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"name": "Diagnostic",
"headline": "Diagnostic sur Maladie de Leigh",
"description": "Comment diagnostique-t-on la maladie de Leigh ?\nQuels examens sont recommandés pour le diagnostic ?\nLes symptômes peuvent-ils aider au diagnostic ?\nQuel rôle joue l'historique familial dans le diagnostic ?\nPeut-on diagnostiquer la maladie de Leigh à tout âge ?",
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"headline": "Symptômes sur Maladie de Leigh",
"description": "Quels sont les symptômes principaux de la maladie de Leigh ?\nLa maladie de Leigh provoque-t-elle des retards de développement ?\nY a-t-il des symptômes spécifiques à surveiller ?\nLes symptômes varient-ils d'un patient à l'autre ?\nLes symptômes peuvent-ils s'aggraver avec le temps ?",
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"description": "Peut-on prévenir la maladie de Leigh ?\nLe dépistage génétique est-il utile ?\nLes conseils génétiques sont-ils recommandés ?\nLes femmes enceintes peuvent-elles être testées ?\nY a-t-il des mesures préventives à prendre ?",
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"headline": "Traitements sur Maladie de Leigh",
"description": "Quels traitements sont disponibles pour la maladie de Leigh ?\nLes suppléments nutritionnels aident-ils ?\nLa physiothérapie est-elle recommandée ?\nY a-t-il des traitements expérimentaux ?\nLes traitements varient-ils selon l'âge ?",
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"headline": "Complications sur Maladie de Leigh",
"description": "Quelles complications peuvent survenir avec la maladie de Leigh ?\nLa maladie de Leigh peut-elle entraîner des handicaps ?\nLes complications sont-elles réversibles ?\nLes patients sont-ils à risque d'autres maladies ?\nComment gérer les complications ?",
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"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Maladie de Leigh",
"description": "Quels sont les facteurs de risque de la maladie de Leigh ?\nLa consanguinité augmente-t-elle le risque ?\nLes facteurs environnementaux jouent-ils un rôle ?\nLes hommes et les femmes sont-ils également affectés ?\nLes enfants sont-ils plus à risque ?",
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"@type": "Question",
"name": "Comment diagnostique-t-on la maladie de Leigh ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'imagerie cérébrale, les tests génétiques et l'analyse du liquide céphalorachidien."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM cérébrale et les tests biochimiques mitochondriaux sont souvent utilisés."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils aider au diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes neurologiques et métaboliques orientent vers un diagnostic de la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'historique familial dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un historique familial de maladies mitochondriales peut augmenter la suspicion de la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Peut-on diagnostiquer la maladie de Leigh à tout âge ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Bien que souvent diagnostiquée chez les enfants, elle peut apparaître à tout âge."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes principaux de la maladie de Leigh ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des troubles neurologiques, des crises, et des problèmes respiratoires."
}
},
{
"@type": "Question",
"name": "La maladie de Leigh provoque-t-elle des retards de développement ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les enfants peuvent présenter des retards de développement moteur et cognitif."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques à surveiller ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Surveillez les troubles de la coordination, la faiblesse musculaire et les crises épileptiques."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils d'un patient à l'autre ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'expression des symptômes peut varier considérablement entre les individus."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils s'aggraver avec le temps ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la maladie de Leigh est progressive et les symptômes peuvent s'aggraver avec le temps."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la maladie de Leigh ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de méthode de prévention connue pour la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Le dépistage génétique est-il utile ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dépistage génétique peut aider à identifier les porteurs dans les familles à risque."
}
},
{
"@type": "Question",
"name": "Les conseils génétiques sont-ils recommandés ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les conseils génétiques sont conseillés pour les familles ayant des antécédents de maladies mitochondriales."
}
},
{
"@type": "Question",
"name": "Les femmes enceintes peuvent-elles être testées ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests peuvent être effectués pendant la grossesse pour détecter des anomalies génétiques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives à prendre ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition à des toxines et maintenir une bonne santé générale peuvent être bénéfiques."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour la maladie de Leigh ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de traitement curatif, mais des soins symptomatiques et de soutien sont proposés."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels aident-ils ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments comme la coenzyme Q10 peuvent être bénéfiques pour certains patients."
