questionsmedicales.fr
Phénomènes microbiologiques
Virulence
Virulence : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Infections
Tests de diagnostic
Symptômes
5
Virulence
Évolution des maladies
Prévention
5
Sensibilisation
Prévention
Contrôle des infections
Virulence
Traitements
5
Résistance aux antibiotiques
Virulence
Traitements
Surveillance médicale
Infections
Résistance aux médicaments
Complications
5
Complications
Maladies chroniques
Gestion des complications
Soins de soutien
Facteurs de risque
Immunodépression
Facteurs de risque
5
Facteurs de risque
Immunité
Immunodépression
Virulence
Environnement
Transmission
Habitudes de vie
Facteurs de risque
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Virulence : Questions médicales les plus fréquentes",
"headline": "Virulence : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Virulence : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-02-16",
"dateModified": "2025-02-10",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Virulence"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Phénomènes microbiologiques",
"url": "https://questionsmedicales.fr/mesh/D008827",
"about": {
"@type": "MedicalCondition",
"name": "Phénomènes microbiologiques",
"code": {
"@type": "MedicalCode",
"code": "D008827",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G06"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Virulence",
"alternateName": "Virulence",
"code": {
"@type": "MedicalCode",
"code": "D014774",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Zhensheng Kang",
"url": "https://questionsmedicales.fr/author/Zhensheng%20Kang",
"affiliation": {
"@type": "Organization",
"name": "Yangling, ShaanxiYangling, China, 712100; kangzs@nwsuaf.edu.cn."
}
},
{
"@type": "Person",
"name": "Tianya Li",
"url": "https://questionsmedicales.fr/author/Tianya%20Li",
"affiliation": {
"@type": "Organization",
"name": "College of Agronomy, Shenyang Agricultural University, Shenyang, Liaoning 110866, China."
}
},
{
"@type": "Person",
"name": "Yiwei Xu",
"url": "https://questionsmedicales.fr/author/Yiwei%20Xu",
"affiliation": {
"@type": "Organization",
"name": "College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China."
}
},
{
"@type": "Person",
"name": "Xianxin Wu",
"url": "https://questionsmedicales.fr/author/Xianxin%20Wu",
"affiliation": {
"@type": "Organization",
"name": "College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China."
}
},
{
"@type": "Person",
"name": "Yazhao Zhang",
"url": "https://questionsmedicales.fr/author/Yazhao%20Zhang",
"affiliation": {
"@type": "Organization",
"name": "College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Siderophore-dependent ferrichelatases.",
"datePublished": "2024-07-08",
"url": "https://questionsmedicales.fr/article/39155116",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/bs.mie.2024.06.015"
}
},
{
"@type": "ScholarlyArticle",
"name": "Drug Repurposing by Siderophore Conjugation: Synthesis and Biological Evaluation of Siderophore-Methotrexate Conjugates as Antibiotics.",
"datePublished": "2022-07-25",
"url": "https://questionsmedicales.fr/article/35802518",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/anie.202204139"
}
},
{
"@type": "ScholarlyArticle",
"name": "Trojan Horse Siderophore Conjugates Induce",
"datePublished": "2022-12-22",
"url": "https://questionsmedicales.fr/article/36548006",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1021/acs.jmedchem.2c01489"
}
},
{
"@type": "ScholarlyArticle",
"name": "Discovery, isolation, and characterization of diazeniumdiolate siderophores.",
"datePublished": "2024-07-20",
"url": "https://questionsmedicales.fr/article/39155111",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/bs.mie.2024.06.006"
}
},
{
"@type": "ScholarlyArticle",
"name": "Discovery of New Siderophores from a Marine",
"datePublished": "2023-04-19",
"url": "https://questionsmedicales.fr/article/37076425",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1021/acs.jafc.3c00234"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Phénomènes microbiologiques",
"item": "https://questionsmedicales.fr/mesh/D008827"
},
{
"@type": "ListItem",
"position": 3,
"name": "Virulence",
"item": "https://questionsmedicales.fr/mesh/D014774"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Virulence - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Virulence",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-05",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Virulence",
"description": "Comment évaluer la virulence d'un pathogène ?\nQuels tests sont utilisés pour diagnostiquer une infection virulente ?\nLa virulence peut-elle être mesurée quantitativement ?\nQuels signes cliniques indiquent une virulence élevée ?\nComment les tests génétiques aident-ils au diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Virulence",
"description": "Quels sont les symptômes d'une infection virulente ?\nLa virulence influence-t-elle la gravité des symptômes ?\nQuels symptômes sont associés à des bactéries hautement virulentes ?\nLes symptômes varient-ils selon le pathogène ?\nComment les symptômes évoluent-ils avec la virulence ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Virulence",
"description": "Comment prévenir les infections virulentes ?\nLes mesures d'hygiène réduisent-elles la virulence ?\nQuel rôle joue la vaccination dans la virulence ?\nLes campagnes de sensibilisation sont-elles efficaces ?\nComment le contrôle des infections aide-t-il à prévenir la virulence ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Virulence",
"description": "Quels traitements sont efficaces contre les infections virulentes ?\nLa résistance aux antibiotiques affecte-t-elle la virulence ?\nComment la virulence influence-t-elle le choix du traitement ?\nLes vaccins peuvent-ils réduire la virulence ?\nQuels sont les défis dans le traitement des infections virulentes ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Virulence",
"description": "Quelles complications peuvent survenir avec une virulence élevée ?\nLa virulence peut-elle entraîner des complications à long terme ?\nComment gérer les complications liées à la virulence ?\nLes complications varient-elles selon le pathogène ?\nQuels facteurs aggravent les complications virulentes ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Virulence",
"description": "Quels sont les principaux facteurs de risque de virulence ?\nL'immunodépression augmente-t-elle la virulence ?\nComment l'environnement influence-t-il la virulence ?\nLes habitudes de vie peuvent-elles affecter la virulence ?\nLes voyages augmentent-ils le risque de virulence ?",
"url": "https://questionsmedicales.fr/mesh/D014774?mesh_terms=Siderophores#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment évaluer la virulence d'un pathogène ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "La virulence peut être évaluée par des tests de culture, des modèles animaux et des analyses génétiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour diagnostiquer une infection virulente ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des cultures microbiologiques, des tests PCR et des sérologies sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "La virulence peut-elle être mesurée quantitativement ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des indices comme le LD50 (dose létale) permettent de quantifier la virulence."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une virulence élevée ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une virulence élevée se manifeste par des symptômes graves, une progression rapide de la maladie."
