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Acides aminés, peptides et protéines
Protéines
Globulines
Sérum-globulines
Immunoglobulines
Anticorps
Autoanticorps
Autoanticorps : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"text": "Les autoanticorps sont détectés par des tests sanguins spécifiques, comme l'ELISA."
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour les autoanticorps ?",
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"@type": "Question",
"name": "Les autoanticorps sont-ils toujours présents dans les maladies auto-immunes ?",
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"@type": "Question",
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"name": "Quels symptômes sont associés aux autoanticorps ?",
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"text": "Les symptômes varient, mais peuvent inclure fatigue, douleurs articulaires et éruptions cutanées."
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"@type": "Question",
"name": "Les autoanticorps causent-ils des douleurs articulaires ?",
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"name": "Peut-on avoir des symptômes neurologiques avec des autoanticorps ?",
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"text": "Oui, certains autoanticorps sont associés à des troubles neurologiques comme la sclérose en plaques."
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"@type": "Question",
"name": "Les éruptions cutanées sont-elles liées aux autoanticorps ?",
"position": 9,
"acceptedAnswer": {
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"text": "Oui, des éruptions cutanées peuvent survenir dans des maladies comme le lupus érythémateux systémique."
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"@type": "Question",
"name": "Les autoanticorps peuvent-ils affecter les organes internes ?",
"position": 10,
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"@type": "Question",
"name": "Peut-on prévenir la production d'autoanticorps ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode garantie, mais un mode de vie sain peut réduire les risques."
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"@type": "Question",
"name": "Les vaccinations influencent-elles les autoanticorps ?",
"position": 12,
"acceptedAnswer": {
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"text": "Certaines vaccinations peuvent déclencher des autoanticorps, mais les bénéfices l'emportent souvent."
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"@type": "Question",
"name": "Le stress peut-il augmenter les autoanticorps ?",
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"acceptedAnswer": {
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"text": "Oui, le stress chronique peut exacerber les maladies auto-immunes et augmenter les autoanticorps."
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"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle dans la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation riche en antioxydants et en oméga-3 peut aider à réduire l'inflammation."
}
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"@type": "Question",
"name": "Les examens médicaux réguliers aident-ils à la prévention ?",
"position": 15,
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"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter précocement les maladies auto-immunes."
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"name": "Comment traite-t-on les maladies liées aux autoanticorps ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des immunosuppresseurs, des anti-inflammatoires et des corticostéroïdes."
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"@type": "Question",
"name": "Les traitements sont-ils les mêmes pour tous les autoanticorps ?",
"position": 17,
"acceptedAnswer": {
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"text": "Non, le traitement dépend du type de maladie auto-immune et des autoanticorps présents."
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"name": "Les thérapies biologiques sont-elles efficaces contre les autoanticorps ?",
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"name": "Peut-on guérir des maladies causées par des autoanticorps ?",
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"name": "Les changements de mode de vie aident-ils à gérer les autoanticorps ?",
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"text": "Oui, une alimentation équilibrée, l'exercice et la gestion du stress peuvent aider à la gestion."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec des autoanticorps ?",
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"text": "Les complications incluent des dommages aux organes, des infections et des troubles auto-immuns."
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"@type": "Question",
"name": "Les autoanticorps peuvent-ils causer des maladies cardiovasculaires ?",
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"text": "Oui, certains autoanticorps sont associés à un risque accru de maladies cardiovasculaires."
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"name": "Les complications sont-elles réversibles ?",
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"text": "Les facteurs incluent des antécédents familiaux, le sexe féminin et certaines infections."
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"@type": "Question",
"name": "L'âge influence-t-il la production d'autoanticorps ?",
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"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme est associé à un risque accru de maladies auto-immunes et d'autoanticorps."
}
},
{
"@type": "Question",
"name": "Les déséquilibres hormonaux affectent-ils les autoanticorps ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les déséquilibres hormonaux, notamment chez les femmes, peuvent influencer la production d'autoanticorps."
}
}
]
}
]
}
Osteoarthritis (OA) is marked by the progressive degradation of joint cartilage and subchondral bone. The precise molecular mechanisms driving meniscus deterioration in OA, especially at the single-ce...
We analyzed two datasets from the GEO database, GSE220243 and GSE98918, focusing on meniscus tissue sequencing data from OA and non-OA patients. The standard Seurat procedure was employed to process s...
After quality control, 34,763 cells from the OA patients and 34,145 cells from the healthy controls were analyzed. UMAP identified and SingleR annotated 14 cell clusters. The 10 largest cell clusters ...
This research highlights crucial genes in the OA meniscus and uncovers their differing regulatory patterns between chondrocytes and non-chondrocytes. These findings enhance our understanding of the mo...
