Comment diagnostiquer le syndrome de Budd-Chiari ?

Le diagnostic repose sur l'échographie, l'IRM et des tests sanguins pour évaluer la fonction hépatique.

Quels tests sanguins sont utiles ?

Les tests incluent les marqueurs de la fonction hépatique et les tests de coagulation.

Quels signes cliniques indiquent ce syndrome ?

Les signes incluent l'ascite, la douleur abdominale et l'hypertrophie du foie.

L'échographie Doppler est-elle utile ?

Oui, elle permet d'évaluer le flux sanguin dans les veines hépatiques et de détecter des obstructions.

Quand envisager une biopsie hépatique ?

Une biopsie peut être envisagée si le diagnostic est incertain ou pour évaluer des lésions hépatiques.

Quels sont les symptômes courants ?

Les symptômes incluent fatigue, douleur abdominale, jaunisse et ascite.

La douleur abdominale est-elle fréquente ?

Oui, la douleur abdominale est un symptôme fréquent, souvent localisée dans la partie supérieure droite.

Qu'est-ce que l'ascite ?

L'ascite est l'accumulation de liquide dans la cavité abdominale, souvent causée par une hypertension portale.

La jaunisse est-elle un symptôme ?

Oui, la jaunisse, due à une accumulation de bilirubine, est un symptôme courant du syndrome.

Peut-on avoir des symptômes asymptomatiques ?

Oui, certains patients peuvent être asymptomatiques, surtout dans les formes chroniques.

Comment prévenir le syndrome de Budd-Chiari ?

La prévention inclut la gestion des facteurs de risque comme les troubles de la coagulation et l'obésité.

Les anticoagulants peuvent-ils prévenir ce syndrome ?

Oui, les anticoagulants peuvent prévenir les thromboses chez les patients à risque.

Quelles habitudes de vie adopter ?

Adopter une alimentation équilibrée, faire de l'exercice et éviter le tabac sont bénéfiques.

Les vaccinations sont-elles importantes ?

Oui, se faire vacciner contre l'hépatite peut réduire le risque de complications hépatiques.

Faut-il surveiller les maladies hépatiques ?

Oui, surveiller les maladies hépatiques et les troubles de la coagulation est crucial pour la prévention.

Quels traitements sont disponibles ?

Les traitements incluent des anticoagulants, des procédures endovasculaires et, dans certains cas, une transplantation hépatique.

Quand utiliser des anticoagulants ?

Les anticoagulants sont utilisés pour traiter les thromboses veineuses hépatiques et prévenir les complications.

Qu'est-ce qu'une procédure endovasculaire ?

C'est une intervention pour débloquer les veines hépatiques, souvent par angioplastie ou stenting.

Quand envisager une transplantation hépatique ?

La transplantation est envisagée en cas d'insuffisance hépatique sévère ou de complications irréversibles.

Y a-t-il des traitements symptomatiques ?

Oui, des traitements symptomatiques comme les diurétiques peuvent aider à gérer l'ascite.

Quelles sont les complications possibles ?

Les complications incluent l'insuffisance hépatique, la thrombose et l'hypertension portale.

L'insuffisance hépatique est-elle fréquente ?

Oui, l'insuffisance hépatique est une complication grave pouvant survenir dans ce syndrome.

Qu'est-ce que l'hypertension portale ?

L'hypertension portale est une augmentation de la pression dans la veine porte, causée par l'obstruction.

Peut-on avoir des complications à long terme ?

Oui, des complications à long terme comme la cirrhose peuvent se développer si non traitées.

Les complications peuvent-elles être évitées ?

Certaines complications peuvent être évitées par un traitement précoce et une surveillance régulière.

Quels sont les principaux facteurs de risque ?

Les facteurs incluent les troubles de la coagulation, l'obésité, et certaines maladies hépatiques.

L'obésité augmente-t-elle le risque ?

Oui, l'obésité est un facteur de risque connu pour le syndrome de Budd-Chiari.

Les maladies hépatiques sont-elles un risque ?

Oui, certaines maladies hépatiques, comme la cirrhose, augmentent le risque de ce syndrome.

Les contraceptifs oraux sont-ils un facteur ?

Oui, l'utilisation prolongée de contraceptifs oraux peut augmenter le risque de thrombose.

Le tabagisme influence-t-il le risque ?

Oui, le tabagisme peut contribuer à des problèmes vasculaires, augmentant le risque de thrombose.

Syndrome de Budd-Chiari - Informations médicales vérifiées

Pharmacokinetic boosting of olaparib: A randomised, cross-over study (PROACTIVE-study).

