The Gain-of-Function Mutation,
Rice spotted-leaf mutants are ideal materials to study the molecular mechanism underlying programmed cell death and disease resistance in plants....
Prostaglandines endoperoxydes : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une dysfonction liée aux prostaglandines ?
Le diagnostic repose sur des tests sanguins et l'évaluation des symptômes cliniques.
#2
Quels tests sont utilisés pour mesurer les prostaglandines ?
Des tests d'immunoessai et des analyses de sang peuvent être utilisés pour mesurer les niveaux.
#3
Les niveaux de prostaglandines peuvent-ils être mesurés dans l'urine ?
Oui, les métabolites des prostaglandines peuvent être détectés dans l'urine.
#4
Quels symptômes indiquent un déséquilibre des prostaglandines ?
Des douleurs, des inflammations et des troubles menstruels peuvent indiquer un déséquilibre.
#5
Les examens d'imagerie sont-ils utiles pour évaluer les prostaglandines ?
Non, les examens d'imagerie ne mesurent pas directement les prostaglandines.
Symptômes 5
#1
Quels symptômes sont associés à une surproduction de prostaglandines ?
Douleurs abdominales, crampes menstruelles et inflammations sont fréquents.
#2
Les prostaglandines peuvent-elles causer des maux de tête ?
Oui, elles peuvent contribuer à des maux de tête, notamment les migraines.
#3
Comment les prostaglandines affectent-elles le cycle menstruel ?
Elles régulent les contractions utérines, influençant ainsi le cycle menstruel.
#4
Les prostaglandines sont-elles liées à des douleurs articulaires ?
Oui, elles jouent un rôle dans l'inflammation et la douleur articulaire.
#5
Peut-on ressentir des nausées à cause des prostaglandines ?
Oui, une surproduction peut entraîner des nausées, surtout lors des menstruations.
Prévention 5
#1
Comment prévenir les déséquilibres de prostaglandines ?
Une alimentation équilibrée et la gestion du stress peuvent aider à prévenir les déséquilibres.
#2
L'exercice physique influence-t-il les niveaux de prostaglandines ?
Oui, l'exercice régulier peut aider à réguler les niveaux de prostaglandines.
#3
Les habitudes alimentaires affectent-elles les prostaglandines ?
Oui, une alimentation riche en oméga-3 peut réduire l'inflammation liée aux prostaglandines.
#4
Le stress a-t-il un impact sur les prostaglandines ?
Oui, le stress peut augmenter la production de prostaglandines et aggraver les symptômes.
#5
Les compléments alimentaires peuvent-ils aider à la prévention ?
Oui, certains compléments comme le curcuma peuvent aider à moduler les prostaglandines.
Traitements 5
#1
Quels médicaments ciblent les prostaglandines ?
Les anti-inflammatoires non stéroïdiens (AINS) inhibent la synthèse des prostaglandines.
#2
Comment les AINS agissent-ils sur les prostaglandines ?
Ils bloquent les enzymes responsables de la production de prostaglandines.
#3
Les traitements hormonaux affectent-ils les prostaglandines ?
Oui, les traitements hormonaux peuvent moduler la production de prostaglandines.
#4
Y a-t-il des traitements naturels pour réguler les prostaglandines ?
Des compléments comme l'huile d'onagre peuvent aider à équilibrer les prostaglandines.
#5
Les prostaglandines peuvent-elles être ciblées par des thérapies biologiques ?
Certaines thérapies biologiques visent à moduler la réponse inflammatoire liée aux prostaglandines.
Complications 5
#1
Quelles complications peuvent survenir avec un excès de prostaglandines ?
Des complications comme l'endométriose et des douleurs chroniques peuvent survenir.
#2
Les prostaglandines peuvent-elles causer des problèmes digestifs ?
Oui, elles peuvent entraîner des troubles digestifs comme des ulcères gastriques.
#3
Comment les prostaglandines affectent-elles la grossesse ?
Elles jouent un rôle dans le travail, mais un excès peut entraîner des complications.
#4
Les prostaglandines sont-elles liées à des maladies cardiovasculaires ?
Oui, un déséquilibre peut contribuer à des maladies cardiovasculaires par inflammation.
#5
Peut-on développer une hypersensibilité aux prostaglandines ?
Oui, certaines personnes peuvent développer une hypersensibilité, entraînant des douleurs accrues.
Facteurs de risque 5
#1
Quels facteurs augmentent le risque de déséquilibre des prostaglandines ?
Le stress, une mauvaise alimentation et des antécédents familiaux augmentent le risque.
