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Pyridines
Composés de pyridinium
1-Méthyl-4-phényl-pyridinium
1-Méthyl-4-phényl-pyridinium : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Maladie de Parkinson
Neurotoxicité
Imagerie par résonance magnétique
Électromyographie
Analyse sanguine
Toxicologie
Évaluation neurologique
Réflexes
Symptômes
5
Tremblements
Troubles de la marche
Troubles cognitifs
Démence
Système nerveux
Neurones dopaminergiques
Douleurs musculaires
Douleurs articulaires
Prévention
5
Prévention
Équipements de protection
Vaccins
Prévention des maladies
Mode de vie sain
Maladies neurodégénératives
Éducation à la santé
Sensibilisation
Contrôles médicaux
Détection précoce
Traitements
5
Médicaments dopaminergiques
Thérapie physique
Réhabilitation
Qualité de vie
Antioxydants
Stress oxydatif
Acupuncture
Thérapies complémentaires
Traitement précoce
Progression des symptômes
Complications
5
Complications
Troubles moteurs
Chutes
Troubles de la marche
Qualité de vie
Symptômes parkinsoniens
Complications cardiovasculaires
Santé cardiovasculaire
Facteurs de risque
5
Facteurs de risque
Pesticides
Antécédents familiaux
Maladies neurodégénératives
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"name": "Diagnostic",
"headline": "Diagnostic sur 1-Méthyl-4-phényl-pyridinium",
"description": "Comment diagnostiquer l'exposition au MPP+ ?\nQuels examens sont recommandés pour le MPP+ ?\nQuels symptômes indiquent une intoxication au MPP+ ?\nLe MPP+ peut-il être détecté dans le sang ?\nQuels tests neurologiques sont utiles pour le MPP+ ?",
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"@type": "Question",
"name": "Comment diagnostiquer l'exposition au MPP+ ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests biologiques et des évaluations neurologiques sont utilisés pour diagnostiquer l'exposition."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour le MPP+ ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'IRM et l'électromyographie peuvent aider à évaluer les dommages neurologiques."
}
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{
"@type": "Question",
"name": "Quels symptômes indiquent une intoxication au MPP+ ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tremblements, rigidité et bradykinésie peuvent indiquer une intoxication au MPP+."
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"@type": "Question",
"name": "Le MPP+ peut-il être détecté dans le sang ?",
"position": 4,
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{
"@type": "Question",
"name": "Quels tests neurologiques sont utiles pour le MPP+ ?",
"position": 5,
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"text": "Des tests de coordination et de réflexes peuvent évaluer l'impact neurologique du MPP+."
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{
"@type": "Question",
"name": "Quels sont les symptômes principaux du MPP+ ?",
"position": 6,
"acceptedAnswer": {
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"text": "Les symptômes incluent tremblements, rigidité musculaire et troubles de la marche."
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{
"@type": "Question",
"name": "Le MPP+ cause-t-il des troubles cognitifs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition au MPP+ peut entraîner des troubles cognitifs et de la mémoire."
}
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{
"@type": "Question",
"name": "Y a-t-il des symptômes non moteurs liés au MPP+ ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des symptômes comme la dépression et l'anxiété peuvent survenir."
}
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{
"@type": "Question",
"name": "Comment le MPP+ affecte-t-il le système nerveux ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le MPP+ endommage les neurones dopaminergiques, entraînant des symptômes parkinsoniens."
}
},
{
"@type": "Question",
"name": "Le MPP+ provoque-t-il des douleurs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs musculaires et articulaires peuvent être présentes chez les patients."
}
},
{
"@type": "Question",
"name": "Comment prévenir l'exposition au MPP+ ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les environnements contaminés et utiliser des équipements de protection."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins contre le MPP+ ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccin spécifique contre le MPP+."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie aident-ils à prévenir le MPP+ ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sain peut réduire le risque de maladies neurodégénératives."
}
},
{
"@type": "Question",
"name": "L'éducation sur le MPP+ est-elle importante ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'éducation sur les risques et les symptômes est essentielle pour la prévention."
}
},
{
"@type": "Question",
"name": "Les contrôles réguliers sont-ils recommandés ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des contrôles réguliers peuvent aider à détecter précocement les symptômes."
}
},
{
"@type": "Question",
"name": "Quels traitements sont efficaces contre le MPP+ ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments dopaminergiques et des thérapies physiques."
}
},
{
"@type": "Question",
"name": "La réhabilitation est-elle utile pour les patients exposés au MPP+ ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la réhabilitation aide à améliorer la mobilité et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser des antioxydants pour traiter le MPP+ ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antioxydants peuvent être envisagés pour réduire le stress oxydatif lié au MPP+."
}
},
{
"@type": "Question",
"name": "Les thérapies complémentaires sont-elles bénéfiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines thérapies complémentaires, comme l'acupuncture, peuvent soulager les symptômes."
}
},
{
"@type": "Question",
"name": "Le traitement précoce du MPP+ est-il crucial ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un traitement précoce peut ralentir la progression des symptômes parkinsoniens."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le MPP+ ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles moteurs sévères et des problèmes cognitifs."
