Comment diagnostiquer une dysrégulation des kinases à tyrosine ?

Des tests sanguins et des biopsies peuvent révéler des anomalies dans l'activité des kinases.

Quels marqueurs sont utilisés pour le diagnostic ?

Les marqueurs tumoraux comme le CA 19-9 peuvent indiquer une activité kinase anormale.

Les tests génétiques sont-ils utiles ?

Oui, ils peuvent identifier des mutations dans les gènes codant pour les kinases à tyrosine.

Quels examens d'imagerie sont recommandés ?

L'IRM et le scanner peuvent aider à visualiser les tumeurs associées aux kinases.

Les antécédents familiaux influencent-ils le diagnostic ?

Oui, des antécédents de cancers peuvent augmenter le risque de dysrégulation des kinases.

Quels symptômes sont liés à une suractivité des kinases ?

Fatigue, perte de poids, et douleurs osseuses peuvent indiquer une suractivité des kinases.

Les symptômes varient-ils selon le type de kinase ?

Oui, les symptômes dépendent du type de kinase et de la voie de signalisation affectée.

Y a-t-il des symptômes spécifiques aux cancers ?

Oui, des symptômes comme des masses palpables ou des saignements peuvent survenir.

Les symptômes peuvent-ils être confondus avec d'autres maladies ?

Oui, des symptômes comme la fatigue peuvent être communs à plusieurs maladies.

Comment les symptômes évoluent-ils dans le temps ?

Ils peuvent s'aggraver progressivement, nécessitant une surveillance régulière.

Peut-on prévenir les dysfonctionnements des kinases ?

Une alimentation saine et l'exercice régulier peuvent réduire le risque de cancers.

Les dépistages réguliers sont-ils recommandés ?

Oui, des dépistages peuvent aider à détecter précocement des anomalies liées aux kinases.

Y a-t-il des vaccins préventifs ?

Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des kinases.

Le tabagisme influence-t-il le risque ?

Oui, le tabagisme est un facteur de risque connu pour plusieurs cancers liés aux kinases.

Les facteurs environnementaux jouent-ils un rôle ?

Oui, l'exposition à des substances chimiques peut augmenter le risque de dysfonctionnement des kinases.

Quels traitements ciblent les kinases à tyrosine ?

Les inhibiteurs de kinases, comme l'imatinib, sont utilisés pour traiter certains cancers.

Les traitements sont-ils personnalisés ?

Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases.

Quels effets secondaires des traitements sont courants ?

Fatigue, nausées et éruptions cutanées sont des effets secondaires fréquents.

La radiothérapie est-elle utilisée ?

Oui, la radiothérapie peut être utilisée en complément des traitements ciblés.

Les traitements sont-ils efficaces à long terme ?

L'efficacité varie, mais certains patients peuvent bénéficier d'une rémission prolongée.

Quelles complications peuvent survenir avec les kinases ?

Des complications comme la résistance aux traitements et la progression de la maladie peuvent survenir.

Les complications sont-elles réversibles ?

Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.

Comment les complications affectent-elles le pronostic ?

Les complications peuvent aggraver le pronostic et réduire les chances de rémission.

Les complications varient-elles selon le type de cancer ?

Oui, les complications peuvent différer selon le type de cancer et la kinase impliquée.

Les complications nécessitent-elles des traitements supplémentaires ?

Oui, des traitements supplémentaires peuvent être nécessaires pour gérer les complications.

Quels sont les principaux facteurs de risque ?

Les antécédents familiaux, le tabagisme et l'exposition à des produits chimiques sont des facteurs de risque.

L'âge influence-t-il le risque de dysfonctionnement des kinases ?

Oui, le risque augmente généralement avec l'âge, surtout pour certains cancers.

Le mode de vie joue-t-il un rôle ?

Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.

Les infections peuvent-elles être un facteur de risque ?

Certaines infections virales, comme le virus d'Epstein-Barr, peuvent augmenter le risque.

Y a-t-il des facteurs génétiques impliqués ?

Oui, des mutations génétiques héréditaires peuvent prédisposer à des dysfonctionnements des kinases.

Protein-tyrosine kinases - Informations médicales vérifiées

Educational preferences in individuals with cardiometabolic disease differs with age, ethnicity and educational status.

