Titre : alpha-1-Antitrypsine

alpha-1-Antitrypsine : Questions médicales fréquentes

Termes MeSH sélectionnés :

Practice Guidelines as Topic
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nécessite-t-il une biopsie hépatique ?\nQuels examens d'imagerie sont recommandés ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur alpha-1-Antitrypsine", "description": "Quels sont les symptômes pulmonaires du déficit ?\nY a-t-il des symptômes hépatiques associés ?\nLes symptômes varient-ils selon l'âge ?\nComment les symptômes évoluent-ils avec le temps ?\nLes symptômes sont-ils similaires à d'autres maladies ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur alpha-1-Antitrypsine", "description": "Peut-on prévenir le déficit en alpha-1-antitrypsine ?\nQuelles habitudes de vie peuvent aider ?\nLe vaccin contre la grippe est-il recommandé ?\nDes conseils nutritionnels sont-ils utiles ?\nLe suivi médical régulier est-il important ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur alpha-1-Antitrypsine", "description": "Quel est le traitement principal pour le déficit ?\nDes médicaments sont-ils prescrits pour les symptômes ?\nLa chirurgie est-elle une option de traitement ?\nY a-t-il des traitements expérimentaux disponibles ?\nComment la physiothérapie aide-t-elle ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur alpha-1-Antitrypsine", "description": "Quelles sont les complications pulmonaires possibles ?\nLe déficit peut-il causer des maladies hépatiques ?\nY a-t-il un risque accru de cancer ?\nComment le déficit affecte-t-il la qualité de vie ?\nLes complications sont-elles réversibles ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur alpha-1-Antitrypsine", "description": "Quels sont les facteurs de risque génétiques ?\nLe tabagisme est-il un facteur de risque ?\nL'exposition à des polluants est-elle préoccupante ?\nL'âge influence-t-il le risque de complications ?\nLes infections respiratoires fréquentes sont-elles un facteur ?", "url": "https://questionsmedicales.fr/mesh/D000515?mesh_terms=Practice+Guidelines+as+Topic&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer un déficit en alpha-1-antitrypsine ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Un test sanguin mesure le niveau d'alpha-1-antitrypsine pour confirmer le déficit." } }, { "@type": "Question", "name": "Quels symptômes indiquent un déficit en alpha-1-antitrypsine ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Essoufflement, toux chronique et maladies hépatiques peuvent indiquer un déficit." } }, { "@type": "Question", "name": "Quels tests génétiques sont utilisés pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques identifient les mutations du gène SERPINA1 responsables du déficit." } }, { "@type": "Question", "name": "Le diagnostic nécessite-t-il une biopsie hépatique ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Une biopsie hépatique peut être réalisée si des lésions hépatiques sont suspectées." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont recommandés ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Une échographie ou un scanner peut être utilisé pour évaluer l'état du foie et des poumons." } }, { "@type": "Question", "name": "Quels sont les symptômes pulmonaires du déficit ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent essoufflement, toux persistante et infections respiratoires fréquentes." } }, { "@type": "Question", "name": "Y a-t-il des symptômes hépatiques associés ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, jaunisse, fatigue, et douleurs abdominales peuvent indiquer des problèmes hépatiques." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon l'âge ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes peuvent apparaître dès l'enfance ou à l'âge adulte, selon la gravité." } }, { "@type": "Question", "name": "Comment les symptômes évoluent-ils avec le temps ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent s'aggraver progressivement, surtout sans traitement approprié." } }, { "@type": "Question", "name": "Les symptômes sont-ils similaires à d'autres maladies ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent être confondus avec d'autres maladies pulmonaires ou hépatiques." } }, { "@type": "Question", "name": "Peut-on prévenir le déficit en alpha-1-antitrypsine ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention est limitée, mais le dépistage précoce peut aider à gérer la maladie." } }, { "@type": "Question", "name": "Quelles habitudes de vie peuvent aider ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Éviter le tabac et l'alcool, et maintenir un poids santé peuvent réduire les risques." } }, { "@type": "Question", "name": "Le vaccin contre la grippe est-il recommandé ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la vaccination contre la grippe est recommandée pour prévenir les infections respiratoires." } }, { "@type": "Question", "name": "Des conseils nutritionnels sont-ils utiles ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut soutenir la santé du foie et des poumons." } }, { "@type": "Question", "name": "Le suivi médical régulier est-il important ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des consultations régulières permettent de surveiller l'évolution de la maladie." } }, { "@type": "Question", "name": "Quel est le traitement principal pour le déficit ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement principal est la thérapie de remplacement d'alpha-1-antitrypsine par perfusion." } }, { "@type": "Question", "name": "Des médicaments sont-ils prescrits pour les symptômes ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des bronchodilatateurs et des corticostéroïdes peuvent être prescrits pour soulager les symptômes." } }, { "@type": "Question", "name": "La chirurgie est-elle une option de traitement ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Dans les cas graves, une transplantation hépatique peut être envisagée." } }, { "@type": "Question", "name": "Y a-t-il des traitements expérimentaux disponibles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Des essais cliniques explorent de nouvelles thérapies, mais leur efficacité varie." } }, { "@type": "Question", "name": "Comment la physiothérapie aide-t-elle ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "La physiothérapie respiratoire peut améliorer la fonction pulmonaire et la qualité de vie." } }, { "@type": "Question", "name": "Quelles sont les complications pulmonaires possibles ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les complications incluent emphysème, infections pulmonaires et insuffisance respiratoire." } }, { "@type": "Question", "name": "Le déficit peut-il causer des maladies hépatiques ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il peut entraîner des maladies hépatiques comme la cirrhose et le cancer du foie." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les personnes atteintes de déficit ont un risque accru de cancer du foie." } }, { "@type": "Question", "name": "Comment le déficit affecte-t-il la qualité de vie ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Il peut réduire la qualité de vie en limitant l'activité physique et en causant des douleurs." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être irréversibles." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque génétiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux de déficit en alpha-1-antitrypsine augmentent le risque." } }, { "@type": "Question", "name": "Le tabagisme est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme aggrave les symptômes et augmente le risque de complications pulmonaires." } }, { "@type": "Question", "name": "L'exposition à des polluants est-elle préoccupante ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des polluants environnementaux peut aggraver les symptômes respiratoires." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de complications ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de complications augmente avec l'âge, surtout sans traitement." } }, { "@type": "Question", "name": "Les infections respiratoires fréquentes sont-elles un facteur ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des infections respiratoires fréquentes peuvent aggraver l'état des patients atteints." } } ] } ] }

