questionsmedicales.fr
Systèmes sanguin et immunitaire
Système immunitaire
Leucocytes
Granulocytes
Granulocytes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Granulocytes
Granulocytopénie
Numération formule sanguine
Granulocytes
Symptômes
5
Granulocytopénie
Infection
Réaction allergique
Granulocytes
Inflammation
Granulocytes
Infection bactérienne
Granulocytes
Prévention
5
Prévention des infections
Granulocytes
Complications
Granulocytes
Traitements
5
Granulocytopénie
Transfusion
Corticostéroïdes
Inflammation
Greffe de moelle osseuse
Granulocytes
Complications
5
Granulocytopénie
Infection
Leucémie myéloïde
Granulocytes
Cicatrisation
Granulocytes
Immunosuppresseurs
Granulocytes
Effets secondaires
Granulocytes
Facteurs de risque
5
Immunodépression
Infection
Maladies auto-immunes
Granulocytes
Produits chimiques
Granulocytes
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Granulocytes : Questions médicales les plus fréquentes",
"headline": "Granulocytes : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Granulocytes : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-04-22",
"dateModified": "2025-04-17",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Granulocytes"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Leucocytes",
"url": "https://questionsmedicales.fr/mesh/D007962",
"about": {
"@type": "MedicalCondition",
"name": "Leucocytes",
"code": {
"@type": "MedicalCode",
"code": "D007962",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A15.382.490"
}
}
},
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Granulocytes basophiles",
"alternateName": "Basophils",
"url": "https://questionsmedicales.fr/mesh/D001491",
"about": {
"@type": "MedicalCondition",
"name": "Granulocytes basophiles",
"code": {
"@type": "MedicalCode",
"code": "D001491",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A15.382.490.315.120"
}
}
},
{
"@type": "MedicalWebPage",
"name": "Granulocytes éosinophiles",
"alternateName": "Eosinophils",
"url": "https://questionsmedicales.fr/mesh/D004804",
"about": {
"@type": "MedicalCondition",
"name": "Granulocytes éosinophiles",
"code": {
"@type": "MedicalCode",
"code": "D004804",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "A15.382.490.315.251"
}
}
}
],
"about": {
"@type": "MedicalCondition",
"name": "Granulocytes",
"alternateName": "Granulocytes",
"code": {
"@type": "MedicalCode",
"code": "D006098",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Cathy Conry-Cantilena",
"url": "https://questionsmedicales.fr/author/Cathy%20Conry-Cantilena",
"affiliation": {
"@type": "Organization",
"name": "Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD."
}
},
{
"@type": "Person",
"name": "Michael Gruber",
"url": "https://questionsmedicales.fr/author/Michael%20Gruber",
"affiliation": {
"@type": "Organization",
"name": "Department of Anesthesiology, University Hospital Regensburg, Raubling, Germany."
}
},
{
"@type": "Person",
"name": "Hans-Uwe Simon",
"url": "https://questionsmedicales.fr/author/Hans-Uwe%20Simon",
"affiliation": {
"@type": "Organization",
"name": "Institute of Pharmacology, University of Bern, Bern, Switzerland; email: thomas.kaufmann@pki.unibe.ch, hans-uwe.simon@pki.unibe.ch."
}
},
{
"@type": "Person",
"name": "Yu Hao",
"url": "https://questionsmedicales.fr/author/Yu%20Hao",
"affiliation": {
"@type": "Organization",
"name": "Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China."
}
},
{
"@type": "Person",
"name": "Can Zhang",
"url": "https://questionsmedicales.fr/author/Can%20Zhang",
"affiliation": {
"@type": "Organization",
"name": "Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "RNA editing: Expanding the potential of RNA therapeutics.",
"datePublished": "2023-01-07",
"url": "https://questionsmedicales.fr/article/36620962",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.ymthe.2023.01.005"
}
},
{
"@type": "ScholarlyArticle",
"name": "RNA editing in Mycobacterium tuberculosis.",
"datePublished": "2022-08-23",
"url": "https://questionsmedicales.fr/article/36067705",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.micres.2022.127174"
}
},
{
"@type": "ScholarlyArticle",
"name": "KRGG1 function in RNA editing in",
"datePublished": "2022-11-18",
"url": "https://questionsmedicales.fr/article/36400448",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1261/rna.079418.122"
}
},
{
"@type": "ScholarlyArticle",
"name": "C-to-U RNA Editing: A Site Directed RNA Editing Tool for Restoration of Genetic Code.",
"datePublished": "2022-09-12",
"url": "https://questionsmedicales.fr/article/36140804",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/genes13091636"
}
},
{
"@type": "ScholarlyArticle",
"name": "Effect of salinity on ccmfn gene RNA editing of mitochondria in wild barley and uncommon types of RNA editing.",
"datePublished": "2023-01-27",
"url": "https://questionsmedicales.fr/article/36707470",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s10142-023-00978-5"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Systèmes sanguin et immunitaire",
"item": "https://questionsmedicales.fr/mesh/D006424"
},
{
"@type": "ListItem",
"position": 3,
"name": "Système immunitaire",
"item": "https://questionsmedicales.fr/mesh/D007107"
},
{
"@type": "ListItem",
"position": 4,
"name": "Leucocytes",
"item": "https://questionsmedicales.fr/mesh/D007962"
},
{
"@type": "ListItem",
"position": 5,
"name": "Granulocytes",
"item": "https://questionsmedicales.fr/mesh/D006098"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Granulocytes - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Granulocytes",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-17",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Granulocytes",
"description": "Comment diagnostiquer une granulocytopénie ?\nQuels tests pour évaluer les granulocytes ?\nQuels signes indiquent une infection liée aux granulocytes ?\nComment évaluer la fonction des granulocytes ?\nQuel rôle joue la biopsie dans le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Granulocytes",
