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"description": "Comment diagnostiquer la leucémie myéloïde chronique ?\nQuels tests sont utilisés pour confirmer la présence du chromosome de Philadelphie ?\nQuels signes cliniques indiquent une LMC ?\nQuel rôle joue l'hémogramme dans le diagnostic ?\nQuand faut-il suspecter une LMC ?",
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"headline": "Prévention sur Philadelphie",
"description": "Peut-on prévenir la LMC ?\nQuels facteurs de risque sont associés à la LMC ?\nLe tabagisme influence-t-il le risque de LMC ?\nLes antécédents familiaux jouent-ils un rôle ?\nComment réduire le risque de LMC ?",
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"description": "Quels traitements sont disponibles pour la LMC ?\nQuel est le rôle des inhibiteurs de tyrosine kinase ?\nLa greffe de moelle osseuse est-elle une option ?\nQuels effets secondaires peuvent survenir avec le traitement ?\nComment surveiller l'efficacité du traitement ?",
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"headline": "Complications sur Philadelphie",
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"headline": "Facteurs de risque sur Philadelphie",
"description": "Quels sont les principaux facteurs de risque de la LMC ?\nL'âge influence-t-il le risque de LMC ?\nLes maladies génétiques augmentent-elles le risque ?\nLe sexe joue-t-il un rôle dans le risque de LMC ?\nLes infections virales sont-elles un facteur de risque ?",
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"@type": "Question",
"name": "Comment diagnostiquer la leucémie myéloïde chronique ?",
"position": 1,
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"text": "Le diagnostic se fait par un test sanguin et une analyse cytogénétique pour détecter le chromosome de Philadelphie."
}
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{
"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer la présence du chromosome de Philadelphie ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de fluorescence in situ hybridation (FISH) et la PCR sont utilisés."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques indiquent une LMC ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de poids, sueurs nocturnes et splénomégalie sont des signes courants."
}
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{
"@type": "Question",
"name": "Quel rôle joue l'hémogramme dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
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"text": "L'hémogramme révèle une augmentation des globules blancs, un indicateur clé de la LMC."
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"name": "Quand faut-il suspecter une LMC ?",
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"text": "En cas de symptômes persistants et d'anomalies dans les tests sanguins, la LMC doit être suspectée."
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{
"@type": "Question",
"name": "Quels sont les symptômes courants de la LMC ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, fièvre, douleurs osseuses et saignements fréquents."
}
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{
"@type": "Question",
"name": "La splénomégalie est-elle un symptôme de la LMC ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la splénomégalie est fréquente et peut causer des douleurs abdominales."
}
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{
"@type": "Question",
"name": "Les sueurs nocturnes sont-elles liées à la LMC ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les sueurs nocturnes sont un symptôme courant chez les patients atteints de LMC."
}
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{
"@type": "Question",
"name": "Comment la LMC affecte-t-elle l'énergie du patient ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les patients peuvent ressentir une fatigue intense due à l'anémie et à la maladie elle-même."
}
},
{
"@type": "Question",
"name": "Les infections fréquentes sont-elles un symptôme de la LMC ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les infections fréquentes peuvent survenir en raison d'une immunité affaiblie."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la LMC ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique pour la LMC, car elle est souvent liée à des facteurs génétiques."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés à la LMC ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition aux radiations et certains produits chimiques augmentent le risque de LMC."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il le risque de LMC ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque potentiel, bien que moins étudié que d'autres facteurs."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers hématologiques peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Comment réduire le risque de LMC ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter l'exposition aux produits chimiques nocifs et aux radiations peut aider à réduire le risque."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour la LMC ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent les inhibiteurs de tyrosine kinase, la chimiothérapie et la greffe de moelle."
}
},
{
"@type": "Question",
"name": "Quel est le rôle des inhibiteurs de tyrosine kinase ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils ciblent spécifiquement les cellules cancéreuses et bloquent leur croissance."
}
},
{
"@type": "Question",
"name": "La greffe de moelle osseuse est-elle une option ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la greffe peut être envisagée pour les cas avancés ou résistants au traitement."
}
},
{
"@type": "Question",
"name": "Quels effets secondaires peuvent survenir avec le traitement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires incluent nausées, fatigue, et risque accru d'infections."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins réguliers et des examens de suivi sont nécessaires pour évaluer la réponse."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la LMC ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections, des saignements et des crises blastiques."
}
},
{
"@type": "Question",
"name": "Qu'est-ce qu'une crise blastique ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "C'est une progression de la LMC vers une forme plus agressive, ressemblant à une leucémie aiguë."
}
},
{
"@type": "Question",
"name": "La résistance au traitement est-elle une complication ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains patients peuvent développer une résistance aux inhibiteurs de tyrosine kinase."
}
},
{
"@type": "Question",
"name": "Comment les complications affectent-elles le pronostic ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent aggraver le pronostic et nécessiter des traitements plus intensifs."
