Titre : Maladies de l'appareil génital féminin

Maladies de l'appareil génital féminin : Questions médicales fréquentes

Nom anglais: Genital Diseases, Female

Descriptor UI: D005831

Tree Number: C12.100.250

Termes MeSH sélectionnés :

Methotrexate

Questions fréquentes et termes MeSH associés

Diagnostic 5

#1

Comment diagnostiquer une infection vaginale ?

Un examen pelvien et des tests de laboratoire comme un frottis vaginal sont nécessaires.
Infections vaginales Examen pelvien
#2

Quels tests pour détecter des fibromes utérins ?

L'échographie pelvienne et l'IRM sont couramment utilisés pour diagnostiquer les fibromes.
Fibromes utérins Échographie
#3

Comment identifier une endométriose ?

L'IRM et la laparoscopie sont des méthodes efficaces pour diagnostiquer l'endométriose.
Endométriose Laparoscopie
#4

Quels signes indiquent un cancer du col de l'utérus ?

Des saignements anormaux et des douleurs pelviennes peuvent signaler un cancer du col.
Cancer du col de l'utérus Saignements vaginaux
#5

Quel rôle joue le frottis cervical ?

Le frottis cervical permet de détecter des cellules anormales et prévenir le cancer du col.
Frottis cervical Cancer du col de l'utérus

Symptômes 5

#1

Quels sont les symptômes d'une vaginite ?

Les symptômes incluent démangeaisons, écoulement vaginal anormal et odeur désagréable.
Vaginite Écoulement vaginal
#2

Comment reconnaître une infection pelvienne ?

Douleurs abdominales, fièvre et écoulement vaginal peuvent indiquer une infection pelvienne.
Infection pelvienne Douleurs abdominales
#3

Quels signes d'endométriose ?

Les douleurs menstruelles intenses et les douleurs pendant les rapports sexuels sont fréquents.
Endométriose Douleurs menstruelles
#4

Quels symptômes d'un kyste ovarien ?

Les kystes peuvent provoquer des douleurs pelviennes, des irrégularités menstruelles ou être asymptomatiques.
Kystes ovariens Douleurs pelviennes
#5

Quels symptômes d'un cancer de l'ovaire ?

Ballonnements, douleurs abdominales et changements d'appétit peuvent signaler un cancer de l'ovaire.
Cancer de l'ovaire Ballonnements

Prévention 5

#1

Comment prévenir les infections vaginales ?

Maintenir une bonne hygiène, éviter les douches vaginales et porter des sous-vêtements en coton.
Infections vaginales Hygiène
#2

Quelles mesures pour prévenir le cancer du col ?

Vaccination contre le HPV et dépistage régulier par frottis cervical sont essentiels.
Cancer du col de l'utérus Vaccination HPV
#3

Comment réduire le risque d'endométriose ?

Un diagnostic précoce et un traitement hormonal peuvent aider à gérer les symptômes.
Endométriose Traitement hormonal
#4

Quelles pratiques pour éviter les fibromes ?

Maintenir un poids santé et une alimentation équilibrée peut réduire le risque de fibromes.
Fibromes utérins Poids santé
#5

Comment prévenir le cancer de l'ovaire ?

Un suivi médical régulier et une connaissance des antécédents familiaux sont importants.
Cancer de l'ovaire Antécédents familiaux

Traitements 5

#1

Comment traiter une vaginite ?

Le traitement dépend de la cause : antifongiques pour mycoses, antibiotiques pour infections.
Vaginite Antifongiques
#2

Quelles options pour les fibromes utérins ?

Les options incluent médicaments, embolisation ou chirurgie selon la gravité des symptômes.
Fibromes utérins Chirurgie
#3

Quel traitement pour l'endométriose ?

Les traitements incluent médicaments anti-inflammatoires, hormonaux ou chirurgie pour enlever les lésions.
Endométriose Médicaments anti-inflammatoires
#4

Comment traiter le cancer du col de l'utérus ?