#2
L'âge influence-t-il les niveaux de prostaglandines ?
Oui, les niveaux de prostaglandines peuvent varier avec l'âge, surtout chez les femmes.
#3
Les maladies chroniques affectent-elles les prostaglandines ?
Oui, des maladies comme l'arthrite peuvent perturber la production de prostaglandines.
#4
Le tabagisme influence-t-il les niveaux de prostaglandines ?
Oui, le tabagisme peut augmenter l'inflammation et affecter les niveaux de prostaglandines.
#5
Les déséquilibres hormonaux sont-ils un facteur de risque ?
Oui, les déséquilibres hormonaux peuvent influencer la production de prostaglandines.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 30/04/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
3 au totalAuteurs principaux
Wei Mao
4 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin D
Prostaglandins & other lipid mediators 2023-09-03
-
Prostaglandin E
Animal reproduction science 2018-11-20
Jinshan Cao
4 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China. Electronic address: Jinshancao@imau.edu.cn.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin D
Prostaglandins & other lipid mediators 2023-09-03
-
Prostaglandin E
Animal reproduction science 2018-11-20
Bo Liu
4 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China. Electronic address: liubo8510@imau.edu.cn.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin D
Prostaglandins & other lipid mediators 2023-09-03
-
Prostaglandin E
Animal reproduction science 2018-11-20
Ruifeng Gao
3 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin E
Animal reproduction science 2018-11-20
Yang Deng
3 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin E
Animal reproduction science 2018-11-20
Jindi Wu
3 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin E
Animal reproduction science 2018-11-20
Shuangyi Zhang
3 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin D
Prostaglandins & other lipid mediators 2023-09-03
-
Prostaglandin E
Animal reproduction science 2018-11-20
Yuan Shen
3 publications dans cette catégorie
Affiliations :
- Laboratory of Veterinary Pharmacology, College of Veterinary Medicine, Inner Mongolia Agricultural University, Hohhot, China; Key Laboratory of Clinical Diagnosis and Treatment Techniques for Animal Disease, Ministry of Agriculture, China.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin F
Animal reproduction science 2020-01-08
-
Prostaglandin E
Theriogenology 2019-05-08
-
Prostaglandin E
Animal reproduction science 2018-11-20
Yukihiko Sugimoto
3 publications dans cette catégorie
Affiliations :
- Department of Pharmaceutical Biochemistry, Graduate School of Pharmaceutical Sciences, Kumamoto University, Kumamoto, 862-0973, Japan.
Publications dans "Prostaglandines endoperoxydes" :
-
Prostaglandin E
Communications biology 2022-11-10
-
Prostaglandin E
Genes to cells : devoted to molecular & cellular mechanisms 2020-02-07
-
Prostaglandin E
Cell reports
Aftab Alam
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Mumtaz Ali
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan. Electronic address: mumtazali@uom.edu.pk.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Najeeb Ur Rehman
2 publications dans cette catégorie
Affiliations :
- Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Abdul Latif
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Abdul Jabbar Shah
2 publications dans cette catégorie
Affiliations :
- Cardiovascular Research Group, Department of Pharmacy, COMSATS University Islamabad, Abbottabad Campus-22060, Khyber Pakhtunkhwa, Pakistan.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Muhammad Ayaz
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Ahmed Al-Harrasi
2 publications dans cette catégorie
Affiliations :
- Natural and Medical Sciences Research Center, University of Nizwa, P.O. Box 33, PC 616, Birkat Al Mauz, Nizwa, Oman. Electronic address: aharrasi@unizwa.edu.om.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Manzoor Ahmad
2 publications dans cette catégorie
Affiliations :
- Department of Chemistry, University of Malakand, P.O. Box 18800, Dir Lower, Khyber Pakhtunkhwa, Pakistan. Electronic address: manzoorahmad@uom.edu.pk.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis and characterization of biologically active flurbiprofen amide derivatives as selective prostaglandin-endoperoxide synthase II inhibitors: In vivo anti-inflammatory activity and molecular docking.
International journal of biological macromolecules 2022-12-27
-
Discovery of (S)-flurbiprofen-based novel azine derivatives as prostaglandin endoperoxide synthase-II inhibitors: Synthesis, in-vivo analgesic, anti-inflammatory activities, and their molecular docking.
Bioorganic chemistry 2023-09-12
Patrícia S M Amado
2 publications dans cette catégorie
Affiliations :
- Center of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
- Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, FCT, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.