}
},
{
"@type": "Question",
"name": "Les complications peuvent-elles être gérées ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la gestion des complications est essentielle pour améliorer la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque de la LMC ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition aux radiations, certains produits chimiques et des antécédents familiaux sont des facteurs clés."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de LMC ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la LMC est plus fréquente chez les adultes âgés de 50 à 70 ans."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines maladies génétiques, comme le syndrome de Down, peuvent augmenter le risque de LMC."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de LMC ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes sont légèrement plus susceptibles de développer la LMC que les femmes."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un facteur de risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales, comme le virus d'Epstein-Barr, peuvent être associées à un risque accru."
}
}
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The Distribution of Co-Care Activities Scale was adapted into Chinese for the purposes of this study, and then the psychometric characteristics of the Chinese version of the DoCCA scale were confirmed...
A total of 434 patients with chronic diseases were recruited from three Chinese cities. A cross-cultural adaptation procedure was used to translate the Distribution of Co-Care Activities Scale into Ch...
The Chinese DoCCA scale includes five domains: demands, unnecessary tasks, role clarity, needs support, and goal orientation. The S-CVI was 0.964. Exploratory factor analysis yielded a five-factor str...
The Chinese version of the Distribution of Co-Care Activities Scale had high levels of validity and reliability for chronic conditions. The scale can assess how patients with chronic diseases feel abo...
In digital identity authentication, credentials are typically stored in a digital wallet and authenticated through a single key-based signature and public key verification. However, ensuring compatibi...
Organophosphate esters (OPEs), chemicals widely used in industrial production, electronics and domestic products, have become ubiquitous environmental contaminants. In this study, the levels and spati...
To assess whether therapeutic and toxic effects of intravesical lidocaine are determined by coincident serum levels....
Published clinical trials and case studies on instilled lidocaine 1-2% that reported serum lidocaine levels were analyzed using model independent pharmacokinetic equations to compute the absorbed dose...
Rapid absorption of intravesical lidocaine is evinced by the serum levels of 0.16±0.3 mg/L at 5 min in bladder cancer patients coinciding with the rapid onset of pain relief (<5 min) and blood pressur...
Whether rapid absorption of instilled lidocaine is complicated by an equally rapid and extensive dilution in body weight dependent Vd can be resolved by early blood sampling (<30 min) for: evidence-ba...
The quantitative susceptibility mapping (QSM) technique was used to analyze the distribution pattern of iron deposition in the basal ganglia region of patients with motor subtypes of Parkinson's disea...
The study included 76 patients with PD and 37 healthy controls (HC). Patients with PD were divided into two groups: postural instability/gait disorder (PIGD)(n = 48), and tremor dominance (TD)(n = 28)...
(1) Compared with the HC, the bilateral SN in the PD-PIGD and TD group showed greater susceptibility values. The susceptibility values in the left CN, bilateral PUT were also greater in the PD-PIGD gr...
There were different iron deposition patterns in the basal ganglia between the PD-PIGD and TD groups. There also seems to be a difference in iron deposition in PD motor subtypes on different major mot...
Epirubicin is an anthracycline antineoplastic drug that is primarily used in combination therapies for the treatment of breast, gastric, lung and ovarian cancers and lymphomas. Epirubicin is administe...
In vitro experiments were conducted to determine the kinetics of epirubicin glucuronidation by human liver microsomes in the presence and absence of validated UGT2B7 inhibitors. A full physiologically...
Multivariable linear regression modelling demonstrated that variability in simulated systemic epirubicin exposure following intravenous injection was primarily driven by differences in hepatic and ren...
The present study describes the development and evaluation of a full-body PBPK model to assess systemic and individual organ exposure to epirubicin. Variability in epirubicin exposure was primarily dr...
Impaired iron transport (IIT) is a form of iron deficiency (ID) defined as transferrin saturation (TSAT) < 20% irrespective of serum ferritin levels. It is frequently observed in heart failure (HF) wh...
In this retrospective study we searched for a surrogate biomarker of IIT....
We tested the predictive power of red distribution width (RDW), mean corpuscular volume (MCV) and mean corpuscular haemoglobin concentration (MCHC) to detect IIT in 797 non-anaemic HF patients....
At ROC analysis, RDW provided the best AUC (0.6928). An RDW cut-off value of 14.2% identified patients with IIT, with positive and negative predictive values of 48 and 80%, respectively. Comparison be...
RDW may be seen as a reliable marker to exclude IIT in non-anaemic HF patients with eGFR ≥60 ml/min/1.73 m...
Fault detection for distributed parameter systems (DPSs) generally requires the complete model information to be known so far. However, for numerous industrial applications, it is common that accurate...
The aim of this study was to examine associations of gut microbiome diversity and composition with directly measured regional fat distribution, including central fat, in a large community-based cohort...
A cross-sectional investigation was conducted in the Baltimore Longitudinal Study of Aging (N = 815, 55.2% female, 65.9% White). The fecal microbiome was assessed using whole-genome shotgun metagenomi...
Trunk fat, leg fat, BMI, and waist circumference all significantly explained similar amounts of variance in microbiome structure. Differential abundance testing identified 11 bacterial species signifi...
Microbiome diversity and composition, in particular higher abundance of Ruminococcus gnavus, were associated with greater trunk fat, in addition to other measures of obesity. Longitudinal studies are ...
Sediment microbes are crucial for maintaining biogeochemical cycles in aquatic ecosystems, yet the influence of sediment geophysical structure on microbial communities remains unclear. In this study, ...