Le traitement peut inclure chirurgie, radiothérapie et chimiothérapie selon le stade du cancer.
Cancer du col de l'utérus Chirurgie
#5

Quelles thérapies pour le cancer de l'ovaire ?

Chirurgie, chimiothérapie et thérapies ciblées sont les principales options de traitement.
Cancer de l'ovaire Chimiothérapie

Complications 5

#1

Quelles complications des infections pelviennes ?

Les infections pelviennes non traitées peuvent entraîner des abcès, infertilité ou douleurs chroniques.
Infections pelviennes Infertilité
#2

Quels risques liés aux fibromes ?

Les fibromes peuvent causer des saignements abondants, douleurs et complications pendant la grossesse.
Fibromes utérins Saignements abondants
#3

Quelles complications de l'endométriose ?

L'endométriose peut entraîner des adhérences, infertilité et douleurs chroniques.
Endométriose Infertilité
#4

Quels risques du cancer du col ?

Le cancer du col peut se propager à d'autres organes et nécessiter des traitements plus agressifs.
Cancer du col de l'utérus Traitements agressifs
#5

Quelles complications du cancer de l'ovaire ?

Le cancer de l'ovaire peut entraîner des métastases et des complications liées aux traitements.
Cancer de l'ovaire Métastases

Facteurs de risque 5

#1

Quels facteurs de risque pour les infections vaginales ?

Les antibiotiques, le diabète et une hygiène inadéquate augmentent le risque d'infections vaginales.
Infections vaginales Diabète
#2

Quels facteurs augmentent le risque de fibromes ?

L'obésité, les antécédents familiaux et les déséquilibres hormonaux sont des facteurs de risque.
Fibromes utérins Obésité
#3

Quels facteurs de risque pour l'endométriose ?

Les antécédents familiaux, menstruations précoces et cycles menstruels longs augmentent le risque.
Endométriose Antécédents familiaux
#4

Quels facteurs de risque pour le cancer du col ?

Infection par le HPV, tabagisme et antécédents familiaux augmentent le risque de cancer du col.
Cancer du col de l'utérus Infection HPV
#5

Quels facteurs de risque pour le cancer de l'ovaire ?

