questionsmedicales.fr
Métabolisme
Désalkylation
Déméthylation
Déméthylation : Questions médicales fréquentes
Termes MeSH sélectionnés :
Ventricular Function, Left
Diagnostic
5
Déméthylation
Analyse de l'ADN
Marqueurs épigénétiques
5-méthylcytosine
Tests sanguins
ADN circulant
Biopsie
Analyse tissulaire
Troubles neurologiques
Cancers
Symptômes
5
Troubles cognitifs
Anomalies de croissance
Maladies génétiques
Cancer
Changements de comportement
Anomalies physiques
Système immunitaire
Infections
Prévention
5
Alimentation équilibrée
Mode de vie sain
Suppléments
Acide folique
Exercice physique
Santé épigénétique
Toxines environnementales
Perturbation épigénétique
Traitements
5
Thérapie génique
Médicaments ciblés
Thérapies épigénétiques
Cancer
Médecine personnalisée
Profil génétique
Complications
5
Cancers
Maladies auto-immunes
Réversibilité
Modifications épigénétiques
Maladies chroniques
Troubles de développement
Fertilité
Fonction reproductive
Effets à long terme
Prédispositions
Facteurs de risque
5
Facteurs de risque
Toxines
Hérédité
Facteurs génétiques
Maladies chroniques
Risque
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"text": "Des tests génétiques et des analyses de l'ADN peuvent révéler des modifications de méthylation."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont utilisés pour la déméthylation ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs épigénétiques comme 5-méthylcytosine sont souvent analysés."
}
},
{
"@type": "Question",
"name": "Quels tests sanguins peuvent indiquer une déméthylation ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de métabolites et d'ADN circulant peuvent fournir des indices."
}
},
{
"@type": "Question",
"name": "La biopsie est-elle nécessaire pour diagnostiquer la déméthylation ?",
"position": 4,
"acceptedAnswer": {
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"@type": "Question",
"name": "Quels symptômes peuvent alerter sur une déméthylation ?",
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"@type": "Question",
"name": "Quels symptômes sont associés à la déméthylation ?",
"position": 6,
"acceptedAnswer": {
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{
"@type": "Question",
"name": "La déméthylation peut-elle causer des maladies ?",
"position": 7,
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{
"@type": "Question",
"name": "Y a-t-il des signes cliniques de déméthylation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes cliniques peuvent inclure des changements de comportement et des anomalies physiques."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent se manifester différemment selon l'âge et le développement."
}
},
{
"@type": "Question",
"name": "La déméthylation affecte-t-elle le système immunitaire ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut altérer la réponse immunitaire, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Comment prévenir la déméthylation ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les suppléments peuvent-ils aider ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme l'acide folique peuvent soutenir la méthylation."
}
},
{
"@type": "Question",
"name": "Le stress influence-t-il la déméthylation ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régulier peut améliorer la santé épigénétique et la méthylation."
}
},
{
"@type": "Question",
"name": "Les toxines environnementales jouent-elles un rôle ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber les mécanismes de méthylation."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour la déméthylation ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies géniques et des médicaments ciblés."
}
},
{
"@type": "Question",
"name": "La nutrition peut-elle influencer la déméthylation ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains nutriments comme l'acide folique peuvent moduler la méthylation."
}
},
{
"@type": "Question",
"name": "Les thérapies épigénétiques sont-elles efficaces ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles montrent un potentiel prometteur dans le traitement de certains cancers."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la déméthylation par des médicaments ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques peuvent être utilisés pour prévenir la déméthylation."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles neurologiques et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "La déméthylation est-elle réversible ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines modifications peuvent être réversibles, mais pas toutes."
}
},
{
"@type": "Question",
"name": "Quels risques sont associés à la déméthylation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les risques incluent des maladies chroniques et des troubles de développement."
}
},
{
"@type": "Question",
"name": "La déméthylation peut-elle affecter la fertilité ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut influencer la fertilité en altérant la fonction reproductive."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets à long terme peuvent inclure des prédispositions à diverses maladies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de déméthylation ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'alimentation, le stress, et l'exposition à des toxines."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des facteurs génétiques peuvent influencer la déméthylation."
}
},
{
"@type": "Question",
"name": "Les maladies chroniques augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies chroniques peuvent augmenter le risque de déméthylation."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il la déméthylation ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie malsain peut favoriser la déméthylation."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles affecter la déméthylation ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections peuvent perturber les mécanismes de méthylation."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 19/04/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
St. Vincent's Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genomics and Epigenetics Division, Garvan Institute of Medical Research, Sydney, Australia.
School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney 22, Australia.
Centro Andaluz de Biología del Desarrollo, CSIC-Universidad Pablo de Olavide-Junta de Andalucía, Seville, Spain.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Environmental Sciences, University of California, Riverside, California 92521, United States.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Genetics, Stem Cells, Department of Cell and Molecular Biology, Faculty of Life Sciences and Biotechnology, Shahid Beheshti University, Tehran, 1983963113, Iran. Electronic address: s_farivar@sbu.ac.ir.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
State Key Laboratory of Molecular Biology, Shanghai Key Laboratory of Molecular Andrology, CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Jiangsu Key Laboratory of TCM Evaluation and Translational Research, School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, 211198, Jiangsu, China. liujihua@cpu.edu.cn.
