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Antimétabolites
Antimétabolites : Questions médicales fréquentes
Termes MeSH sélectionnés :
DNA Copy Number Variations
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"name": "Comment diagnostique-t-on une toxicité aux antimétabolites ?",
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"text": "La toxicité est diagnostiquée par des tests sanguins et l'évaluation des symptômes cliniques."
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'efficacité des antimétabolites ?",
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"@type": "Question",
"name": "Quels signes cliniques indiquent une surdose d'antimétabolites ?",
"position": 3,
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"@type": "Question",
"name": "Comment évaluer les effets secondaires des antimétabolites ?",
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"@type": "Question",
"name": "Quels sont les symptômes courants des effets secondaires ?",
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"@type": "Question",
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"@type": "Question",
"name": "Quels symptômes indiquent une réaction allergique ?",
"position": 8,
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"@type": "Question",
"name": "Les antimétabolites causent-ils des douleurs ?",
"position": 9,
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"name": "Quels symptômes peuvent indiquer une anémie due aux antimétabolites ?",
"position": 10,
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{
"@type": "Question",
"name": "Comment prévenir les effets secondaires des antimétabolites ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance régulière et des ajustements de dose peuvent aider à prévenir les effets secondaires."
}
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{
"@type": "Question",
"name": "Y a-t-il des mesures préventives avant le traitement ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, des tests de fonction hépatique et rénale sont souvent effectués avant le traitement."
}
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"@type": "Question",
"name": "Comment gérer les nausées induites par les antimétabolites ?",
"position": 13,
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"text": "Des antiémétiques peuvent être prescrits pour gérer les nausées et vomissements."
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"@type": "Question",
"name": "Quelles précautions prendre lors de l'administration ?",
"position": 14,
"acceptedAnswer": {
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}
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{
"@type": "Question",
"name": "Les patients doivent-ils être informés des effets secondaires ?",
"position": 15,
"acceptedAnswer": {
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"text": "Oui, l'éducation des patients sur les effets secondaires est cruciale pour une bonne observance."
}
},
{
"@type": "Question",
"name": "Quels types d'antimétabolites existent ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les principaux types incluent les analogues des purines et des pyrimidines."
}
},
{
"@type": "Question",
"name": "Comment sont administrés les antimétabolites ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent être administrés par voie orale ou intraveineuse, selon le médicament."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements combinés avec les antimétabolites ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils sont souvent combinés avec des agents alkylants ou des inhibiteurs de la tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Quelle est la durée typique d'un traitement par antimétabolites ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée varie, mais elle est généralement de plusieurs semaines à plusieurs mois."
}
},
{
"@type": "Question",
"name": "Les antimétabolites sont-ils utilisés en traitement adjuvant ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils sont souvent utilisés en traitement adjuvant après chirurgie pour réduire les récidives."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles des antimétabolites ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent l'immunosuppression, l'anémie et des troubles gastro-intestinaux."
}
},
{
"@type": "Question",
"name": "Les antimétabolites peuvent-ils causer des cancers secondaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains antimétabolites sont associés à un risque accru de cancers secondaires."
}
},
{
"@type": "Question",
"name": "Comment gérer une infection due à l'immunosuppression ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un traitement antibiotique précoce et une surveillance étroite sont essentiels."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de toxicité hépatique ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antimétabolites peuvent provoquer une hépatotoxicité, nécessitant un suivi régulier."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications liées aux antimétabolites ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance régulière et des ajustements de traitement peuvent aider à prévenir les complications."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'effets secondaires ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, les comorbidités et les interactions médicamenteuses augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux influencent-ils le traitement ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de maladies hépatiques ou rénales peuvent influencer le choix du traitement."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il l'efficacité des antimétabolites ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation déséquilibrée et le tabagisme peuvent réduire l'efficacité du traitement."
}
},
{
"@type": "Question",
"name": "Les interactions médicamenteuses sont-elles un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines interactions peuvent augmenter la toxicité ou diminuer l'efficacité des antimétabolites."