Antécédents familiaux, âge avancé et mutations génétiques comme BRCA augmentent le risque.
Cancer de l'ovaire Mutations BRCA
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diagnostiquer l'endométriose." } }, { "@type": "Question", "name": "Quels signes indiquent un cancer du col de l'utérus ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des saignements anormaux et des douleurs pelviennes peuvent signaler un cancer du col." } }, { "@type": "Question", "name": "Quel rôle joue le frottis cervical ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Le frottis cervical permet de détecter des cellules anormales et prévenir le cancer du col." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une vaginite ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent démangeaisons, écoulement vaginal anormal et odeur désagréable." } }, { "@type": "Question", "name": "Comment reconnaître une infection pelvienne ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Douleurs abdominales, fièvre et écoulement vaginal peuvent indiquer une infection pelvienne." } }, { "@type": "Question", "name": "Quels signes d'endométriose ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Les douleurs menstruelles intenses et les douleurs pendant les rapports sexuels sont fréquents." } }, { "@type": "Question", "name": "Quels symptômes d'un kyste ovarien ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Les kystes peuvent provoquer des douleurs pelviennes, des irrégularités menstruelles ou être asymptomatiques." } }, { "@type": "Question", "name": "Quels symptômes d'un cancer de l'ovaire ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Ballonnements, douleurs abdominales et changements d'appétit peuvent signaler un cancer de l'ovaire." } }, { "@type": "Question", "name": "Comment prévenir les infections vaginales ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Maintenir une bonne hygiène, éviter les douches vaginales et porter des sous-vêtements en coton." } }, { "@type": "Question", "name": "Quelles mesures pour prévenir le cancer du col ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Vaccination contre le HPV et dépistage régulier par frottis cervical sont essentiels." } }, { "@type": "Question", "name": "Comment réduire le risque d'endométriose ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Un diagnostic précoce et un traitement hormonal peuvent aider à gérer les symptômes." } }, { "@type": "Question", "name": "Quelles pratiques pour éviter les fibromes ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Maintenir un poids santé et une alimentation équilibrée peut réduire le risque de fibromes." } }, { "@type": "Question", "name": "Comment prévenir le cancer de l'ovaire ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Un suivi médical régulier et une connaissance des antécédents familiaux sont importants." } }, { "@type": "Question", "name": "Comment traiter une vaginite ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement dépend de la cause : antifongiques pour mycoses, antibiotiques pour infections." } }, { "@type": "Question", "name": "Quelles options pour les fibromes utérins ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Les options incluent médicaments, embolisation ou chirurgie selon la gravité des symptômes." } }, { "@type": "Question", "name": "Quel traitement pour l'endométriose ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Les traitements incluent médicaments anti-inflammatoires, hormonaux ou chirurgie pour enlever les lésions." } }, { "@type": "Question", "name": "Comment traiter le cancer du col de l'utérus ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Le traitement peut inclure chirurgie, radiothérapie et chimiothérapie selon le stade du cancer." } }, { "@type": "Question", "name": "Quelles thérapies pour le cancer de l'ovaire ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Chirurgie, chimiothérapie et thérapies ciblées sont les principales options de traitement." } }, { "@type": "Question", "name": "Quelles complications des infections pelviennes ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Les infections pelviennes non traitées peuvent entraîner des abcès, infertilité ou douleurs chroniques." } }, { "@type": "Question", "name": "Quels risques liés aux fibromes ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Les fibromes peuvent causer des saignements abondants, douleurs et complications pendant la grossesse." } }, { "@type": "Question", "name": "Quelles complications de l'endométriose ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "L'endométriose peut entraîner des adhérences, infertilité et douleurs chroniques." } }, { "@type": "Question", "name": "Quels risques du cancer du col ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Le cancer du col peut se propager à d'autres organes et nécessiter des traitements plus agressifs." } }, { "@type": "Question", "name": "Quelles complications du cancer de l'ovaire ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Le cancer de l'ovaire peut entraîner des métastases et des complications liées aux traitements." } }, { "@type": "Question", "name": "Quels facteurs de risque pour les infections vaginales ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antibiotiques, le diabète et une hygiène inadéquate augmentent le risque d'infections vaginales." } }, { "@type": "Question", "name": "Quels facteurs augmentent le risque de fibromes ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "L'obésité, les antécédents familiaux et les déséquilibres hormonaux sont des facteurs de risque." } }, { "@type": "Question", "name": "Quels facteurs de risque pour l'endométriose ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, menstruations précoces et cycles menstruels longs augmentent le risque." } }, { "@type": "Question", "name": "Quels facteurs de risque pour le cancer du col ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Infection par le HPV, tabagisme et antécédents familiaux augmentent le risque de cancer du col." } }, { "@type": "Question", "name": "Quels facteurs de risque pour le cancer de l'ovaire ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Antécédents familiaux, âge avancé et mutations génétiques comme BRCA augmentent le risque." } } ] } ] }
Dr Olivier Menir

