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"description": "Comment diagnostiquer une tumeur sensible aux ellipticines ?\nQuels tests sont utilisés pour évaluer l'efficacité des ellipticines ?\nLes ellipticines sont-elles utilisées pour tous les types de cancer ?\nQuels signes cliniques indiquent un traitement par ellipticines ?\nComment évaluer les effets secondaires des ellipticines ?",
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"name": "Comment diagnostiquer une tumeur sensible aux ellipticines ?",
"position": 1,
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"text": "Un diagnostic est établi par biopsie et analyses histopathologiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'efficacité des ellipticines ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests d'imagerie comme l'IRM et des marqueurs tumoraux sont utilisés."
}
},
{
"@type": "Question",
"name": "Les ellipticines sont-elles utilisées pour tous les types de cancer ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elles sont principalement efficaces contre certains cancers comme le cancer du poumon."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent un traitement par ellipticines ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes de progression tumorale ou de résistance aux autres traitements peuvent indiquer leur utilisation."
}
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"@type": "Question",
"name": "Comment évaluer les effets secondaires des ellipticines ?",
"position": 5,
"acceptedAnswer": {
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"@type": "Question",
"name": "Quels symptômes peuvent indiquer un cancer traité par ellipticines ?",
"position": 6,
"acceptedAnswer": {
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"text": "Les symptômes incluent douleur, fatigue, perte de poids et changements d'appétit."
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{
"@type": "Question",
"name": "Les ellipticines provoquent-elles des effets secondaires ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent causer nausées, vomissements, et troubles hématologiques."
}
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{
"@type": "Question",
"name": "Comment reconnaître une réaction allergique aux ellipticines ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des éruptions cutanées, démangeaisons ou gonflements peuvent indiquer une allergie."
}
},
{
"@type": "Question",
"name": "Les ellipticines affectent-elles le système immunitaire ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent entraîner une immunosuppression, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une toxicité des ellipticines ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes de toxicité incluent fatigue extrême, saignements inhabituels et jaunisse."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les cancers traités par ellipticines ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mesures préventives incluent un mode de vie sain et des dépistages réguliers."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés aux cancers traités par ellipticines ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent le tabagisme, l'exposition à des agents carcinogènes et des antécédents familiaux."
}
},
{
"@type": "Question",
"name": "Les vaccinations peuvent-elles aider à prévenir le cancer ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines vaccinations, comme celles contre le HPV, peuvent réduire le risque de cancer."
}
},
{
"@type": "Question",
"name": "Comment un mode de vie sain influence-t-il le risque de cancer ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain, incluant alimentation équilibrée et exercice, peut réduire le risque."
}
},
{
"@type": "Question",
"name": "Les examens de santé réguliers sont-ils importants ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils permettent de détecter précocement des anomalies et d'initier un traitement rapide."
}
},
{
"@type": "Question",
"name": "Comment les ellipticines sont-elles administrées ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles sont généralement administrées par voie intraveineuse ou orale."
}
},
{
"@type": "Question",
"name": "Les ellipticines sont-elles utilisées en monothérapie ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent être utilisées seules ou en association avec d'autres traitements anticancéreux."
}
},
{
"@type": "Question",
"name": "Quel est le mécanisme d'action des ellipticines ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles agissent en interférant avec l'ADN des cellules cancéreuses, inhibant leur prolifération."
}
},
{
"@type": "Question",
"name": "Quelles sont les alternatives aux ellipticines ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les alternatives incluent d'autres chimiothérapies, thérapies ciblées et immunothérapies."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement par ellipticines ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'efficacité est surveillée par des examens d'imagerie et des bilans sanguins réguliers."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec les ellipticines ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections, des saignements et des réactions allergiques."
}
},
{
"@type": "Question",
"name": "Les ellipticines peuvent-elles causer des dommages aux organes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent entraîner des toxicités hépatiques et rénales, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Comment gérer les effets secondaires graves des ellipticines ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut l'ajustement de la dose, l'utilisation de médicaments symptomatiques et le suivi."
}
},
{
"@type": "Question",
"name": "Les ellipticines augmentent-elles le risque de récidive du cancer ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent réduire le risque de récidive, mais un suivi régulier est essentiel."
}
},
{
"@type": "Question",
"name": "Quels sont les risques de surdosage d'ellipticines ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le surdosage peut entraîner des effets toxiques graves, nécessitant une intervention médicale immédiate."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque pour les cancers traités par ellipticines ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les principaux facteurs incluent le tabagisme, l'exposition à des produits chimiques et l'âge."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle dans le risque de cancer ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancer augmentent le risque de développer certaines tumeurs."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le risque de cancer ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en fruits et légumes peut réduire le risque de certains cancers."
