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NADH, NADPH oxidoreductases : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une déficience en NADH oxydoréductases ?
Des tests enzymatiques et des analyses génétiques peuvent être utilisés pour diagnostiquer.
#2
Quels tests sanguins sont utiles pour évaluer NADPH ?
Les dosages de NADPH et d'autres coenzymes dans le sang peuvent être effectués.
#3
Quels symptômes indiquent un problème avec ces enzymes ?
Fatigue, faiblesse musculaire et troubles métaboliques peuvent indiquer un problème.
#4
Les tests d'activité enzymatique sont-ils fiables ?
Oui, ils sont souvent utilisés pour évaluer la fonction des NADH et NADPH oxydoréductases.
#5
Peut-on détecter des anomalies génétiques liées à ces enzymes ?
Oui, des tests génétiques peuvent identifier des mutations affectant ces enzymes.
Symptômes 5
#1
Quels sont les symptômes d'une carence en NADH ?
Les symptômes incluent fatigue, troubles cognitifs et faiblesse musculaire.
#2
Comment se manifeste une déficience en NADPH ?
Elle peut se manifester par des infections fréquentes et des troubles métaboliques.
#3
Y a-t-il des symptômes neurologiques associés ?
Oui, des troubles neurologiques peuvent survenir en cas de dysfonctionnement enzymatique.
#4
Les symptômes varient-ils selon l'âge ?
Oui, les symptômes peuvent varier en fonction de l'âge et de l'état de santé général.
#5
Des symptômes digestifs peuvent-ils apparaître ?
Oui, des troubles digestifs peuvent être liés à des anomalies dans le métabolisme énergétique.
Prévention 5
#1
Comment prévenir les déficiences en NADH ?
Une alimentation équilibrée riche en nutriments essentiels peut aider à prévenir ces déficiences.
#2
Y a-t-il des habitudes de vie à adopter ?
Oui, un mode de vie sain incluant exercice et gestion du stress est recommandé.
#3
Les bilans de santé réguliers sont-ils utiles ?
Oui, des bilans réguliers peuvent aider à détecter précocement des anomalies enzymatiques.
#4
Les vaccinations peuvent-elles jouer un rôle ?
Certaines vaccinations peuvent prévenir des infections qui aggravent les déficiences.
#5
L'éducation nutritionnelle est-elle importante ?
Oui, comprendre l'importance des nutriments peut aider à prévenir les carences.
Traitements 5
#1
Quels traitements existent pour les déficiences enzymatiques ?
Les traitements peuvent inclure des suppléments enzymatiques et des modifications diététiques.
#2
La thérapie génique est-elle une option ?
Oui, la thérapie génique est explorée pour traiter certaines déficiences enzymatiques.
#3
Les médicaments peuvent-ils aider à réguler ces enzymes ?
Certains médicaments peuvent aider à moduler l'activité des NADH et NADPH oxydoréductases.
#4
Y a-t-il des traitements naturels recommandés ?
Des antioxydants et des nutriments peuvent soutenir la fonction enzymatique.
#5
Les transfusions sanguines sont-elles nécessaires ?
Dans certains cas graves, des transfusions peuvent être nécessaires pour corriger des déficiences.
Complications 5
#1
Quelles complications peuvent survenir avec une déficience en NADH ?
Des complications incluent des troubles métaboliques graves et des problèmes neurologiques.
#2
Les infections sont-elles une complication fréquente ?
Oui, les personnes avec des déficiences enzymatiques sont plus susceptibles aux infections.
#3
Y a-t-il des risques de maladies chroniques ?
Oui, des déficiences peuvent augmenter le risque de maladies chroniques comme le diabète.
#4
Les complications cardiovasculaires sont-elles possibles ?
Oui, des troubles métaboliques peuvent entraîner des complications cardiovasculaires.
#5
Des complications hématologiques peuvent-elles survenir ?
Oui, des anomalies dans le métabolisme peuvent entraîner des complications hématologiques.
Facteurs de risque 5
#1
Quels facteurs de risque sont associés aux déficiences enzymatiques ?
