Le diagnostic repose sur des tests sanguins pour détecter les anticorps ou l'ARN viral.
DengueDiagnostic médical
#2
Quels tests pour le paludisme au Vietnam ?
Un frottis sanguin ou un test de diagnostic rapide sont utilisés pour le paludisme.
PaludismeTests de diagnostic
#3
Comment identifier la tuberculose ?
La tuberculose est diagnostiquée par des tests cutanés, des radiographies et des cultures.
TuberculoseDiagnostic médical
#4
Quels signes pour le choléra ?
Le choléra se diagnostique par des selles liquides et des tests de laboratoire.
CholéraDiagnostic médical
#5
Comment détecter une infection à VIH ?
Des tests sanguins spécifiques détectent les anticorps ou l'ARN du VIH.
VIHDiagnostic médical
Symptômes
5
#1
Quels symptômes de la dengue ?
Fièvre, douleurs articulaires, éruptions cutanées et fatigue sont fréquents.
DengueSymptômes
#2
Quels signes du paludisme ?
Fièvre, frissons, sueurs, maux de tête et douleurs musculaires sont typiques.
PaludismeSymptômes
#3
Quels symptômes de la tuberculose ?
Toux persistante, perte de poids, sueurs nocturnes et fatigue sont courants.
TuberculoseSymptômes
#4
Quels signes du choléra ?
Diarrhée aqueuse sévère, vomissements et déshydratation rapide sont caractéristiques.
CholéraSymptômes
#5
Quels symptômes d'une infection à VIH ?
Symptômes initiaux incluent fièvre, fatigue, éruptions cutanées et ganglions enflés.
VIHSymptômes
Prévention
5
#1
Comment prévenir la dengue ?
Éliminer les eaux stagnantes et utiliser des répulsifs contre les moustiques.
DenguePrévention
#2
Quelles mesures pour prévenir le paludisme ?
Utiliser des moustiquaires, des insecticides et prendre des médicaments préventifs.
PaludismePrévention
#3
Comment prévenir la tuberculose ?
Vaccination BCG et dépistage des cas contacts sont essentiels pour la prévention.
TuberculosePrévention
#4
Quelles précautions contre le choléra ?
Boire de l'eau potable, se laver les mains et consommer des aliments cuits.
CholéraPrévention
#5
Comment prévenir le VIH ?
Utiliser des préservatifs et se faire dépister régulièrement pour prévenir le VIH.
VIHPrévention
Traitements
5
#1
Quel traitement pour la dengue ?
Le traitement est symptomatique, avec des analgésiques et une hydratation adéquate.
DengueTraitement
#2
Comment traiter le paludisme ?
Des médicaments antipaludiques comme l'artémisinine sont utilisés pour traiter le paludisme.
PaludismeTraitement
#3
Quel traitement pour la tuberculose ?
La tuberculose nécessite un traitement antibiotique prolongé, souvent sur six mois.
TuberculoseTraitement
#4
Comment traiter le choléra ?
Le choléra est traité par réhydratation orale ou intraveineuse et antibiotiques si nécessaire.
CholéraTraitement
#5
Quel traitement pour le VIH ?
Le VIH est traité par des antirétroviraux pour contrôler la charge virale.
VIHTraitement
Complications
5
#1
Quelles complications de la dengue ?
Les complications incluent la dengue sévère, le choc et des hémorragies.
DengueComplications
#2
Quelles complications du paludisme ?
Le paludisme peut entraîner des anémies, des convulsions et des défaillances organiques.
PaludismeComplications
#3
Quelles complications de la tuberculose ?
Les complications incluent la dissémination à d'autres organes et la résistance aux médicaments.
TuberculoseComplications
#4
Quelles complications du choléra ?
La déshydratation sévère peut entraîner un choc hypovolémique et la mort.
CholéraComplications
#5
Quelles complications du VIH ?
Le VIH peut mener à des infections opportunistes et à des cancers associés.
VIHComplications
Facteurs de risque
5
#1
Quels facteurs de risque pour la dengue ?
Vivre dans des zones tropicales, exposition aux moustiques et manque d'assainissement.
DengueFacteurs de risque
#2
Quels facteurs de risque pour le paludisme ?
Vivre dans des zones endémiques, absence de protection contre les moustiques.
PaludismeFacteurs de risque
#3
Quels facteurs de risque pour la tuberculose ?
Conditions de vie précaires, immunodépression et contact avec des malades.
TuberculoseFacteurs de risque
#4
Quels facteurs de risque pour le choléra ?
Accès limité à l'eau potable et à l'assainissement, ainsi que la consommation d'aliments contaminés.
CholéraFacteurs de risque
#5
Quels facteurs de risque pour le VIH ?
Relations sexuelles non protégées, partage de seringues et absence de dépistage.
VIHFacteurs de risque
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National Institute of Hygiene and Epidemiology, Hanoi, Viet Nam; School of Preventive Medicine and Public Health, Hanoi Medical University, Hanoi, Viet Nam.
School of Biomedical Sciences, The University of Western Australia, Crawley, WA, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA, Australia; Medical, Molecular and Forensic Sciences, Murdoch University, Murdoch, WA, Australia; PathWest Laboratory Medicine, Department of Microbiology, Nedlands, WA, Australia. Electronic address: thomas.riley@uwa.edu.au.
Division of Cancer Control and Population Sciences, University of Pittsburgh Medical Center Hillman Cancer Center, University of Pittsburgh, Pittsburgh, PA.
