questionsmedicales.fr
Comportement et mécanismes comportementaux
Émotions
Affect
Humeur irritable
Humeur irritable : Questions médicales fréquentes
Termes MeSH sélectionnés :
Comparative Genomic Hybridization
Diagnostic
5
Humeur
Évaluation psychologique
Tests psychologiques
Humeur
Troubles de l'humeur
Anxiété
Psychiatrie
Professionnels de la santé
Critères diagnostiques
Humeur
Symptômes
5
Symptômes psychologiques
Humeur
Troubles du sommeil
Humeur
Symptômes physiques
Humeur
Comportement enfantin
Humeur
Fluctuation de l'humeur
Humeur
Prévention
5
Prévention
Gestion du stress
Traitements
5
Thérapie
Médicaments psychotropes
Thérapie comportementale
Humeur
Médecine alternative
Humeur
Durée du traitement
Humeur
Complications
5
Complications psychologiques
Humeur
Impact professionnel
Humeur
Troubles comorbides
Humeur
Comportements à risque
Humeur
Facteurs de risque
5
Facteurs de risque
Humeur
Changements hormonaux
Humeur
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Humeur irritable : Questions médicales les plus fréquentes",
"headline": "Humeur irritable : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Humeur irritable : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-18",
"dateModified": "2025-04-12",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Humeur irritable"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Affect",
"url": "https://questionsmedicales.fr/mesh/D000339",
"about": {
"@type": "MedicalCondition",
"name": "Affect",
"code": {
"@type": "MedicalCode",
"code": "D000339",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "F01.470.047"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Humeur irritable",
"alternateName": "Irritable Mood",
"code": {
"@type": "MedicalCode",
"code": "D007508",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Ellen Leibenluft",
"url": "https://questionsmedicales.fr/author/Ellen%20Leibenluft",
"affiliation": {
"@type": "Organization",
"name": "Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA."
}
},
{
"@type": "Person",
"name": "Erica Bell",
"url": "https://questionsmedicales.fr/author/Erica%20Bell",
"affiliation": {
"@type": "Organization",
"name": "Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia."
}
},
{
"@type": "Person",
"name": "Melissa A Brotman",
"url": "https://questionsmedicales.fr/author/Melissa%20A%20Brotman",
"affiliation": {
"@type": "Organization",
"name": "Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA."
}
},
{
"@type": "Person",
"name": "Gabrielle A Carlson",
"url": "https://questionsmedicales.fr/author/Gabrielle%20A%20Carlson",
"affiliation": {
"@type": "Organization",
"name": "Psychiatry and Pediatrics, Renaissance School of Medicine at Stony Brook University."
}
},
{
"@type": "Person",
"name": "Tim Outhred",
"url": "https://questionsmedicales.fr/author/Tim%20Outhred",
"affiliation": {
"@type": "Organization",
"name": "Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Prenatal diagnosis study using array comparative genomic hybridization for genotype-phenotype correlation in 772 fetuses.",
"datePublished": "2022-10-28",
"url": "https://questionsmedicales.fr/article/36343605",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.anndiagpath.2022.152059"
}
},
{
"@type": "ScholarlyArticle",
"name": "The NIH Comparative Genomics Resource: addressing the promises and challenges of comparative genomics on human health.",
"datePublished": "2023-09-27",
"url": "https://questionsmedicales.fr/article/37759191",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s12864-023-09643-4"
}
},
{
"@type": "ScholarlyArticle",
"name": "Identification of copy number alternation profiles in metastatic oral squamous carcinoma patients by using microarray-based comparative genomic hybridization: A study on Turkish patients.",
"datePublished": "2023-07-31",
"url": "https://questionsmedicales.fr/article/37532081",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.jormas.2023.101583"
}
},
{
"@type": "ScholarlyArticle",
"name": "Amplifications of EVX2 and HOXD9-HOXD13 on 2q31 in mature cystic teratomas of the ovary identified by array comparative genomic hybridization may explain teratoma characteristics in chondrogenesis and osteogenesis.",
"datePublished": "2024-06-21",
"url": "https://questionsmedicales.fr/article/38907278",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1186/s13048-024-01458-5"
}
},
{
"@type": "ScholarlyArticle",
"name": "Functional annotation and comparative genomics analysis of Balamuthia mandrillaris reveals potential virulence-related genes.",
"datePublished": "2023-08-31",
"url": "https://questionsmedicales.fr/article/37653073",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1038/s41598-023-41657-6"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Comportement et mécanismes comportementaux",
"item": "https://questionsmedicales.fr/mesh/D001520"
},
{
"@type": "ListItem",
"position": 3,
"name": "Émotions",
"item": "https://questionsmedicales.fr/mesh/D004644"
},
{
"@type": "ListItem",
"position": 4,
"name": "Affect",
"item": "https://questionsmedicales.fr/mesh/D000339"
},
{
"@type": "ListItem",
"position": 5,
"name": "Humeur irritable",
