Retinal detachment.
Retinal detachment (RD) occurs when the neurosensory retina, the neurovascular tissue responsible for phototransduction, is separated from the underlying retinal pigment epithelium (RPE). Given the im...
Syk kinase : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une dysfonction de la Syk kinase ?
Des tests génétiques et des analyses de sang peuvent aider à diagnostiquer des anomalies.
#2
Quels tests sont utilisés pour évaluer l'activité de la Syk kinase ?
Des tests enzymatiques et des dosages de protéines spécifiques sont utilisés.
#3
Y a-t-il des biomarqueurs associés à la Syk kinase ?
Oui, des biomarqueurs comme le phospho-Syk peuvent indiquer son activation.
#4
Quels symptômes peuvent indiquer un problème avec la Syk kinase ?
Des symptômes immunitaires ou inflammatoires peuvent suggérer une dysfonction.
#5
La Syk kinase est-elle impliquée dans des maladies spécifiques ?
Oui, elle est liée à des maladies auto-immunes et des cancers.
Symptômes 5
#1
Quels symptômes sont liés à une activation excessive de la Syk kinase ?
Une activation excessive peut entraîner des inflammations et des douleurs articulaires.
#2
La Syk kinase affecte-t-elle le système immunitaire ?
Oui, elle joue un rôle clé dans la régulation des réponses immunitaires.
#3
Quels signes cliniques peuvent indiquer une dysfonction de la Syk kinase ?
Des signes comme des infections fréquentes ou des réactions allergiques peuvent apparaître.
#4
Les troubles de la Syk kinase provoquent-ils des symptômes neurologiques ?
Des études suggèrent un lien potentiel, mais des recherches supplémentaires sont nécessaires.
#5
Y a-t-il des symptômes associés à des inhibiteurs de la Syk kinase ?
Des effets secondaires comme des nausées ou des infections peuvent survenir.
Prévention 5
#1
Peut-on prévenir les dysfonctionnements de la Syk kinase ?
Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir la santé immunitaire.
#2
Y a-t-il des mesures préventives pour les maladies liées à la Syk kinase ?
Éviter les facteurs de risque comme le tabagisme peut réduire les maladies associées.
#3
Les vaccinations influencent-elles la Syk kinase ?
Oui, certaines vaccinations peuvent moduler l'activité de la Syk kinase dans le système immunitaire.
#4
Comment le stress affecte-t-il la Syk kinase ?
Le stress chronique peut altérer la signalisation de la Syk kinase, affectant l'immunité.
#5
L'exercice physique influence-t-il la Syk kinase ?
Oui, l'exercice régulier peut améliorer la fonction immunitaire et la signalisation de Syk.
Traitements 5
#1
Quels traitements ciblent la Syk kinase ?
Des inhibiteurs de Syk sont utilisés pour traiter certaines maladies auto-immunes.
#2
Les traitements de la Syk kinase sont-ils efficaces ?
Oui, ils montrent des résultats prometteurs dans le contrôle des maladies inflammatoires.
#3
Quels médicaments inhibent la Syk kinase ?
Des médicaments comme le fostamatinib sont des inhibiteurs spécifiques de Syk.
#4
Y a-t-il des effets secondaires des traitements de la Syk kinase ?
Oui, des effets comme des troubles gastro-intestinaux et des infections peuvent survenir.
#5
Comment les traitements de la Syk kinase sont-ils administrés ?
Ils peuvent être administrés par voie orale ou intraveineuse, selon le médicament.
Complications 5
#1
Quelles complications peuvent survenir avec une dysfonction de la Syk kinase ?
Des complications comme des infections récurrentes et des maladies auto-immunes peuvent survenir.
#2
La Syk kinase est-elle liée à des cancers ?
Oui, une activation anormale de Syk est associée à certains types de cancers.
#3
Quels risques sont associés aux inhibiteurs de la Syk kinase ?
Les inhibiteurs peuvent augmenter le risque d'infections et de troubles hématologiques.
#4
Les complications de la Syk kinase affectent-elles la qualité de vie ?
Oui, les complications peuvent gravement affecter la qualité de vie des patients.
#5
Y a-t-il des complications neurologiques liées à la Syk kinase ?