}
},
{
"@type": "Question",
"name": "La physiothérapie est-elle recommandée ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut aider à améliorer la mobilité et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des essais cliniques sur des thérapies géniques et des traitements ciblés sont en cours."
}
},
{
"@type": "Question",
"name": "Les traitements varient-ils selon l'âge ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction de l'âge et de la gravité des symptômes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la maladie de Leigh ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des troubles respiratoires, des problèmes cardiaques et des infections."
}
},
{
"@type": "Question",
"name": "La maladie de Leigh peut-elle entraîner des handicaps ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut causer des handicaps physiques et cognitifs significatifs chez les patients."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La plupart des complications ne sont pas réversibles et nécessitent une gestion à long terme."
}
},
{
"@type": "Question",
"name": "Les patients sont-ils à risque d'autres maladies ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients peuvent être plus susceptibles de développer d'autres maladies métaboliques."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une approche multidisciplinaire est nécessaire pour gérer les complications et améliorer la qualité de vie."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de la maladie de Leigh ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux de maladies mitochondriales et des mutations génétiques."
}
},
{
"@type": "Question",
"name": "La consanguinité augmente-t-elle le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la consanguinité peut augmenter le risque de transmission de maladies génétiques comme la maladie de Leigh."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux jouent-ils un rôle ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs environnementaux peuvent influencer l'expression des maladies mitochondriales, mais leur rôle est encore étudié."
}
},
{
"@type": "Question",
"name": "Les hommes et les femmes sont-ils également affectés ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la maladie de Leigh affecte les deux sexes de manière égale, sans prédisposition spécifique."
}
},
{
"@type": "Question",
"name": "Les enfants sont-ils plus à risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les enfants sont plus souvent diagnostiqués, mais la maladie peut également apparaître chez les adultes."
}
}
]
}
]
}
The effect of systemic hormone therapy (HT) on dementia risk is unclear. Our aim was to investigate the association between HT and dementia....
This register-based study consists of a nested case-control study and a co-twin control design, which controls for familial confounding, including shared genetics....
Through Danish national registries from 1995 to 2011, we identified: a) 2700 female singletons with incident dementia and 13,492 matched controls; b) 288 female twins with incident dementia and co-twi...
The odds ratio (OR) for the association between systemic HT and dementia was 1.05, 95% CI = [0.93-1.19] in singletons and 2.10, 95% CI = [0.99-4.46] in twins. A statistically significant association w...
Using Danish nationwide registries and controlling for education and for familial factors in a subsample, systemic HT was found to be associated with increased dementia risk if used before 2003, when ...
Recently, a history of endometriosis has been reported to be associated with several perinatal complications. However, it is unknown whether pre-pregnancy treatment for endometriosis reduces perinatal...
This case-control study included 2781 deliveries at the Hirosaki University Hospital between January 2008 and December 2019. The deliveries were divided into a case group with a history of endometrios...
Patients with a history of endometriosis had a significantly higher risk of placenta previa (crude odds ratio, 2.66; 95% confidence interval, 1.37‒4.83). Multiple logistic regression analysis showed t...
A history of endometriosis is an independent risk factor for placenta previa. Given the limitations of this study, further research is needed to determine the impact of endometriosis surgery on perina...
Xenoestrogens are synthetic or naturally occurring chemicals capable of altering the endocrine system of humans and animals owing to their molecular similarity to endogenous hormones. There is limited...
To examine xenoestrogen concentration (TEXB-α) differences between women with leiomyomas or endometriosis and control women, and to study the relationship between the clinical and sociodemographic cha...
Prospective case-control study. We selected 221 women who underwent surgery at Quironsalud Madrid University Hospital between 2017 and 2021. The cases included 117 patients: 74 women who underwent sur...
A significant majority of study participants (68.8%) had detectable levels of xenoestrogens. We found no association between TEXB-α levels in omental fat and the presence of myomas or endometriosis. I...
This study found no association between omental xenoestrogen levels and leiomyomas or endometriosis. However, their presence in most participants and their association with highly polluted areas empha...
To identify atypical masturbatory behaviors (AMB) and to reveal their effects on both sexual and masturbational erection hardness in men with erectile dysfunction (ED)....