"item": "https://questionsmedicales.fr/mesh/D007508"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Humeur irritable - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Humeur irritable",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-16",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Humeur irritable",
"description": "Comment diagnostiquer une humeur irritable ?\nQuels tests sont utilisés pour l'humeur irritable ?\nL'humeur irritable est-elle un trouble mental ?\nQui peut diagnostiquer l'humeur irritable ?\nQuels critères sont utilisés pour le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Humeur irritable",
"description": "Quels sont les symptômes de l'humeur irritable ?\nL'humeur irritable peut-elle affecter le sommeil ?\nY a-t-il des signes physiques associés ?\nComment l'humeur irritable se manifeste-t-elle chez les enfants ?\nL'humeur irritable est-elle constante ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Humeur irritable",
"description": "Comment prévenir l'humeur irritable ?\nL'exercice physique aide-t-il à prévenir l'irritabilité ?\nLe sommeil influence-t-il l'humeur ?\nLes techniques de relaxation sont-elles utiles ?\nUne alimentation équilibrée peut-elle aider ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Humeur irritable",
"description": "Quels traitements sont disponibles pour l'humeur irritable ?\nLes antidépresseurs sont-ils efficaces ?\nLa thérapie comportementale aide-t-elle ?\nY a-t-il des remèdes naturels pour l'humeur irritable ?\nCombien de temps dure le traitement ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Humeur irritable",
"description": "Quelles complications peuvent survenir ?\nL'humeur irritable peut-elle affecter le travail ?\nY a-t-il un risque d'isolement social ?\nL'humeur irritable peut-elle aggraver d'autres troubles ?\nDes comportements à risque peuvent-ils survenir ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Humeur irritable",
"description": "Quels sont les facteurs de risque de l'humeur irritable ?\nLe manque de soutien social est-il un facteur ?\nLes changements hormonaux influencent-ils l'humeur ?\nLe surmenage professionnel est-il un risque ?\nLes troubles de l'humeur sont-ils héréditaires ?",
"url": "https://questionsmedicales.fr/mesh/D007508?mesh_terms=Comparative+Genomic+Hybridization#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une humeur irritable ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'évaluation clinique des symptômes et de leur impact sur la vie quotidienne."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour l'humeur irritable ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de tests spécifiques, mais des questionnaires d'évaluation peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "L'humeur irritable est-elle un trouble mental ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut être un symptôme de troubles mentaux comme le trouble dépressif ou l'anxiété."
}
},
{
"@type": "Question",
"name": "Qui peut diagnostiquer l'humeur irritable ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un professionnel de la santé mentale, comme un psychiatre ou un psychologue, peut poser le diagnostic."
}
},
{
"@type": "Question",
"name": "Quels critères sont utilisés pour le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les critères incluent la durée, l'intensité des symptômes et leur impact fonctionnel."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes de l'humeur irritable ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent l'agitation, la frustration, l'impatience et des sautes d'humeur."
}
},
{
"@type": "Question",
"name": "L'humeur irritable peut-elle affecter le sommeil ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des troubles du sommeil, comme l'insomnie ou des réveils fréquents."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes physiques associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tensions musculaires, des maux de tête et des troubles digestifs peuvent survenir."
}
},
{
"@type": "Question",
"name": "Comment l'humeur irritable se manifeste-t-elle chez les enfants ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Chez les enfants, elle peut se manifester par des colères fréquentes et des comportements opposants."
}
},
{
"@type": "Question",
"name": "L'humeur irritable est-elle constante ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle peut fluctuer en fonction des situations et des interactions sociales."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'humeur irritable ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion du stress, une bonne hygiène de vie et des relations saines peuvent aider."
}
},
{
"@type": "Question",
"name": "L'exercice physique aide-t-il à prévenir l'irritabilité ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer l'humeur et réduire l'irritabilité."
}
},
{
"@type": "Question",
"name": "Le sommeil influence-t-il l'humeur ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un sommeil de qualité est crucial pour maintenir une humeur stable et éviter l'irritabilité."
}
},
{
"@type": "Question",
"name": "Les techniques de relaxation sont-elles utiles ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des techniques comme la méditation et le yoga peuvent réduire l'irritabilité."
