Titre : Protein-tyrosine kinases

Protein-tyrosine kinases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Polyneuropathies
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Protein-tyrosine kinases : Questions médicales les plus fréquentes", "headline": "Protein-tyrosine kinases : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Protein-tyrosine kinases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-05-05", "dateModified": "2025-04-30", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Protein-tyrosine kinases" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Protéines et peptides de signalisation intracellulaire", "url": "https://questionsmedicales.fr/mesh/D047908", "about": { "@type": "MedicalCondition", "name": "Protéines et peptides de signalisation intracellulaire", "code": { "@type": "MedicalCode", "code": "D047908", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Agammaglobulinaemia tyrosine kinase", "alternateName": "Agammaglobulinaemia Tyrosine Kinase", "url": "https://questionsmedicales.fr/mesh/D000077329", "about": { "@type": "MedicalCondition", "name": "Agammaglobulinaemia tyrosine kinase", "code": { "@type": "MedicalCode", "code": "D000077329", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.025" } } }, { "@type": "MedicalWebPage", "name": "Focal adhesion protein-tyrosine kinases", "alternateName": "Focal Adhesion Protein-Tyrosine Kinases", "url": "https://questionsmedicales.fr/mesh/D051416", "about": { "@type": "MedicalCondition", "name": "Focal adhesion protein-tyrosine kinases", "code": { "@type": "MedicalCode", "code": "D051416", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.049" } } }, { "@type": "MedicalWebPage", "name": "Janus kinases", "alternateName": "Janus Kinases", "url": "https://questionsmedicales.fr/mesh/D053612", "about": { "@type": "MedicalCondition", "name": "Janus kinases", "code": { "@type": "MedicalCode", "code": "D053612", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Janus kinase 1", "alternateName": "Janus Kinase 1", "url": "https://questionsmedicales.fr/mesh/D053613", "about": { "@type": "MedicalCondition", "name": "Janus kinase 1", "code": { "@type": "MedicalCode", "code": "D053613", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.100" } } }, { "@type": "MedicalWebPage", "name": "Janus kinase 3", "alternateName": "Janus Kinase 3", "url": "https://questionsmedicales.fr/mesh/D053616", "about": { "@type": "MedicalCondition", "name": "Janus kinase 3", "code": { "@type": "MedicalCode", "code": "D053616", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.300" } } }, { "@type": "MedicalWebPage", "name": "TYK2 Kinase", "alternateName": "TYK2 Kinase", "url": "https://questionsmedicales.fr/mesh/D053634", "about": { "@type": "MedicalCondition", "name": "TYK2 Kinase", "code": { "@type": "MedicalCode", "code": "D053634", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.124.650" } } } ] }, { "@type": "MedicalWebPage", "name": "Mitogen-Activated Protein Kinase Kinases", "alternateName": "Mitogen-Activated Protein Kinase Kinases", "url": "https://questionsmedicales.fr/mesh/D020929", "about": { "@type": "MedicalCondition", "name": "Mitogen-Activated Protein Kinase Kinases", "code": { "@type": "MedicalCode", "code": "D020929", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 1", "alternateName": "MAP Kinase Kinase 1", "url": "https://questionsmedicales.fr/mesh/D048369", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 1", "code": { "@type": "MedicalCode", "code": "D048369", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.100" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 2", "alternateName": "MAP Kinase Kinase 2", "url": "https://questionsmedicales.fr/mesh/D048370", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 2", "code": { "@type": "MedicalCode", "code": "D048370", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.200" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 3", "alternateName": "MAP Kinase Kinase 3", "url": "https://questionsmedicales.fr/mesh/D048371", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 3", "code": { "@type": "MedicalCode", "code": "D048371", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.300" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 4", "alternateName": "MAP Kinase Kinase 4", "url": "https://questionsmedicales.fr/mesh/D048670", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 4", "code": { "@type": "MedicalCode", "code": "D048670", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.400" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 5", "alternateName": "MAP Kinase