Method evaluation in the clinical laboratory.
Method evaluation is one of the critical components of the quality system that ensures the ongoing quality of a clinical laboratory. As part of implementing new methods or reviewing best practices, th...
Protéines de fusion virale : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une infection virale liée aux protéines de fusion ?
Le diagnostic repose sur des tests sérologiques et des cultures virales.
#2
Quels tests sont utilisés pour détecter les protéines de fusion ?
Des tests ELISA et des techniques de PCR peuvent être utilisés pour détecter ces protéines.
#3
Les biopsies sont-elles utiles pour le diagnostic ?
Oui, les biopsies peuvent aider à identifier des infections virales spécifiques.
#4
Quels symptômes peuvent indiquer une infection virale ?
Fièvre, fatigue, éruptions cutanées et douleurs musculaires peuvent être des indicateurs.
#5
Les tests d'imagerie sont-ils nécessaires ?
Généralement non, mais ils peuvent être utilisés pour évaluer des complications.
Symptômes 5
#1
Quels sont les symptômes courants d'une infection virale ?
Fièvre, toux, fatigue, douleurs musculaires et éruptions cutanées sont fréquents.
#2
Les symptômes varient-ils selon le virus ?
Oui, chaque virus peut provoquer des symptômes spécifiques selon son type.
#3
Les symptômes peuvent-ils être graves ?
Oui, certaines infections virales peuvent entraîner des complications graves.
#4
Comment les symptômes évoluent-ils avec le temps ?
Ils peuvent s'aggraver ou s'améliorer selon la réponse immunitaire de l'hôte.
#5
Les symptômes sont-ils similaires à ceux d'autres maladies ?
Oui, ils peuvent être confondus avec ceux de maladies bactériennes ou auto-immunes.
Prévention 5
#1
Comment prévenir les infections virales ?
La vaccination, l'hygiène des mains et l'évitement des contacts sont essentiels.
#2
Les masques aident-ils à prévenir la transmission virale ?
Oui, les masques peuvent réduire la transmission des virus respiratoires.
#3
Les voyages augmentent-ils le risque d'infection virale ?
Oui, les voyages peuvent exposer à de nouveaux virus et augmenter le risque d'infection.
#4
L'alimentation influence-t-elle la prévention des infections ?
Une alimentation équilibrée renforce le système immunitaire et aide à prévenir les infections.
#5
Les mesures de distanciation sociale sont-elles efficaces ?
Oui, elles réduisent la propagation des infections virales dans la communauté.
Traitements 5
#1
Quels traitements sont disponibles pour les infections virales ?
Les antiviraux, les soins de soutien et les traitements symptomatiques sont courants.
#2
Les antibiotiques sont-ils efficaces contre les infections virales ?
Non, les antibiotiques ne sont pas efficaces contre les virus, seulement contre les bactéries.
#3
La vaccination peut-elle prévenir les infections virales ?
Oui, certaines vaccinations peuvent prévenir des infections virales spécifiques.
#4
Les traitements varient-ils selon le type de virus ?
Oui, chaque virus peut nécessiter un traitement spécifique adapté à son mécanisme.
#5
Les traitements sont-ils efficaces contre toutes les souches virales ?
Non, certaines souches peuvent être résistantes aux traitements disponibles.
Complications 5
#1
Quelles sont les complications possibles des infections virales ?
Pneumonie, encéphalite et défaillance organique sont des complications graves.
#2
Les complications varient-elles selon le virus ?
Oui, chaque virus peut entraîner des complications spécifiques selon son tropisme.
#3
Comment prévenir les complications des infections virales ?
Un traitement précoce et une surveillance médicale peuvent aider à prévenir les complications.
#4
Les complications peuvent-elles être mortelles ?
Oui, certaines complications peuvent entraîner la mort si elles ne sont pas traitées rapidement.
#5
Les personnes âgées sont-elles plus à risque de complications ?
Oui, les personnes âgées ont un risque accru de complications graves liées aux infections virales.
Facteurs de risque 5
#1
Quels sont les principaux facteurs de risque d'infection virale ?
L'immunodépression, le vieillissement et les conditions de santé préexistantes augmentent le risque.
#2
Le mode de vie influence-t-il le risque d'infection ?
Oui, un mode de vie sain peut réduire le risque d'infections virales.
#3
Les voyages à l'étranger augmentent-ils le risque ?
Oui, voyager dans des zones à forte prévalence virale augmente le risque d'infection.
#4
Les contacts avec des animaux peuvent-ils être un facteur de risque ?
Oui, certains virus zoonotiques peuvent être transmis par contact avec des animaux infectés.
