processing (NLP) components added to i...
Natural language processing has been increasingly used in palliative care research over the last 5 years for its versatility and accuracy....
To evaluate and characterize natural language processing use in palliative care research, including the most commonly used natural language processing software and computational methods, data sources,...
A scoping review using the framework by Arksey and O'Malley and the updated recommendations proposed by Levac et al. was conducted....
PubMed, Web of Science, Embase, Scopus, and IEEE Xplore databases were searched for palliative care studies that utilized natural language processing tools. Data on study characteristics and natural l...
197 relevant references were identified. Of these, 82 were included after full-text review. Studies were published in 48 different journals from 2007 to 2022. The average sample size was 21,541 (media...
We found 82 papers on palliative care using natural language processing methods for a wide-range of topics and sources of data that could expand the use of this methodology. We encourage researchers t...
Methods relying on diagnostic codes to identify suicidal ideation and suicide attempt in Electronic Health Records (EHRs) at scale are suboptimal because suicide-related outcomes are heavily under-cod...
This article proposes a Riemannian adaptive optimization algorithm to optimize the parameters of deep neural networks. The algorithm is an extension of both AMSGrad in Euclidean space and RAMSGrad on ...
The evolution of the Exposome concept revolutionised the research in exposure assessment and epidemiology by introducing the need for a more holistic approach on the exploration of the relationship be...
We conduct a literature search on PubMed, Scopus and Web of Science for scientific articles published between 2011 and 2021. We use both quantitative and qualitative methods to screen papers and provi...
Overall, 6420 articles were screened for the suitability of this review, where we review 37 articles in depth. Finally, we discuss future avenues of research and outline challenges in existing work....
Our results show that (i) there has been an increase in articles published that focus on applying NLP to exposure and epidemiology research, (ii) most work uses existing NLP tools and (iii) traditiona...
Abstraction of critical data from unstructured radiologic reports using natural language processing (NLP) is a powerful tool to automate the detection of important clinical features and enhance resear...
We trained machine learning classifiers to identify categorical outcomes of edema, midline shift (MLS), hemorrhagic transformation, and parenchymal hematoma, as well as rule-based systems (RBS) to ide...
In all data sets, a deep neural network with pretrained biomedical word embeddings (BioClinicalBERT) achieved the highest discrimination performance for binary prediction of edema (area under precisio...
Our study demonstrates robust performance and external validity of a core NLP tool kit for identifying both categorical and continuous outcomes of ischemic stroke from unstructured radiographic text d...
To establish whether or not a natural language processing technique could identify two common inpatient neurosurgical comorbidities using only text reports of inpatient head imaging....
A training and testing dataset of reports of 979 CT or MRI scans of the brain for patients admitted to the neurosurgery service of a single hospital in June 2021 or to the Emergency Department between...
For "brain compression", a random forest classifier outperformed other candidate algorithms with an accuracy of 0.81 and area under the curve of 0.90 in the testing dataset. For "brain edema", a rando...
A natural language processing-based machine learning algorithm can reliably and reproducibly identify selected common neurosurgical comorbidities from radiology reports....
This result may justify the use of machine learning-based decision support to augment provider documentation....