Les facteurs incluent des antécédents familiaux, des maladies métaboliques et une mauvaise nutrition.
#2
L'âge est-il un facteur de risque ?
Oui, certaines déficiences peuvent être plus fréquentes chez les personnes âgées.
#3
Le mode de vie influence-t-il le risque ?
Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.
#4
Les maladies génétiques sont-elles un facteur ?
Oui, certaines maladies génétiques prédisposent aux déficiences en NADH et NADPH.
#5
Le stress oxydatif joue-t-il un rôle ?
Oui, le stress oxydatif peut aggraver les déficiences enzymatiques et leurs effets.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 01/04/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
8 au total
└─
Cytochrome reductases
Cytochrome ReductasesD003579 -
D08.811.682.608.191
└─
NADH tetrazolium reductase
NADH Tetrazolium ReductaseD009246 -
D08.811.682.608.530
└─
NADP transhydrogenases
NADP TranshydrogenasesD009250 -
D08.811.682.608.540
└─
NADPH dehydrogenase
NADPH DehydrogenaseD009252 -
D08.811.682.608.550
└─
Quinone reductases
Quinone ReductasesD011808 -
D08.811.682.608.800
└─└─
NADPH-ferrihemoprotéine reductase
NADPH-Ferrihemoprotein ReductaseD009251 -
D08.811.682.608.191.500
└─└─
NADP transhydrogenase, AB-specific
NADP Transhydrogenase, AB-SpecificD061087 -
D08.811.682.608.540.500
└─└─
NADPH dehydrogenase (quinone)
NAD(P)H Dehydrogenase (Quinone)D016660 -
D08.811.682.608.800.500
Auteurs principaux
Fei-Long Li
2 publications dans cette catégorie
Affiliations :
- School of Pharmacy, United Pharmaceutical Institute of Jiangsu University and Shandong Tianzhilvye Biotechnology Co. Ltd., Jiangsu University, Zhenjiang 212013, People's Republic of China.
Publications dans "NADH, NADPH oxidoreductases" :
-
Switching the substrate specificity from NADH to NADPH by a single mutation of NADH oxidase from Lactobacillus rhamnosus.
International journal of biological macromolecules 2019-05-22
-
Expression, biochemical characterization, and mutation of a water forming NADH: FMN oxidoreductase from Lactobacillus rhamnosus.
Enzyme and microbial technology 2019-11-17
Ye-Wang Zhang
2 publications dans cette catégorie
Affiliations :
- School of Pharmacy, United Pharmaceutical Institute of Jiangsu University and Shandong Tianzhilvye Biotechnology Co. Ltd., Jiangsu University, Zhenjiang 212013, People's Republic of China; College of Petroleum and Chemical Engineering, Beibu Gulf University, Qinzhou 535011, People's Republic of China. Electronic address: zhangyewang@ujs.edu.cn.
Publications dans "NADH, NADPH oxidoreductases" :
-
Switching the substrate specificity from NADH to NADPH by a single mutation of NADH oxidase from Lactobacillus rhamnosus.
International journal of biological macromolecules 2019-05-22
-
Expression, biochemical characterization, and mutation of a water forming NADH: FMN oxidoreductase from Lactobacillus rhamnosus.
Enzyme and microbial technology 2019-11-17
Chuanwu Xia
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase.
Archives of biochemistry and biophysics 2021-02-05
-
Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase.
Biochemistry 2019-05-01
Anna L Shen
2 publications dans cette catégorie
Affiliations :
- McArdle Laboratory for Cancer Research, Department of Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI, 53706, USA.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase.
Archives of biochemistry and biophysics 2021-02-05
-
Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase.
Biochemistry 2019-05-01
Jung-Ja P Kim
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 53226, USA. Electronic address: jjkim@mcw.edu.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural and kinetic investigations of the carboxy terminus of NADPH-cytochrome P450 oxidoreductase.
Archives of biochemistry and biophysics 2021-02-05
-
Structural and Functional Studies of the Membrane-Binding Domain of NADPH-Cytochrome P450 Oxidoreductase.