#5
Les conditions de vie en collectivité augmentent-elles le risque ?
Oui, les environnements surpeuplés favorisent la transmission des infections virales.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 08/05/2025
Contenu vérifié selon les dernières recommandations médicales
Sous-catégories
1 au totalAuteurs principaux
Jiachen Huang
3 publications dans cette catégorie
Affiliations :
- Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
-
Antibody Epitopes of Pneumovirus Fusion Proteins.
Frontiers in immunology 2019-11-29
Jarrod J Mousa
3 publications dans cette catégorie
Affiliations :
- Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Department of Biochemistry and Molecular Biology, Franklin College of Arts and Sciences, University of Georgia; Athens, GA 30602, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
-
Antibody Epitopes of Pneumovirus Fusion Proteins.
Frontiers in immunology 2019-11-29
Wen Chang
3 publications dans cette catégorie
Affiliations :
- Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Publications dans "Protéines de fusion virale" :
-
Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex.
Journal of virology 2023-11-17
-
Vaccinia viral A26 protein is a fusion suppressor of mature virus and triggers membrane fusion through conformational change at low pH.
PLoS pathogens 2019-06-20
-
Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations.
PLoS pathogens 2023-11-10
Rebecca Ellis Dutch
3 publications dans cette catégorie
Affiliations :
- Department of Molecular and Cellular Biochemistry, University of Kentucky, 741 South Limestone Street, Lexington, KY 40536, USA.
Publications dans "Protéines de fusion virale" :
-
Viral Membrane Fusion and the Transmembrane Domain.
Viruses 2020-06-27
-
A Hydrophobic Target: Using the Paramyxovirus Fusion Protein Transmembrane Domain To Modulate Fusion Protein Stability.
Journal of virology 2019-08-13
-
Human metapneumovirus fusion protein triggering: Increasing complexities by analysis of new HMPV fusion proteins.
Virology 2019-03-07
Markus Hoffmann
3 publications dans cette catégorie
Affiliations :
- Infection Biology Unit, German Primate Center, Leibniz Institute for Primate Research, Göttingen, Germany.
- Faculty of Biology and Psychology, Georg August University Göttingen, Göttingen, Germany.
Publications dans "Protéines de fusion virale" :
-
The Amino Acid at Position 8 of the Proteolytic Cleavage Site of the Mumps Virus Fusion Protein Affects Viral Proteolysis and Fusogenicity.
Journal of virology 2020-10-27
-
LY6E impairs coronavirus fusion and confers immune control of viral disease.
Nature microbiology 2020-07-23
-
LY6E impairs coronavirus fusion and confers immune control of viral disease.
bioRxiv : the preprint server for biology 2020-03-07
Anne Moscona
2 publications dans cette catégorie
Affiliations :
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
- Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
- Department of Microbiology & Immunology, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
- Department of Physiology & Cellular Biophysics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
Publications dans "Protéines de fusion virale" :
-
Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein.
ACS nano 2021-07-22
-
Effects of Single α-to-β Residue Replacements on Recognition of an Extended Segment in a Viral Fusion Protein.
ACS infectious diseases 2020-07-27
Matteo Porotto
2 publications dans cette catégorie
Affiliations :
- Center for Host-Pathogen Interaction, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
- Department of Pediatrics, Columbia University Vagelos College of Physicians and Surgeons, New York, New York 10032, United States.
- Department of Experimental Medicine, University of Campania "Luigi Vanvitelli", 81100 Caserta, Italy.
Publications dans "Protéines de fusion virale" :
-
Inhibition of Measles Viral Fusion Is Enhanced by Targeting Multiple Domains of the Fusion Protein.
ACS nano 2021-07-22
-
Effects of Single α-to-β Residue Replacements on Recognition of an Extended Segment in a Viral Fusion Protein.
ACS infectious diseases 2020-07-27
Lukas K Tamm
2 publications dans cette catégorie
Affiliations :
- Center for Membrane and Cell Physiology, University of Virginia, Charlottesville, Virginia, USA.
- Department of Molecular Physiology and Biological Physics, University of Virginia, Charlottesville, Virginia, USA.
Publications dans "Protéines de fusion virale" :
-
Viral Membrane Fusion: A Dance Between Proteins and Lipids.
Annual review of virology
-
Mechanisms of SNARE proteins in membrane fusion.