Contenu validé par Dr Olivier Menir

Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale

Validation scientifique effectuée le 26/04/2025

Contenu vérifié selon les dernières recommandations médicales

En savoir plus sur Dr Menir

Sous-catégories

35 au total
└─

Maladies des annexes de l'utérus

Adnexal Diseases D000291 - C12.100.250.056
└─

Endométriose

Endometriosis D004715 - C12.100.250.163
└─

Gynatrésie

Gynatresia D006175 - C12.100.250.320
└─

Maladies de l'utérus

Uterine Diseases D014591 - C12.100.250.852
└─

Maladies du vagin

Vaginal Diseases D014623 - C12.100.250.894
└─

Maladies de la vulve

Vulvar Diseases D014845 - C12.100.250.944
└─└─

Maladies des trompes de Fallope

Fallopian Tube Diseases D005184 - C12.100.250.056.390
└─└─

Maladie inflammatoire pelvienne

Pelvic Inflammatory Disease D000292 - C12.100.250.056.750
└─└─

Endométriose intra-utérine

Adenomyosis D062788 - C12.100.250.852.113
└─└─

Hyperplasie endométriale

Endometrial Hyperplasia D004714 - C12.100.250.852.228
└─└─

Endométrite

Endometritis D004716 - C12.100.250.852.299
└─└─

Hématométrie

Hematometra D006409 - C12.100.250.852.495
└─└─

Pyométrie

Pyometra D055112 - C12.100.250.852.544
└─└─

Maladies du col utérin

Uterine Cervical Diseases D002577 - C12.100.250.852.593
└─└─

Inversion utérine

Uterine Inversion D019687 - C12.100.250.852.726
└─└─

Hématocolpos

Hematocolpos D006399 - C12.100.250.894.300
└─└─

Hydrocolpos

Hydrocolpos D052202 - C12.100.250.894.500
└─└─

Perte vaginale

Vaginal Discharge D019522 - C12.100.250.894.700
└─└─

Vaginite

Vaginitis D014627 - C12.100.250.894.906
└─└─

Kraurosis vulvaire

Vulvar Lichen Sclerosus D007724 - C12.100.250.944.815
└─└─

Vulvite

Vulvitis D014847 - C12.100.250.944.902
└─└─

Vulvodynie

Vulvodynia D056650 - C12.100.250.944.951
└─└─└─

Paramétrite

Parametritis D010249 - C12.100.250.056.750.750
└─└─└─

Salpingite

Salpingitis D012488 - C12.100.250.056.750.875
└─└─└─

Dysplasie du col utérin

Uterine Cervical Dysplasia D002578 - C12.100.250.852.593.074
└─└─└─

Érosion du col utérin

Uterine Cervical Erosion D002579 - C12.100.250.852.593.112
└─└─└─

Béance cervico-isthmique

Uterine Cervical Incompetence D002581 - C12.100.250.852.593.120
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Cervicite

Uterine Cervicitis D002575 - C12.100.250.852.593.150
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Leucorrhée

Leukorrhea D007973 - C12.100.250.894.700.500
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Vaginite atrophique

Atrophic Vaginitis D059268 - C12.100.250.894.906.316
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Vaginite à Trichomonas

Trichomonas Vaginitis D014247 - C12.100.250.894.906.633
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Vaginose bactérienne

Vaginosis, Bacterial D016585 - C12.100.250.894.906.800
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Vestibulite vulvaire

Vulvar Vestibulitis D054515 - C12.100.250.944.902.368
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Vulvovaginite

Vulvovaginitis D014848 - C12.100.250.944.902.737
└─└─└─└─

Candidose vulvovaginale

Candidiasis, Vulvovaginal D002181 - C12.100.250.944.902.737.500

Auteurs principaux

Sangeeta Sharma

2 publications dans cette catégorie

Affiliations :
  • Department of Paediatrics, National Institute of Tuberculosis and Respiratory Diseases, New Delhi, India.
Publications dans "Maladies de l'appareil génital féminin" :

Eshani Sharma

2 publications dans cette catégorie

Affiliations :
  • Department of Medicine, KU School of Medicine, Wichita, Kansas, USA.
Publications dans "Maladies de l'appareil génital féminin" :

Sona Dharmendra

2 publications dans cette catégorie

Affiliations :
  • Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, New Delhi, India.
Publications dans "Maladies de l'appareil génital féminin" :

Heather J Furnas

2 publications dans cette catégorie

Affiliations :
  • From the Division of Plastic Surgery, Department of Surgery, Stanford School of Medicine; the Department of Plastic Surgery, University of Texas Southwestern Medical Center; the Division of Plastic Surgery, Department of Surgery, University of Pennsylvania; and the Center for Total Joint Replacement, Department of Orthopedic Surgery, Palo Alto Medical Foundation.
Publications dans "Maladies de l'appareil génital féminin" :

