Comment diagnostiquer une dysrégulation des kinases à tyrosine ?

Des tests sanguins et des biopsies peuvent révéler des anomalies dans l'activité des kinases.

Quels marqueurs sont utilisés pour le diagnostic ?

Les marqueurs tumoraux comme le CA 19-9 peuvent indiquer une activité kinase anormale.

Les tests génétiques sont-ils utiles ?

Oui, ils peuvent identifier des mutations dans les gènes codant pour les kinases à tyrosine.

Quels examens d'imagerie sont recommandés ?

L'IRM et le scanner peuvent aider à visualiser les tumeurs associées aux kinases.

Les antécédents familiaux influencent-ils le diagnostic ?

Oui, des antécédents de cancers peuvent augmenter le risque de dysrégulation des kinases.

Quels symptômes sont liés à une suractivité des kinases ?

Fatigue, perte de poids, et douleurs osseuses peuvent indiquer une suractivité des kinases.

Les symptômes varient-ils selon le type de kinase ?

Oui, les symptômes dépendent du type de kinase et de la voie de signalisation affectée.

Y a-t-il des symptômes spécifiques aux cancers ?

Oui, des symptômes comme des masses palpables ou des saignements peuvent survenir.

Les symptômes peuvent-ils être confondus avec d'autres maladies ?

Oui, des symptômes comme la fatigue peuvent être communs à plusieurs maladies.

Comment les symptômes évoluent-ils dans le temps ?

Ils peuvent s'aggraver progressivement, nécessitant une surveillance régulière.

Peut-on prévenir les dysfonctionnements des kinases ?

Une alimentation saine et l'exercice régulier peuvent réduire le risque de cancers.

Les dépistages réguliers sont-ils recommandés ?

Oui, des dépistages peuvent aider à détecter précocement des anomalies liées aux kinases.

Y a-t-il des vaccins préventifs ?

Actuellement, il n'existe pas de vaccins spécifiques pour prévenir les dysfonctionnements des kinases.

Le tabagisme influence-t-il le risque ?

Oui, le tabagisme est un facteur de risque connu pour plusieurs cancers liés aux kinases.

Les facteurs environnementaux jouent-ils un rôle ?

Oui, l'exposition à des substances chimiques peut augmenter le risque de dysfonctionnement des kinases.

Quels traitements ciblent les kinases à tyrosine ?

Les inhibiteurs de kinases, comme l'imatinib, sont utilisés pour traiter certains cancers.

Les traitements sont-ils personnalisés ?

Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases.

Quels effets secondaires des traitements sont courants ?

Fatigue, nausées et éruptions cutanées sont des effets secondaires fréquents.

La radiothérapie est-elle utilisée ?

Oui, la radiothérapie peut être utilisée en complément des traitements ciblés.

Les traitements sont-ils efficaces à long terme ?

L'efficacité varie, mais certains patients peuvent bénéficier d'une rémission prolongée.

Quelles complications peuvent survenir avec les kinases ?

Des complications comme la résistance aux traitements et la progression de la maladie peuvent survenir.

Les complications sont-elles réversibles ?

Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.

Comment les complications affectent-elles le pronostic ?

Les complications peuvent aggraver le pronostic et réduire les chances de rémission.

Les complications varient-elles selon le type de cancer ?

Oui, les complications peuvent différer selon le type de cancer et la kinase impliquée.

Les complications nécessitent-elles des traitements supplémentaires ?

Oui, des traitements supplémentaires peuvent être nécessaires pour gérer les complications.

Quels sont les principaux facteurs de risque ?

Les antécédents familiaux, le tabagisme et l'exposition à des produits chimiques sont des facteurs de risque.

L'âge influence-t-il le risque de dysfonctionnement des kinases ?

Oui, le risque augmente généralement avec l'âge, surtout pour certains cancers.

Le mode de vie joue-t-il un rôle ?

Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque.

Les infections peuvent-elles être un facteur de risque ?

Certaines infections virales, comme le virus d'Epstein-Barr, peuvent augmenter le risque.

