Appareil de Golgi : Questions médicales fréquentes
Nom anglais: Golgi Apparatus
Descriptor UI:D006056
Tree Number:A11.284.430.214.190.875.336
Termes MeSH sélectionnés :
Predictive Value of Tests
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"description": "Quelles techniques sont utilisées pour étudier le Golgi ?\nQuels sont les modèles animaux pour étudier le Golgi ?\nComment les chercheurs étudient-ils les maladies du Golgi ?\nY a-t-il des traitements ciblant l'appareil de Golgi ?\nQuels sont les défis de la recherche sur le Golgi ?",
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"name": "Quelles techniques sont utilisées pour étudier le Golgi ?",
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"text": "Des techniques comme la microscopie électronique et la biologie moléculaire sont utilisées."
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{
"@type": "Question",
"name": "Quels sont les modèles animaux pour étudier le Golgi ?",
"position": 2,
"acceptedAnswer": {
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"text": "Les souris et les drosophiles sont souvent utilisés pour étudier les fonctions du Golgi."
}
},
{
"@type": "Question",
"name": "Comment les chercheurs étudient-ils les maladies du Golgi ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils utilisent des modèles cellulaires et des études génétiques pour comprendre les mécanismes."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements ciblant l'appareil de Golgi ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours pour développer des thérapies ciblant les dysfonctionnements du Golgi."
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{
"@type": "Question",
"name": "Quels sont les défis de la recherche sur le Golgi ?",
"position": 5,
"acceptedAnswer": {
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"text": "Les défis incluent la complexité de ses fonctions et la diversité des maladies associées."
}
},
{
"@type": "Question",
"name": "Comment enseigner le rôle du Golgi en biologie ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Utiliser des modèles 3D et des animations pour illustrer ses fonctions et interactions."
}
},
{
"@type": "Question",
"name": "Quels sont les concepts clés à enseigner sur le Golgi ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les concepts de modification des protéines, de transport et de pathologies associées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des ressources en ligne sur le Golgi ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des sites éducatifs et des vidéos explicatives sont disponibles en ligne."
}
},
{
"@type": "Question",
"name": "Comment les étudiants peuvent-ils visualiser le Golgi ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent utiliser des logiciels de modélisation et des images de microscopie."
}
},
{
"@type": "Question",
"name": "Quels sont les outils pédagogiques pour le Golgi ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des manuels, des vidéos et des simulations interactives sont des outils efficaces."
}
},
{
"@type": "Question",
"name": "Quelles maladies sont liées à des dysfonctionnements du Golgi ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des maladies comme le syndrome de Golgi et certaines maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "Comment les maladies du Golgi affectent-elles les cellules ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner des défauts de sécrétion et des accumulations de protéines."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques peuvent-elles affecter l'appareil de Golgi ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines mutations génétiques peuvent perturber sa fonction."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une dysfonction de l'appareil de Golgi ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent inclure des troubles métaboliques et des anomalies cellulaires."
}
},
{
"@type": "Question",
"name": "L'appareil de Golgi est-il impliqué dans le cancer ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des altérations de son fonctionnement peuvent contribuer à la progression tumorale."
}
},
{
"@type": "Question",
"name": "Quel est le rôle principal de l'appareil de Golgi ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il modifie, trie et emballe les protéines et lipides pour leur transport."
}
},
{
"@type": "Question",
"name": "Comment l'appareil de Golgi interagit-il avec le réticulum endoplasmique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il reçoit des protéines du réticulum endoplasmique pour les modifier et les expédier."
}
},
{
"@type": "Question",
"name": "Quels types de modifications subissent les protéines dans le Golgi ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les protéines peuvent subir des glycosylations, des phosphorylations et des sulfatations."
}
},
{
"@type": "Question",
"name": "L'appareil de Golgi est-il impliqué dans la sécrétion cellulaire ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il joue un rôle clé dans la sécrétion des protéines vers l'extérieur de la cellule."
}
},
{
"@type": "Question",
"name": "Quelles sont les structures associées à l'appareil de Golgi ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il est composé de citernes aplaties et de vésicules de transport."
