Carence en vitamine B12 : Questions médicales fréquentes
Nom anglais: Vitamin B 12 Deficiency
Descriptor UI:D014806
Tree Number:C18.654.521.500.133.699.923
Termes MeSH sélectionnés :
Complement C5
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"description": "Comment diagnostiquer une carence en vitamine B12 ?\nQuels tests sont utilisés pour confirmer la carence ?\nQuels signes cliniques indiquent une carence ?\nLa carence en B12 peut-elle être asymptomatique ?\nQuel rôle joue l'historique médical dans le diagnostic ?",
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"@type": "Question",
"name": "Comment diagnostiquer une carence en vitamine B12 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par des analyses sanguines mesurant les niveaux de vitamine B12."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer la carence ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests incluent la mesure de la vitamine B12, de l'homocystéine et de la méthylmalonyl-CoA."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une carence ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme l'anémie, la fatigue, et des troubles neurologiques peuvent indiquer une carence."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle être asymptomatique ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines personnes peuvent avoir une carence sans présenter de symptômes visibles."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'historique médical dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'historique médical aide à identifier des facteurs de risque comme des troubles d'absorption."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants de la carence en B12 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, faiblesse, engourdissements et troubles de l'humeur."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle causer des problèmes neurologiques ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des troubles neurologiques comme des démences ou des neuropathies."
}
},
{
"@type": "Question",
"name": "Comment la carence affecte-t-elle la peau ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut provoquer des changements cutanés comme une pâleur ou des lésions cutanées."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes digestifs associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme des nausées, des diarrhées ou des troubles digestifs peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées en raison de l'absorption réduite."
}
},
{
"@type": "Question",
"name": "Comment prévenir la carence en vitamine B12 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée incluant des sources de B12 et des suppléments si nécessaire aide."
}
},
{
"@type": "Question",
"name": "Les personnes âgées doivent-elles prendre des suppléments ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les personnes âgées peuvent avoir besoin de suppléments en raison d'une absorption réduite."
}
},
{
"@type": "Question",
"name": "Les végétaliens peuvent-ils éviter la carence ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils doivent prendre des suppléments de B12 ou consommer des aliments enrichis pour éviter la carence."
}
},
{
"@type": "Question",
"name": "Les tests réguliers sont-ils recommandés ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des tests réguliers sont conseillés pour les personnes à risque de carence."
}
},
{
"@type": "Question",
"name": "Les maladies digestives augmentent-elles le risque ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme la maladie de Crohn peuvent affecter l'absorption de la vitamine B12."
}
},
{
"@type": "Question",
"name": "Comment traiter une carence en vitamine B12 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut des suppléments oraux ou des injections de vitamine B12 selon la gravité."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée dépend de la gravité, mais peut durer de quelques mois à plusieurs années."
}
},
{
"@type": "Question",
"name": "Les aliments peuvent-ils aider à corriger la carence ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, consommer des aliments riches en B12 comme la viande, le poisson et les produits laitiers aide."
}
},
{
"@type": "Question",
"name": "Les personnes végétariennes sont-elles à risque ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elles peuvent être à risque en raison d'un apport alimentaire limité en vitamine B12."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les enfants ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements sont similaires, mais les doses peuvent varier selon l'âge et le poids."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent l'anémie mégaloblastique, des troubles neurologiques et des problèmes cardiaques."
}
},
{
"@type": "Question",
"name": "La carence peut-elle entraîner des problèmes cognitifs ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence prolongée peut causer des troubles cognitifs et des pertes de mémoire."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies cardiovasculaires ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une carence en B12 peut augmenter le risque de maladies cardiovasculaires en élevant l'homocystéine."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non."
}
},
{
"@type": "Question",
"name": "La carence en B12 peut-elle affecter la grossesse ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des complications pendant la grossesse, comme des malformations congénitales."
}
},
{
"@type": "Question",
"name": "Qui est le plus à risque de carence en B12 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées, les végétariens, et ceux ayant des troubles d'absorption sont à risque."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des maladies comme la gastrite atrophique peuvent affecter l'absorption de la B12."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments comme les inhibiteurs de la pompe à protons peuvent réduire l'absorption."
}
},
{
"@type": "Question",
"name": "Les troubles digestifs sont-ils un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme la maladie cœliaque peuvent nuire à l'absorption de la vitamine B12."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de carence peuvent augmenter le risque chez certains individus."
}
}
]
}
]
}
Hemolysis in paroxysmal nocturnal hemoglobinuria (PNH) is complement-mediated due to the lack of complement inhibitors in the hemopoietic cell membranes, making complement inhibition the best approach...
