questionsmedicales.fr
Composés hétérocycliques
Composés hétéromonocycliques
Pipérazines
Trimétazidine
Trimétazidine : Questions médicales fréquentes
Diagnostic
5
Angine de poitrine
Électrocardiographie
Échocardiographie
Tests de stress
Ischémie myocardique
Symptômes
Efficacité thérapeutique
Angine de poitrine
Angiographie
Imagerie médicale
Symptômes
5
Angine de poitrine
Symptômes
Effets secondaires
Vertiges
Crise angineuse
Douleur thoracique
Consultation urgente
Essoufflement
Traitement
Tolérance à l'effort
Prévention
5
Prévention
Mode de vie sain
Tabagisme
Maladies cardiaques
Bilan de santé
Cholestérol
Exercice physique
Circulation sanguine
Gestion du stress
Méditation
Traitements
5
Métabolisme cellulaire
Consommation d'oxygène
Bêtabloquants
Inhibiteurs calciques
Posologie
Administration orale
Efficacité
Caractéristiques individuelles
Effets indésirables
Arrêt du traitement
Complications
5
Infarctus du myocarde
Insuffisance cardiaque
Complications
Troubles du mouvement
Prévention
Facteurs de risque
Signes d'alerte
Attention médicale
Facteurs de risque
5
Facteurs de risque
Hypertension
Cholestérol
Maladies coronariennes
Hérédité
Antécédents familiaux
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Comment évaluer l'efficacité de la trimétazidine ?",
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"@type": "Question",
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"@type": "Question",
"name": "Quels sont les symptômes de l'angine de poitrine ?",
"position": 6,
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"@type": "Question",
"name": "La trimétazidine peut-elle provoquer des effets secondaires ?",
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"@type": "Question",
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"position": 8,
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{
"@type": "Question",
"name": "Quels signes d'alerte nécessitent une consultation urgente ?",
"position": 9,
"acceptedAnswer": {
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"text": "Douleur thoracique persistante, essoufflement sévère ou évanouissement."
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"@type": "Question",
"name": "La trimétazidine soulage-t-elle immédiatement les symptômes ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle agit sur le long terme pour améliorer la tolérance à l'effort."
}
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{
"@type": "Question",
"name": "Comment prévenir l'angine de poitrine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Adopter un mode de vie sain : alimentation équilibrée, exercice régulier et gestion du stress."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il l'angine de poitrine ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme augmente le risque de maladies cardiaques, y compris l'angine."
}
},
{
"@type": "Question",
"name": "Quels examens préventifs sont recommandés ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des bilans de santé réguliers, y compris des tests de cholestérol et de pression artérielle."
}
},
{
"@type": "Question",
"name": "L'exercice physique aide-t-il à prévenir l'angine ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier renforce le cœur et améliore la circulation sanguine."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress pour prévenir l'angine ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques comme la méditation, le yoga et la thérapie peuvent aider."
}
},
{
"@type": "Question",
"name": "Comment la trimétazidine agit-elle sur le cœur ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle améliore le métabolisme cellulaire et réduit la consommation d'oxygène par le cœur."
}
},
{
"@type": "Question",
"name": "Quels autres traitements sont associés à la trimétazidine ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les bêtabloquants, les inhibiteurs calciques et les nitrates sont souvent utilisés."
}
},
{
"@type": "Question",
"name": "Quelle est la posologie habituelle de trimétazidine ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "La posologie standard est de 35 mg par jour, répartie en deux ou trois prises."
}
},
{
"@type": "Question",
"name": "La trimétazidine est-elle efficace pour tous les patients ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est généralement efficace, mais son utilisation dépend des caractéristiques individuelles."
}
},
{
"@type": "Question",
"name": "Quels sont les critères d'arrêt du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'arrêt est envisagé en cas d'effets indésirables graves ou d'inefficacité."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles de l'angine de poitrine ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent l'infarctus du myocarde et l'insuffisance cardiaque."
}
},
{
"@type": "Question",
"name": "La trimétazidine peut-elle causer des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications rares comme des troubles du mouvement peuvent survenir avec la trimétazidine."