}
}
]
}
]
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Thrombosis is a major clinical complication of COVID-19 infection. COVID-19 patients show changes in coagulation factors that indicate an important role for the coagulation system in the pathogenesis ...
Requisite to the application of clinical databases for observational research in hidradenitis suppurativa (HS) is the identification of an accurate case cohort. There is limited information on the val...
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In this retrospective study, we evaluated a case-finding algorithm for HS which included the presence of at least one diagnosis code for HS and no diagnosis codes for CA of the axilla, groin, perineum...
Among 100 HS patients, median age (interquartile range) in the HS cohort was 33 (24.75, 43.25) years. HS patients were predominantly female (82%) and white (70%). Median age among 100 CA patients was ...
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1,613 deaths attributed to pSAH were identified (mean 322/year). pSAH classification frequencies were as follows: very likely 528 (32.7%); very unlikely 433 (26.8%); and status unknown 652 (40.4%)....
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An ED in Melbourne, Australia, with 63 000 annual presentations in 2021....
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94 participants were enrolled (female: 46; male: 48), 34% of participants (tested positive for COVID-19 according to PCR results, with a background incidence among all adult ED attenders of 2.5%. The ...
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Laryngoscopy corresponding with laryngeal electromyography (LEMG) is essential in diagnosing vocal fold paresis. However, baseline asymmetry or other diseases oftentimes confound the exam, making diag...
We performed a retrospective review of patients with laryngeal asymmetry on laryngoscopy. Patients were divided into two groups: those with consistent paresis triad findings across all pitches and int...
Twelve patients met inclusion criteria (age 50 +/-15, 7F:5M). Nine had the paresis triad. Three had an inconsistent triad. All patients with the paresis triad had LEMG findings consistent with neurolo...
Our findings suggest the proposed laryngoscopic paresis triad may be useful objective criteria to diagnose paresis without the need for LEMG. Further prospective studies should examine a larger series...
4 Laryngoscope, 133:1712-1716, 2023....
The purpose of this study was to validate the humeral fracture diagnoses for adults in the Danish National Patient Registry (DNPR)....
This was a population-based validity study, including adult patients (≥ 18 years) with a humeral fracture referred to the emergency department of hospitals in three Danish regions from March 2017 to F...
In total, 661 patients were sampled between all available diagnosis codes. Overall, the PPV for humeral fracture was 89.3% (95% CI: 86.6-91.4%). PPVs for the subdivision codes were 91.0% (95% CI: 84.0...
The validity of the humeral fracture diagnosis and the classifications of proximal and diaphyseal fractures in the DNPR is high, and the DNPR may therefore be used in registry research. Diagnosis of d...
none....
not relevant....
To analyze the predictive value of hyperglycemia on the extrapancreatic infection (EPI) and infected pancreatic necrosis (IPN) of severe patients with acute pancreatitis (AP). We enrolled 234 patients...
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A combination of four z-scores based on the following three tests provided good discrimination of patients with RHD from matched healthy controls: the starting point and the difference between the num...
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Stone size and location are key factors in predicting spontaneous stone passage (SSP), but little attention has been paid to the influence of radiological signs of stone impaction (RSSI). This researc...
To calculate the predictive value and thus the clinical usefulness of transvaginal ultrasound (US) imaging for the management of deep endometriosis, knowing that the positive predictive value (PPV) va...
After registration on PROSPERO (CRD42022366323), PubMed was searched for all reports describing the diagnostic accuracy of US imaging for deep endometriosis published between January 1, 2000, and Octo...
The 536 articles on "endometriosis AND US And diagnosis" were hand searched, and 30 reports describing sensitivity and specificity of deep endometriosis were found. Besides sensitivity and specificity...
Prevalences of deep endometriosis were reported only twice as 12% and 32% by ultrasonographers. In women undergoing surgery, prevalences vary between 40% and 100% because of the variable inclusion cri...
The reported sensitivities and specificities of transvaginal US are not only those of imaging but include symptoms and clinical examinations. In referral centers, the reported PPVs are high (94%-100%)...