12 2022

DOI: 10.1016/j.pec.2022.08.016 PMID: 36150978

To evaluate how sociodemographic factors influence educational modality preferences in people with cardiometabolic disease.... This was a cross-sectional study performed in people with diabetes and cardiovascular disease, who completed a questionnaire to denote their previous experience and ranked preferences for different ed... The questionnaire was completed by 3751 people, of whom 59% were men, median (interquartile range) age was 68 (59-76) years, and 78% were White European. In total, 73% had diabetes, 35% had heart dise... We highlight the importance of considering factors that could influence selection of educational modalities including age, ethnicity, gender and educational level. We anticipate this approach will aid... Given the influence of multiple demographic factors and previous experiences on expressed preferences, providers should support individuals to make informed decisions about educational interventions t...

Male Humans Aged Female Ethnicity +4 autres

Immigration Status, Educational Level, and Perceived Discrimination in Europe.

26 01 2023

DOI: 10.3390/ijerph20032222 PMID: 36767588

Multiple studies have been conducted to test the moderating effect of immigration on the positive health results yielded through educational attainment. However, no study has been conducted to examine... We aimed to study whether an inverse association exists between educational level and perceived discrimination in European countries and whether immigration status moderates the association between ed... Data from the 10th round of the cross-sectional European Social Survey (ESS) were used in this cross-sectional study. A total of 17,596 participants between 15-90 years old who lived in European count... Of 17,596 participants, 16,632 (94.5%) were native-born and 964 were immigrants (5.5%). We found that higher levels of educational level were protective against perceived discrimination, which was als... This study found that educational level was a protective factor against perceived discrimination. This effect, however, was more robust in the native-born participants than in their immigrant counterp...

Humans Adolescent Young Adult Adult Middle Aged +8 autres

Children oral health and parents education status: a cross sectional study.

24 10 2023

DOI: 10.1186/s12903-023-03424-x PMID: 37875845

Oral diseases are common and affect millions of people worldwide. They can range from mild and easily treatable conditions to more severe and serious diseases. Proper oral hygiene and regular dental m... We enrolled consecutively healthy subjects aged between 0-16 and their parents at the Dental Clinic of the University of Campania "L. Vanvitelli". The Italian version of the ECOHIS (I-ECOHIS) was admi... We found a significative association of a higher I-ECOHIS total score (coeff. 4.04244; CI 95%: 1.530855-6.554026; p = 0,002) and higher I-ECOHIS children section score (coeff. 3.2794; CI 95%: 1.29002-... Father unemployed status and a lower educational level for both parents may negatively affect oral health status....

Female Humans Child Infant, Newborn Infant +9 autres

Nature, Nurture, and the Meaning of Educational Attainment: Differences by Sex and Socioeconomic Status.

Feb 2023

DOI: 10.1017/thg.2023.6 PMID: 36912114

Estimated heritability of educational attainment (EA) varies widely, from 23% to 80%, with growing evidence suggesting the degree to which genetic variation contributes to individual differences in EA...

Female Humans Male Academic Success Educational Status +4 autres

The association between educational status and colorectal neoplasia: results from a screening cohort.

05 Apr 2023

DOI: 10.1007/s00384-023-04383-z PMID: 37017795

Educational status is used as a proxy for socioeconomic status. While lower levels of education are generally associated with poorer health, the data on the relationship between educational status and... We included 5977 participants undergoing a screening colonoscopy in Austria. We split the cohort into patients with lower (n = 2156), medium (n = 2933), and higher (n = 459) educational status. Multiv... We found that the rates of any neoplasia (32%) were similar between the educational strata. However, patients with higher (10%) educational status evidenced significantly higher rates of advanced colo... Our study found that higher educational status was associated with a higher prevalence of advanced colorectal neoplasia compared to medium and lower educational status. This finding remained significa...

Humans Colorectal Neoplasms Colonoscopy Educational Status Risk Factors +1 autres

Healthy and Respectful Relationship Education: Differences by Disability Status and Associations With Sexual Abuse.