Kinase 5", "url": "https://questionsmedicales.fr/mesh/D048671", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 5", "code": { "@type": "MedicalCode", "code": "D048671", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.500" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 6", "alternateName": "MAP Kinase Kinase 6", "url": "https://questionsmedicales.fr/mesh/D048669", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 6", "code": { "@type": "MedicalCode", "code": "D048669", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.600" } } }, { "@type": "MedicalWebPage", "name": "MAP Kinase Kinase 7", "alternateName": "MAP Kinase Kinase 7", "url": "https://questionsmedicales.fr/mesh/D048688", "about": { "@type": "MedicalCondition", "name": "MAP Kinase Kinase 7", "code": { "@type": "MedicalCode", "code": "D048688", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.200.700" } } } ] }, { "@type": "MedicalWebPage", "name": "Syk kinase", "alternateName": "Syk Kinase", "url": "https://questionsmedicales.fr/mesh/D000072377", "about": { "@type": "MedicalCondition", "name": "Syk kinase", "code": { "@type": "MedicalCode", "code": "D000072377", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.650" } } }, { "@type": "MedicalWebPage", "name": "src-Family kinases", "alternateName": "src-Family Kinases", "url": "https://questionsmedicales.fr/mesh/D019061", "about": { "@type": "MedicalCondition", "name": "src-Family kinases", "code": { "@type": "MedicalCode", "code": "D019061", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.800" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "CSK tyrosine-protein kinase", "alternateName": "CSK Tyrosine-Protein Kinase", "url": "https://questionsmedicales.fr/mesh/D000081247", "about": { "@type": "MedicalCondition", "name": "CSK tyrosine-protein kinase", "code": { "@type": "MedicalCode", "code": "D000081247", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.800.158" } } } ] }, { "@type": "MedicalWebPage", "name": "ZAP-70 Protein-tyrosine kinase", "alternateName": "ZAP-70 Protein-Tyrosine Kinase", "url": "https://questionsmedicales.fr/mesh/D051746", "about": { "@type": "MedicalCondition", "name": "ZAP-70 Protein-tyrosine kinase", "code": { "@type": "MedicalCode", "code": "D051746", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.476.568.900" } } } ], "about": { "@type": "MedicalCondition", "name": "Protein-tyrosine kinases", "alternateName": "Protein-Tyrosine Kinases", "code": { "@type": "MedicalCode", "code": "D011505", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Angela L Tyner", "url": "https://questionsmedicales.fr/author/Angela%20L%20Tyner", "affiliation": { "@type": "Organization", "name": "Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, Chicago, Illinois, USA; University of Illinois Cancer Center, University of Illinois at Chicago, Chicago, Illinois, USA. Electronic address: atyner@uic.edu." } }, { "@type": "Person", "name": "Eiji Kinoshita", "url": "https://questionsmedicales.fr/author/Eiji%20Kinoshita", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Emiko Kinoshita-Kikuta", "url": "https://questionsmedicales.fr/author/Emiko%20Kinoshita-Kikuta", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Tohru Koike", "url": "https://questionsmedicales.fr/author/Tohru%20Koike", "affiliation": { "@type": "Organization", "name": "Department of Functional Molecular Science, Institute of Biomedical & Health Sciences, Hiroshima University, Hiroshima 734-8553, Japan." } }, { "@type": "Person", "name": "Gongqin Sun", "url": "https://questionsmedicales.fr/author/Gongqin%20Sun", "affiliation": { "@type": "Organization", "name": "Department of Cell and Molecular Biology, University of Rhode Island, Kingston, RI, United States." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.", "datePublished": "2023-11-13", "url": "https://questionsmedicales.fr/article/37957759", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s13054-023-04676-3" } }, { "@type": "ScholarlyArticle", "name": "Axonal polyneuropathy and ataxia in children: consider Perrault Syndrome, a case report.", "datePublished": "2023-11-06", "url": "https://questionsmedicales.fr/article/37932750", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12920-023-01599-4" } }, { "@type": "ScholarlyArticle", "name": "Natural history and survival rate of familial amyloidosis with polyneuropathy: A nationwide databank.", "datePublished": "2023-04-12", "url": "https://questionsmedicales.fr/article/37042639", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1002/acn3.51765" } }, { "@type": "ScholarlyArticle", "name": "Early-onset