Nature reviews. Molecular cell biology 2023-10-17
Karen J Gonzalez
2 publications dans cette catégorie
Affiliations :
- Institute of Bioinformatics, Franklin College of Arts and Sciences, University of Georgia; Athens, GA 30602, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
Miria F Criado
2 publications dans cette catégorie
Affiliations :
- Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Department of Pathobiology, Auburn University; Auburn, AL 36849, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
Avik Banerjee
2 publications dans cette catégorie
Affiliations :
- Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Center for Vaccines and Immunology, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
Eva-Maria Strauch
2 publications dans cette catégorie
Affiliations :
- Institute of Bioinformatics, Franklin College of Arts and Sciences, University of Georgia; Athens, GA 30602, USA.
- Department of Infectious Diseases, College of Veterinary Medicine, University of Georgia; Athens, GA 30602, USA.
- Department of Pharmaceutical and Biomedical Sciences, College of Pharmacy, University of Georgia; Athens, GA 30602, USA.
Publications dans "Protéines de fusion virale" :
-
A general computational design strategy for stabilizing viral class I fusion proteins.
bioRxiv : the preprint server for biology 2023-03-17
-
A general computational design strategy for stabilizing viral class I fusion proteins.
Nature communications 2024-02-13
Makoto Takeda
2 publications dans cette catégorie
Affiliations :
- Department of Virology III, National Institute of Infectious Diseases, Musashimurayama, Tokyo, Japan.
Publications dans "Protéines de fusion virale" :
-
SNARE protein USE1 is involved in the glycosylation and the expression of mumps virus fusion protein and important for viral propagation.
PLoS pathogens 2022-12-08
-
The Anticoagulant Nafamostat Potently Inhibits SARS-CoV-2 S Protein-Mediated Fusion in a Cell Fusion Assay System and Viral Infection In Vitro in a Cell-Type-Dependent Manner.
Viruses 2020-06-10
Chi-Fei Kao
2 publications dans cette catégorie
Affiliations :
- Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan.
Publications dans "Protéines de fusion virale" :
Kathleen Joyce D Carillo
2 publications dans cette catégorie
Affiliations :
- Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
Publications dans "Protéines de fusion virale" :
Der-Lii M Tzou
2 publications dans cette catégorie
Affiliations :
- Institute of Chemistry, Academia Sinica, Taipei, Taiwan.
Publications dans "Protéines de fusion virale" :
Hao-Ching Wang
2 publications dans cette catégorie
Affiliations :
- The PhD Program for Translational Medicine, College of Medical Science and Technology, Taipei Medical University and Academia Sinica, Taipei, Taiwan.
- Graduate Institute of Translational Medicine, College of Medical Science and Technology, Taipei Medical University, Taipei, Taiwan.
Publications dans "Protéines de fusion virale" :
Dedong Wang
2 publications dans cette catégorie
Affiliations :
- College of Veterimary Medicine, Yangzhou University, Yangzhou 225009, China.
- Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Publications dans "Protéines de fusion virale" :
-
Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.
Viruses 2022-06-27
-
A Receptor Integrin β1 Promotes Infection of Avian Metapneumovirus Subgroup C by Recognizing a Viral Fusion Protein RSD Motif.
International journal of molecular sciences 2024-01-09
Lei Hou
2 publications dans cette catégorie
Affiliations :
- College of Veterimary Medicine, Yangzhou University, Yangzhou 225009, China.
- Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Publications dans "Protéines de fusion virale" :
-
Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.
Viruses 2022-06-27
-
A Receptor Integrin β1 Promotes Infection of Avian Metapneumovirus Subgroup C by Recognizing a Viral Fusion Protein RSD Motif.
International journal of molecular sciences 2024-01-09
Jianwei Zhou
2 publications dans cette catégorie
Affiliations :
- College of Veterimary Medicine, Yangzhou University, Yangzhou 225009, China.
- Jiangsu Co-Innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China.
Publications dans "Protéines de fusion virale" :
-
Interaction of Nucleolin with the Fusion Protein of Avian Metapneumovirus Subgroup C Contributes to Viral Replication.
Viruses 2022-06-27
-
A Receptor Integrin β1 Promotes Infection of Avian Metapneumovirus Subgroup C by Recognizing a Viral Fusion Protein RSD Motif.
International journal of molecular sciences 2024-01-09
Sources (10000 au total)
The publication quality of laboratory values in clinical studies in neonates.
There are no generally accepted age-appropriate reference ranges for laboratory values in neonates. This also matters for drug development. The International Neonatal Consortium (INC) is engaged to de... A structured literature search was performed to identify standards or recommendations for publications that present neonatal laboratory data to assess the publication quality of laboratory values in n... On 2908 hits, 281 papers were retained for full reading and 257 for data extraction. None of the papers reported a publication standard. Using the extraction instrument, most papers presented single c... Published information on laboratory values for neonates is sparse, not systematic, and incomplete. This undermines efforts to compare treatments, safety monitoring, or clinical management. Furthermore... There are no generally accepted age-appropriate reference ranges for laboratory values in neonates, leading to a significant knowledge gap, also for safety reporting and drug development in neonates. ...