Y a-t-il des facteurs génétiques impliqués ?

Oui, des mutations génétiques héréditaires peuvent prédisposer à des dysfonctionnements des kinases.

Protein-tyrosine kinases - Informations médicales vérifiées

Prevention of the social isolation of older persons: the impact of community environmental satisfaction on social isolation.

2023

DOI: 10.3389/fpubh.2023.1177483 PMID: 37342271

To explore how to prevent the social isolation of the older adult, this study constructed a model of the influence of community environmental satisfaction on the social isolation of the older adult fr... (1) Environmental facilities, transportation, and community surrounding facilities promoted community environment satisfaction (... Environmental satisfaction can directly affect the social isolation of the older adult in the community and can be used as an intermediate variable of environmental facilities, transportation, and sur...

Social Isolation Social Environment Personal Satisfaction Environment

Sex-dependent signaling of social isolation.

19 07 2022

DOI: 10.1126/scisignal.add9512 PMID: 35857634

The neurological effects of social isolation stress differ between males and females....

Female Humans Male Sex Characteristics Signal Transduction +2 autres

The pandemic and social experience: For whom did discrimination and social isolation increase?

Jan 2024

DOI: 10.1037/cdp0000561 PMID: 36095238

The objective of this study was to examine whether experiences of discrimination have increased during the pandemic, particularly among negatively stigmatized racial/ethnic groups, and whether such ex... Discrimination and social isolation were assessed before and during the pandemic in a sample of 263 Black and White young adults attending a large, predominantly White 4-year research university in th... Increases in discrimination were evident among Black but not White participants. Black participants also reported greater increases in social isolation than White participants, and changes in discrimi... Findings are consistent with theoretical perspectives on discrimination during times of stress and suggest the need for broader attention to the impact of the pandemic on unfair treatment of stigmatiz...

Female Humans Male Young Adult Emotions +8 autres

Emotional and social loneliness and their unique links with social isolation, depression and anxiety.

15 05 2023

DOI: 10.1016/j.jad.2023.02.096 PMID: 36842647

Loneliness and social isolation are known to be associated with depression, general anxiety, and social anxiety. However, knowledge on the overlapping and unique features of these relationships, while... We constructed a network analysis to examine the relationships between self-reported social loneliness, emotional loneliness, social isolation, depression, general anxiety and social anxiety in a larg... The network analysis showed that social loneliness was most strongly explained by social isolation, whereas emotional loneliness was most strongly explained by social anxiety and depression. General a... Differences found between loneliness types may be influenced by a methodological artifact of the DJGLS.... These findings highlight the importance of social anxiety over general anxiety in relation to loneliness. Also, it showed unique relationships for social- and emotional loneliness with psycho-social v...

Female Humans Young Adult Adult Child, Preschool +6 autres

Gender and Social Isolation across the Life Course.

09 2022

DOI: 10.1177/00221465221109634 PMID: 35856404

Social isolation has robust adverse effects on health, well-being, dementia risk, and longevity. Although most studies suggest similar effects of isolation on the health of men and women, there has be...

Adolescent Female Humans Life Change Events Male +3 autres

Sociodemographic Heterogeneity in the Associations of Social Isolation With Mortality.

01 May 2024

DOI: 10.1001/jamanetworkopen.2024.13132 PMID: 38787557

There are limited data on whether the vulnerabilities and impacts of social isolation vary across populations.... To explore the association between social isolation and mortality due to all causes, cardiovascular diseases (CVD), and malignant neoplasms focusing on heterogeneity by sociodemographic factors.... This cohort study used a moderator-wide approach to examine the heterogeneity in the association of social isolation with all-cause, CVD, and malignant neoplasm mortality using baseline data from the ... Social isolation, determined by a 3-item scale (scores of 2 or 3 indicating isolation) was the primary exposure variable.... Six-year all-cause, CVD, and malignant neoplasms mortality.... This study included 37 604 older adults, with a mean (SD) age of 73.5 (5.9) years (21 073 women [56.0%]). A total of 10 094 participants (26.8%) were classified as experiencing social isolation. Socia... Social isolation was associated with increased risks of all-cause, CVD, and malignant neoplasm mortality, with associations varying across populations. This study fills an important gap in research on...