Sources (10000 au total)

Systematic review of clinical practice guidelines for traumatic dental injuries.

Traumatic dental injuries (TDI) are considered a public health problem due to their high prevalence and associated physical, economic, psychological and social consequences. Hence, good Clinical Pract... A systematic search for existing guidelines on TDI was performed on PubMed, EMBASE, CINAHL, Cochrane Library, ProQuest, National Institute for Health Care Excellence, BMJ Best Practice, Trip database,... Of the 7736 titles screened, three guidelines, namely the International Association of Dental Traumatology Guidelines (IADT), and the Italian and Malaysian guidelines, were included for the final anal... Several deficiencies exist in the methodological quality of existing CPGs on TDI. Future guidelines should consider improvements for domains such as 'rigour of development', 'stakeholder involvement' ...

Representation of evidence-based clinical practice guideline recommendations on FHIR.

Various formalisms have been developed to represent clinical practice guideline recommendations in a computer-interpretable way. However, none of the existing formalisms leverage the structured and co... We identified the information required to represent evidence-based clinical practice guideline recommendations and reviewed the knowledge artifacts emerging during the evidence-based guideline develop... The information model of evidence-based clinical guideline recommendations and its EBMonFHIR-/CPG-on-FHIR-based representation contain the clinical contents of individual guideline recommendations, a ... The FHIR implementation guide presented here can be used to directly link the evidence assessment process of evidence-based guideline recommendation development, i.e. systematic reviews and evidence g...

Malignancy risk stratification for solitary pulmonary nodule: A clinical practice guideline.