}
},
{
"@type": "Question",
"name": "Comment les tests génétiques aident-ils au diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests génétiques identifient des gènes de virulence spécifiques, facilitant le diagnostic."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une infection virulente ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes varient, mais incluent fièvre, douleur, inflammation et fatigue intense."
}
},
{
"@type": "Question",
"name": "La virulence influence-t-elle la gravité des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une virulence élevée entraîne souvent des symptômes plus graves et des complications."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à des bactéries hautement virulentes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme septicémie, choc toxique et défaillance multi-organes peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le pathogène ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, chaque pathogène a un profil symptomatique distinct en fonction de sa virulence."
}
},
{
"@type": "Question",
"name": "Comment les symptômes évoluent-ils avec la virulence ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une virulence accrue peut entraîner une progression rapide et des symptômes plus sévères."
}
},
{
"@type": "Question",
"name": "Comment prévenir les infections virulentes ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention inclut l'hygiène, la vaccination et l'éducation sur les modes de transmission."
}
},
{
"@type": "Question",
"name": "Les mesures d'hygiène réduisent-elles la virulence ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une bonne hygiène diminue la transmission et donc l'impact de la virulence."
}
},
{
"@type": "Question",
"name": "Quel rôle joue la vaccination dans la virulence ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "La vaccination prépare le système immunitaire, réduisant ainsi la virulence des infections."
}
},
{
"@type": "Question",
"name": "Les campagnes de sensibilisation sont-elles efficaces ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles augmentent la connaissance des risques et des mesures préventives contre la virulence."
}
},
{
"@type": "Question",
"name": "Comment le contrôle des infections aide-t-il à prévenir la virulence ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le contrôle des infections limite la propagation des agents pathogènes virulents dans la population."
}
},
{
"@type": "Question",
"name": "Quels traitements sont efficaces contre les infections virulentes ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antibiotiques, antiviraux et traitements symptomatiques sont utilisés selon le pathogène."
}
},
{
"@type": "Question",
"name": "La résistance aux antibiotiques affecte-t-elle la virulence ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la résistance peut augmenter la virulence en rendant les infections plus difficiles à traiter."
}
},
{
"@type": "Question",
"name": "Comment la virulence influence-t-elle le choix du traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une virulence élevée nécessite souvent des traitements plus agressifs et une surveillance étroite."
}
},
{
"@type": "Question",
"name": "Les vaccins peuvent-ils réduire la virulence ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccins peuvent diminuer la virulence en préparant le système immunitaire à réagir."
}
},
{
"@type": "Question",
"name": "Quels sont les défis dans le traitement des infections virulentes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les défis incluent la résistance aux médicaments, la virulence variable et les co-infections."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une virulence élevée ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme la septicémie, l'insuffisance organique et la mort peuvent survenir."
}
},
{
"@type": "Question",
"name": "La virulence peut-elle entraîner des complications à long terme ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections virulentes peuvent causer des séquelles chroniques et des maladies persistantes."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées à la virulence ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion inclut un traitement rapide, un suivi médical et des soins de soutien appropriés."
}
},
{
"@type": "Question",
"name": "Les complications varient-elles selon le pathogène ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, chaque pathogène peut entraîner des complications spécifiques en fonction de sa virulence."
}
},
{
"@type": "Question",
"name": "Quels facteurs aggravent les complications virulentes ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge, les comorbidités et l'immunodépression peuvent aggraver les complications virulentes."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque de virulence ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent l'âge, l'état immunitaire, les maladies chroniques et l'exposition environnementale."