Des recherches sont en cours pour explorer les liens entre Syk et des troubles neurologiques.
Facteurs de risque 5
#1
Quels sont les facteurs de risque pour les maladies liées à la Syk kinase ?
Des facteurs comme l'âge, le sexe et des antécédents familiaux peuvent influencer le risque.
#2
Le tabagisme affecte-t-il la Syk kinase ?
Oui, le tabagisme peut altérer la signalisation de la Syk kinase et augmenter les risques de maladies.
#3
L'alimentation influence-t-elle la Syk kinase ?
Une alimentation riche en antioxydants peut aider à réguler l'activité de la Syk kinase.
#4
Le stress est-il un facteur de risque pour la Syk kinase ?
Oui, le stress chronique peut exacerber les dysfonctionnements de la Syk kinase.
#5
Y a-t-il des prédispositions génétiques liées à la Syk kinase ?
Certaines variations génétiques peuvent augmenter le risque de dysfonctionnement de Syk.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 26/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Andy Pike
4 publications dans cette catégorie
Affiliations :
- DMPK (A.P., R.M., B.J.) and Discovery Biology, Discovery Sciences, BioPharmaceuticals R&D, AstraZeneca, Cambridge, United Kingdom andrew.pike@astrazeneca.com.
Publications dans "Syk kinase" :
-
Impact of Interindividual Differences in Plasma Fraction Unbound on the Pharmacokinetics of a Novel Syk Kinase Inhibitor in Beagle Dogs.
Drug metabolism and disposition: the biological fate of chemicals 2021-06-16
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Antonella Pantaleo
3 publications dans cette catégorie
Affiliations :
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
Publications dans "Syk kinase" :
-
Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in
Antioxidants (Basel, Switzerland) 2020-08-14
-
Signaling Response to Transient Redox Stress in Human Isolated T Cells: Molecular Sensor Role of Syk Kinase and Functional Involvement of IL2 Receptor and L-Selectine.
Sensors (Basel, Switzerland) 2020-01-14
-
Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in
International journal of molecular sciences 2020-09-23
Jinhua Wang
3 publications dans cette catégorie
Affiliations :
- Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA, USA.
Publications dans "Syk kinase" :
-
The combination of FLT3 and SYK kinase inhibitors is toxic to leukaemia cells with CBL mutations.
Journal of cellular and molecular medicine 2020-01-14
-
A new role for the SRC family kinase HCK as a driver of SYK activation in MYD88 mutated lymphomas.
Blood advances
-
Inhibition of the deubiquitinase USP10 induces degradation of SYK.
British journal of cancer 2020-02-04
Jae Youl Cho
3 publications dans cette catégorie
Affiliations :
- Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, 16419, Republic of Korea; Biomedical Institute for Convergence at SKKU (BICS), Sungkyunkwan University, Suwon, 16419, Republic of Korea; Department of Biocosmetics, Sungkyunkwan University, Suwon 16419, Republic of Korea. Electronic address: jaecho@skku.edu.
Publications dans "Syk kinase" :
-
Millingtonia hortensis L.f. ethanol extract exerts in vivo and in vitro anti-inflammatory activities through inhibition of Syk kinase in NF-κB pathway.
Journal of ethnopharmacology 2024-05-21
-
Cocculus hirsutus ameliorates gastric and lung injuries by suppressing Src/Syk.
Phytomedicine : international journal of phytotherapy and phytopharmacology 2021-09-27
-
Syk-MyD88 Axis Is a Critical Determinant of Inflammatory-Response in Activated Macrophages.
Frontiers in immunology 2021-12-23
Bernard Barlaam
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Cambridge, United Kingdom. Electronic address: Bernard.barlaam2@astrazeneca.com.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Scott Boiko
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Hannah Dry
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Lakshmaiah Gingipalli
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Sameer Kawatkar
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Jon Read
3 publications dans cette catégorie
Affiliations :
- Discovery Sciences, AstraZeneca, Cambridge, United Kingdom.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Qibin Su
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Peng Wang
3 publications dans cette catégorie
Affiliations :
- Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing 100176, PR China.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Scott D Edmondson
3 publications dans cette catégorie
Affiliations :
- R&D Oncology, AstraZeneca, Boston, MA, United States.