}
},
{
"@type": "Question",
"name": "Le MPP+ peut-il entraîner des chutes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les troubles de la marche augmentent le risque de chutes chez les patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de dépression avec le MPP+ ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients exposés au MPP+ présentent un risque accru de dépression."
}
},
{
"@type": "Question",
"name": "Le MPP+ peut-il affecter la qualité de vie ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes parkinsoniens peuvent significativement réduire la qualité de vie."
}
},
{
"@type": "Question",
"name": "Des complications cardiovasculaires sont-elles possibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études suggèrent un lien entre MPP+ et complications cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque du MPP+ ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exposition à des pesticides et à des produits chimiques industriels augmente le risque."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque pour le MPP+ ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque d'effets néfastes du MPP+ augmente avec l'âge."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies neurodégénératives augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le risque de MPP+ ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études montrent que les hommes sont plus à risque que les femmes."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de MPP+ ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 11/03/2025
Contenu vérifié selon les dernières recommandations médicales
5 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3-Methyl-5-(4-methyl-phen-oxy)-1-phenyl-1
IUCrData
2022-09-27
Crystal structure studies of 4-ethyl-piperazin-1-ium 3,5-di-nitro-benzoate, 4-methyl-piperazin-1-ium 3,5-di-nitro-benzoate and 4-methyl-piperazin-1-ium 4-iodo-benzoate.
Acta crystallographica. Section E, Crystallographic communications
2021-10-21
Crystal-structure studies of 4-phenyl-piperazin-1-ium 4-eth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-meth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-methyl-benzoate monohydrate and 4-phenyl-piperazin-1-ium tri-fluoro-acetate 0.12-hydrate.
Acta crystallographica. Section E, Crystallographic communications
2022-06-10
5-(4-Fluoro-phen-yl)-1-[4-(4-methyl-phen-yl)thia-zol-2-yl]-3-[4-(prop-2-yn-yloxy)phen-yl]-4,5-di-hydro-1
IUCrData
2022-10-25
Syntheses and crystal structures of 4-(4-meth-oxy-phen-yl)piperazin-1-ium 4-methyl-benzoate monohydrate and bis-[4-(4-meth-oxy-phen-yl)piperazin-1-ium] benzene-1,2-di-carboxyl-ate.
Acta crystallographica. Section E, Crystallographic communications
2022-08-26
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan. yuka@kms.ac.jp.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Research Team for Neuroimaging, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
4 publications dans cette catégorie
Affiliations :
Department of Radiology, Faculty of Medicine, Kagawa University, 1750-1 Ikenobe, Miki-cho, Kita-gun, Kagawa, 761-0793, Japan.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3 publications dans cette catégorie
Affiliations :
Department of Chemistry, Howard University, 525 College Street NW, Washington DC 20059, USA.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
3 publications dans cette catégorie
Affiliations :
Department of Physics, Faculty of Sciences, Erciyes University, 38039 Kayseri, Türkiye.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
Crystal structures and Hirshfeld surface analyses of methyl 4-{2,2-di-chloro-1-[(
Acta crystallographica. Section E, Crystallographic communications
2024-01-26
Crystal-structure studies of 4-phenyl-piperazin-1-ium 4-eth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-meth-oxy-benzoate monohydrate, 4-phenyl-piperazin-1-ium 4-methyl-benzoate monohydrate and 4-phenyl-piperazin-1-ium tri-fluoro-acetate 0.12-hydrate.
Acta crystallographica. Section E, Crystallographic communications
2022-06-10
Crystal structures of 1-(4-chloro-phen-yl)-4-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carb-oxy-lic acid and 4-(4-meth-oxy-phen-yl)-1-(4-methyl-phen-yl)-2,5-dioxo-1,2,5,6,7,8-hexa-hydro-quinoline-3-carbo-nitrile.
Acta crystallographica. Section E, Crystallographic communications
2021-03-05
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Neuroprotective Drug Discovery Center, Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Division of Clinical Pharmacy, Department of Pharmacy, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Orthopedics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, Neuroprotective Drug Discovery Center, Nanjing Medical University, Nanjing, China.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry Mangalore University Mangalagangotri, Mangalore-574 199, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry Mangalore University Mangalagangotri, Mangalore-574 199, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Thomas Jefferson High School for Science and Technology, 6560 Braddock Rd Alexandria VA 22312, USA.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry and Biochemistry, School of Basic Sciences and Research, Sharda University, Greater Noida 201306, India.
Department of Chemistry, Pondicherry University, Puducherry 605 014, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Chemistry, Pondicherry University, Puducherry 605 014, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida 201306, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
2 publications dans cette catégorie
Affiliations :
Department of Studies in Chemistry, University of Mysore, Manasagangotri, Mysore-570 006, India.
Publications dans "1-Méthyl-4-phényl-pyridinium" :
The role of nimodipine and milrinone in the management of delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) was studied using clinical and TCD (transcranial Doppler) param...
In this prospective observational study, patients with DCI after aneurysmal SAH presenting between November 2020 and June 2021 who were treated by either intra-arterial nimodipine (IAN) or intravenous...
