Fibroblastes associés au cancer : Questions médicales fréquentes
Nom anglais: Cancer-Associated Fibroblasts
Descriptor UI:D000072645
Tree Number:A11.329.228.105
Termes MeSH sélectionnés :
Subtalar Joint
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"name": "Diagnostic",
"headline": "Diagnostic sur Fibroblastes associés au cancer",
"description": "Comment identifier les CAF dans une tumeur ?\nQuels tests sont utilisés pour détecter les CAF ?\nLes CAF sont-ils visibles par imagerie ?\nPeut-on quantifier les CAF dans un échantillon ?\nLes CAF peuvent-ils être distingués des fibroblastes normaux ?",
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"description": "Quels symptômes sont liés aux CAF ?\nLes CAF affectent-ils la douleur tumorale ?\nLes CAF sont-ils impliqués dans la fatigue liée au cancer ?\nLes CAF influencent-ils les symptômes de métastases ?\nLes CAF sont-ils liés à des symptômes spécifiques ?",
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"description": "Peut-on prévenir la formation de CAF ?\nLes facteurs environnementaux influencent-ils les CAF ?\nL'alimentation joue-t-elle un rôle dans la prévention des CAF ?\nL'exercice physique peut-il réduire les CAF ?\nLes dépistages précoces aident-ils à prévenir les CAF ?",
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"description": "Comment cibler les CAF dans le traitement du cancer ?\nLes CAF peuvent-ils être une cible pour l'immunothérapie ?\nQuels médicaments affectent les CAF ?\nLes CAF peuvent-ils influencer la résistance aux traitements ?\nY a-t-il des essais cliniques sur les CAF ?",
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"description": "Quels sont les risques associés aux CAF ?\nLes CAF sont-ils liés à des complications post-chirurgicales ?\nLes CAF peuvent-ils affecter la qualité de vie ?\nLes CAF sont-ils impliqués dans des complications métastatiques ?\nLes CAF peuvent-ils influencer la survie des patients ?",
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"description": "Quels facteurs augmentent le risque de CAF ?\nL'âge influence-t-il le développement des CAF ?\nLes antécédents familiaux de cancer sont-ils un facteur de risque ?\nLe stress peut-il influencer les CAF ?\nLes infections chroniques sont-elles un facteur de risque ?",
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"@type": "Question",
"name": "Comment identifier les CAF dans une tumeur ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les CAF peuvent être identifiés par des marqueurs spécifiques comme FAP et α-SMA."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour détecter les CAF ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'immunohistochimie et la cytométrie en flux sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Les CAF sont-ils visibles par imagerie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les CAF ne sont pas directement visibles, mais leur effet sur la tumeur peut être évalué par imagerie."
}
},
{
"@type": "Question",
"name": "Peut-on quantifier les CAF dans un échantillon ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques comme la PCR et l'analyse de l'expression génique permettent leur quantification."
}
},
{
"@type": "Question",
"name": "Les CAF peuvent-ils être distingués des fibroblastes normaux ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF présentent des caractéristiques morphologiques et fonctionnelles distinctes."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés aux CAF ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les CAF ne causent pas de symptômes directs, mais influencent la progression tumorale."
}
},
{
"@type": "Question",
"name": "Les CAF affectent-ils la douleur tumorale ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent moduler la douleur en influençant l'inflammation et la croissance tumorale."
}
},
{
"@type": "Question",
"name": "Les CAF sont-ils impliqués dans la fatigue liée au cancer ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Indirectement, les CAF peuvent contribuer à la fatigue en favorisant la progression tumorale."
}
},
{
"@type": "Question",
"name": "Les CAF influencent-ils les symptômes de métastases ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent favoriser la migration des cellules tumorales et donc les symptômes de métastases."
