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"headline": "Diagnostic sur Cellules A549",
"description": "Comment identifier les cellules A549 en laboratoire ?\nQuelles techniques sont utilisées pour étudier les cellules A549 ?\nLes cellules A549 sont-elles tumorales ?\nPeut-on détecter des marqueurs spécifiques dans les A549 ?\nLes cellules A549 sont-elles sensibles à des médicaments ?",
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"@type": "Question",
"name": "Comment identifier les cellules A549 en laboratoire ?",
"position": 1,
"acceptedAnswer": {
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"text": "Les cellules A549 peuvent être identifiées par leur morphologie et leur croissance en culture."
}
},
{
"@type": "Question",
"name": "Quelles techniques sont utilisées pour étudier les cellules A549 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les techniques incluent la microscopie, la cytométrie en flux et les tests de viabilité cellulaire."
}
},
{
"@type": "Question",
"name": "Les cellules A549 sont-elles tumorales ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les cellules A549 proviennent d'un adénocarcinome, ce qui les rend tumorales."
}
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{
"@type": "Question",
"name": "Peut-on détecter des marqueurs spécifiques dans les A549 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des marqueurs comme le CD44 et le p53 peuvent être analysés dans les A549."
}
},
{
"@type": "Question",
"name": "Les cellules A549 sont-elles sensibles à des médicaments ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour tester la sensibilité aux chimiothérapies."
}
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{
"@type": "Question",
"name": "Quels symptômes sont associés aux cellules A549 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les cellules A549 ne présentent pas de symptômes, car elles sont in vitro."
}
},
{
"@type": "Question",
"name": "Les cellules A549 peuvent-elles simuler des symptômes humains ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier des symptômes liés aux maladies pulmonaires."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les symptômes du cancer ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier la réponse des cellules tumorales aux traitements et aux facteurs de croissance."
}
},
{
"@type": "Question",
"name": "Les cellules A549 montrent-elles des signes de stress cellulaire ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent montrer des signes de stress en réponse à des agents cytotoxiques."
}
},
{
"@type": "Question",
"name": "Peut-on observer des symptômes de résistance dans les A549 ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent être utilisées pour étudier la résistance aux médicaments anticancéreux."
}
},
{
"@type": "Question",
"name": "Les cellules A549 aident-elles à la prévention du cancer ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, elles sont utilisées pour étudier les mécanismes de la carcinogenèse."
}
},
{
"@type": "Question",
"name": "Comment les A549 contribuent-elles à la recherche préventive ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'identifier des biomarqueurs et des cibles pour la prévention du cancer."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser les A549 pour étudier des facteurs de risque ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour étudier l'impact de divers facteurs environnementaux sur le cancer."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utiles pour la recherche sur le tabagisme ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour étudier les effets du tabagisme sur les cellules pulmonaires."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre la prévention des maladies ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'explorer les mécanismes de protection et les interventions préventives."
}
},
{
"@type": "Question",
"name": "Quels traitements sont testés sur les cellules A549 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements anticancéreux et les thérapies ciblées sont souvent testés sur ces cellules."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utilisées pour des essais cliniques ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elles sont utilisées pour des études précliniques et non pour des essais cliniques directs."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à développer de nouveaux traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'efficacité et la toxicité des nouveaux composés thérapeutiques."
}
},
{
"@type": "Question",
"name": "Les cellules A549 peuvent-elles prédire la réponse au traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent fournir des indications sur la réponse aux traitements, mais ne sont pas définitives."
}
},
{
"@type": "Question",
"name": "Quels agents sont souvent testés sur les A549 ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des agents chimiothérapeutiques comme le cisplatine et des inhibiteurs de tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent être étudiées avec les A549 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les complications liées aux traitements du cancer et aux métastases."
}
},
{
"@type": "Question",
"name": "Les A549 peuvent-elles simuler des complications pulmonaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont utilisées pour modéliser des complications comme la fibrose pulmonaire."
}
},
{
"@type": "Question",
"name": "Comment les A549 aident-elles à comprendre les complications du cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'étudier les interactions entre les cellules tumorales et le microenvironnement."
}
},
{
"@type": "Question",
"name": "Peut-on étudier la résistance aux traitements avec les A549 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour comprendre les mécanismes de résistance aux traitements."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles impliquées dans des complications métaboliques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier les effets métaboliques des traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont étudiés avec les A549 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs comme le tabagisme, l'exposition à des agents chimiques et la pollution."
}
},
{
"@type": "Question",
"name": "Les A549 aident-elles à identifier des facteurs génétiques ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées pour étudier l'expression génique liée à des prédispositions au cancer."
}
},
{
"@type": "Question",
"name": "Comment les A549 sont-elles utilisées pour étudier l'environnement ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles permettent d'évaluer l'impact des toxines environnementales sur les cellules pulmonaires."
}
},
{
"@type": "Question",
"name": "Peut-on étudier l'alimentation avec les A549 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, elles peuvent être utilisées pour explorer l'impact des nutriments sur le cancer."
}
},
{
"@type": "Question",
"name": "Les A549 sont-elles utiles pour étudier le stress oxydatif ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles sont souvent utilisées pour examiner les effets du stress oxydatif sur les cellules."
}
}
]
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Public awareness of Developmental Language Disorder (DLD) is lower than other neurodevelopmental disorders, despite its high prevalence of 7.6%. This lower awareness means recruitment for DLD research...
This paper aims to describe the families of children with DLD and adults with DLD in the database thus far....
E-DLD members sign up via our website, reporting demographic characteristics as part of this procedure. We request all E-DLD members subsequently fill in a yearly survey. The content of the yearly sur...