Thirty-four patients fulfilled the inclusion criteria (IVM, 13/34 [38%]; IAN, 21/34 [62%]); patients in the IVM group (vs. IAN group) had poorer median Glasgow Coma Scale score (12 vs. 13), poorer mot...
In this single-center small study, patients in the IAN group had significantly less mortality compared with the IVM group in the management of DCI after aneurysmal SAH....
The aim of this study was to assess the safety and efficacy of long-term milrinone therapy in children with acute decompensated heart failure due to dilated cardiomyopathy (DCM)....
A single-centre retrospective study of all children ≤18 years with acute decompensated heart failure and DCM who received continuous long-term (≥7 consecutive days) intravenous milrinone between Janua...
The 47 patients had a median age of 3.3 months [interquartile range (IQR) 1.0-18.1], weight of 5.7 kg [IQR 4.3-10.1] and fractional shortening of 11.9% [±4.7]. Idiopathic DCM (n = 19) and myocarditis ...
Long-term intravenous milrinone is safe and effective in paediatric acute decompensated DCM. Combined with conventional heart failure therapies, it can act as a bridge to recovery and thereby potentia...
Mean arterial pressure to mean pulmonary arterial pressure ratio (mAP/mPAP) has been identified as a strong predictor of perioperative complications in cardiac surgery. We therefore investigated the p...
Knowledge on the spectral properties of the tautomers of milrinone (MLR) in solvents and solid-state, as well as under light conditions is of critical importance from both theoretical and practical po...
The symptom profile of children dying from cardiac disease, especially heart failure, differs from those with cancer and other non-cardiac conditions. Treatment with vasoactive infusions at home may b...
We report our experience using outpatient milrinone in children receiving hospice care for end-stage heart failure....
Retrospective review of a contemporary cohort of all patients at Lucile Packard Children's Hospital, Stanford who were discharged on intravenous milrinone and hospice care between 2008 and 2021. Clini...
Among 8 patients, median duration of home milrinone infusion was 191 (33, 572) days with the longest support duration 1,054 days. All (100%) patients were also receiving diuretics at the time of death...
We used milrinone with oral diuretics effectively for symptom control in children with heart failure on palliative care. Our experience was that this combination can be used safely in the outpatient s...
Both milrinone and levosimendan have been used in patients undergoing surgical closure of ventricular septal defects (VSD) with pulmonary artery hypertension (PAH); however, the evidence base for thei...
A prospective, randomized, controlled trial....
At a tertiary-care center....
Children between 1 month and 12 years presenting with VSD and PAH between 2018 and 2020....
A total of 132 patients were randomized into the following 2 groups: Group L (levosimendan group) and Group M (milrinone group)....
In addition to conventional hemodynamic parameters, the authors also included a myocardial performance index assessment to compare the groups. The levosimendan group had significantly lower mean arter...
In patients undergoing surgical repair for VSD with PAH, levosimendan does not confer any additional benefit compared to milrinone. Both milrinone and levosimendan appear to be safe in this cohort....
Pulmonary hypertension (PH) and right ventricular (RV) dysfunction are major complications in cardiac surgery. This study aimed to evaluate the change in RV pressure waveform in patients receiving a c...
A prospective single-centre cohort study of adult patients undergoing cardiac surgery administered iE&iM through an ultrasonic mesh nebulizer. RV pressure waveform monitoring was obtained by continuou...
The final analysis included 26 patients receiving iE&iM. There was a significant drop in mean PA pressure (MPAP) (-4.8 ± 8.7, P = 0.010), systolic PA pressure (SPAP) (-8.2 ± 12.8, P = 0.003), RV end-d...
Coadministration of iE&iM in cardiac surgery patients presenting with PH or signs of RV dysfunction is a safe and effective treatment approach in improving RV function. Appearance of a transient incre...
The role of intravenous (IV) inotropes in the treatment of ambulatory patients with advanced heart failure (HF) remains controversial....
This was a retrospective study of patients with advanced HF. Patients on home IV milrinone, who remained on it for at least 3 months, were included. We compared the data from 3 months before starting ...
A total of 90 patients remained on continuous IV milrinone for 3 months, and 55 patients were treated for 6 months or longer. In both groups, improvements in cardiac index (1.86-2.25, p<0.001 and 1.9-...
Long-term IV use of milrinone is associated with improvement in haemodynamics, functional class, tolerance of medical therapy, and decrease in hospitalised days....
This study aims to determine the incidence of all-cause hospitalization in patients with advanced heart failure (AHF) receiving ambulatory continuous, intravenous dobutamine versus milrinone for palli...
We sought to describe and compare outcomes among advanced patients with heart failure (not candidates for orthotopic heart transplant/left ventricular assist device) on long-term milrinone or dobutami...
We included adults with refractory stage D heart failure who were not candidates for orthotopic heart transplant or left ventricular assist device and discharged on palliative dobutamine or milrinone....
The 1-year mortality from palliative inotropes remains high. Compared with dobutamine, use of milrinone was associated with improved survival owing to better optimization of guideline-directed medical...