Biochemistry 2019-05-01
Albert Godoy-Hernandez
2 publications dans cette catégorie
Affiliations :
- Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Publications dans "NADH, NADPH oxidoreductases" :
Duncan G G McMillan
2 publications dans cette catégorie
Affiliations :
- Department of Biotechnology, Delft University of Technology, Van der Maasweg 9, 2629 HZ Delft, The Netherlands.
Publications dans "NADH, NADPH oxidoreductases" :
Masakazu Sugishima
2 publications dans cette catégorie
Affiliations :
- Department of Medical Biochemistry, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Publications dans "NADH, NADPH oxidoreductases" :
-
Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction.
Antioxidants (Basel, Switzerland) 2020-07-28
-
Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP
FEBS letters 2019-03-25
Hideaki Sato
2 publications dans cette catégorie
Affiliations :
- Department of Medical Biochemistry, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Publications dans "NADH, NADPH oxidoreductases" :
-
Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction.
Antioxidants (Basel, Switzerland) 2020-07-28
-
Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP
FEBS letters 2019-03-25
Ken Yamamoto
2 publications dans cette catégorie
Affiliations :
- Department of Medical Biochemistry, Kurume University School of Medicine, 67 Asahi-machi, Kurume 830-0011, Japan.
Publications dans "NADH, NADPH oxidoreductases" :
-
Conformational Equilibrium of NADPH-Cytochrome P450 Oxidoreductase Is Essential for Heme Oxygenase Reaction.
Antioxidants (Basel, Switzerland) 2020-07-28
-
Crystal structure of a NADPH-cytochrome P450 oxidoreductase (CYPOR) and heme oxygenase 1 fusion protein implies a conformational change in CYPOR upon NADPH/NADP
FEBS letters 2019-03-25
Paul Urayama
2 publications dans cette catégorie
Affiliations :
- Department of Physics, Miami University, Oxford, OH 45056, USA.
Publications dans "NADH, NADPH oxidoreductases" :
-
Cellular NADH and NADPH Conformation as a Real-Time Fluorescence-Based Metabolic Indicator under Pressurized Conditions.
Molecules (Basel, Switzerland) 2021-08-19
-
Distinguishing chemically induced NADPH- and NADH-related metabolic responses using phasor analysis of UV-excited autofluorescence.
RSC advances 2021-05-24
Yulia V Bertsova
1 publication dans cette catégorie
Affiliations :
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Vorobievy Gory 1/40, Moscow 119234, Russia.
Publications dans "NADH, NADPH oxidoreductases" :
-
A new water-soluble bacterial NADH: fumarate oxidoreductase.
FEMS microbiology letters
Ilya P Oleynikov
1 publication dans cette catégorie
Affiliations :
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Vorobievy Gory 1/40, Moscow 119234, Russia.
Publications dans "NADH, NADPH oxidoreductases" :
-
A new water-soluble bacterial NADH: fumarate oxidoreductase.
FEMS microbiology letters
Alexander V Bogachev
1 publication dans cette catégorie
Affiliations :
- Belozersky Institute of Physico-Chemical Biology, Lomonosov Moscow State University, Vorobievy Gory 1/40, Moscow 119234, Russia.
Publications dans "NADH, NADPH oxidoreductases" :
-
A new water-soluble bacterial NADH: fumarate oxidoreductase.
FEMS microbiology letters
Robert J Mayer
1 publication dans cette catégorie
Affiliations :
- Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 8 Allée Gaspard Monge, 67000 Strasbourg, France. rjmayer@unistra.fr.
Publications dans "NADH, NADPH oxidoreductases" :
-
Quantification of the hydride donor abilities of NADH, NADPH, and BH
Organic & biomolecular chemistry 2022-12-21
Joseph Moran
1 publication dans cette catégorie
Affiliations :
- Institut de Science et d'Ingénierie Supramoléculaires (ISIS), CNRS UMR 7006, Université de Strasbourg, 8 Allée Gaspard Monge, 67000 Strasbourg, France. rjmayer@unistra.fr.