}
},
{
"@type": "Question",
"name": "Comment prévenir les complications cardiaques ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "En suivant un traitement approprié, en contrôlant les facteurs de risque et en adoptant un mode de vie sain."
}
},
{
"@type": "Question",
"name": "Quels signes indiquent une complication grave ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Douleur thoracique intense, sueurs, nausées ou perte de conscience nécessitent une attention immédiate."
}
},
{
"@type": "Question",
"name": "Les complications de l'angine sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement rapide et approprié."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque de l'angine ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'hypertension, le diabète, le tabagisme et l'obésité."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque d'angine ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'angine augmente avec l'âge, surtout après 45 ans chez les hommes."
}
},
{
"@type": "Question",
"name": "Le stress est-il un facteur de risque pour l'angine ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à l'augmentation du risque cardiaque."
}
},
{
"@type": "Question",
"name": "Comment le cholestérol affecte-t-il le risque d'angine ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un taux élevé de cholestérol LDL augmente le risque de maladies coronariennes et d'angine."
}
},
{
"@type": "Question",
"name": "L'hérédité joue-t-elle un rôle dans le risque d'angine ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies cardiaques augmentent le risque d'angine."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 06/07/2026
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan, China.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan, China.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan, China.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Doctoral School of Clinical Neuroscience, Medical School, University of Pécs, Pécs, Hungary.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Medical School, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Department of Neurology, Medical School, University of Pécs, Pécs, Hungary; MTA-PTE Clinical Neuroscience MR Research Group, Pécs, Hungary. Electronic address: kovacsnorbert06@gmail.com.
Publications dans "Trimétazidine" :
3 publications dans cette catégorie
Affiliations :
Department of Physiology, School of Medicine, Hamadan University of Medical Sciences, Hamadan, Iran. F.ramezani@umsha.ac.ir.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopaedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Division of Cardiology, Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Hubei Key Laboratory of Genetics and Molecular Mechanism of Cardiologic Disorders, Huazhong University of Science and Technology, Wuhan, China.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Faculty of Pharmacy, Karadeniz Technical University, Trabzon, Turkey.
Drug and Pharmaceutical Technology Application and Research Center, Karadeniz Technical University, Trabzon, Turkey.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Doctoral School of Clinical Neuroscience, Medical School, University of Pécs, Pécs, Hungary; Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Doctoral School of Clinical Neuroscience, Medical School, University of Pécs, Pécs, Hungary; Department of Neurology, Medical School, University of Pécs, Pécs, Hungary.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Department of Experimental Medicine, University of Roma "La Sapienza", 00185 Rome, Italy.
IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Department of Systems Medicine, Tor Vergata University of Rome, 00133 Rome, Italy.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy.
Institute of Translational Pharmacology (IFT), National Research Council (CNR), 00133 Rome, Italy.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul, Republic of Korea.
Publications dans "Trimétazidine" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacy and Yonsei Institute of Pharmaceutical Sciences, College of Pharmacy, Yonsei University, Incheon, Republic of Korea.
Department of Pharmaceutical Medicine and Regulatory Sciences, Colleges of Medicine and Pharmacy, Yonsei University, Incheon, Republic of Korea.
Publications dans "Trimétazidine" :
Abnormal myocardial metabolism is a common pathophysiological process underlying ischemic heart disease and heart failure (HF). Trimetazidine is an antianginal agent with a unique mechanism of action ...
Coenzyme Q10 (CoQ10) is considered to be beneficial for patients with acute viral myocarditis (AVM). In addition, trimetazidine may be also beneficial to patients with AVM by promoting cardiac energy ...
PubMed, Embase, the Cochrane Library, Wanfang, and China National Knowledge Infrastructure (CNKI) databases were searched for relevant randomized controlled trials (RCTs). An analysis of random effect...
Sixteen RCTs that included 1,364 patients with AVM contributed to the meta-analysis. Overall, 687 patients received the combined treatment, while 677 received the CoQ10 alone for a duration of 2-12 we...
Trimetazidine combined with CoQ10 is an effective and safe treatment for AVM....