The expert recommendations presented here were created using a Delphi-like process by a group of expert PNH specialists across Central Europe. Based on an initial advisory board meeting discussion, re...
Using a systematic approach, literature databases were searched for relevant studies, and 50 articles were reviewed by the experts and included as supporting evidence....
Implementation of these recommendations uniformly across healthcare institutions will promote the best use of complement inhibition in managing PNH, and has the potential to positively impact patient ...
In the absence of head-to-head trials, this study compared treatment outcomes with the C3 complement inhibitor pegcetacoplan versus the C5 complement inhibitor eculizumab or ravulizumab in complement ...
A matching-adjusted indirect comparison was conducted using individual patient data from the pegcetacoplan arm of the PRINCE trial (NCT04085601; n = 34) and aggregate data from the ravulizumab (n = 12...
After weighting, treatment with pegcetacoplan was associated with statistically significant improvements in most clinical endpoints compared with ravulizumab or eculizumab treatment. These included: g...
Pegcetacoplan provides clinical benefits as first-line treatment for complement inhibitor-naïve patients with PNH....
ClinicalTrials.gov identifier, NCT04085601....
In myelin oligodendrocyte glycoprotein IgG-associated disease (MOGAD) and aquaporin-4 IgG+ neuromyelitis optica spectrum disorder (AQP4+NMOSD), the autoantibodies are mainly composed of IgG1, and comp...
CSF-C3a, CSF-C4a, CSF-C5a, and CSF-C5b-9 levels during the acute phase before treatment in patients with MOGAD (n = 12), AQP4+NMOSD (n = 11), multiple sclerosis (MS) (n = 5), and noninflammatory neuro...
CSF-C3a and CSF-C5a levels were significantly higher in MOGAD (mean ± SD, 5,629 ± 1,079 pg/mL and 2,930 ± 435.8 pg/mL) and AQP4+NMOSD (6,017 ± 3,937 pg/mL and 2,544 ± 1,231 pg/mL) than in MS (1,507 ± ...
The complement pathway is activated in both MOGAD and AQP4+NMOSD, but MAC formation is lower in MOGAD, particularly in those with mild attacks, than in AQP4+NMOSD. These findings may have pathogenetic...
Complement-mediated thrombotic microangiopathy (CM-TMA) is a rare and life-threatening complication that can occur in kidney transplant recipients, with various potential triggers including immunosupp...
Atypical-hemolytic uremic syndrome (aHUS) is a rare thrombotic microangiopathy often due to uncontrolled complement activation, characterized by high risk of end-stage kidney disease (ESKD). Eculizuma...
To identify characteristics associated with treatment response, we analyzed 244 aHUS patients referred to our center. Patients were classified according to the presence/absence of complement abnormali...
Patients had a better outcome with eculizumab compared to conventional treatment, with a response rate of 81.9% vs 56.9%, p < 0.001 and a long-term cumulative incidence of ESKD of 5.8% vs 22.5% (hazar...
Our data show a better outcome in aHUS patients treated with C5-inhibition, particularly in the primary and combined forms, which have a high risk of relapse after discontinuation that is not observed...
Diabetic nephropathy is a common microvascular complication of diabetes mellitus. It is characterized by progressive chronic kidney disease (CKD) with decline of kidney function by hyperfiltration. On...
Complement C5 (C5) is the key component for the complement activation pathway, which is important for innate immunity, and inhibition of C5 is considered to be effective in antibody-mediated rejection...
Like rheumatoid arthritis (RA) in humans, collagen-induced arthritis (CIA) in mice is associated with not only MHC class II genetic polymorphism but also, to some extent, with other loci including gen...
Several diseases caused by the dysregulation of complement activation can be treated with inhibitors of the complement components C5 and/or C3. However, complement is required for serum bactericidal a...
Serum from adults was collected before and after vaccination with the meningococcal serogroup B vaccine 4CMenB and tested for meningococcal killing. Since the B capsular polysaccharide is structurally...
While only a few pre-vaccination sera showed SBA against the tested B meningococcal isolates, 4CMenB vaccination induced potent complement-activating IgG titers against isolates expressing a matching ...
Compared to the SBA triggered by A,C,W,Y capsule polysaccharide conjugate vaccination, SBA against B meningococci expressing a matching fHbp allele was remarkably resilient against the alternative pat...
A potent effector of innate immunity, the complement system contributes significantly to the pathophysiology of traumatic brain injury (TBI). This study investigated the role of the complement cascade...