Patients with ED and healthy controls were questioned about their masturbation habits. Accordingly, "rubbing in a prone position," "pressure on penis," and "masturbation through clothes" were included...
The data of 448 participants, 266 (59%) from the patient group, and 182 (41%) from the control group were analyzed. The mean ages were 30 years in both groups (p = 0.734). The rate of "rubbing in a pr...
Atypical masturbatory behaviors are more common in young men presenting with erectile dysfunction. These patients have higher erection hardness scores during masturbation compared to partnered sex....
Gallstone disease (GSD) and its complications are major public health issues globally. Although many community-based studies had addressed the risk factors for GSD, little is known about the associati...
In this case-control study, 189 GSD patients with less than one month of diagnosis and 342 age‑matched controls were enrolled. Dietary intakes were assessed using a 168-item semi-quantitative validate...
Comparing the highest versus the lowest tertile, significant reverse associations were observed between odds of GSD and each category of dietary fiber intake including total (OR...
Comprehensive assessment of the associations of dietary fiber intake with GSD showed that higher intakes of dietary fiber were significantly associated with reduced GSD risk....
Childhood cancer (CC) is a leading cause of death among children aged 0-19 years worldwide. Each year, 400,000 new cases of CC are diagnosed globally. Given the between-country differences in CC incid...
We used a case-control study design and enrolled participants from the only specialized pediatric hematology and oncology center in Armenia. Cases included patients ≤ 14 years old diagnosed and treate...
Overall, 234 participants (117 cases, 117 controls) were included in the study. Based on the fitted model, maternal usage of folic acid during pregnancy was protective against CC, almost twice decreas...
Despite the limited sample size of the study, significant modifiable risk factors for CC in Armenia were identified, all of which were linked to the period of pregnancy. The data from this study adds ...
Hidradenitis suppurativa (HS) is a chronic inflammatory disease of the hair follicles. The aim of this case-control study was to assess whether HS is associated with disturbances in trabecular bone sc...
Acromegaly is associated with oxidative stress and inflammation parameters. Chitotriosidase (CHITO) is a marker of macrophage activation and plays a pivotal role in the activation of inflammatory and ...
Thirty controlled acromegaly patients and 41 age- and sex-matched control cases were studied. We obtained demographic data, hormonal and metabolic parameters, and cIMT. CHITO activity was measured wit...
Higher CHITO, AGE, and hsCRP concentrations were observed in patients with acromegaly compared to controls. SOD levels were non-significantly higher in the acromegaly group, while catalase activities ...
This is the first study investigating CHITO and AGE levels in patients with acromegaly. Serum CHITO, AGE, and hsCRP levels in acromegalic patients were significantly increased. It may be important to ...
Most patients with a clinically suspected scaphoid fracture and normal initial radiograph are unnecessarily treated. Previously developed prediction rules using demographic and clinical risk are unabl...
We retrospectively included adult patients with a clinically suspected scaphoid fracture between 2013 and 2019 in our case-control study. There were 82 patients with a scaphoid fracture and 158 patien...
Of the 15 posteroanterior modes and 8 lateral modes identified and linear measurements performed, 1 PA mode was associated with a scaphoid fracture (PA mode 4; OR 1.40, CI 1.04-1.93, p = 0.031). We de...
There was one complex wrist shape significantly associated with a scaphoid fracture. Since the association was weak and the shape is difficult to identify radiographs, we believe this morphological ri...
The incidence of ampullary tumors is increasing but data on association with an increased exposure to certain risk factors are scanty....
To investigate risk and protective factors associated with the occurrence of ampullary tumors and whether these factors differ between ampullary tumors of the intestinal and pancreatobiliary subtypes ...
The association between a large set of exposome features and ampullary tumors occurrence was investigated in a bi-centric case-control study after ethic committee approval and power calculation....
In 223 histologically confirmed patients and 446 controls, previous cholecystectomy (odd ratio [OR] = 2.07; 95% confidence interval [CI] = 1.34-3.20) and proton pump inhibitors use (OR = 1.66; 95% CI ...
This is the first case-control study specifically highlighting factors associated with the occurrence of ampullary tumors. We report factors that are novel and plausible, in keeping with mechanisms de...