Molecules (Basel, Switzerland) 2022-08-24
-
1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World
Pharmaceuticals (Basel, Switzerland) 2022-04-03
Sofia Cortes
2 publications dans cette catégorie
Affiliations :
- Global Health and Tropical Medicine-GHTM, Instituto de Higiene e Medicina Tropical-IHMT, Universidade Nova de Lisboa-NOVA, 1349-008 Lisboa, Portugal.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.
Molecules (Basel, Switzerland) 2022-08-24
-
1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World
Pharmaceuticals (Basel, Switzerland) 2022-04-03
Maria L S Cristiano
2 publications dans cette catégorie
Affiliations :
- Center of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
- Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, FCT, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.
Publications dans "Prostaglandines endoperoxydes" :
-
Synthesis, Structure and Antileishmanial Evaluation of Endoperoxide-Pyrazole Hybrids.
Molecules (Basel, Switzerland) 2022-08-24
-
1,2,4-Trioxolane and 1,2,4,5-Tetraoxane Endoperoxides against Old-World
Pharmaceuticals (Basel, Switzerland) 2022-04-03
Sources (10000 au total)
Gain-of-function mutations in the catalytic domain of
Lung cancer is a lethal malignancy lacking effective therapies. Emerging evidence suggests that epigenetic enzyme mutations are closely related to the malignant phenotype of lung cancer. Here, we iden...
Gain-of-function STAT1 mutation and visceral leishmaniasis.
Gain-of-function mutations in the STAT1 gene have been initially associated with chronic mucocutaneous candidiasis. However, further research has shown that STAT1 GOF variants may increase susceptibil...
JAKs and STATs from a Clinical Perspective: Loss-of-Function Mutations, Gain-of-Function Mutations, and Their Multidimensional Consequences.
The JAK/STAT signaling pathway plays a key role in cytokine signaling and is involved in development, immunity, and tumorigenesis for nearly any cell. At first glance, the JAK/STAT signaling pathway a...
Somatic gain-of-function mutations in BUD13 promote oncogenesis by disrupting Fbw7 function.
Somatic mutations occurring on key enzymes are extensively studied and targeted therapies are developed with clinical promises. However, context-dependent enzyme function through distinct substrates c...
SCN1A gain-of-function mutation causing an early onset epileptic encephalopathy.
Loss-of-function variants in SCN1A cause Dravet syndrome, the most common genetic developmental and epileptic encephalopathy (DEE). However, emerging evidence suggests separate entities of SCN1A-relat... Individuals carrying the recurrent SCN1A p.R1636Q variant were identified through diagnostic testing. Whole cell voltage-clamp electrophysiological recording in HEK-293 T cells was performed to compar... All four individuals had an early onset DEE characterized by focal tonic seizures and additional seizure types starting in the first few weeks of life. Electrophysiological analysis showed a mixed gai... The recurrent SCN1A p.R1636Q variant causes a clinical entity with a wider clinical spectrum than previously reported, characterized by neonatal onset epilepsy and absence of prominent movement disord...
Gain-of-function mutations in KCNK3 cause a developmental disorder with sleep apnea.
Sleep apnea is a common disorder that represents a global public health burden. KCNK3 encodes TASK-1, a K...
Somatic GJA4 gain-of-function mutation in orbital cavernous venous malformations.
Orbital cavernous venous malformation (OCVM) is a sporadic vascular anomaly of uncertain etiology characterized by abnormally dilated vascular channels. Here, we identify a somatic missense mutation, ...
Cellular Mechanisms Underlying B Cell Abnormalities in Patients With Gain-of-Function Mutations in the
Activated phosphoinositide 3 kinase (PI3K) -delta syndrome (APDS) is an inborn error of immunity with variable clinical phenotype of immunodeficiency and immune dysregulation and caused by gain-of-fun... To explore unique B cell subsets and the pathomechanisms driving B cell dysregulation beyond the transitional B cell stage in APDS.... Clinical and immunological data was collected from 24 patients with APDS. In five cases, we performed an in-depth analysis of B cell phenotypes and cultured purified naïve B cells to evaluate their su... The patients had increased B cell sizes and higher proportions of IgM... The present study suggests additional mechanistic insight into B cell pathology of APDS: (1) decreased peripheral B cell numbers may be due to the increased death of naïve B cells; (2) larger B cell s...
Gain-of-Function Dynamin-2 Mutations Linked to Centronuclear Myopathy Impair Ca
Gain-of-function mutations of dynamin-2, a mechano-GTPase that remodels membrane and actin filaments, cause centronuclear myopathy (CNM), a congenital disease that mainly affects skeletal muscle tissu...