}
},
{
"@type": "Question",
"name": "Une alimentation équilibrée peut-elle aider ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en nutriments peut soutenir la santé mentale et l'humeur."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour l'humeur irritable ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent la thérapie cognitivo-comportementale et, si nécessaire, des médicaments."
}
},
{
"@type": "Question",
"name": "Les antidépresseurs sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains antidépresseurs peuvent aider à stabiliser l'humeur et réduire l'irritabilité."
}
},
{
"@type": "Question",
"name": "La thérapie comportementale aide-t-elle ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle aide à identifier et à modifier les pensées et comportements négatifs."
}
},
{
"@type": "Question",
"name": "Y a-t-il des remèdes naturels pour l'humeur irritable ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques comme la méditation, l'exercice et une alimentation équilibrée peuvent aider."
}
},
{
"@type": "Question",
"name": "Combien de temps dure le traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée du traitement varie selon la gravité des symptômes et la réponse au traitement."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'anxiété, la dépression et des problèmes relationnels."
}
},
{
"@type": "Question",
"name": "L'humeur irritable peut-elle affecter le travail ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des difficultés de concentration et des conflits au travail."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque d'isolement social ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'irritabilité peut conduire à l'isolement social et à des relations tendues."
}
},
{
"@type": "Question",
"name": "L'humeur irritable peut-elle aggraver d'autres troubles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut exacerber des troubles préexistants comme l'anxiété ou la dépression."
}
},
{
"@type": "Question",
"name": "Des comportements à risque peuvent-ils survenir ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'humeur irritable peut conduire à des comportements impulsifs ou à des abus de substances."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de l'humeur irritable ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent le stress, les antécédents familiaux de troubles mentaux et des événements traumatiques."
}
},
{
"@type": "Question",
"name": "Le manque de soutien social est-il un facteur ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un faible soutien social peut augmenter le risque d'humeur irritable."
}
},
{
"@type": "Question",
"name": "Les changements hormonaux influencent-ils l'humeur ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les fluctuations hormonales, comme celles liées au cycle menstruel, peuvent affecter l'humeur."
}
},
{
"@type": "Question",
"name": "Le surmenage professionnel est-il un risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le surmenage et le stress au travail peuvent contribuer à l'humeur irritable."
}
},
{
"@type": "Question",
"name": "Les troubles de l'humeur sont-ils héréditaires ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de troubles de l'humeur augmentent le risque d'humeur irritable."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 12/04/2025
Contenu vérifié selon les dernières recommandations médicales
5 publications dans cette catégorie
Affiliations :
Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Publications dans "Humeur irritable" :
5 publications dans cette catégorie
Affiliations :
Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Department of Psychological Medicine, The University of Sydney Northern Clinical School, St Leonards, New South Wales, Australia.
Publications dans "Humeur irritable" :
4 publications dans cette catégorie
Affiliations :
Section on Mood Dysregulation and Neuroscience, Intramural Research Program, National Institute of Mental Health, Bethesda, MD, USA.
Publications dans "Humeur irritable" :
4 publications dans cette catégorie
Affiliations :
Psychiatry and Pediatrics, Renaissance School of Medicine at Stony Brook University.
Publications dans "Humeur irritable" :
3 publications dans cette catégorie
Affiliations :
Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Department of Psychological Medicine, The University of Sydney Northern Clinical School, St Leonards, New South Wales, Australia.
Publications dans "Humeur irritable" :
3 publications dans cette catégorie
Affiliations :
Department of Psychological Medicine, University of Otago, Christchurch, New Zealand.
Publications dans "Humeur irritable" :
3 publications dans cette catégorie
Affiliations :
Department of Psychiatry, Faculty of Medicine and Health, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia.
Academic Department of Psychiatry, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia.
Department of Psychiatry, CADE Clinic, Royal North Shore Hospital, Level 3, Main Hospital Building, Northern Sydney Local Health District, St Leonards, NSW, 2065, Australia.
Publications dans "Humeur irritable" :
3 publications dans cette catégorie
Affiliations :
State University of New York at Stony Brook, NY.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Department of Psychological Medicine, The University of Sydney Northern Clinical School, St Leonards, New South Wales, Australia.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Sydney Medical School, The University of Sydney, Sydney, New South Wales, Australia.
Department of Psychological Medicine, The University of Sydney Northern Clinical School, St Leonards, New South Wales, Australia.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Academic Department of Psychiatry, Kolling Institute, Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Australia; CADE Clinic, Royal North Shore Hospital, Northern Sydney Local Health District, Australia; and NSW Health, Royal North Shore Hospital, Northern Sydney Local Health District, Australia.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy, alessandro.serretti@unibo.it.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Emotion and Development Branch, National Institute of Mental Health, Bethesda, MD, USA.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Academic Child Psychiatry Unit, Department of Paediatrics, University of Melbourne.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Developmental Neuropsychiatry Program, Royal Children's Hospital, Parkville, VIC, Australia.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Clinical Enteric Neuroscience Translational and Epidemiological Research and Division of Gastroenterology and Hepatology, Department of Medicine, Mayo Clinic, Rochester, MN, USA.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: l.vork@maastrichtuniversity.nl.
Publications dans "Humeur irritable" :
2 publications dans cette catégorie
Affiliations :
Division of Gastroenterology-Hepatology, Department of Internal Medicine, Maastricht University Medical Centre, Maastricht, the Netherlands. Electronic address: z.mujagic@maastrichtuniversity.nl.
Publications dans "Humeur irritable" :
The aim was to evaluate the main indications for prenatal diagnosis, the prevalence of abnormal copy number variations (CNVs), correlate them with clinical findings, analyze the prevalence of VUS, rep...
We retrospectively analyzed a cohort of 772 fetuses with indication for genetic study in two tertiary hospitals, in a 9-years-period, using aCGH....
Our results demonstrated 8.3 % (6.4-10.5 %, 95 % CI) detection rate of pathogenic CNVs. Within this group, the main indication was structural malformations (57 %) mainly involving central nervous syst...
Our findings demonstrate 4.9 % (4.2-5.6 %, 95 % CI) increased in the diagnostic yield using aCGH compared to the use of conventional karyotype alone, confirming that the aCGH can improve the accuracy ...
Comparative genomics is the comparison of genetic information within and across organisms to understand the evolution, structure, and function of genes, proteins, and non-coding regions (Sivashankari ...
Oral squamous cell carcinoma (OSCC) is a severe form of cancer affecting different anatomic sites of the oral cavity. OSCC ranks as the sixth most common cancer type with an increasing prevalence glob...
The Illumina CytoSNP-12 Array was used to determine copy number variations in OSCC cancer genome. Hybridization procedures were performed according to the manufacturer procedures (Illumina). Arrays we...
We reported that gains in 8q21.11-ter, 9p21.3, 13q14.11-ter, 13q13.3-ter and losses in 5q14.3-ter, 5q35 and 17p13.3-12 were associated with the development of OSCC. In addition, we also detected that ...
Our results were also showed that gains in 11q13.3-q13.4 and 2q13.2 chromosomal regions could promote the metastatic OSCC process. We believe that results of the study will help to find new biomarkers...
Teratomas are a common type of germ cell tumor. However, only a few reports on their genomic constitution have been published. The study of teratomas may provide a better understanding of their stepwi...
In the present study, we analyzed the copy number aberrations of nine ovarian mature cystic teratomas using array comparative genomic hybridization in an attempt to reveal their genomic aberrations....
The many chromosomal aberrations observed on array comparative genomic hybridization analysis reveal the complex genetics of this tumor. Amplifications and deletions of large DNA fragments were observ...
Our results indicated that amplifications of these genes may play an important etiological role in teratoma formation. Moreover, amplifications of EVX2 and HOXD9-HOXD13 on 2q31.1, found on array compa...
Balamuthia mandrillaris is a pathogenic protozoan that causes a rare but almost always fatal infection of the central nervous system and, in some cases, cutaneous lesions. Currently, the genomic data ...
Biological denitrification has been commonly adopted for the removal of nitrogen from sewage effluents. However, due to the low temperature during winter, microorganisms in the wastewater biological t...
Here, the basic characteristics and genetic diversity of strains PMCC200344 and PMCC200367 were described, together with the complete genomes and comparative genomic results. The genome of Pseudomonas...
These analytical results provide insights into the genomic basis of microbial denitrification in cold environments, indicating the potential of Arctic Pseudomonas strains in nitrogen removal from sewa...
Huangjiu is a popular Chinese traditional alcoholic beverage, while its brewing processes have rarely been explored. We herein report the first gapless, near-finished genome assembly of the industrial...
Human pluripotent stem cells (hPSCs) have generated unprecedented interest in the scientific community, given their potential applications in regenerative medicine, disease modeling, toxicology and dr...
The immense progress in molecular biology observed in the last decades has led to a fundamental change in our understanding of the etiology of human diseases. Whole genome analyses, both DNA sequencin...
A small but growing body of scientific literature is emerging about clinical findings in patients with 19p13.3 microdeletion or duplication. Recently, a proximal 19p13.3 microduplication syndrome was ...