The database currently consists of 196 parents of children with DLD and 20 individuals over the age of 16 with DLD or suspected DLD across a range of socioeconomic status (SES) backgrounds. Our initia...
The findings indicate that a participant database for DLD research is feasible and useful. The rates of emotional, behavioural and sleep difficulties among the child probands are higher than reported ...
What is already known on this subject Developmental Language Disorder (DLD) is characterised by expressive and/or receptive language difficulties in the absence of another biomedical condition that co...
To prevent or mitigate long-lasting learning problems and emotional, behavioral, and social-adaption difficulties associated with language disorders, age-appropriate German language competence at scho...
To develop a screening instrument to identify increased risk of LD and to evaluate its validity and feasibility within the constraints of regular universal pre-school language screening....
A two-component screening instrument including direct assessment of expressive and receptive grammar was used in a sample of 374 children with German as their dominant language attending a public pre-...
The combination of the expressive and receptive grammar scales demonstrated excellent accuracy (area under the curve score 0.928). A cut-off of 18 resulted in a failing rate of 21.8% and showed good s...
The differential diagnosis of developmental language disorder (DLD) in bilingual children represents a unique challenge due to their distributed language exposure and knowledge. The current evidence i...
Eighty-four Spanish-English bilingual second graders with (...
Results demonstrated moderate overall item-by-item scoring agreement (...
This study provides preliminary support for the technical feasibility of ASR as a bilingual expressive language assessment tool....
https://doi.org/10.23641/asha.20249994....
Language sample analysis is widely regarded as the gold standard of language assessment. However, the uncertainty regarding the optimal length of sample and the limited availability of developmental l...
The study involved 30 typically developing Afrikaans-speaking children aged between 3;6 and 9;6 (years;months). A descriptive research design was used to transcribe and analyze 1-hr interactions colle...
Results indicated that mean length of utterance in words per minute, number of different words per minute, and total number of words per minute stabilized at 30 min and no significant differences were...
The study concluded that a 30-min interaction segment provides a representative language sample for Afrikaans-speaking children who are between 3;6 and 9;6. It provides promising preliminary developme...
While it has been posited that young people with language needs may be viewed more negatively (e.g., as more rude, less cooperative) than those without language needs, the impact of knowing about a pe...
To examine whether the presence of a developmental language disorder (DLD) diagnosis in a defendant's information would affect mock juror ratings of guilt, sentence length, credibility and blameworthi...
A total of 143 jury eligible participants read a vignette of a non-violent crime. Half of the participants (N = 73) were told the defendant has a diagnosis of DLD, while half (N = 70) were not told....
Preregistered analyses found that DLD information affected ratings of credibility and blameworthiness, though not judgements of guilt or sentence length. Unregistered content analyses were applied to ...
Unlike in previous studies of the impact of autism information, information about a defendant's DLD did not affect mock jurors' likelihood of finding them guilty, or lead participants to give longer s...
What is already known on the subject There is already evidence that some conditions that affect communication, specifically autism, also affect juror perceptions. Research also shows that knowing whet...
Many mental disorders (MD) share common etiology, fuelling debates about the specificity of clinical categories and whether the presence of specific risk factors (RF) can distinguish among them. The s...
Developmental language disorder (DLD) has clear functional ramifications in the areas of social competency, emotion recognition, emotional well-being and literacy skill, which have been found to persi...
To investigate the association between psychosocial domains, literacy skill and concerns about school during the transition to secondary school for adolescents with DLD, LL and their TD peers. The fir...
Participants (aged 10-11 years) with DLD (n = 30), LL ((n = 29) and TD (n = 42) were recruited for this longitudinal study from eight UK primary schools. Standardized language and psychosocial assessm...
Regression analyses showed pre-transition school concern to be predicted by emotion recognition for the DLD group, by social competence and emotional well-being for the LL group, and by social compete...
This study concludes that transition interventions must be differentiated according to language ability; support for DLD adolescents should focus on emotion recognition skill, provision for LL adolesc...
What is already known on the subject There is limited research exploring the transition from primary school to secondary for adolescents with DLD or LL ability. Research on TD has highlighted vulnerab...
Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restrictive interests and/or repetitive behaviors and deficits in social interaction and communication. ASD is a multif...
The spatiotemporal index (STI) is a standard metric for quantifying the stability and patterning of speech movements. The STI has often been applied to individual speech articulators, but an STI deriv...
A total of 85 children with DLD and with typical language development (or typically developing [TD] children), aged 4-8 years, were studied. In this methodological article, two experiments were conduc...
In sentence production, most group differences aligned across kinematic and acoustic STI measures. The acoustic, but not the kinematic, STI showed higher variability in children with DLD compared with...
The kinematic and acoustic STIs assess different components of speech movement patterning. However, the relationship between acoustic and kinematic spatiotemporal stability is strong in two tasks of v...
Developmental language disorder (DLD) is a common (with up to 7% prevalence) yet underdiagnosed childhood disorder whose underlying biological profile and comorbidities are not fully understood, espec...
To identify clinically relevant conditions that co-occur with DLD at the population level....
This case-control study used an electronic health record (EHR)-based population-level approach to compare the prevalence of comorbid health phenotypes between DLD cases and matched controls. These cas...
Common and rare comorbidities of DLD at the population level were identified using EHRs and a phecode-based enrichment analysis....
Comorbidity analysis was conducted for 5273 DLD cases (mean [SD] age, 16.8 [7.2] years; 3748 males [71.1%]) and 26 353 matched controls (mean [SD] age, 14.6 [5.5] years; 18 729 males [71.1%]). Relevan...
This study found both rare and common comorbidities of DLD. Comorbidity profiles may be leveraged to identify risk of additional health challenges, beyond language impairment, among children with DLD....