Andréa Maria Novaes Machado

2 publications dans cette catégorie

Affiliations :
  • Hospital Israelita Albert Einstein, São Paulo, SP, Brazil. Electronic address: andrea.novaes@einstein.br.
Publications dans "Maladies de l'appareil génital féminin" :

Nelson Hamerschlak

2 publications dans cette catégorie

Affiliations :
  • Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Publications dans "Maladies de l'appareil génital féminin" :

Morgani Rodrigues

2 publications dans cette catégorie

Affiliations :
  • Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Publications dans "Maladies de l'appareil génital féminin" :

Carla de Azevedo Piccinato

2 publications dans cette catégorie

Affiliations :
  • Hospital Israelita Albert Einstein, São Paulo, SP, Brazil.
Publications dans "Maladies de l'appareil génital féminin" :

Olimpia Lamberti

2 publications dans cette catégorie

Affiliations :
  • Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Publications dans "Maladies de l'appareil génital féminin" :

Amaya L Bustinduy

2 publications dans cette catégorie

Affiliations :
  • Department of Clinical Research, London School of Hygiene and Tropical Medicine, London, UK.
Publications dans "Maladies de l'appareil génital féminin" :

Fiammetta Bozzani

2 publications dans cette catégorie

Affiliations :
  • Department of Global Health and Development, London School of Hygiene and Tropical Medicine, London, UK.
Publications dans "Maladies de l'appareil génital féminin" :

Samuel Kimani

2 publications dans cette catégorie

Affiliations :
  • African Coordinating Centre for Abandonment of FGM/C, University of Nairobi, Kenyatta National Hospital, Nairobi, Kenya.
Publications dans "Maladies de l'appareil génital féminin" :

Nina Van Eekert

2 publications dans cette catégorie

Affiliations :
  • Centre for Population, Family, and Health, Department of Sociology, University of Antwerp, Antwerp, Belgium.
  • FWO, Fonds Wetenschappelijk Onderzoek, Research Foundation Flanders, Brussels, Belgium.
Publications dans "Maladies de l'appareil génital féminin" :

Humphrey D Mazigo

1 publication dans cette catégorie

Affiliations :
  • Department of Parasitology and Entomology, Weill Bugando School of Medicine, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Publications dans "Maladies de l'appareil génital féminin" :

Anna Samson

1 publication dans cette catégorie

Affiliations :
  • Department of Behavioral Sciences, School of Public Health, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Publications dans "Maladies de l'appareil génital féminin" :

Valencia J Lambert

1 publication dans cette catégorie

Affiliations :
  • Center for Global Health, Weill Cornell Medicine, New York, NY, United States of America.
Publications dans "Maladies de l'appareil génital féminin" :

Agnes L Kosia

1 publication dans cette catégorie

Affiliations :
  • School of Nursing, Catholic University of Health and Allied Sciences, Mwanza, Tanzania.
Publications dans "Maladies de l'appareil génital féminin" :

Deogratias D Ngoma

1 publication dans cette catégorie

Affiliations :
  • Accelerating the Sustainable Control and Elimination of Neglected Tropical Diseases-Crown Agents, London, United Kingdom.
Publications dans "Maladies de l'appareil génital féminin" :

Rachel Murphy

1 publication dans cette catégorie

Affiliations :
  • Crown Agents, London, United Kingdom.
Publications dans "Maladies de l'appareil génital féminin" :

Dunstan J Matungwa

1 publication dans cette catégorie

Affiliations :
  • Department of Sexual and Reproductive Health, National Institute for Medical Research, Mwanza, Tanzania.
  • Department of Anthropology, School of Arts and Sciences, Rutgers University, New Brunswick, NJ, United States of America.
Publications dans "Maladies de l'appareil génital féminin" :

Sources (1439 au total)

Medication error with methotrexate.