State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, 210009, Jiangsu, China. liujihua@cpu.edu.cn.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Plant Science, Research Institute for Agriculture and Life Sciences, and Plant Genomics and Breeding Institute, Seoul National University, Seoul 08826, Korea huhjh@snu.ac.kr.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Harvard Stem Cell Institute, Harvard Medical School, Boston, MA 02115 USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115, USA.
Publications dans "Déméthylation" :
2 publications dans cette catégorie
Affiliations :
Cancer Science Institute of Singapore, National University of Singapore, Singapore 117599, Singapore.
Publications dans "Déméthylation" :
Heart failure (HF) is often categorized by left ventricular (LV) ejection fraction (LVEF). A new category of HF characterized by supra-normal LVEF (>65%), named HF with supra-normal ejection fraction ...
Ventricular arrhythmia (VA) commonly originate from the left ventricular summit (LVS) and results in left ventricular (LV) dysfunction in some patients; however, factors related to LV cardiomyopathy h...
Between 2013 and 2018, a total of 139 patients (60.7% men; mean age 53.2 ± 13.9 years old) underwent catheter ablation for LVS VA in two centers. Detailed patient demographics, electrocardiograms, ele...
Acute procedural success was achieved in 92.8% of patients. There were 40 patients (28.8%) with LV cardiomyopathy, and the mean LVEF improved from 37.5 ± 9.3% to 48.5 ± 10.2% after ablation (p < .001)...
In patients with VA from the LVS, PVC QRSd and AEAD are factors associated with deteriorating LV systolic function. Catheter ablation can reverse LV remodeling. Narrower QRSd and better LVEF are assoc...
Ascending aortic dilatation is a common clinical issue. In the present study, we aimed to evaluate the relationship between ascending aortic diameter with left ventricular (LV) and left atrial (LA) fu...
A total of 127 healthy participants with normal LV systolic function took part in the study. Echocardiographic measurements were obtained from each subject....
The mean age of the participants was 43 ± 14.1 years and 76 (59.8%) were female. The mean aortic diameter of the participants was 32.2 ± 4.7 mm. A negative correlation was found between aortic diamete...
A strong correlation between ascending aortic diameter with LV and LA functions, and LVMI in individuals with normal LV systolic function....
Positron emission tomography (PET) myocardial perfusion imaging (MPI) can be used to evaluate left ventricular (LV) volumes and function. We performed a head-to-head comparison of LV function and volu...
In this prospective study, 51 patients underwent [...
LVEF and LV wall motion can be accurately assessed using [...
CZT-SPECT has good agreement in the evaluation of mechanical synchronization compared with conventional SPECT. The aim of this study was to evaluate the correlation between left ventricular mechanical...
This retrospective study involved 371 patients (239 males and 132 females, mean age 61.06 ± 11.78 years old) who underwent GMPI at the Nuclear Medicine Department of Shanxi Cardiovascular Hospital fro...
PP, PSD, PHB, HS and HK were significantly different among the four groups (F = 5.20, 188.72, 202.88, 171.05, 101.36, P < 0.001). Pairwise comparison tests showed significant differences in PSD and PH...
CZT SPECT GMPI provided left ventricular mechanical contraction synchrony parameters that correlated well with left ventricular systolic function. Worse left ventricular mechanical contraction synchro...
Left ventricle myocardium has a complex micro-architecture, which was revealed to consist of myocyte bundles arranged in a series of laminar sheetlets. Recent imaging studies demonstrated that these s...
The perioperative quantification of left and right ventricular function is cornerstone to provide optimal patient care. Echocardiography has emerged as the most important cardiac imaging modality in t...
Myocardial contractility is poorly defined and difficult to compare between studies. Contractance or myocardial active strain energy density (MASED) measures the mechanical work done per unit volume (...
Data obtained from three previously published experimental studies using trabecular tissue was used to provide contemporaneous nominal stress and strain data in 18 different scenarios with different l...
We showed that calculating MASED was feasible and provided a measure of energy production (work done) per unit volume of myocardium during contraction. The new term for contractile function, contracta...
The right ventricle (RV) in hypertrophic cardiomyopathy (HCM) tends to be neglected, as previous efforts have predominantly focused on examining the prognostic value of left ventricular (LV) abnormali...
Two hundred and ninety HCM patients with preserved LV ejection fraction (LVEF ≥ 55%) and 30 age- and sex-matched controls underwent cardiovascular magnetic resonance (CMR). All patients were followed ...
When compared to controls, HCM patients exhibited lower RV and LV peak global longitudinal systolic strains on feature-tracking analysis of cine images, while RVEF and LVEF were within the normal rang...
In HCM, RV function, including RV strain, and LV strain decrease over time despite preserved LVEF. Reduction in RV but not LV function is associated with adverse cardiovascular outcomes. Assessing RV ...
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The onset of the arrhythmia can significantly impair cardiac function. This hemodynamic deterioration has been explained by ...
Twelve patients undergoing catheter ablation for paroxysmal AF were paced simultaneously from the proximal coronary sinus and the His bundle region according to prescribed sequences of irregular R-R i...
Simulated AF led to significant impairment of left ventricular systolic and diastolic function. Both loss of atrial contraction and heart rate irregularity significantly contributed to hemodynamic imp...
Our findings strengthen the rationale for therapeutic strategies aiming at rhythm control and heart rate regularization in patients with AF....