Publications dans "Syk kinase" :
-
Novel potent and selective pyrazolylpyrimidine-based SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-08-30
-
Optimization of a series of potent, selective and orally bioavailable SYK inhibitors.
Bioorganic & medicinal chemistry letters 2020-07-24
-
Optimization of a series of novel, potent and selective Macrocyclic SYK inhibitors.
Bioorganic & medicinal chemistry letters 2023-06-02
Kohei Kume
2 publications dans cette catégorie
Affiliations :
- Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA.
Publications dans "Syk kinase" :
-
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Cellular signalling 2022-04-07
-
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Molecular cell 2021-04-19
Markus Müschen
2 publications dans cette catégorie
Affiliations :
- Center of Molecular and Cellular Oncology, Yale University, New Haven, CT 06511, USA; Department of Immunobiology, Yale University, CT 06520, USA. Electronic address: markus.muschen@yale.edu.
Publications dans "Syk kinase" :
-
SYK and ZAP70 kinases in autoimmunity and lymphoid malignancies.
Cellular signalling 2022-04-07
-
Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.
Molecular cell 2021-04-19
Helen T Hobbs
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Biomedical Engineering, University of California, Irvine, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Neel H Shah
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, Columbia University, New York, New York, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Susan Marqusee
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
- California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
John Kuriyan
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of California, Berkeley, California, USA.
- Department of Molecular and Cell Biology, University of California, Berkeley, California, USA.
- California Institute for Quantitative Biosciences, University of California, Berkeley, California, USA.
- Howard Hughes Medical Institute, University of California, Berkeley, California, USA.
Publications dans "Syk kinase" :
-
Saturation mutagenesis of a predicted ancestral Syk-family kinase.
Protein science : a publication of the Protein Society
-
Differences in the dynamics of the tandem-SH2 modules of the Syk and ZAP-70 tyrosine kinases.
Protein science : a publication of the Protein Society 2021-10-23
Ioannis Tsamesidis
2 publications dans cette catégorie
Affiliations :
- Department of Biomedical Sciences, University of Sassari, 07100 Sassari, Italy.
- UMR 152 Pharma-Dev, Université de Toulouse, IRD, UPS, 31000 Toulouse, France.
Publications dans "Syk kinase" :
-
Syk Kinase Inhibitors Synergize with Artemisinins by Enhancing Oxidative Stress in
Antioxidants (Basel, Switzerland) 2020-08-14
-
Syk Inhibitors: New Computational Insights into Their Intraerythrocytic Action in
International journal of molecular sciences 2020-09-23
Sources (6543 au total)
Re-vitrectomy for recurrent retinal detachment in post-vitrectomy eyes of rhegmatogenous retinal detachment.
Recurrent retinal detachment (Re-RD) usually affects the prognosis of surgery for rhegmatogenous retinal detachment (RRD). Previous clinical studies of Re-RD were not specific. This study aimed to ana... This is a retrospective case series analyzed the ocular characteristics of 20 recurrent and contralateral eyes, evaluated the significance of the associations between variables before reoperation and ... Patients with phakic eyes, those undergoing only one surgery, and those with more than one break had better final BCVA. The final BCVA was negatively correlated with the axial length and positively co... Revitrectomy without retinectomy or scleral buckling can effectively treat Re-RD in post-vitrectomy eyes. In Re-RD patients with no definite retinal break detected preoperatively, the retinal hole usu...
Characteristics of Bilateral Retinal Detachment.
Rhegmatogenous retinal detachment (RD) is still a sight-threatening and potentially blinding disease, especially if both eyes are affected. The purpose of this study is analysing the specific characte... The files of all 5,791 consecutive eyes undergoing vitreoretinal surgery for uncomplicated RD in a single tertiary retinal centre between January 2005 and June 2021 were retrospectively reviewed.... A total of 300 patients (600 eyes) had bilateral retinal detachment. Interval between initial and subsequent RD surgery was 2.6 ± 2.8 (mean ± SD, median 1.5) years. Symptoms were reported by the patie... Patients with bilateral RD were more commonly male and younger than the group of all RD patients. The proportion of pseudophakia was not different. The majority of fellow eye RD occurred within 2 year...
