questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Oxidoreductases
NADH, NADPH oxidoreductases
NADH, NADPH oxidoreductases : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Déficience enzymatique
Tests génétiques
Fatigue
Troubles métaboliques
Activité enzymatique
Évaluation fonctionnelle
Anomalies génétiques
Mutations
Symptômes
5
Déficience en NADPH
Infections fréquentes
Troubles neurologiques
Dysfonctionnement enzymatique
Troubles digestifs
Métabolisme énergétique
Prévention
5
Alimentation équilibrée
Nutriments essentiels
Mode de vie sain
Exercice
Bilans de santé
Anomalies enzymatiques
Éducation nutritionnelle
Carences
Traitements
5
Suppléments enzymatiques
Modifications diététiques
Thérapie génique
Déficiences enzymatiques
Médicaments
Modulation enzymatique
Transfusions sanguines
Déficiences
Complications
5
Complications
Troubles métaboliques
Infections
Déficiences enzymatiques
Maladies chroniques
Diabète
Complications cardiovasculaires
Troubles métaboliques
Complications hématologiques
Métabolisme
Facteurs de risque
5
Antécédents familiaux
Maladies métaboliques
Mode de vie sédentaire
Mauvaise alimentation
Maladies génétiques
Prédisposition
Stress oxydatif
Déficiences enzymatiques
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"text": "Des tests enzymatiques et des analyses génétiques peuvent être utilisés pour diagnostiquer."
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"@type": "Question",
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"position": 8,
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"@type": "Question",
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"@type": "Question",
"name": "Des symptômes digestifs peuvent-ils apparaître ?",
"position": 10,
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"@type": "Question",
"name": "Comment prévenir les déficiences en NADH ?",
"position": 11,
"acceptedAnswer": {
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"text": "Une alimentation équilibrée riche en nutriments essentiels peut aider à prévenir ces déficiences."
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"@type": "Question",
"name": "Y a-t-il des habitudes de vie à adopter ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, un mode de vie sain incluant exercice et gestion du stress est recommandé."
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"@type": "Question",
"name": "Les bilans de santé réguliers sont-ils utiles ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des bilans réguliers peuvent aider à détecter précocement des anomalies enzymatiques."
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"@type": "Question",
"name": "Les vaccinations peuvent-elles jouer un rôle ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines vaccinations peuvent prévenir des infections qui aggravent les déficiences."
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"@type": "Question",
"name": "L'éducation nutritionnelle est-elle importante ?",
"position": 15,
"acceptedAnswer": {
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"text": "Oui, comprendre l'importance des nutriments peut aider à prévenir les carences."
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"@type": "Question",
"name": "Quels traitements existent pour les déficiences enzymatiques ?",
"position": 16,
"acceptedAnswer": {
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"text": "Les traitements peuvent inclure des suppléments enzymatiques et des modifications diététiques."
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"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 17,
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"text": "Oui, la thérapie génique est explorée pour traiter certaines déficiences enzymatiques."
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"@type": "Question",
"name": "Les médicaments peuvent-ils aider à réguler ces enzymes ?",
"position": 18,
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"text": "Certains médicaments peuvent aider à moduler l'activité des NADH et NADPH oxydoréductases."
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"@type": "Question",
"name": "Y a-t-il des traitements naturels recommandés ?",
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"text": "Des antioxydants et des nutriments peuvent soutenir la fonction enzymatique."
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"@type": "Question",
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"@type": "Question",
"name": "Les infections sont-elles une complication fréquente ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes avec des déficiences enzymatiques sont plus susceptibles aux infections."
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"position": 23,
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"text": "Oui, des déficiences peuvent augmenter le risque de maladies chroniques comme le diabète."
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"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques sont-elles un facteur ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines maladies génétiques prédisposent aux déficiences en NADH et NADPH."
}
},
{
"@type": "Question",
"name": "Le stress oxydatif joue-t-il un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress oxydatif peut aggraver les déficiences enzymatiques et leurs effets."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
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Obsessive-compulsive disorder (OCD) and major depressive disorder (MDD) both showed cognitive impairment, and the altered neurometabolic may associate with cognitive impairment. However, there are lim...
A total of 64 unmedicated patients (32 OCD and 32 MDD), and 33 healthy controls (HC) were included to conduct WM assessment comprising Digit Span Test (DST), 2-back task and Stroop Color and Word Test...
Compared with HC, both OCD and MDD patients exhibited a lower accuracy rate in the 2-back task, and only MDD patients performed worse in DST scores and longer reaction times in SCWT (all p < 0.05). Bo...