07 2023

DOI: 10.1111/josh.13317 PMID: 36815452

Education about healthy and respectful relationships (HRR) is a key component of comprehensive sexual health curricula and is supposed to be universally provided in Oregon. This study: (1) assesses th... Using data from the 2019 Oregon Healthy Teens survey, we conducted multivariable Poisson regression to compare 11th grade students with and without disabilities on self-reported receipt of school base... Students with disabilities were 41% more likely than students without disabilities to say they had never been taught in school about HRR (adjusted prevalence ratio 1.41, 95% confidence interval: 1.25-... Students with disabilities are less likely to have received school-based HRR education than their peers without disabilities. Providing inclusive HRR education may help reduce risk of sexual abuse and...

Adolescent Humans Sex Offenses Health Status Schools +3 autres

Marital Status, Father Acknowledgement, and Birth Outcomes: Does the Maternal Education Matter?

10 03 2023

DOI: 10.3390/ijerph20064868 PMID: 36981777

We evaluated whether the maternal marital status and father acknowledgement (proxy for paternal presence) affect birth weight, and if so, whether the maternal educational attainment modifies this effe...

Female Humans Male Pregnancy Educational Status +5 autres

Health and health behaviours in adolescence as predictors of education and socioeconomic status in adulthood - a longitudinal study.

26 Apr 2024

DOI: 10.1186/s12889-024-18668-7 PMID: 38671433

The positive association of health with education level and socioeconomic status (SES) is well-established. Two theoretical frameworks have been delineated to understand main mechanisms leading to soc... Surveys on health and health behaviours were sent to representative samples of 12-18-year-old Finns in 1981-1997 every second year (response rate 77.8%, N = 55,682). The survey data were linked with t... In logistic regression analyses, good health, health-enhancing behaviours, and lack of health-compromising behaviours were related to higher education and SES, also after controlling for family backgr... Health and health behaviours in adolescence predicted education and SES in adulthood. Even though the relationships were modest, they support the health selection hypotheses and emphasise the importan...

Humans Adolescent Health Behavior Finland Male +8 autres

[Extremely preterm infants with severe intraventricular hemorrhage: neurological evolution and long term and educational status].

Apr 2024

DOI: 10.32641/andespediatr.v95i2.4604 PMID: 38801364

Extensive intraventricular hemorrhage (IVH) in very preterm newborns (VPNB) is associated with mortality and severe long-term neurological sequelae.... To know the most frequent neurological pathologies associated with extensive IVH, to determine the functional outcomes of mobility in the motor area and intellectual capacity in the cognitive area, to... Descriptive and longitudinal study in VPNB with extensive IVH born between 2001 and 2014. They underwent protocolized neurological follow-up until school age. The functional outcomes in mobility and i... 74 children completed the follow-up; the most frequent associated neurological pathologies were neurodevelopmental disorders, hypertensive hydrocephalus, and epilepsy. Independent mobility (normal or ... 2/3 VPNB with extensive IVH showed positive functional outcomes, from normal to mild limitations that allow an almost autonomous life; in 1/3 the outcomes were unfavorable in mobility and cognitive pe...

Humans Male Infant, Newborn Longitudinal Studies Female +12 autres

Educational impacts of the COVID-19 pandemic in the United States: Inequities by race, ethnicity, and socioeconomic status.

08 2023

DOI: 10.1016/j.copsyc.2023.101643 PMID: 37442079

The COVID-19 pandemic caused reverberations throughout the educational system that disproportionately impacted students of color and those from lower socioeconomic backgrounds. In this review, we exam...

Humans United States Ethnicity COVID-19 Pandemics +2 autres

Protein-tyrosine kinases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Agammaglobulinaemia tyrosine kinase

Focal adhesion protein-tyrosine kinases

Janus kinases

Mitogen-Activated Protein Kinase Kinases

Syk kinase

src-Family kinases

ZAP-70 Protein-tyrosine kinase

Janus kinase 1

Janus kinase 3

TYK2 Kinase

MAP Kinase Kinase 1

MAP Kinase Kinase 2

MAP Kinase Kinase 3

MAP Kinase Kinase 4

MAP Kinase Kinase 5

MAP Kinase Kinase 6

MAP Kinase Kinase 7

CSK tyrosine-protein kinase

Auteurs principaux

Sources (10000 au total)