}
},
{
"@type": "Question",
"name": "Les CAF sont-ils liés à des symptômes spécifiques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils ne causent pas de symptômes spécifiques, mais leur présence peut aggraver l'état général du patient."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la formation de CAF ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention des CAF est complexe, mais un mode de vie sain peut réduire le risque de cancer."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils les CAF ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs comme l'inflammation chronique et le tabagisme peuvent favoriser les CAF."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la prévention des CAF ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en antioxydants peut aider à réduire le risque de cancer et donc de CAF."
}
},
{
"@type": "Question",
"name": "L'exercice physique peut-il réduire les CAF ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut diminuer l'inflammation et potentiellement réduire les CAF."
}
},
{
"@type": "Question",
"name": "Les dépistages précoces aident-ils à prévenir les CAF ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les dépistages précoces peuvent aider à détecter le cancer avant que les CAF ne se développent."
}
},
{
"@type": "Question",
"name": "Comment cibler les CAF dans le traitement du cancer ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies ciblées et des inhibiteurs de signalisation sont en développement pour cibler les CAF."
}
},
{
"@type": "Question",
"name": "Les CAF peuvent-ils être une cible pour l'immunothérapie ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent être ciblés pour améliorer l'efficacité de l'immunothérapie anticancéreuse."
}
},
{
"@type": "Question",
"name": "Quels médicaments affectent les CAF ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments comme les inhibiteurs de TGF-β et les agents anti-fibrotiques peuvent affecter les CAF."
}
},
{
"@type": "Question",
"name": "Les CAF peuvent-ils influencer la résistance aux traitements ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent contribuer à la résistance aux traitements en modifiant le microenvironnement tumoral."
}
},
{
"@type": "Question",
"name": "Y a-t-il des essais cliniques sur les CAF ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, plusieurs essais cliniques explorent des thérapies ciblant les CAF dans divers cancers."
}
},
{
"@type": "Question",
"name": "Quels sont les risques associés aux CAF ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les CAF peuvent favoriser la progression tumorale et la résistance aux traitements."
}
},
{
"@type": "Question",
"name": "Les CAF sont-ils liés à des complications post-chirurgicales ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent influencer la cicatrisation et augmenter le risque de récidive."
}
},
{
"@type": "Question",
"name": "Les CAF peuvent-ils affecter la qualité de vie ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, leur présence peut aggraver les symptômes et diminuer la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Les CAF sont-ils impliqués dans des complications métastatiques ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les CAF peuvent faciliter la migration des cellules tumorales vers d'autres organes."
}
},
{
"@type": "Question",
"name": "Les CAF peuvent-ils influencer la survie des patients ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la présence de CAF est souvent associée à un pronostic défavorable dans plusieurs cancers."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de CAF ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'inflammation chronique, le tabagisme et l'obésité sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le développement des CAF ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de développer des CAF augmente avec l'âge en raison de changements cellulaires."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux de cancer sont-ils un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux peuvent augmenter le risque de développer des CAF."
}
},
{
"@type": "Question",
"name": "Le stress peut-il influencer les CAF ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter le microenvironnement tumoral et favoriser les CAF."
}
},
{
"@type": "Question",
"name": "Les infections chroniques sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections chroniques peuvent contribuer à l'inflammation et à la formation de CAF."
}
}
]
}
]
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Various surgical techniques have been reported in treating calcaneal malunions over the decades, while the operations on single plane were accompanied by respective limitations. The purpose of this st...
From March 12, 2010, to August 17, 2017, 10 patients (10 feet) with malunited calcaneal fractures were treated with multiple reconstructive osteotomy with subtalar joint-preserving operations. All pat...
All patients were subjectively satisfied with the treatment. The average time to union was 12.2 ± 1.11 weeks. The American Orthopedic Foot and Ankle (AOFAS) ankle and hind foot score was 86.3 ± 4.45 (...
Multiple reconstructive osteotomy is an effective way to restore the calcaneal morphology and preserve the subtalar joint for selected calcaneal malunion....