Renal ischemia/reperfusion (I/R) is a primary culprit of acute kidney injury. Neurodegeneration can result from I/R, but the mechanisms are still challenging. We studied the implications of bilateral ...
Study groups; Sham, I/R, TMZ+I/R, and Nano-TMZ+I/R. Kidney functions, cognition, hippocampal OS markers, Gal-3, NF-қB, p65 and HMGB-1 gene expression, TNF-α level, t-JNK/p-JNK and t-ERK/p-ERK proteins...
Nano-TMZ averted renal I/R-induced hippocampal impairment by virtue of its anti: oxidative, inflammatory, and apoptotic properties....
Nano-TMZ is more than anti-ischemic....
Despite maximal treatment, heart failure (HF) remains a major clinical challenge. Besides neurohormonal overactivation, myocardial energy homoeostasis is also impaired in HF. Trimetazidine has the pot...
We conducted a systematic review to evaluate all available clinical evidence on trimetazidine in HF. We searched Medline/PubMed, Embase, Cochrane CENTRAL and ClinicalTrials.gov to identify relevant st...
Out of 213 records, we included 28 studies in the meta-analysis (containing 2552 unique patients), which almost exclusively randomised patients with HF with reduced ejection fraction (HFrEF). The stud...
Trimetazidine in HFrEF was found to significantly reduce cardiovascular mortality (OR 0.33, 95% CI 0.21 to 0.53) and HF hospitalisations (OR 0.42, 95% CI 0.29 to 0.60). In addition, trimetazidine impr...
Current evidence supports the potential role of trimetazidine in HFrEF, but this is based on multiple smaller trials of varying quality in study design. We recommend a large pragmatic randomised clini...
Amyotrophic Lateral Sclerosis (ALS) is considered the prototype of motor neuron disease, characterized by motor neuron loss and muscle waste. A well-established pathogenic hallmark of ALS is mitochond...
Rheumatoid arthritis (RA) is a debilitating autoimmune condition characterized by chronic synovitis, joint damage, and inflammation, leading to impaired joint functionality. Existing RA treatments, al...
Endothelial dysfunction is a hallmark of cardiovascular diseases, contributing to impaired vasodilation, altered hemodynamics, and atherosclerosis progression. Trimetazidine, traditionally used for an...
The prevalence of diabetes mellitus is increasing year by year globally, and diabetic cardiomyopathy (DCM), as the most common complication of type 2 diabetes mellitus, seriously affects the prognosis...
This study aims to investigate the impact of TMZ on myocardial damage in mice exhibiting diabetic cardiomyopathy (DCM), and to furnish a laboratory foundation for the clinical treatment of diabetic ca...
Male db/db mice (6 weeks old, n = 21) and male wild-type (wt) (6 weeks old, n = 20) mice were selected for the study. The wt mice were randomly assigned to the wt group (n = 10) and wt + TMZ group (n ...
GLU, TC, TG, LDL-C, and CK-MB levels were significantly higher in db/db mice compared to wt mice (GLU: M ± SD wt 5.94 ± 0.37, db/db 17.63 ± 0.89, p < 0.05, ES = 0.991; TC: M ± SD wt 3.01 ± 0.32, db/db...
TMZ can mitigate myocardial damage in db/db mice by downregulating the expression of caspase-12, a protein associated with the endoplasmic reticulum stress (ERS) cell apoptosis pathway, consequently d...
Trimetazidine (TMZ), used for treating stable angina pectoris, has garnered attention in the realm of sports due to its potential performance-enhancing properties, and the World Anti-Doping Agency (WA...
This review aims to examine the impact of trimetazidine on skeletal muscle function in patients suffering from peripheral artery disease (PAD)....
We searched for studies, both experimental and observational research, concerning the comparison of trimetazidine administration to placebo/standard of care in patients with PAD in PubMed, ScienceDire...
Three observational studies involving 378 participants with PAD satisfied predefined criteria. There was no substantial difference between the examined groups' on ABI (pre- and post-intervention) (MD ...
Current evidence from our meta-analysis suggests the beneficial role of trimetazidine's anti-ischemic effect in PAD patients by improving MWD, while it has an insignificant influence on ABI....