A comprehensive review of COVID-19 detection techniques: From laboratory systems to wearable devices.
Screening of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among symptomatic and asymptomatic patients offers unique opportunities for curtailing the transmission of novel coronavirus d...
Compliance with the clinical laboratory quality protocol in public primary healthcare centres.
The clinical and economic relevance of the clinical laboratories procedures in Andalusia (Spain) have led the Regional Department of Health to focus attention on their improvement. A unified laborator...
Analysis of preanalytical errors in a clinical chemistry laboratory: A 2-year study.
Patient safety and medical diagnosis of patients are mainly influenced by laboratory results. The present study aimed to evaluate the errors in the preanalytical phase of testing in a Clinical Chemist...
Clinical decision limits as criteria for setting analytical performance specifications for laboratory tests.
The biological (CV... The sum of the CV... The obtained CAAPS were 44.9% for urine albumin, 0.6% for plasma sodium, 22.9% for plasma pancreatic amylase, and 8.0% for plasma creatinine (z = 3, α = 2.5%, 1-β = 85%). For blood HbA... The CAAPS models pose a new tool for assessing APS in a clinical laboratory. Their usability depends on the relevance of CD limits, required statistical power and the feasibility of repeated measureme...
Interpreting changes in consecutive laboratory results: clinician's perspectives on clinically significant change.
Clinical laboratory tests are inevitably affected by various factors. Therefore, when comparing consecutive test results, it is crucial to consider the inherent uncertainty of the test. Clinical labor... We performed a questionnaire survey on clinicians, which comprised 2 scenarios with 22 laboratory test items suggesting initial test results. Clinicians were asked to choose a result showing clinicall... We received 290 valid questionnaire responses. Clinicians' opinions on clinically significant change was inconsistent between clinicians and scenarios, and was generally larger than RCV. Clinicians co... Clinicians' opinions on clinically significant changes were more prominent than RCV. Meanwhile, they tended to neglect the analytical and biological variation. Laboratories should properly guide clini...
Incorporating informatively collected laboratory data from EHR in clinical prediction models.
Electronic Health Records (EHR) are widely used to develop clinical prediction models (CPMs). However, one of the challenges is that there is often a degree of informative missing data. For example, l... We considered a predictive model for rapid inpatient deterioration as an exemplar implementation. This model incorporated twelve laboratory measures with varying levels of missingness. Five labs had m... We had 105,198 inpatient encounters, with 4.7% having experienced the deterioration outcome of interest. LSTM models generally outperformed other cross-sectional models, where embedding approaches and... Strategies that accounted for the possibility of NMAR missing data yielded better model performance than those did not. The embedding method had an advantage as it did not require prior clinical knowl...
The Nature, Causes, and Clinical Impact of Errors in the Clinical Laboratory Testing Process Leading to Diagnostic Error: A Voluntary Incident Report Analysis.
Diagnostic errors, that is, missed, delayed, or wrong diagnoses, are a common type of medical errors and preventable iatrogenic harm. Errors in the laboratory testing process can lead to diagnostic er... We used a sample of 600 voluntary incident reports concerning diagnostic testing selected from all incident reports filed at the University Medical Center Utrecht in 2017-2018. From these incident rep... Three hundred twenty-seven reports were included in the analysis. In 77.1%, the error occurred in the preanalytical phase, 13.5% in the analytical phase and 8.0% in the postanalytical phase (1.5% unde... Errors in the laboratory testing process often lead to potential diagnostic errors. Although prone to incomplete information on causes and clinical impact, voluntary incident reports are a valuable so...
The experience and reflections of GC labs as an independent clinical laboratory to the COVID-19 pandemic in South Korea.
Amid the COVID-19 pandemic, extensive testing was undertaken by independent clinical laboratories (ICLs), yet limited research exists on this matter. Drawing from Green Cross Laboratories (GC Labs)' p... This retrospective study analyzed the outcomes of SARS-CoV-2 real-time reverse transcription polymerase chain reaction (SARS-CoV-2 rRT PCR) tests administered by GC Labs for COVID-19 diagnosis, upon r... ICLs were responsible for conducting 85.6% of all tests carried out under South Korea's COVID-19 testing policy during the pandemic. The availability of free testing regardless of symptoms led to a si... South Korea's ICLs were able to conduct large volumes of testing during the COVID-19 pandemic because of their logistics and computer systems, scalable testing space, and trained testing personnel. Th...