Both OCD and MDD showed WM impairment and neurometabolic alterations in PFC. Besides, MDD performed more severe and broader WM impairment compared to OCD. Moreover, the dysfunction of PFC may underlie...
The present study aims to examine whether declarative memory dysfunction relates to impaired core memory mechanisms or attentional and executive dysfunction in idiopathic REM Sleep Behavior Disorder (...
In this observational, cross-sectional study, were enrolled 82 individuals with the diagnosis of iRBD according to the International Classification of Sleep Disorders and 49-matched healthy controls f...
We used Bayesian multivariate generalized linear model analysis to evaluate the effect of iRBD on memory performance controlled for effects of age and sex. Individuals with iRBD displayed worse memory...
In iRBD, we replicated findings of reduced free recall based on inefficient retrieval (retrieval deficit), which was small in terms of effect size. Importantly, the memory profile across measures does...
Childhood trauma is commonly experienced by individuals diagnosed with bipolar disorder (BP). In BP, childhood trauma is related to a more severe clinical course, but its association with cognition re...
This study evaluated 405 adult participants diagnosed with BP and 136 controls. Participants completed the Childhood Trauma Questionnaire and a comprehensive neuropsychological battery. High versus lo...
There were significant differences among the three groups, F(16, 968) = 4.05, p < .001, Wilks' Λ = 0.88, partial η...
Analyses of factor score do not address which aspect of the memory process is affected and biomarkers may help guide interventions addressing underlying biological process....
Adults diagnosed with BP with higher childhood trauma have worse memory functioning, beyond the lower childhood trauma BP group, highlighting the importance of understanding the long-term cognitive ou...
Visual memory impairment is one of the most commonly complained symptoms in patients with major depressive disorder (MDD). Pattern glare is also a distorted visual phenomenon that puzzles patients wit...
Sixty-two patients with MDD and forty-nine age-, sex- and education level-matched healthy controls (HCs) were included in this study. The Pattern Recognition Memory (PRM) test and the Brief Visual Mem...
Patients with MDD scored lower on the PRM-PCi, BVMT-R1, BVMT-R2, BVMT-R3, and BVMT-Rt and higher on the PRM-MCLd than HCs (all p < 0.05). Pattern glare scores for MDD patients were higher with mid-SF ...
The present study showed that visual memory and pattern glare are disrupted in MDD. Visual memory may be associated with pattern glare and needs to be studied in future work....
Past studies identified a link between weight loss and dementia, but lacked consistent conclusions. We sought to establish this link by examining the weight change profiles before and after dementia d...
Using data from the Health and Retirement Study (1996-2020), we examined 13,123 participants. We conducted a nested case-control analysis to assess differences in biennial weight change profile while ...
Participants with a memory disorder lost weight (-0.63%) biennially, whereas those without a diagnosis did not (+0.013%,...
We observe that weight loss in dementia is a physiological process independent of genetic factors associated with BMI and longevity. Pre-dementia weight loss may be an important prognostic criterion t...
Working memory (WM) deficits are recognized as serious cognitive impairment in patients with major depressive disorder (MDD). This review aims to clarify the effects of impaired WM function in patient...
Dysregulated consolidation of emotional memories is a core feature of posttraumatic stress disorder (PTSD). Brain Derived Neurotrophic Factor (BDNF) influences synaptic plasticity and emotional memory...
The objective of this review was to identify, critically appraise, and synthesize the available evidence on the experiences of people with progressive memory disorders who are involved in non-pharmaco...
Non-pharmacological interventions are widely used to improve the quality of life and general well-being of people with progressive memory disorders. While many intervention effects have been studied, ...
The review included studies of people of all ages with progressive memory disorders who described their experiences participating in professionally delivered non-pharmacological interventions. Interve...
The search strategy used a three-step approach and sought to locate both published and unpublished studies. Key databases included MEDLINE (PubMed), CINAHL (EBSCO), Medic, Scopus (Elsevier), and PsycA...
Forty-six studies were included in the review. The study designs included qualitative descriptions (n = 31), mixed methods (n = 8), grounded theory (n = 5), and ethnography (n = 2). The total number o...
People with progressive memory disorders welcome non-pharmacological interventions. It is noteworthy that, regardless of what the interventions entailed, the participants experienced strengthened self...
Bipolar disorder (BD) and major depressive disorder (MDD) are associated with cognitive and functional impairment. Cognitive impairment is often associated with dorsal prefrontal cortex (dPFC) hypo-ac...
Heterogeneity has been a persistent challenge in understanding Schizophrenia Spectrum Disorders (SSD). Traditional case-control comparisons often show variable results, and may not map well onto indiv...