The detection rate of the solitary pulmonary nodule (SPN) is increasing with the popularization of CT scanning. Malignancy risk stratification for SPN is a major clinical difficulty.... There have been several guidelines for SPN assessment. Inconsistency of these guidelines makes the clinical application difficult and confusing.... In this Rapid Recommendation, solid and subsolid SPNs are recommended to be evaluated respectively. Six factors, namely the combination of age with sex, smoking history, history of malignancy, family ... This rapid recommendation was developed using the MAGIC (Making GRADE the Irresistible Choice) methodological framework. First, a clinical subcommittee identified the topic of recommendation and reque... A total of 13857 patients with SPNs were included in the meta-analysis and the association between 12 candidate factors and the risk of SPNs being malignant was studied. Eventually, seven factors were... The parameters included are objective. Therefore, this recommendation is feasible in clinical practice. However, there are several uncertainties, such as a lack of further verification. It might be mi...

Models and frameworks for assessing the implementation of clinical practice guidelines: a systematic review.

The implementation of clinical practice guidelines (CPGs) is a cyclical process in which the evaluation stage can facilitate continuous improvement. Implementation science has utilized theoretical app... A systematic review was conducted following the Cochrane methodology, with adaptations to the "selection process" due to the unique nature of this review. The findings were reported following PRISMA (... Database searches yielded 14,395 studies, of which 80 full texts were reviewed. Eight studies were included in the data analysis and four methodological guidelines were additionally included from the ... The use of models and frameworks for assessing the implementation of CPGs is still incipient. This systematic review may help stakeholders choose or adapt the most appropriate model or framework to as... PROSPERO (International Prospective Register of Systematic Reviews) registration number: CRD42022335884. Registered on June 7, 2022....

Intellectual conflicts of interest among cardiology and pulmonology clinical practice guidelines.

Intellectual conflicts of interest (COI), like financial COI, may threaten the validity and trustworthiness of clinical practice guidelines (CPGs). However, comparatively little is known about intelle... We conducted a retrospective document review of CPGs published by cardiology or pulmonology professional societies from the United States, Canada, or Europe from 2018 to 2019 available via the Emergen... Among the 39 CPGs identified (14 cardiology, 25 pulmonology), there were a total of 737 authors, of whom 473 (64%) had at least one intellectual COI. Among all CPGs, a median of 67% (Interquartile Ran... Intellectual conflicts of interest appear to be highly prevalent and under-reported among cardiology and pulmonology CPGs, which may threaten their validity. Greater attention to and improved manageme...

Review of clinical practice guidelines for postpartum hemorrhage according to AGREE II.

Clinical practice guidelines for postpartum hemorrhage (PPH) are available worldwide, but no review has assessed the quality of these guidelines. Poor-quality guidelines for PPH may lead clinicians to... High-quality guidelines for PPH are important in guiding the clinical diagnosis and treatment of PPH and decreasing maternal mortality. The aim of this study was to assess the quality of clinical guid... We collected studies from different countries through a literature search including PubMed (MEDLINE), Web of Science, the Cochrane library, websites of health institutions from multiple countries, and... Seven sets of PPH guidelines published from 2007 to 2022 were identified. An overall high agreement among reviewers in each domain was observed (ICC 0.74 to 0.95). The median scores and ranges for eac... The methodological and reporting quality of the guidelines for PPH included in this review was generally good, but the strength of the recommendations and the quality of the evidence varied, thus pote...

Low-Risk Antenatal Care Enhanced by Telemedicine: A Practical Guideline Model.

To develop a protocol for hybrid low-risk prenatal care adapted to Brazilian guidelines, merging reduced face-to-face consultations and remote monitoring.... The PubMed, Embase, and Cochrane Library databases were systematically searched on telemedicine and antenatal care perspectives and adaptation of the low-risk prenatal care protocols recommended by th... Five relevant articles and three manuals were included in the review, for presented criteria to develop this clinical guideline. We identified, in these studies, that the schedule of consultations is ... The presented guideline comprises the Ministry of Health recommendations for low-risk prenatal care and reduces exposure to the hospital environment and care costs. A randomized clinical trial, to be ...