Effect of Duration of Macular Detachment on Visual Prognosis after Surgery for Macula-Off Retinal Detachment: Japan-Retinal Detachment Registry.
To evaluate the association between the duration of macular detachment (DMD) and visual prognosis in patients with macula-off rhegmatogenous retinal detachment (RD).... Prospective observational cohort study.... This study analyzed 719 eyes with macula-off rhegmatogenous RD registered with the Japan-Retinal Detachment Registry created by the Japan Retina and Vitreous Society.... We included patients with macular detachment without a history of prior surgery, except cataract surgery and vitrectomy. Reoperation cases, hereditary RD, and macular hole RD were excluded. We compare... The best-corrected visual acuity (BCVA) 6 months after surgery.... The final analysis included 719 eyes. For all comparisons, the patients' backgrounds were well balanced after IPTW with standardized differences < 0.10. The IPTW regression analysis revealed that the ... Earlier surgical treatment within 3 days from the onset of macular detachment should be considered, after accounting for social circumstances, such as weekends.... The authors have no proprietary or commercial interest in any materials discussed in this article....
Recurrent retinal detachment after pars plana vitrectomy with silicone oil tamponade for rhegmatogenous retinal detachment.
The recurrence of retinal detachment following rhegmatogenous retinal detachment (RRD) is a relatively common complication that can lead to reduced visual acuity and requires further surgery. The purp... This was a retrospective follow-up study of 343 eyes that underwent initial PPV surgery with silicone oil tamponade for primary RRD. Patients were divided into a recurrence group and a reattachment gr... After retinal reattachment, we observed RRD recurrence after PPV for primary RRD in 42 out of 343 eyes (12.2%) during the follow-up period. Most causes of recurrence (69%) occurred within 6 months of ... Our analysis shows that the predominant risk factor for the recurrence of RRD is a PVR ≥ Grade C. PVR prior to primary surgery, or at the diagnosis of re-detachment, was also shown to limit the recove...
Retinal detachment in Loeys-Dietz syndrome.
Loeys-Dietz syndrome (LDS) is an autosomal-dominant connective-tissue disorder with vascular and musculoskeletal abnormalities similar to Marfan syndrome. However, unlike Marfan, retinal detachment (R...
Rhegmatogenous retinal detachment surgery: A review.
Rhegmatogenous retinal detachment (RRD) is a serious surgical condition with significant ocular morbidity if not managed properly. Once untreatable, approaches to the repair of RRD have greatly evolve...
The impact of 360-laser barricade on outcomes of vitrectomy for pseudophakic retinal detachment; The Manchester Pseudophakic Retinal Detachment Study.
To investigate the anatomical and functional outcomes and specifically, the effect of 360-degree barrier-laser, in pars plana vitrectomy (PPV) for primary pseudophakic rhegmatogenous retinal detachmen... We conducted a single-centre retrospective, continuous and comparative study on eyes that had undergone PPV with focal-retinopexy (laser or cryotherapy) versus 360-laser for PRD repair between 2011-20... We included 467 eyes with a mean follow-up of 388 (161) days. The SSAS was 444/467 (95.1%) overall, and 351/370 (94.9%) and 93/97 (95.9%) in focal-retinopexy and 360-laser groups, respectively (p = 0.... Prophylactic 360-laser does not seem to impact on SSAS and functional outcomes following PPV for primary PRD....
CHRONIC PEDIATRIC RETINAL DETACHMENT WITH MULTIPLE MACROCYSTS.
To describe a case of chronic pediatric retinal detachment with multiple macrocysts, its surgical management, and a review of the literature.... Case report with fundus photography and optical coherence tomography.... We describe a case of an asymptomatic, 11-year-old boy with a chronic rhegmatogenous retinal detachment with multiple peripheral macrocysts. The patient had counting fingers visual acuity on presentat... To the authors' knowledge, this is the first reported case of chronic retinal detachment presenting with multiple peripheral macrocysts in a pediatric patient with Stickler syndrome. More research is ...
The genetics and disease mechanisms of rhegmatogenous retinal detachment.
Rhegmatogenous retinal detachment (RRD) is a sight threatening condition that warrants immediate surgical intervention. To date, 29 genes have been associated with monogenic disorders involving RRD. I...