}
},
{
"@type": "Question",
"name": "Les facteurs génétiques influencent-ils la réponse au traitement ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des variations génétiques peuvent affecter la métabolisation des antimétabolites."
}
}
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Next-generation sequencing (NGS) facilitates comprehensive molecular analyses that help with diagnosing unsolved disorders. In addition to detecting single-nucleotide variations and small insertions/d...
To report a rare case of a patient with a molecular diagnosis of Kleefstra syndrome (KS) who has four other chromosomal alterations involving pathogenic variants....
Male patient, two years old, with global delay, including in neuropsychomotor development, ocular hypertelorism, broad forehead, brachycephaly, hypotonia, ligament laxity, unilateral single palmar cre...
The presence of pathogenic CNVs and/or those of uncertain significance, located on chromosomes 2, 6 and Y, may be contributing to a variability in the patient's clinical condition (arachnoid cyst, sin...
Copy number variants (CNVs) are a major contribution to genome variability, and the presence of CNVs on chromosome 1 is a known cause of morbidity. The main objective of this study was to contribute t...
Copy number variations (CNVs) are defined as deletions, duplications and insertions among individuals of a species. There is growing evidence that CNV is a major factor underlining various autoimmune ...
Despite being a very common type of genetic variation, the distribution of copy-number variations (CNVs) in the population is still poorly understood. The knowledge of the genetic variability, especia...
Here, we present the SPAnish Copy Number Alterations Collaborative Server (SPACNACS), which currently contains copy number variation profiles obtained from more than 400 genomes and exomes of unrelate...
SPACNACS facilitates disease gene discovery by providing detailed information of the local variability of the population and exemplifies how to reuse genomic data produced for other purposes to build ...
Posttraumatic stress disorder (PTSD) is a heritable (h...
Turner syndrome (TS) is one of the most common chromosomal abnormalities with an incidence of approximately one in 2,500 live births. Short stature and primary ovarian insufficiency are two most impor...
Fifty-three patients diagnosed with TS, between the ages of 0-18 were included in the study. Peripheral blood samples were taken from 36 cases for microarray study....
Karyotypes were as follows: thirty-three of cases were 45,X, 7 were 45,X/46,XX, 6 were 45,X/46,Xi(Xq), 2 were 46,Xi(Xq), 2 were 45,X/46,r(X), 1 was 45,X/46,Xi(Xp), 1 was 45,X/46,XY and 1 was 45,X/46,X...
In conclusion, the microarray method has a great contribution in explaining many unexpected findings in TS cases. Moreover, those CNV findings may contribute for the explanation of the underlying mech...
In the last decade, new tumor entities have been described, including...
As an important source of genetic variation, copy number variation (CNV) can alter the dosage of DNA segments, which in turn may affect gene expression level and phenotype. However, our knowledge of C...
In this study, we identified 914,610 CNVs comprising 14,839 CNV regions (CNVRs) from 346 apple accessions, including 289 cultivars and 57 wild relatives. CNVRs summed to 71.19 Mb, accounting for 10.03...
This study was based on identification of CNVs from 346 diverse apple accessions, which to our knowledge was the largest dataset for CNV analysis in apple. Our work presented the first comprehensive C...
Recent findings demonstrate that single nucleotide variants can cause non-obstructive azoospermia (NOA). In contrast, copy number variants (CNVs) were only analysed in few studies in infertile men. So...
This study aimed to elucidate if CNVs are associated with NOA....
We performed array-based comparative genomic hybridisation (aCGH) in 37 men with meiotic arrest, 194 men with Sertoli cell-only phenotype, and 21 control men. We filtered our data for deletions affect...
We determined the cause of infertility in two individuals with homozygous deletions of SYCE1 and in one individual with a heterozygous deletion of SYCE1 combined with a likely pathogenic missense vari...
While SYCE1 and MLH3 encode known meiosis-specific proteins, much less is known about the proteins encoded by the other identified candidate genes, warranting further analyses. We were able to identif...
As aCGH and exome sequencing are both expensive methods, combining both in a clinical routine is not an effective strategy. Instead, using CNV calling from exome data has recently become more precise,...