}
},
{
"@type": "Question",
"name": "Le stress est-il un facteur de risque pour le cancer ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Bien que le stress ne soit pas un facteur direct, il peut affecter le système immunitaire."
}
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{
"@type": "Question",
"name": "Les infections virales augmentent-elles le risque de cancer ?",
"position": 30,
"acceptedAnswer": {
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"text": "Oui, certaines infections virales, comme le HPV, sont liées à un risque accru de cancer."
}
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Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is complement-mediated due to the lack of complement inhibitors in the hemopoietic cell membranes, making complement inhibition the best approach...
The expert recommendations presented here were created using a Delphi-like process by a group of expert PNH specialists across Central Europe. Based on an initial advisory board meeting discussion, re...
Using a systematic approach, literature databases were searched for relevant studies, and 50 articles were reviewed by the experts and included as supporting evidence....
Implementation of these recommendations uniformly across healthcare institutions will promote the best use of complement inhibition in managing PNH, and has the potential to positively impact patient ...
In the absence of head-to-head trials, this study compared treatment outcomes with the C3 complement inhibitor pegcetacoplan versus the C5 complement inhibitor eculizumab or ravulizumab in complement ...
A matching-adjusted indirect comparison was conducted using individual patient data from the pegcetacoplan arm of the PRINCE trial (NCT04085601; n = 34) and aggregate data from the ravulizumab (n = 12...
After weighting, treatment with pegcetacoplan was associated with statistically significant improvements in most clinical endpoints compared with ravulizumab or eculizumab treatment. These included: g...
Pegcetacoplan provides clinical benefits as first-line treatment for complement inhibitor-naïve patients with PNH....
ClinicalTrials.gov identifier, NCT04085601....
In myelin oligodendrocyte glycoprotein IgG-associated disease (MOGAD) and aquaporin-4 IgG+ neuromyelitis optica spectrum disorder (AQP4+NMOSD), the autoantibodies are mainly composed of IgG1, and comp...
CSF-C3a, CSF-C4a, CSF-C5a, and CSF-C5b-9 levels during the acute phase before treatment in patients with MOGAD (n = 12), AQP4+NMOSD (n = 11), multiple sclerosis (MS) (n = 5), and noninflammatory neuro...
CSF-C3a and CSF-C5a levels were significantly higher in MOGAD (mean ± SD, 5,629 ± 1,079 pg/mL and 2,930 ± 435.8 pg/mL) and AQP4+NMOSD (6,017 ± 3,937 pg/mL and 2,544 ± 1,231 pg/mL) than in MS (1,507 ± ...
The complement pathway is activated in both MOGAD and AQP4+NMOSD, but MAC formation is lower in MOGAD, particularly in those with mild attacks, than in AQP4+NMOSD. These findings may have pathogenetic...
Complement-mediated thrombotic microangiopathy (CM-TMA) is a rare and life-threatening complication that can occur in kidney transplant recipients, with various potential triggers including immunosupp...
Atypical-hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy often due to uncontrolled complement activation, characterized by high risk of end-stage kidney disease (ESKD). Eculizuma...
To identify characteristics associated with treatment response, we analyzed 244 aHUS patients referred to our center. Patients were classified according to the presence/absence of complement abnormali...
Patients had a better outcome with eculizumab compared to conventional treatment, with a response rate of 81.9% vs 56.9%, p < 0.001 and a long-term cumulative incidence of ESKD of 5.8% vs 22.5% (hazar...
Our data show a better outcome in aHUS patients treated with C5-inhibition, particularly in the primary and combined forms, which have a high risk of relapse after discontinuation that is not observed...
Diabetic nephropathy is a common microvascular complication of diabetes mellitus. It is characterized by progressive chronic kidney disease (CKD) with decline of kidney function by hyperfiltration. On...
Complement C5 (C5) is the key component for the complement activation pathway, which is important for innate immunity, and inhibition of C5 is considered to be effective in antibody-mediated rejection...
Like rheumatoid arthritis (RA) in humans, collagen-induced arthritis (CIA) in mice is associated with not only MHC class II genetic polymorphism but also, to some extent, with other loci including gen...
Several diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal a...
Serum from adults was collected before and after vaccination with the meningococcal serogroup B vaccine 4CMenB and tested for meningococcal killing. Since the B capsular polysaccharide is structurally...
While only a few pre-vaccination sera showed SBA against the tested B meningococcal isolates, 4CMenB vaccination induced potent complement-activating IgG titers against isolates expressing a matching ...
Compared to the SBA triggered by A,C,W,Y capsule polysaccharide conjugate vaccination, SBA against B meningococci expressing a matching fHbp allele was remarkably resilient against the alternative pat...
A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade...