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"name": "Diagnostic",
"headline": "Diagnostic sur Maladie de Leigh",
"description": "Comment diagnostique-t-on la maladie de Leigh ?\nQuels examens sont recommandés pour le diagnostic ?\nLes symptômes peuvent-ils aider au diagnostic ?\nQuel rôle joue l'historique familial dans le diagnostic ?\nPeut-on diagnostiquer la maladie de Leigh à tout âge ?",
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"description": "Quels traitements sont disponibles pour la maladie de Leigh ?\nLes suppléments nutritionnels aident-ils ?\nLa physiothérapie est-elle recommandée ?\nY a-t-il des traitements expérimentaux ?\nLes traitements varient-ils selon l'âge ?",
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"headline": "Complications sur Maladie de Leigh",
"description": "Quelles complications peuvent survenir avec la maladie de Leigh ?\nLa maladie de Leigh peut-elle entraîner des handicaps ?\nLes complications sont-elles réversibles ?\nLes patients sont-ils à risque d'autres maladies ?\nComment gérer les complications ?",
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"name": "Facteurs de risque",
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"description": "Quels sont les facteurs de risque de la maladie de Leigh ?\nLa consanguinité augmente-t-elle le risque ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes hommes et les femmes sont-ils également affectés ?\nLes enfants sont-ils plus à risque ?",
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"@type": "Question",
"name": "Comment diagnostique-t-on la maladie de Leigh ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'imagerie cérébrale, les tests génétiques et l'analyse du liquide céphalorachidien."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM cérébrale et les tests biochimiques mitochondriaux sont souvent utilisés."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils aider au diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes neurologiques et métaboliques orientent vers un diagnostic de la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'historique familial dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un historique familial de maladies mitochondriales peut augmenter la suspicion de la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Peut-on diagnostiquer la maladie de Leigh à tout âge ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Bien que souvent diagnostiquée chez les enfants, elle peut apparaître à tout âge."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes principaux de la maladie de Leigh ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des troubles neurologiques, des crises, et des problèmes respiratoires."
}
},
{
"@type": "Question",
"name": "La maladie de Leigh provoque-t-elle des retards de développement ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les enfants peuvent présenter des retards de développement moteur et cognitif."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques à surveiller ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveillez les troubles de la coordination, la faiblesse musculaire et les crises épileptiques."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils d'un patient à l'autre ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'expression des symptômes peut varier considérablement entre les individus."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils s'aggraver avec le temps ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la maladie de Leigh est progressive et les symptômes peuvent s'aggraver avec le temps."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la maladie de Leigh ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de méthode de prévention connue pour la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Le dépistage génétique est-il utile ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dépistage génétique peut aider à identifier les porteurs dans les familles à risque."
}
},
{
"@type": "Question",
"name": "Les conseils génétiques sont-ils recommandés ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les conseils génétiques sont conseillés pour les familles ayant des antécédents de maladies mitochondriales."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes peuvent-elles être testées ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests peuvent être effectués pendant la grossesse pour détecter des anomalies génétiques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives à prendre ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition à des toxines et maintenir une bonne santé générale peuvent être bénéfiques."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour la maladie de Leigh ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de traitement curatif, mais des soins symptomatiques et de soutien sont proposés."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels aident-ils ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme la coenzyme Q10 peuvent être bénéfiques pour certains patients."
}
},
{
"@type": "Question",
"name": "La physiothérapie est-elle recommandée ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut aider à améliorer la mobilité et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des essais cliniques sur des thérapies géniques et des traitements ciblés sont en cours."
}
},
{
"@type": "Question",
"name": "Les traitements varient-ils selon l'âge ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction de l'âge et de la gravité des symptômes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la maladie de Leigh ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles respiratoires, des problèmes cardiaques et des infections."
}
},
{
"@type": "Question",
"name": "La maladie de Leigh peut-elle entraîner des handicaps ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut causer des handicaps physiques et cognitifs significatifs chez les patients."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La plupart des complications ne sont pas réversibles et nécessitent une gestion à long terme."
}
},
{
"@type": "Question",
"name": "Les patients sont-ils à risque d'autres maladies ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent être plus susceptibles de développer d'autres maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une approche multidisciplinaire est nécessaire pour gérer les complications et améliorer la qualité de vie."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de la maladie de Leigh ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux de maladies mitochondriales et des mutations génétiques."
}
},
{
"@type": "Question",
"name": "La consanguinité augmente-t-elle le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la consanguinité peut augmenter le risque de transmission de maladies génétiques comme la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs environnementaux peuvent influencer l'expression des maladies mitochondriales, mais leur rôle est encore étudié."