14 May 2024
DOI: 10.4045/tidsskr.23.0657 PMID: 38747669

A woman in her seventies presented to the accident and emergency department (A&E) with shortness of breath that had increased over a period of three weeks. She had a history of COPD, hypertension and ... The patient arrived with stable vital signs, including 94 % oxygen saturation and a respiratory rate of 20 breaths/min. She had been taking 2.5 mg of methotrexate daily for the past three weeks instea... Considering her medical history and exclusion of other differential diagnoses, methotrexate toxicity was suspected. The patient was admitted to the hospital and intravenous folinic acid was initiated ...

Humans Medication Errors Female Methotrexate Aged +4 autres

Adherence to low-dose methotrexate in children with juvenile idiopathic arthritis using a sensitive methotrexate assay.

07 May 2024
DOI: 10.1186/s12969-024-00988-y PMID: 38715014

Low-dose weekly methotrexate (MTX) is the mainstay of treatment in juvenile idiopathic arthritis. Unfortunately, a substantial part of patients has insufficient efficacy of MTX. A potential cause of t... This was a retrospective, observational study using plasma samples from juvenile idiopathic arthritis patients. An ultrasensitive liquid chromatography-tandem mass spectrometry method was developed fo... Plasma samples of 43 patients with juvenile idiopathic arthritis were analysed. Adherence to MTX in this population was 88% shortly after initiation of MTX therapy and decreased to 77% after one year ... Quantification of MTX in plasma is a feasible and objective method to assess adherence in patients using low-dose weekly MTX. In clinical practice, the use of this method could be a helpful tool for p...

Humans Methotrexate Arthritis, Juvenile Retrospective Studies Child +8 autres

A meta-analysis of methotrexate polyglutamates in relation to efficacy and toxicity of methotrexate in inflammatory arthritis, colitis and dermatitis.

01 2023
DOI: 10.1111/bcp.15579 PMID: 36326810

In immune-mediated inflammatory diseases (IMIDs), early symptom control is a key therapeutic goal. Methotrexate (MTX) is the first-line treatment across IMIDs. However, MTX is underutilized and subopt... Studies analysing MTX-PG in relation to disease activity and/or toxicity were included for inflammatory arthritis (rheumatoid [RA] and juvenile idiopathic arthritis [JIA]), inflammatory bowel disease ... Twenty-five studies were included. In RA and JIA, higher MTX-PG was significantly associated with lower disease activity at 3 months (β: -0.002; 95% confidence interval [CI]: -0.004 to -0.001) and aft... We showed that higher concentrations of erythrocyte MTX-PG were associated with lower disease activity in RA, JIA and psoriasis. These findings are an important step towards implementation of TDM for ...

Humans Antirheumatic Agents Arthritis Colitis Dermatitis +4 autres

Genetic variations in methotrexate metabolic pathway genes influence methotrexate responses in rheumatoid arthritis patients in Malaysia.

13 07 2022
DOI: 10.1038/s41598-022-15991-0 PMID: 35831345

Methotrexate (MTX) is the most widely used disease-modifying anti-rheumatic drug (DMARD) for rheumatoid arthritis (RA). Many studies have attempted to understand the genetic risk factors that affect t...

Antirheumatic Agents Arthritis, Rheumatoid Humans Malaysia Metabolic Networks and Pathways +2 autres

Methotrexate Polyglutamate Concentrations as a Possible Predictive Marker for Effectiveness of Methotrexate Therapy in Patients with Sarcoidosis: A Pilot Study.

12 2023
DOI: 10.1007/s00408-023-00656-0 PMID: 37973683

Methotrexate (MTX), a folate antagonist, is often used as second-line treatment in patients with sarcoidosis. Effectiveness of MTX has large inter-patient variability and at present therapeutic drug m... We retrospectively included patients with sarcoidosis that had started on MTX therapy and from whom blood samples and FDG-PET/CT were available 3 and 6-12 months after MTX initiation, respectively. FD... We included 42 sarcoidosis patients treated with MTX (15 mg/week); 31 with cardiac sarcoidosis and 11 with pulmonary sarcoidosis. In MTXPG... These results suggest a relation between MTXPG...

Humans Methotrexate Pilot Projects Chromatography, Liquid Retrospective Studies +5 autres