motor polyneuropathy associated with a novel dominant NAGLU mutation.", "datePublished": "2023-01-17", "url": "https://questionsmedicales.fr/article/36648562", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1007/s10072-023-06607-0" } }, { "@type": "ScholarlyArticle", "name": "Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial.", "datePublished": "2022-09-18", "url": "https://questionsmedicales.fr/article/36120830", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1080/13506129.2022.2118043" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines et peptides de signalisation intracellulaire", "item": "https://questionsmedicales.fr/mesh/D047908" }, { "@type": "ListItem", "position": 5, "name": "Protein-tyrosine kinases", "item": "https://questionsmedicales.fr/mesh/D011505" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Protein-tyrosine kinases - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Protein-tyrosine kinases", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-17", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Protein-tyrosine kinases", "description": "Comment diagnostiquer une dysrégulation des kinases à tyrosine ?\nQuels marqueurs sont utilisés pour le diagnostic ?\nLes tests génétiques sont-ils utiles ?\nQuels examens d'imagerie sont recommandés ?\nLes antécédents familiaux influencent-ils le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Protein-tyrosine kinases", "description": "Quels symptômes sont liés à une suractivité des kinases ?\nLes symptômes varient-ils selon le type de kinase ?\nY a-t-il des symptômes spécifiques aux cancers ?\nLes symptômes peuvent-ils être confondus avec d'autres maladies ?\nComment les symptômes évoluent-ils dans le temps ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Protein-tyrosine kinases", "description": "Peut-on prévenir les dysfonctionnements des kinases ?\nLes dépistages réguliers sont-ils recommandés ?\nY a-t-il des vaccins préventifs ?\nLe tabagisme influence-t-il le risque ?\nLes facteurs environnementaux jouent-ils un rôle ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Protein-tyrosine kinases", "description": "Quels traitements ciblent les kinases à tyrosine ?\nLes traitements sont-ils personnalisés ?\nQuels effets secondaires des traitements sont courants ?\nLa radiothérapie est-elle utilisée ?\nLes traitements sont-ils efficaces à long terme ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Protein-tyrosine kinases", "description": "Quelles complications peuvent survenir avec les kinases ?\nLes complications sont-elles réversibles ?\nComment les complications affectent-elles le pronostic ?\nLes complications varient-elles selon le type de cancer ?\nLes complications nécessitent-elles des traitements supplémentaires ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Protein-tyrosine kinases", "description": "Quels sont les principaux facteurs de risque ?\nL'âge influence-t-il le risque de dysfonctionnement des kinases ?\nLe mode de vie joue-t-il un rôle ?\nLes infections peuvent-elles être un facteur de risque ?\nY a-t-il des facteurs génétiques impliqués ?", "url": "https://questionsmedicales.fr/mesh/D011505?mesh_terms=Polyneuropathies&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysrégulation des kinases à tyrosine ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests sanguins et des biopsies peuvent révéler des anomalies dans l'activité des kinases." } }, { "@type": "Question", "name": "Quels marqueurs sont utilisés pour le diagnostic ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les marqueurs tumoraux comme le CA 19-9 peuvent indiquer une activité kinase anormale." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils utiles ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent identifier des mutations dans les gènes codant pour les kinases à tyrosine." } }, { "@type": "Question", "name": "Quels examens d'imagerie sont recommandés ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "L'IRM et le scanner peuvent aider à visualiser les tumeurs associées aux kinases." } }, { "@type": "Question", "name": "Les antécédents familiaux influencent-ils le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents de cancers peuvent augmenter le risque de dysrégulation des kinases." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une suractivité des kinases ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, perte de poids, et douleurs osseuses peuvent indiquer une suractivité des kinases." } }, { "@type": "Question", "name": "Les symptômes varient-ils selon le type de kinase ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les symptômes dépendent du type de kinase et de la voie de signalisation affectée." } }, { "@type": "Question", "name": "Y a-t-il des symptômes spécifiques aux cancers ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme des masses palpables ou des saignements peuvent survenir." } }, { "@type": "Question", "name": "Les symptômes peuvent-ils être confondus avec d'autres maladies ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des symptômes comme la fatigue peuvent être communs à plusieurs maladies." } }, { "@type": "Question", "name": "Comment les symptômes évoluent-ils dans le temps ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent s'aggraver progressivement, nécessitant une surveillance régulière." } }, { "@type": "Question", "name": "Peut-on prévenir les dysfonctionnements des kinases ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation saine et l'exercice régulier peuvent réduire le risque de cancers." } }, { "@type": "Question", "name": "Les dépistages réguliers sont-ils recommandés ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dépistages peuvent aider à détecter précocement des anomalies liées aux kinases." } }, { "@type": "Question", "name": "Y a-t-il des vaccins préventifs ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des kinases." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il le risque ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme est un facteur de risque connu pour plusieurs cancers liés aux kinases." } }, { "@type": "Question", "name": "Les facteurs environnementaux jouent-ils un rôle ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des substances chimiques peut augmenter le risque de dysfonctionnement des kinases." } }, { "@type": "Question", "name": "Quels traitements ciblent les kinases à tyrosine ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Les inhibiteurs de kinases, comme l'imatinib, sont utilisés pour traiter certains cancers." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases." } }, { "@type": "Question", "name": "Quels effets secondaires des traitements sont courants ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, nausées et éruptions cutanées sont des effets secondaires fréquents." } }, { "@type": "Question", "name": "La radiothérapie est-elle utilisée ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la radiothérapie peut être utilisée en complément des traitements ciblés." } }, { "@type": "Question", "name": "Les traitements sont-ils efficaces à long terme ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "L'efficacité varie, mais certains patients peuvent bénéficier d'une rémission prolongée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec les kinases ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme la résistance aux traitements et la progression de la maladie peuvent survenir." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes." } }, { "@type": "Question", "name": "Comment les complications affectent-elles le pronostic ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Les complications peuvent aggraver le pronostic et réduire les chances de rémission." } }, { "@type": "Question", "name": "Les complications varient-elles selon le type de cancer ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les complications peuvent différer selon le type de cancer et la kinase impliquée." } }, { "@type": "Question", "name": "Les complications nécessitent-elles des traitements supplémentaires ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des traitements supplémentaires peuvent être nécessaires pour gérer les complications." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les antécédents familiaux, le tabagisme et l'exposition à des produits chimiques sont des facteurs de risque." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque de dysfonctionnement des kinases ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque augmente généralement avec l'âge, surtout pour certains cancers." } }, { "@type": "Question", "name": "Le mode de vie joue-t-il un rôle ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque." } }, { "@type": "Question", "name": "Les infections peuvent-elles être un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Certaines infections virales, comme le virus d'Epstein-Barr, peuvent augmenter le risque." } }, { "@type": "Question", "name": "Y a-t-il des facteurs génétiques impliqués ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des mutations génétiques héréditaires peuvent prédisposer à des dysfonctionnements des kinases." } } ] } ] }