}
},
{
"@type": "Question",
"name": "Les hommes et les femmes sont-ils également affectés ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la maladie de Leigh affecte les deux sexes de manière égale, sans prédisposition spécifique."
}
},
{
"@type": "Question",
"name": "Les enfants sont-ils plus à risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les enfants sont plus souvent diagnostiqués, mais la maladie peut également apparaître chez les adultes."
}
}
]
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More than half of Bhutan's under-five mortality is attributed to neonatal deaths. Despite this, there is a lack of local evidence on determinants of neonatal mortality. It is critical to generate new ...
It has been reported that antipsychotic use is associated with lower bone mineral density and bone quality. We aimed to determine whether antipsychotic use is associated with fracture risk in a popula...
To determine if oral hygiene is associated with infective endocarditis (IE) among those at moderate risk for IE....
This is a case control study of oral hygiene among hospitalized patients with IE (cases) and outpatients with heart valve disease but without IE (controls). The primary outcome was the mean dental cal...
The 62 case participants had 53% greater mean dental calculus index than the 119 control participants (0.84, 0.55, respectively; difference = 0.29, 95% CI: 0.11, 0.48; P = .002) and 26% greater mean d...
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The stroke group exhibited significantly lower values in both MIP for men (p<0.001) and women (p=0.013) and maximal expiratory pressure for men (p<0.001) and women (p=0.042), compared with the healthy...
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Allergies may either have a protective or a promoting effect on cancers. This study seeks to explore the relationship between various types of allergies and three specific cancer types: lung, breast, ...
Among the 556 patients, there were 115 cases of colorectal cancer, 305 cases of breast cancer, and 136 cases of lung cancer. The ratio of the case group to the control group was 1:1. We assessed the a...
The results showed a protective association between itching or urticaria due to environmental factors and colorectal cancer (adjusted odds ratio [AOR]: 0.4, 95% CI: 0.17-0.94), as well as lung cancer ...
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Conditional logistic regression trees have been proposed as a flexible alternative to the standard method of conditional logistic regression for the analysis of matched case-control studies. While the...
A random forest method for the analysis of matched case-control studies based on conditional logistic regression trees is proposed, which overcomes the issue of high variability. It provides an accura...
The proposed random forest method is a promising add-on to the toolbox for the analysis of matched case-control studies and addresses the need for machine-learning methods in this field. It provides a...
AGD is the distance measured from the anus to the genital tubercle. Recent evidence suggests that a shorter AGD, a sensitive biomarker of the prenatal hormonal environment, could be associated with hi...
To analyze the socioeconomic, demographic, environmental, reproductive, behavioral, and health-care factors associated with preterm birth....
Case-control study, with case group composed of preterm infants and the control group by full term live births. Each case was paired with two controls according to sex and date of birth. Interviews we...
221 live births were allocated in the case group and 442 in the control group. After analysis adjusted for other factors under study, the highest chances of prematurity were associated with being the ...
The factors associated with a higher chance of prematurity were: higher family income, previous preterm child, primiparity, violence against pregnant women and cesarean section. Having attended more t...
Multiple sclerosis (MS) is one of the most common autoimmune diseases worldwide, and various autoimmune comorbidities have been reported with MS. The aim of this study was to estimate the prevalence o...
In this retrospective multicentre study, we investigated a group of patients with MS, and their relatives, in terms of age, gender, and the presence of simultaneous autoimmune diseases such as Graves'...
This study included 381 patients with MS, of whom 52.23% were women. 27 patients (7.09%) had at least one autoimmune disease. The most common comorbidity was Hashimoto's thyroiditis (14 patients). 77 ...
Our study revealed that the probability of autoimmune diseases co-occurring in patients with MS, and in their relatives, is higher and we found the greatest risk to be for Hashimoto's thyroiditis....
An international outbreak of the monkeypox (MPX) virus is ongoing with a different clinical presentation than previously reported....
A monocentric retrospective study was designed to investigate clinical predictors of confirmed MPX cases among a group of patients referred for MPX screening. Furthermore, the additional value of perf...
Between 28/05/2022 and 22/07/2022, the medical records of patients referred for MPX screening were investigated. Patients with positive RT-PCR were defined as cases, while the ones with negative RT-PC...
Among the 141 included patients, 85 (60%) had at least one positive RT-PCR for MPX. Carrying out RT-PCR only on the swab obtained by skin lesion sampling, 7 patients (7/85: 8%) would have been misdiag...
MPX diagnosis was associated with being MSM, living with HIV, having multiple sexual partners, and presenting with anogenital skin lesions. In this study, the derived score had good sensitivity and sp...