"description": "Quels symptômes d'une carence en granulocytes ?\nComment se manifeste une réaction allergique ?\nQuels symptômes d'une inflammation ?\nQuels signes d'une infection bactérienne ?\nQuels symptômes d'une leucémie ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Granulocytes",
"description": "Comment prévenir les infections chez les patients à faible granulocytes ?\nQuels vaccins sont recommandés ?\nComment éviter les complications liées aux granulocytes ?\nQuel rôle de l'alimentation dans la prévention ?\nComment gérer le stress pour la santé des granulocytes ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Granulocytes",
"description": "Comment traiter une granulocytopénie ?\nQuels médicaments stimulent les granulocytes ?\nComment traiter une infection liée aux granulocytes ?\nQuel rôle des corticostéroïdes dans le traitement ?\nQuand envisager une greffe de moelle osseuse ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Granulocytes",
"description": "Quelles complications d'une granulocytopénie sévère ?\nQuels risques d'une leucémie myéloïde ?\nComment les granulocytes affectent-ils la cicatrisation ?\nQuelles sont les complications des traitements immunosuppresseurs ?\nQuels effets secondaires des médicaments sur les granulocytes ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Granulocytes",
"description": "Quels facteurs augmentent le risque d'infections ?\nQuel rôle des maladies auto-immunes ?\nComment le tabagisme affecte-t-il les granulocytes ?\nQuels risques liés à l'exposition aux produits chimiques ?\nQuel impact de la génétique sur les granulocytes ?",
"url": "https://questionsmedicales.fr/mesh/D006098?mesh_terms=RNA+Editing#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une granulocytopénie ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un hémogramme révèle une diminution des granulocytes dans le sang."
}
},
{
"@type": "Question",
"name": "Quels tests pour évaluer les granulocytes ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins comme la numération formule sanguine sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une infection liée aux granulocytes ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, fatigue et inflammation peuvent signaler une infection."
}
},
{
"@type": "Question",
"name": "Comment évaluer la fonction des granulocytes ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests de phagocytose et de dégranulation peuvent être réalisés."
}
},
{
"@type": "Question",
"name": "Quel rôle joue la biopsie dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une biopsie médullaire peut aider à évaluer la production de granulocytes."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une carence en granulocytes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections fréquentes, fièvre et fatigue sont des symptômes courants."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une réaction allergique ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éruptions cutanées, démangeaisons et œdème peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une inflammation ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Rougeur, chaleur, gonflement et douleur sont des signes d'inflammation."
}
},
{
"@type": "Question",
"name": "Quels signes d'une infection bactérienne ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fièvre, frissons et douleur localisée peuvent indiquer une infection."
}
},
{
"@type": "Question",
"name": "Quels symptômes d'une leucémie ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, ecchymoses et infections fréquentes peuvent être présents."
}
},
{
"@type": "Question",
"name": "Comment prévenir les infections chez les patients à faible granulocytes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir une bonne hygiène et éviter les foules sont essentiels."
}
},
{
"@type": "Question",
"name": "Quels vaccins sont recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccins contre la grippe et le pneumocoque sont souvent conseillés."
}
},
{
"@type": "Question",
"name": "Comment éviter les complications liées aux granulocytes ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveiller les signes d'infection et consulter rapidement un médecin."
}
},
{
"@type": "Question",
"name": "Quel rôle de l'alimentation dans la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée renforce le système immunitaire."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress pour la santé des granulocytes ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques de relaxation peuvent aider à réduire le stress."
}
},
{
"@type": "Question",
"name": "Comment traiter une granulocytopénie ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des transfusions de granulocytes ou des médicaments stimulants peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels médicaments stimulent les granulocytes ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le filgrastim et le pegfilgrastim sont des agents couramment utilisés."
}
},
{
"@type": "Question",
"name": "Comment traiter une infection liée aux granulocytes ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antibiotiques sont prescrits pour traiter les infections bactériennes."
}
},
{
"@type": "Question",
"name": "Quel rôle des corticostéroïdes dans le traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent réduire l'inflammation et moduler la réponse immunitaire."
}
},
{
"@type": "Question",
"name": "Quand envisager une greffe de moelle osseuse ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "En cas de maladies graves affectant la production de granulocytes."
}
},
{
"@type": "Question",
"name": "Quelles complications d'une granulocytopénie sévère ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections graves, septicémie et complications hémorragiques peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quels risques d'une leucémie myéloïde ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Risque accru d'infections et de saignements en raison de la production anormale."