Humans Social Isolation Female Male Aged +9 autres

Climate Anxiety, Loneliness and Perceived Social Isolation.

14 11 2022

DOI: 10.3390/ijerph192214991 PMID: 36429713

The goal of this study was to investigate the association of climate anxiety with loneliness and perceived social isolation (also stratified by age group).... Data were taken from the general adult population aged 18 to 74 years (n = 3091). Data collection took place in March 2022. Climate anxiety was measured using the Climate Anxiety Scale. The De Jong Gi... Multiple linear regressions revealed an association between higher climate anxiety and higher loneliness (β = 0.06,... Our current study adds first evidence regarding the link between climate anxiety and loneliness as well as perceived social isolation and can serve as a basis for upcoming studies....

Adult Humans Loneliness Social Isolation Anxiety Disorders +2 autres

Social isolation and social connectedness among young adult cancer survivors: A systematic review.

01 10 2023

DOI: 10.1002/cncr.34934 PMID: 37489837

Social isolation and connectedness are social determinants of health that have demonstrated effects on cancer-related outcomes. These constructs have been systematically evaluated among pediatric and ... Peer-reviewed articles published in English before June 2021 were identified from database searches and included articles' reference lists according to PRISMA (Preferred Reporting Items for Systematic... In total, 5094 unique records were identified; 4143 were excluded after title/abstract screening, and 907 were excluded after full-text review. Forty-four articles were included. Few studies used vali... This growing literature underscores the relevance of social isolation and connectedness as important health determinants among YA cancer survivors. The identified risk and protective factors can ident...

Humans Young Adult Child Aged Cancer Survivors +2 autres

Economic gradients in loneliness, social isolation and social support: Evidence from the UK Biobank.

08 2022

DOI: 10.1016/j.socscimed.2022.115122 PMID: 35751988

Despite the substantial literature on how loneliness is associated with poor health and premature mortality, there is little detailed research on the extent of its economic gradients. We provide this ...

Biological Specimen Banks Female Humans Loneliness Male +4 autres

Social-Ecological Correlates of Social Isolation as a Structural Indicator of Social Connectedness Among Young Adult U.S. Males.

11 2022

DOI: 10.1177/08901171221103755 PMID: 35606679

We examined the intrapersonal, interpersonal, community, and societal correlates of a structural indicator of social connectedness (ie, social isolation) among a sample of young adult U.S. males.... Cross-sectional. Setting: Online survey.... Males (n = 495) aged 18-25 years residing in the U.S.... Social isolation was assessed as an index measure of social integration (inverse scored). The correlates consisted of the following variables: 1) intrapersonal (eg, social-demographic characteristics)... Four-block hierarchical regression.... The intra- and interpersonal variables significantly shared 17% and an incremental 5%, respectively, of the explained variance in social isolation. Several intra- (eg, financial vulnerability β... The current study's findings have important implications for understanding and shaping social connectedness in young adult U.S. males, with micro-level influences potentially being most important in p...

Male Young Adult Humans Adolescent Adult +5 autres

Protein-tyrosine kinases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Agammaglobulinaemia tyrosine kinase

Focal adhesion protein-tyrosine kinases

Janus kinases

Mitogen-Activated Protein Kinase Kinases

Syk kinase

src-Family kinases

ZAP-70 Protein-tyrosine kinase

Janus kinase 1

Janus kinase 3

TYK2 Kinase

MAP Kinase Kinase 1

MAP Kinase Kinase 2

MAP Kinase Kinase 3

MAP Kinase Kinase 4

MAP Kinase Kinase 5

MAP Kinase Kinase 6

MAP Kinase Kinase 7

CSK tyrosine-protein kinase

Auteurs principaux

Sources (10000 au total)