}
},
{
"@type": "Question",
"name": "L'immunodépression augmente-t-elle la virulence ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes immunodéprimées sont plus susceptibles de développer des infections virulentes."
}
},
{
"@type": "Question",
"name": "Comment l'environnement influence-t-il la virulence ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conditions environnementales comme l'hygiène et la densité de population affectent la virulence."
}
},
{
"@type": "Question",
"name": "Les habitudes de vie peuvent-elles affecter la virulence ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des habitudes comme le tabagisme et l'alcoolisme peuvent augmenter le risque d'infections virulentes."
}
},
{
"@type": "Question",
"name": "Les voyages augmentent-ils le risque de virulence ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les voyages peuvent exposer à des agents pathogènes virulents non présents localement."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 10/02/2025
Contenu vérifié selon les dernières recommandations médicales
2 publications dans cette catégorie
Affiliations :
Yangling, ShaanxiYangling, China, 712100; kangzs@nwsuaf.edu.cn.
Publications dans "Virulence" :
2 publications dans cette catégorie
Affiliations :
College of Agronomy, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Publications dans "Virulence" :
2 publications dans cette catégorie
Affiliations :
College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Publications dans "Virulence" :
2 publications dans cette catégorie
Affiliations :
College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Publications dans "Virulence" :
2 publications dans cette catégorie
Affiliations :
College of Plant Protection, Shenyang Agricultural University, Shenyang, Liaoning 110866, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
School of Biological Sciences, University of Canterbury, Christchurch 8140, New Zealand.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
College of Earth and Planetary Sciences, University of Chinese Academy of Sciences, Beijing, China.
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Deep Sea Research Center, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratory for Marine Biology and Biotechnology, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China.
CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Microbiology, Institute of Biological Sciences, Federal University of Minas Gerais (UFMG), Belo Horizonte, Brazil.
Laboratório de Desenvolvimento de Vacinas, Butantan Institute, São Paulo, Brazil.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Laboratório de Desenvolvimento de Vacinas, Butantan Institute, São Paulo, Brazil.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biochemistry, Cancer Institute of the Second Affiliated Hospital (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biochemistry, Cancer Institute of the Second Affiliated Hospital (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biochemistry, Cancer Institute of the Second Affiliated Hospital (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biochemistry, Cancer Institute of the Second Affiliated Hospital (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biochemistry, Cancer Institute of the Second Affiliated Hospital (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education), School of Medicine, Zhejiang University, Hangzhou, China.
Publications dans "Virulence" :
1 publication dans cette catégorie
Affiliations :
Department of Biomedical Sciences, Carlson College of Veterinary Medicine, Corvallis, OR, USA.
Publications dans "Virulence" :
Iron is a crucial secondary metabolite for bacterial proliferation, but its bioavailability under infection conditions is limited by the low solubility of ferric ion and the host's ability to sequeste...
Drug repurposing is considered a promising strategy to fight antimicrobial resistance (AMR). Methotrexate (Mtx), a classical anticancer drug, could strongly inhibit bacterial dihydrofolate reductase (...
Rising infection rates with multidrug-resistant pathogens calls for antibiotics with novel modes of action. Herein, we identify the inner membrane protein TonB, a motor of active uptake in Gram-negati...
The C-diazeniumdiolate (N-nitrosohydroxylamine) group in the amino acid graminine (Gra) is a newly discovered Fe(III) ligand in microbial siderophores. Graminine was first identified in the siderophor...
Siderophore-antibiotic conjugates (SACs) are of past and current interest for delivering antibacterials into Gram-negative bacterial pathogens that express siderophore receptors. Studies of SACs are o...
Encryption makes information available only to those with the decoding key. We propose that microbes, living in a chemical environment, encrypt nutrients, thereby making them available only to those w...
Predictive markers for fecal microbiota transplantation (FMT) outcomes in patients with active ulcerative colitis (UC) are poorly defined. We aimed to investigate changes in gut microbiota pre- and po...
Patients with active UC (Mayo score ≥ 3) who had undergone two FMT procedures were enrolled. Fecal samples were collected before and 8 weeks after each FMT session. Patients were classified into clini...
Seventy patients with UC had undergone FMT. The clinical response and remission rates were 50% and 10% after the first FMT procedure, increasing to 72.41% and 27.59% after the second FMT. The cumulati...
A significant increase in Faecalibacterium, and decrease in Enterobacteriaceae and the total fecal siderophore genes copy number were observed in responders after FMT. The siderophore genes and its en...
Streptomycetes are bacteria known for their extraordinary biosynthetic capabilities. Herein, we describe the genome and metabolome of a particularly talented strain, Streptomyces ID71268. Its 8.4-Mbp ...
Understanding the intrinsic mechanisms of bacterial competition is a fundamental question. Iron is an essential trace nutrient that bacteria compete for. The most prevalent manner for iron scavenging ...
We performed predation and bacterial competition assays to investigate the function of siderophore transport on myxobacterial predation....
Deletion of...
This work provides insight into the mechanism of siderophore-mediated competition in myxobacteria....