}
},
{
"@type": "Question",
"name": "Comment les granulocytes affectent-ils la cicatrisation ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une diminution des granulocytes peut retarder la cicatrisation des plaies."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications des traitements immunosuppresseurs ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Infections opportunistes et cancers peuvent survenir avec ces traitements."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires des médicaments sur les granulocytes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains médicaments peuvent entraîner une diminution des granulocytes."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'infections ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une immunodépression, le diabète et l'âge avancé augmentent le risque."
}
},
{
"@type": "Question",
"name": "Quel rôle des maladies auto-immunes ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elles peuvent entraîner une destruction accrue des granulocytes."
}
},
{
"@type": "Question",
"name": "Comment le tabagisme affecte-t-il les granulocytes ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme peut altérer la fonction des granulocytes et augmenter l'inflammation."
}
},
{
"@type": "Question",
"name": "Quels risques liés à l'exposition aux produits chimiques ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains produits chimiques peuvent endommager la moelle osseuse et réduire les granulocytes."
}
},
{
"@type": "Question",
"name": "Quel impact de la génétique sur les granulocytes ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des prédispositions génétiques peuvent influencer la production et la fonction des granulocytes."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 17/04/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Department of Transfusion Medicine, Clinical Center, National Institutes of Health, Bethesda, MD.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Department of Anesthesiology, University Hospital Regensburg, Raubling, Germany.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Institute of Pharmacology, University of Bern, Bern, Switzerland; email: thomas.kaufmann@pki.unibe.ch, hans-uwe.simon@pki.unibe.ch.
Department of Clinical Immunology and Allergology, Sechenov University, Moscow, Russia.
Laboratory of Molecular Immunology, Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia.
Brandenburg Medical School, Neuruppin, Germany.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China.
Publications dans "Granulocytes" :
2 publications dans cette catégorie
Affiliations :
Biomedical Innovation Center, Beijing Shijitan Hospital, Capital Medical University, Beijing 100038, China; Beijing Key Laboratory for Therapeutic Cancer Vaccines, Beijing 100038, China. Electronic address: zhangju@mail.ccmu.edu.cn.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Clinical Immunology, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Laboratory Medicine, Faculty of Pharmacy, Jagiellonian University Medical College, 30-688 Krakow, Poland.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Clinical Immunology, Jagiellonian University Medical College, 30-663 Krakow, Poland.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Cayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA; Weill Cornell Medicine. Electronic address: dmac92077@gmail.com.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Cayuga Medical Center, 101 Dates Drive, Ithaca, NY 14850, USA.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Animal Morphology, Physiology and Genetics, Faculty of AgriSciences, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Clinical Studies, University of Pennsylvania, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Comparative Pathobiology, Tufts University, Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA.
Publications dans "Granulocytes" :
1 publication dans cette catégorie
Affiliations :
Department of Clinical Studies, University of Pennsylvania, New Bolton Center, 382 West Street Road, Kennett Square, PA 19348, USA. Electronic address: rnolenw@upenn.edu.
Publications dans "Granulocytes" :
RNA therapeutics have had a tremendous impact on medicine, recently exemplified by the rapid development and deployment of mRNA vaccines to combat the COVID-19 pandemic. In addition, RNA-targeting dru...
RNA editing, while studied thoroughly in humans, has been sporadically described in bacteria, and to our knowledge, has not been reported in Mycobacterium tuberculosis (Mtb). After thorough quality co...
Mitochondrial gene expression in trypanosomes requires numerous multiprotein complexes that are unique to kinetoplastids. Among these, the most well characterized are RNA editing catalytic complexes (...
The restoration of genetic code by editing mutated genes is a potential method for the treatment of genetic diseases/disorders. Genetic disorders are caused by the point mutations of thymine (T) to cy...
The primary function of mitochondria is cellular respiration and energy production. Cytochrome C complex is an essential complex that transports electrons in the respiratory chain between complex III ...
Viruses rely on hosts for life and reproduction, cause a variety of symptoms from common cold to AIDS to COVID-19 and provoke public health threats claiming millions of lives around the globe. RNA edi...
Although more than 9100 plant plastomes have been sequenced, RNA editing sites of the whole plastome have been experimentally verified in only approximately 21 species, which seriously hampers the com...
Therapeutic human gene editing technologies continue to advance, with the endonuclease, clustered regularly interspaced short palindromic repeats (CRISPR) being one of the most rapidly developing tech...
RNA editing allows correction of pathological point mutations without permanently altering genomic DNA. Theoretically targetable to any RNA type and site, its flexibility and reversibility makes it a ...
Adenosine-to-inosine (A-to-I) editing is an important RNA posttranscriptional process related to a multitude of cellular and molecular activities. However, systematic characterizations of whether and ...
With the RNA-seq and RBP eCLIP-seq datasets from the ENCODE project, we quantitatively survey the binding preferences of 150 RBPs to RNA editing events, followed by experimental validations. Such anal...
These results highlight the relevance of RNA editing in the functions of many RBPs and therefore serve as a resource for further characterization of the functional associations between various RNA edi...