(1) Purpose: Retrospective back-to-back comparisons were performed to evaluate the accuracy, effectiveness, and incremental yield of chromosome microarray analysis (CMA) and exome sequencing (ES) anal...
Down syndrome (DS) is the most common congenital cause of intellectual disability and also leads to numerous metabolic and structural problems. This study aims to explore the application value of chro...
The study recruited 1452 pregnant women with abnormal DS screening results including 493 with an enlarged nuchal translucency thickness (NT ≥ 2.5 mm) and 959 with an abnormal second-trimester maternal...
CMA identified 74/1452 abnormal results, which was more efficient than karyotyping (51/1452, P < 0.05.) CMA is equivalent to traditional karyotyping for identifying aneuploidies. Compared to karyotypi...
CMA and karyotyping have both advantages and disadvantages in prenatal diagnosis of pregnant women with abnormal DS screening results. However, there was not enough evidence to support routine CMA in ...
Though copy number variants (CNVs) have been suggested to play a significant role in inborn errors of immunity (IEI), the precise nature of this role remains largely unexplored. We sought to determine...
We performed exome sequencing (ES) and CMA for 332 unrelated pediatric probands referred for evaluation of IEI. The analysis included primary, secondary, and incidental findings....
Of the 332 probands, 134 (40.4%) received molecular diagnoses. Of these, 116/134 (86.6%) were diagnosed by ES alone. An additional 15/134 (11.2%) were diagnosed by CMA alone, including two likely...
Pairing ES and CMA can provide a comprehensive evaluation to clarify the complex factors that contribute to both immune and non-immune phenotypes. Such a combined approach to genetic testing helps unt...
The aim of this study was to investigate the contribution of chromosomal microarray analysis (CMA) and next-generation sequencing (NGS) to genetic diagnosis in fetuses with normal karyotype who underw...
The results of invasive genetic testing performed at a tertiary center between September 2020 and March 2022 were retrospectively analyzed. Indications for invasive tests were classified as fetal stru...
A total of 830 invasive tests were performed and aneuploidy was detected in 11.2% of the fetuses. CMA was performed in 465 fetuses with normal karyotype, and pCNVs were detected in 6.9%. pCNVs were de...
pCNVs can be significantly detected not only in fetuses with structural malformations, but also in invasive testing with other indications. NGS significantly contributes to genetic diagnosis in fetuse...
Chromosomal microarray analysis (CMA) may detect variants of uncertain clinical significance (VUS) and susceptibility loci (SL) with incomplete penetrance for neurodevelopmental disorders. This qualit...
Semi-structured interviews were conducted with women who received a VUS and/or SL from prenatal CMA in the last 2-4 years and were analyzed using Grounded Theory....
The vast majority of women recalled being stressed by the findings. All women sought further advice and information to be able to decide whether to continue or terminate their pregnancy. The three pre...
Although uncertain/probabilistic information commonly involves a psychological burden, it may also be perceived as valuable and actionable. Pre-test parental choice regarding the disclosure of such in...
Aneuploidies are the most common chromosomal abnormality and the main genetic cause of adverse pregnancy outcomes. Since numerous studies have focused on common trisomies, relatively little is known a...
A total of 90 RAAs were detected, of which 83 cases were mosaic trisomies and 7 were non-mosaic trisomies. Chromosomes 16, 22, and 9 were identified as the major chromosomes involving RAAs. The four p...
Variable phenotypes and outcomes were observed, which were highly heterogeneous in cases of prenatal RAAs. Thus, a cautious and comprehensive strategy should be implemented during prenatal counseling ...
Alzheimer's disease is a prevalent health problem with a heavy global burden. Definitely diagnosed by autopsy, the clear mechanism of Alzheimer's disease pathogenesis process needs to be illustrated. ...
We attempted to discover the role of microRNA in Alzheimer's disease by microarray bioinformatics analysis using autopsy sample data from the GEO database. Temporal cortex samples were included in thi...
After filtering out significantly differential expressed microRNAs and genes, enrichment analyses of both microRNAs and genes were conducted, respectively. Then, we constructed a transcription factor-...
Hsa-miR-365b-5p act as a key target in Alzheimer's disease. It regulates Alzheimer's disease pathogenesis process via neuroinflammation, Wnt and oxidative stress pathway which provides a potential tar...
Background: There are few studies on the detection rate by chromosomal microarray analysis (CMA) of the prenatal diagnosis of talipes equinovarus (TE) compared to conventional karyotyping. We aimed to...
(1) Objective: To evaluate the application of chromosomal microarray analysis (CMA) in fetuses with pulmonary atresia (PA) and to explore the risk factors for predicting chromosomal imbalances and adv...