Sous-catégories

18 au total
└─

Agammaglobulinaemia tyrosine kinase

Agammaglobulinaemia Tyrosine Kinase D000077329 - D12.776.476.568.025
└─

Focal adhesion protein-tyrosine kinases

Focal Adhesion Protein-Tyrosine Kinases D051416 - D12.776.476.568.049
└─

Janus kinases

Janus Kinases D053612 - D12.776.476.568.124
└─

Mitogen-Activated Protein Kinase Kinases

Mitogen-Activated Protein Kinase Kinases D020929 - D12.776.476.568.200
└─

Syk kinase

Syk Kinase D000072377 - D12.776.476.568.650
└─

src-Family kinases

src-Family Kinases D019061 - D12.776.476.568.800
└─

ZAP-70 Protein-tyrosine kinase

ZAP-70 Protein-Tyrosine Kinase D051746 - D12.776.476.568.900
└─└─

Janus kinase 1

Janus Kinase 1 D053613 - D12.776.476.568.124.100
└─└─

Janus kinase 3

Janus Kinase 3 D053616 - D12.776.476.568.124.300
└─└─

TYK2 Kinase

TYK2 Kinase D053634 - D12.776.476.568.124.650
└─└─

MAP Kinase Kinase 1

MAP Kinase Kinase 1 D048369 - D12.776.476.568.200.100
└─└─

MAP Kinase Kinase 2

MAP Kinase Kinase 2 D048370 - D12.776.476.568.200.200
└─└─

MAP Kinase Kinase 3

MAP Kinase Kinase 3 D048371 - D12.776.476.568.200.300
└─└─

MAP Kinase Kinase 4

MAP Kinase Kinase 4 D048670 - D12.776.476.568.200.400
└─└─

MAP Kinase Kinase 5

MAP Kinase Kinase 5 D048671 - D12.776.476.568.200.500
└─└─

MAP Kinase Kinase 6

MAP Kinase Kinase 6 D048669 - D12.776.476.568.200.600
└─└─

MAP Kinase Kinase 7

MAP Kinase Kinase 7 D048688 - D12.776.476.568.200.700
└─└─

CSK tyrosine-protein kinase

CSK Tyrosine-Protein Kinase D000081247 - D12.776.476.568.800.158

Sources (442 au total)

Illness Weakness, Polyneuropathy and Myopathy: Diagnosis, treatment, and long-term outcomes.

Severe weakness associated with critical illness (CIW) is common. This narrative review summarizes the latest scientific insights and proposes a guide for clinicians to optimize the diagnosis and mana... CIW arises as diffuse, symmetrical weakness after ICU admission, which is an important differentiating factor from other diseases causing non-symmetrical muscle weakness or paralysis. In patients with... Early ICU mobilization combined with the best evidence-based ICU practices can effectively reduce short-term weakness. Multi-professional collaborations are needed to guarantee a multi-dimensional eva...

Axonal polyneuropathy and ataxia in children: consider Perrault Syndrome, a case report.

Perrault Syndrome (PRLTS) is a rare, autosomal recessive disorder that presents with bilateral sensorineural hearing loss in all patients and gonadal dysfunction in females. It has been linked to vari... A 4.5-year-old female presented to neuromuscular clinic due to ataxia. Neurological examination revealed truncal ataxia and steppage gait, reduced deep tendon reflexes, and axonal sensorimotor polyneu... Perrault Syndrome should be considered in the differential for children who present with bilateral sensorineural hearing loss, axonal polyneuropathy, and ataxia. Further examination includes testing f...

Natural history and survival rate of familial amyloidosis with polyneuropathy: A nationwide databank.

Hereditary amyloid transthyretin (ATTRv) amyloidosis with polyneuropathy, a rare autosomal-dominant disease, has gained attention in recent years owing to treatment improvements. However, epidemiologi... Taiwan National Health Insurance Research Database contains data from over 23 million individuals; Among them, 175 ATTRv amyloidosis patients validated by rare disease registry were enrolled. Multivar... From 2008 to 2020, the annual incidence and prevalence rates of specific mutations (Ala97Ser) leading to ATTRv amyloidosis with polyneuropathy were 0.04-1.14 and 0.04-4.79 per million in Taiwan, respe... The annual prevalence rate of specific mutation (Ala97Ser)-dominant ATTRv amyloidosis with polyneuropathy in Taiwan is comparable to the mid- to high-prevalence country level of the research by Schmid...

Early-onset motor polyneuropathy associated with a novel dominant NAGLU mutation.

NAGLU encodes N-acetyl-alpha-glucosaminidase, an enzyme that degrades heparan sulfate. Biallelic NAGLU mutations cause mucopolysaccharidosis IIIB, a severe childhood-onset neurodegenerative disease, w... Here we describe a patient with early-onset motor polyneuropathy harboring a novel monoallelic NAGLU mutation. We found reduced NAGLU enzymatic activity thus corroborating the pathogenic role of the n... Our report represents the second ever described case with dominant NAGLU-related neuropathy and the first case with early-onset motor symptoms. We underlie the importance of a thorough clinical descri...