11 2023

DOI: 10.1016/j.ejca.2023.113346 PMID: 37806255

Pharmacokinetic (PK) boosting is the intentional use of a drug-drug interaction to enhance systemic drug exposure. PK boosting of olaparib, a CYP3A-substrate, has the potential to reduce PK variabilit... This cross-over, multicentre trial compared olaparib 300 mg twice daily (BID) with olaparib 100 mg BID boosted with the strong CYP3A-inhibitor cobicistat 150 mg BID. Patients were randomised to the st... Of 15 included patients, 12 were eligible for PK analysis. The GMR of the AUC... Boosting a 100 mg BID olaparib dose with cobicistat increases olaparib exposure 1.45-fold, compared to the standard dose of 300 mg BID. Equivalence of the boosted olaparib was thus not established. Bo...

Humans Cross-Over Studies Cytochrome P-450 CYP3A Piperazines Cobicistat

A randomized cross-over study of cryopreserved platelets in prophylactic transfusions of thrombocytopenic patients.

09 2023

DOI: 10.1111/trf.17503 PMID: 37596937

The short shelf-life of liquid-stored platelets (LP) at 20-24°C poses shortage and wastage challenges. Cryopreserved platelets have significantly extended shelf-life, and were safe and efficacious for... We performed a phase 1b/2a randomized cross-over study comparing the safety and efficacy of cryopreserved buffy coat-derived pooled platelets (CP) to LP in the prophylactic transfusions of thrombocyto... A total of 18 adults were randomly assigned 1:1 to CP and LP for their first thrombocytopenic period (TP) of up to 28-days. A total of 14 crossed over to the other platelet-arm for the second TP. Over... During shortages, CP may supplement LP in prophylactic transfusions of thrombocytopenic patients....

Adult Humans Blood Platelets Cross-Over Studies Blood Transfusion +2 autres

Webtool to enhance the accuracy of diagnostic algorithms for HFpEF: a prospective cross-over study.

Dec 2023

DOI: 10.1002/ehf2.14525 PMID: 37724334

Diagnosis of heart failure with preserved ejection fraction (HFpEF) can be challenging. This study aimed to evaluate the potential of a webtool to enhance the scoring accuracy when applying the comple... We developed an online tool, the HFpEF calculator, that enables the automatic calculation of current HFpEF algorithms. We assessed the accuracy of manual vs. automatic scoring, defined as the percenta... Manual calculation of HFpEF diagnostic algorithms is often inaccurate. Using an automated webtool to calculate HFpEF algorithms significantly improved correct scoring. This new approach may impact the...

Humans Heart Failure Cross-Over Studies Stroke Volume Prospective Studies +1 autres

Physical intradialytic patient-reported outcome measures in haemodialysis and haemodiafiltration: A cross-over study.

May 2023

DOI: 10.1111/nep.14154 PMID: 36861385

Standard haemodialysis (sHD) is associated with a poor survival and marked adverse intradialytic patient-reported outcome measures (ID-PROMs). Whereas physical ID-PROMs (PID-PROMs) are alleviated by c... To assess whether PID-PROMs and thermal perception differ between sHD, cHD, low volume HDF (lvHDF) and high volume HDF (hvHDF), 40 patients were cross-over randomized to each modality for 2 weeks. Dia... Except for the item 'feeling cold' during cHD (p = .01), PID-PROMs did not differ between modalities, but varied markedly between patients (11/13 items, p < .05). T... (1) PID-PROMs did not differ between modalities, but varied markedly between patients. Hence, PID-PROMs are largely patient-dependent. (2) While T...

Humans Renal Dialysis Hemodiafiltration Cross-Over Studies Temperature +2 autres

Caution with competitive gamification in medical education: unexpected results of a randomised cross-over study.

19 Apr 2023

DOI: 10.1186/s12909-023-04258-5 PMID: 37072842

To intrinsically motivate students in the long term, longitudinal e-learning systems combined with repeated testing and competitive gamification seem promising. The effects of this approach have never... Participants were 5.-9. semester medical students (n = 48), recruited in an elective evidence-based medicine subject and randomly distributed to two groups (group 1: n = 23; group 2: n = 25). Both acc... Students' improvements in e-test scores after training with the corresponding topics in the learning application can be attributed to chance. Even though the majority enjoyed playing and felt motivate... The authors found no evidence for benefits of the investigated learning programme on students' risk competence or on their internal motivation. The majority disapproved the competitive concept, indica...

Humans Cross-Over Studies Gamification Prospective Studies Education, Medical +1 autres

Face masks while exercising trial (MERIT): a cross-over randomised controlled study.