- Institut Universitaire de France (IUF), 75005 Paris, France.
Publications dans "NADH, NADPH oxidoreductases" :
-
Quantification of the hydride donor abilities of NADH, NADPH, and BH
Organic & biomolecular chemistry 2022-12-21
Sanaz Göppert-Asadollahpour
1 publication dans cette catégorie
Affiliations :
- Albert-Ludwigs-Universität Freiburg, Institut für Biochemie, Albertstr. 21, D-79104 Freiburg, Germany.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochimica et biophysica acta. Bioenergetics 2024-07-01
Daniel Wohlwend
1 publication dans cette catégorie
Affiliations :
- Albert-Ludwigs-Universität Freiburg, Institut für Biochemie, Albertstr. 21, D-79104 Freiburg, Germany.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochimica et biophysica acta. Bioenergetics 2024-07-01
Thorsten Friedrich
1 publication dans cette catégorie
Affiliations :
- Albert-Ludwigs-Universität Freiburg, Institut für Biochemie, Albertstr. 21, D-79104 Freiburg, Germany. Electronic address: friedrich@bio.chemie.uni-freiburg.de.
Publications dans "NADH, NADPH oxidoreductases" :
-
Structural robustness of the NADH binding site in NADH:ubiquinone oxidoreductase (complex I).
Biochimica et biophysica acta. Bioenergetics 2024-07-01
Qiang Zhou
1 publication dans cette catégorie
Affiliations :
- School of Pharmacy, United Pharmaceutical Institute of Jiangsu University and Shandong Tianzhilvye Biotechnology Co. Ltd., Jiangsu University, Zhenjiang 212013, People's Republic of China.
Publications dans "NADH, NADPH oxidoreductases" :
-
Switching the substrate specificity from NADH to NADPH by a single mutation of NADH oxidase from Lactobacillus rhamnosus.
International journal of biological macromolecules 2019-05-22
Sources (10000 au total)
Methodological quality of network meta-analysis in dentistry: a meta-research.
This meta-research aimed to provide an overview of the methodological quality and risk of bias of network meta-analyses (NMA) in dentistry. Searches for NMA of randomized clinical trials with clinical...
Effects of non-pharmacological interventions for adults with subjective cognitive decline: a network meta-analysis and component network meta-analysis.
Non-pharmacological interventions have a myriad of available intervention options and contain multiple components. Whether specific components of non-pharmacological interventions or combinations are ... PubMed, Embase, Cochrane, CINAHL, PsycINFO, CENTRAL, Web of Science, and China's two largest databases, CNKI and Wanfang, were searched from inception to 22nd, January 2023. Randomized controlled tria... A total of 39 trials with 2959 patients were included (range of mean ages, 58.79-77.41 years). Resistance exercise might be the optimal intervention for reducing memory complaints in adults with subje... The form of physical activity performed appears to be more beneficial than cognitive interventions in reducing subjective memory complaints for adults with subjective cognitive decline, and this diffe... PROSPERO registry number. CRD42022355363....
Network meta-interpolation: Effect modification adjustment in network meta-analysis using subgroup analyses.
Effect modification (EM) may cause bias in network meta-analysis (NMA). Existing population adjustment NMA methods use individual patient data to adjust for EM but disregard available subgroup informa...
Treatments for alopecia areata: a network meta-analysis.
Alopecia areata is an autoimmune disease leading to nonscarring hair loss on the scalp or body. There are different treatments including immunosuppressants, hair growth stimulants, and contact immunot... To assess the benefits and harms of the treatments for alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) in children and adults.... The Cochrane Skin Specialised Register, CENTRAL, MEDLINE, Embase, ClinicalTrials.gov and WHO ICTRP were searched up to July 2022.... We included randomised controlled trials (RCTs) that evaluated classical immunosuppressants, biologics, small molecule inhibitors, contact immunotherapy, hair growth stimulants, and other therapies in... We used the standard procedures expected by Cochrane including assessment of risks of bias using RoB2 and the certainty of the evidence using GRADE. The primary outcomes were short-term hair regrowth ... We included 63 studies that tested 47 different treatments in 4817 randomised participants. All trials used a parallel-group design except one that used a cross-over design. The mean sample size was 7... We found that treatment with baricitinib results in an increase in short- and long-term hair regrowth compared to placebo. Although we found inconclusive results for the risk of serious adverse effect...