This study focuses on the assessment of the mechanical effect produced by Morton's extension as an orthopedic intervention in patients with bilateral foot pronation posture, through a variation in hin...
Varus ankle osteoarthritis (OA) is typically associated with peritalar instability, which may result in altered subtalar joint position. This study aimed to determine the extent to which total ankle r...
Fourteen patients (15 ankles, mean age 61 ± 6 years) who underwent TAR for varus ankle OA were analyzed using semi-automated measurements based on weight-bearing computed tomography. Twenty healthy in...
All angles improved between preoperative and a minimum of 1 year (mean 2.1 years) postoperative and were statistically significant in 6 out of 8 angles (P < 0.05)....
Our findings indicate that talus repositioning after TAR restores the subtalar joint alignment which may improve hindfoot biomechanics. Future studies are required to implement these findings for TAR ...
IV....
Subtalar joint arthrodesis is a commonly used procedure for numerous pathologic conditions in the foot and ankle. Although rarely performed in isolation, this procedure can provide successful resoluti...
This study aimed to determine the clinical effect of incongruent subtalar joint space on total ankle arthroplasty (TAA)....
Thirty-four consecutive patients who underwent TAA were grouped according to the status of subtalar joint incongruency. A comparison of clinical and radiographic parameters between groups as well as m...
The final American Orthopaedic Foot and Ankle Society (AOFAS) score was significantly higher in the congruent group compared to that of the incongruent group (p = 0.007). There were no significant dif...
A thorough preoperative investigation should be taken into the state of the subtalar joint for TAA....
A comprehensive insight into the effects of subtalar- and mid-tarsal joint osteoarthritis on lower limb's biomechanical characteristics during walking is lacking. Our goal was to assess joint kinemati...
Patients with symptomatic and radiographically confirmed osteoarthritis of the subtalar and mid-tarsal (n = 10) and an asymptomatic control group (n = 10) were compared. Foot joint kinematics and kine...
During pre-swing phase, the tibio-talar range of motion in the sagittal plane of the patient group decreased significantly (P = 0.001), whereas the tarso-metatarsal joint range of motion in the sagitt...
These findings suggest that patients with subtalar and mid-tarsal joint osteoarthritis adopt a cautious walking strategy potentially dictated by pain, muscle weakness, kinesiophobia and stiffness. Sin...
This study sought to determine whether range of motion (ROM) of the ankle and subtalar joint complex (STJ) is correlated with ankle injuries in National Basketball Association (NBA) G-league and colle...
This prospective cohort study encompassed 103 player-seasons (68 collegiate, 35 NBA G-League). Patient demographics, passive ankle and STJ range of motion measurements, anterior drawer, and talar tilt...
Twenty-one ankle injuries occurred with 10 405 player exposures yielding an incidence of 2.11/1000 exposures, resulting in 113 days of missed playing time. No direct measures of ankle, subtalar, or co...
Using the predictive subtalar mobility thresholds found in this study may help identify at-risk players that may benefit from targeted ankle injury prevention programs....
Level II, prospective cohort study....
It remains unclear whether to perform a bone graft is necessary during posterior arthroscopic subtalar arthrodesis. The present research aimed to comparatively analyze the outcomes of arthroscopic sub...
A total of 93 patients with subtalar arthritis who underwent posterior arthroscopic subtalar arthrodesis were retrospectively examined. The patients were divided into two groups according to whether t...
Among the 93 patients included, 53 received bone graft and 40 did not. The union rate and time to osseous fusion suggested no significant difference between the two groups. The improvement of clinical...
In the present study, bone graft could not effectively reduce the risk of nonunion and improve the outcome....
It has been suggested that subtalar and tibiofemoral kinematics are coupled, such that abnormal subtalar inversion during the impact and push-off portions of stance may affect tibial rotation, leading...
This study aimed to establish a low-risk zone to avoid neurovascular injury during a temporary extra-articular calcaneo-tibial pin fixation in an unstable ankle or subtalar joint. A line from the calc...