Impact of baseline polyneuropathy severity on patisiran treatment outcomes in the APOLLO trial.

Assess how baseline polyneuropathy severity impacts response to patisiran regarding neurologic impairment and quality of life (QOL) in patients with hereditary transthyretin-mediated amyloidosis (ATTR... This... Across all baseline NIS quartiles, patisiran improved several clinical markers of disease compared with placebo at 18 months. Patients in lower NIS quartiles, treated with patisiran earlier in the dis... Patisiran treatment improved neurologic function and QOL across a wide range of baseline polyneuropathy severities versus placebo. Timing of treatment initiation in patients with ATTRv amyloidosis rem...

Ultrasound of cervical nerve root enlargement in polyneuropathy is not confounded by neuroforaminal stenoses.

Ultrasound can detect enlargement of cervical nerve roots, which has been described in polyneuropathies (PNP), mainly of demyelinating pathology. This study investigates whether neuroforaminal stenosi... We retrospectively studied 182 patients (62 demyelinating, 71 axonal PNP; 49 without evidence of PNP) who had undergone ultrasound of the cervical nerve roots C5 and C6 and magnetic resonance or compu... Patients with demyelinating PNP had larger nerve roots than those with axonal/without PNP. No significant differences in cervical nerve root diameters were found between groups with vs. without neurof... Neuroforaminal stenosis per se does not entail relevant cervical nerve root enlargement detectable by nerve ultrasound.... Ultrasound assessment of cervical nerve root size in the diagnostic evaluation of PNP is unlikely to be confounded by common degenerative changes of the cervical spine....

The impact of inotersen on Neuropathy Impairment Score in patients with hereditary transthyretin amyloidosis with polyneuropathy.

Patients with hereditary transthyretin amyloidosis (ATTRv) frequently experience symptoms of polyneuropathy (PN) that worsen over time and impair daily functioning. Previous analyses supported efficac... Post hoc analyses used data from the NEURO-TTR phase 3 trial of inotersen in patients with ATTRv-PN (NCT01737398). Treatment differences in mean changes on NIS/NIS-LL total and subscale scores from ba... Within each patient subgroup, mean increases in NIS/NIS-LL total and muscle weakness subscales were significantly smaller after 65 weeks of treatment with inotersen compared to placebo. Similar patter... This study supports previous evidence for efficacy of inotersen in this patient population and provides interpretation guidelines for clinically meaningful changes in NIS/NIS-LL scores....

Serum neurofilament light chain: a novel biomarker for early diabetic sensorimotor polyneuropathy.

No established blood-based biomarker exists to monitor diabetic sensorimotor polyneuropathy (DSPN) and evaluate treatment response. The neurofilament light chain (NFL), a blood biomarker of neuroaxona... This cross-sectional study included 423 adults with type 1 and type 2 diabetes and known diabetes duration of less than 1 year from the prospective observational German Diabetes Study cohort. NFL was ... DSPN was found in 16% of the study sample. Serum NFL levels increased with age. After adjustment for age, sex, waist circumference, height, HbA... Our findings in individuals recently diagnosed with diabetes provide new evidence associating higher serum NFL levels with DSPN and peripheral nerve dysfunction. The present study advocates NFL as a p...

Nitrous oxide-induced polyneuropathy, pancytopenia and pulmonary embolism: a case report.

Nitrous oxide is a medical and household gas that has seen its use drift to recreational purpose among the young population in recent years. Significant neurological, hematological and psychiatric sid... A 22-year-old woman of North African origin experienced an exceptional combination of polyneuropathy, bilateral pulmonary embolism and severe pancytopenia related to vitamin B12 deficiency and hyperho... This case report brings elements to support our knowledge about pathological pathway, recovery and prognosis of recreational N2O abuse complications. The general and medical population should be aware...