Department of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA.
Autoantibodies against C1-inhibitor (C1-INH-Ab) have a diagnostic value in acquired angioedema due to C1-inhibitor deficiency (C1-INH-AAE), even though antibodies can circulate in complexes, which can...
19 patients were diagnosed with C1-INH-AAE in the Hungarian Angioedema Center of Reference and Excellence; 79% of them had an underlying disease. Samples were examined with a newly developed in-house ...
Free circulating and complex antibodies are in a dynamically changing equilibrium. CAC measurements can help to predict the development of an underlying disease. The efficiency of the treatment for un...
ACE inhibitor (ACEi) induced angioedema predominantly affects the upper aerodigestive tract. As ACEi induced angioedema is mediated by bradykinin, therapeutic response to antihistamines and glucocorti...
We performed a double-blind, parallel-group, multicentre randomised placebo-controlled trial between December 2013 and September 2018. Eligible were adults with ACEi induced angioedema with airway obs...
30 patients (16 C1INH, 14 placebo) were randomised and dosed. 25 (9 C1INH, 12 placebo) completed the study. TCER was 29.63 h ± 15.56 h in the C1INH and 17.29 h ± 10.40 h in the placebo arm (p = 0.0457...
In the context of baseline application of steroids and antihistamines C1INH was inferior in the treatment of ACEi induced angioedema when compared to placebo with respect to time to complete resolutio...
Detailed demographic data on people with hereditary angioedema (HAE) and acquired C1 inhibitor deficiency in the United Kingdom are relatively limited. Better demographic data would be beneficial in p...
To obtain more accurate data on the demographics of HAE and acquired C1 inhibitor deficiency in the United Kingdom, including treatment modalities and services available to patients....
A survey was distributed to all centers in the United Kingdom that look after patients with HAE and acquired C1 inhibitor deficiency to collect these data....
The survey identified 1152 patients with HAE-1/2 (58% female and 92% type 1), 22 patients with HAE with normal C1 inhibitor, and 91 patients with acquired C1 inhibitor deficiency. Data were provided b...
Data obtained from the survey provide useful information about the demographics and treatment modalities used in HAE and acquired C1 inhibitor deficiency in the United Kingdom. These data are useful f...
Hereditary angioedema (HAE) is a rare disorder characterized by cutaneous and submucosal swelling caused mostly by excessive local bradykinin production. Bradykinin is a vasoactive peptide generated b...
Hereditary angioedema (HAE) with normal C1-INH (HAE-nl-C1INH) is phenotypically similar to HAE resulting from C1-INH deficiency (HAE-C1INH). Confirmatory diagnostic tests for HAE-nl-C1INH are limited ...
To estimate the prevalence and describe current management patterns for HAE-nl-C1INH in the United States (US)....
We conducted an Internet-based survey of US physicians to estimate the prevalence of the HAE-nl-C1INH population in the United States. Potential participating physicians were identified from the US He...
A total of 113 physicians provided data for the estimation of HAE-nl-C1INH prevalence and 81 physicians treating HAE-nl-C1INH patients provided data about treatment patterns. In bias-corrected analysi...
These survey data provide estimates of HAE-nl-C1INH prevalence in the United States as well as current diagnosis and management strategies. Results may be useful for developing studies to assess treat...
Chronic recurrent angioedema without wheals (CRA) with normal C1 inhibitor (C1-INH) that is unresponsive to antihistamines may involve patients with recurrent angioedema of unknown cause (ie, so-calle...
To identify patients with one of type of HAEnCI in a group of patients with CRA with normal C1-INH that was unresponsive to antihistamines....
A total of 132 patients with CRA and normal C1-INH that was unresponsive to antihistamines underwent mutational and clinical analysis. The presence of hereditary angioedema-specific mutations in Facto...
In 116 of 132 solitary patients with CRA (87.9%), none of the six HAEnCI-linked mutations could be found. Ten patients (7.6%) had the Factor XII mutation c.983C>A (p.T328K) and six (4.5%) the plasmino...
A search for HAEnCI-linked mutations in patients with solitary CRA may lead to the detection of patients and families with HAEnCI. This is important because family members can be identified who are at...
Coronavirus disease 2019 (COVID-19) caused by SARS-CoV-2 is associated with a clinical spectrum ranging from asymptomatic carriers to critically ill patients with complications including thromboemboli...
Patients with hereditary angioedema experience recurrent, sometimes life-threatening, attacks of edema. It is a rare genetic disorder characterized by genetic and clinical heterogenicity. Most cases a...
The aim was to describe trans-inhibitory effects of full-length or near full-length C1INH encoded by 28 disease-associated SERPING1 variants....
HeLa cells were transfected with expression constructs encoding the studied SERPING1 variants. Extensive and comparative studies of C1INH expression, secretion, functionality, and intracellular locali...
Our findings characterized functional properties of a subset of SERPING1 variants allowing the examined variants to be subdivided into 5 different clusters, each containing variants sharing specific m...
We provide a functional classification of SERPING1 gene variants suggesting that different SERPING1 variants drive the pathogenicity through different and in some cases overlapping molecular disease m...
Hereditary angioedema (HAE) due to C1-inhibitor (C1-INH) deficiency is a rare hereditary disease characterized by recurrent subcutaneous or submucosal angioedema due to uncontrolled bradykinin product...