Bias propagation in network meta-analysis models.
Network meta-analysis combines direct and indirect evidence to compare multiple treatments. As direct evidence for one treatment contrast may be indirect evidence for other treatment contrasts, biases...
Does type of funding affect reporting in network meta-analysis? A scoping review of network meta-analyses.
Evidence has shown that private industry-sponsored randomized controlled trials (RCTs) and meta-analyses are more likely to report intervention-favourable results compared with other sources of fundin... To (a) explore the recommendation rate of industry-sponsored NMAs on their company's intervention, and (b) assess reporting in NMAs of pharmacologic interventions according to their funding type.... Design: Scoping review of published NMAs with RCTs.... We used a pre-existing NMA database including 1,144 articles from MEDLINE, EMBASE and Cochrane Database of Systematic Reviews, published between January 2013 and July 2018.... NMAs with transparent funding information and comparing pharmacologic interventions with/without placebo.... We captured whether NMAs recommended their own or another company's intervention, classified NMAs according to their primary outcome findings (i.e., statistical significance and direction of effect), ... We retrieved 658 NMAs, which reported a median of 23 items in the PRISMA-NMA checklist (interquartile range [IQR]: 21-26). NMAs were categorized as 314 publicly-sponsored (PRISMA-NMA median 24.5, IQR ... Differences in completeness of reporting and author characteristics were apparent among NMAs with different types of funding. Publicly-sponsored NMAs had the best reporting and published their finding...
Efficacy of innovative therapies in myasthenia gravis: A systematic review, meta-analysis and network meta-analysis.
Therapy for myasthenia gravis (MG) is undergoing a profound change, with new treatments being tested. These include complement inhibitors and neonatal Fc receptor (FcRn) blockers. The aim of this stud... We assessed statistical heterogeneity across trials based on the Cochrane Q test and I... We observed an overall mean Myasthenia Gravis-Activities of Daily Living scale (MG-ADL) score change of -2.17 points (95% confidence interval [CI] -2.67, -1.67; p < 0.001) as compared to placebo. No s... Anti-complement and FcRn treatments both proved to be effective in MG patients, whereas rituximab did not show a significant benefit for patients. Within the limitations of this meta-analysis, includi...
Effectiveness of aerobic exercise in the prevention and treatment of postpartum depression: Meta-analysis and network meta-analysis.
Aerobic exercise is widely recognized for improving mental health and reducing negative emotions, including anxiety. However, research on its role in preventing and treating postpartum depression (PPD... We conducted a quantitative systematic review of the study in 5 representative databases for the effect of aerobic exercise on PPD. Meta-analysis and network meta-analysis were performed with Review-M... Twenty-six studies with 2,867 participants were eventually included and the efficacy of aerobic exercise in preventing and treating postpartum depression is significant compared to standard care. (MD ... The efficacy of aerobic exercise in preventing and treating postpartum depression is significant compared to standard care, with a greater emphasis on prevention. The optimal prescribed exercise volum...
Antibiotic Prophylaxis in Reduction Mammaplasty: A Network Meta-Analysis.
Mounting evidence suggests that breast reduction surgery displays higher rates of surgical site infections (SSI) than initially presumed. Objective of this network meta-analysis is to evaluate the eff... A network meta-analysis was conducted using a predetermined protocol after searching the electronic databases MEDLINE, Scopus, the Cochrane Library and US National Institutes of Health Ongoing Trials ... A total of 10 studies was included in the analysis involving 1331 patients. All but one study controlled for major risk factors, and no differences were observed in patients' baseline characteristics.... Antibiotics mitigate the SSI rate after breast reduction. This meta-analysis provides an evidence-based strategy to optimize antibiotic administration. Further research is needed though to examine ant... This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Inst...