05 01 2023

DOI: 10.1136/bmjopen-2022-063014 PMID: 36604128

Physical exertion is a high-risk activity for aerosol emission of respiratory pathogens. We aimed to determine the safety and tolerability of healthy young adults wearing different types of face mask ... Cross-over randomised controlled study, completed between June 2021 and January 2022.... Volunteers aged 18-35 years, who exercised regularly and had no significant pre-existing health conditions.... Comparison of wearing a surgical, cloth and filtering face piece (FFP3) mask to no mask during 4×15 min bouts of exercise. Exercise was running outdoors or indoor rowing at moderate-to-high intensity,... The primary outcome was change in oxygen saturations. Secondary outcomes were change in heart rate, perceived impact of face mask wearing during exercise and willingness to wear a face mask for future... All 72 volunteers (mean age 23.9) completed the study. Changes in oxygen saturations did not exceed the prespecified non-inferiority margin (2% difference) with any mask type compared with no mask. At... This study adds to previous findings (mostly from non-randomised studies) that exercising at moderate-to-high intensity wearing a face mask appears to be safe in healthy, young adults.... NCT04932226....

Young Adult Humans Adult COVID-19 Masks +3 autres

The Effects of Potato Presentation on Vegetable Intake in School-Aged Children: A Cross-Over Study.

24 Oct 2023

DOI: 10.3390/nu15214496 PMID: 37960149

Vegetables are an essential component of a healthy dietary pattern in children; however, their consumption is often insufficient due to lack of preference. To address this, the influence of combining ...

Child Humans Male Cross-Over Studies Diet +6 autres

The effect of pre-match sexual intercourse on football players' performance: a prospective cross over study.

Feb 2023

DOI: 10.23736/S0022-4707.22.14022-3 PMID: 35816144

Current research suggests that pre-competition sexual intercourse does not influence athletes' performance. Yet, high quality studies in this field are scarce.... We aimed to investigate whether sexual activity negatively influences physiological performance. We conducted a prospective cross over study, which enrolled active players from the first team of a foo... We enrolled 14 participants who participated in 88 football matches. The mean age was 29.7 (±3.8) years and the majority were in permanent relationships for longer than 6 months (78.6%). We identified... To the best of our knowledge, this study is the first to show that sexual intercourse the night before a football match may have a negative influence on players' performance....

Humans Adult Football Cross-Over Studies Prospective Studies +3 autres

Characterising applied forces during positive pressure ventilation: a randomised cross-over simulation study.

24 Jul 2024

DOI: 10.1136/bmjpo-2024-002828 PMID: 39053968

To characterise applied force on the face and head during simulated mask ventilation with varying mask, device and expertise level.... Randomised cross-over simulation study.... A quiet, empty room in the children's hospital.... Neonatal healthcare providers, categorised as novices and experts in positive pressure ventilation (PPV).... PPV for 2 min each in a 2×2 within-subjects design with two masks (round and anatomic) and two ventilation devices (T-piece and self-inflating bag (SIB)).... Applied force (Newton (N)) measured under the head and at four locations on the manikin's face (nasal bridge, mentum, left and right zygomatic arches) and symmetry of force applied around the mask rim... For the 51 participants, force applied to the head was greater with the SIB than the T-piece (mean (SD): 16.03 (6.96) N vs 14.31 (5.16) N) and greater with the anatomic mask than the round mask (mean ... We characterised an initial dataset of applied forces on the face and head during simulated PPV and described differences in force when considering mask type, device type and expertise....

Humans Cross-Over Studies Manikins Masks Positive-Pressure Respiration +9 autres

It is the habit not the handle that affects tooth brushing - a randomised counterbalanced cross over study with young and healthy adults.

02 Jul 2024

DOI: 10.1186/s12903-024-04538-6 PMID: 38956565

To assess the effect of the toothbrush handle on video-observed toothbrushing behaviour and toothbrushing effectiveness.... This is a randomized counterbalanced cross-over study. N = 50 university students and employees brushed their teeth at two occasions, one week apart, using either a commercial ergonomically designed m... The study participants found the BV1 significantly more cumbersome than the M1 or their brush at home. (p < 0.05). However, correlation analyses revealed a strong consistency of brushing behavior with... The results of the study indicate that the brushing handle does not play a major role in brushing behavior or brushing effectiveness....

Humans Toothbrushing Cross-Over Studies Male Female +12 autres

Syndrome de Budd-Chiari : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Auteurs principaux

Sources (10000 au total)