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Acides aminés, peptides et protéines
Protéines
Protéines du sang
Immunoprotéines
Protéines du système du complément
Complément C3
Complément C3b
Complément C3c
Complément C3c : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"@type": "Question",
"name": "Comment mesurer le complément C3c ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le complément C3c est mesuré par un test sanguin spécifique en laboratoire."
}
},
{
"@type": "Question",
"name": "Quels tests sont associés au C3c ?",
"position": 2,
"acceptedAnswer": {
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"text": "Les tests de C3c sont souvent associés à des dosages de C3 et C4."
}
},
{
"@type": "Question",
"name": "Quand évaluer le C3c ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le C3c est évalué lors de suspicion de maladies auto-immunes ou inflammatoires."
}
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{
"@type": "Question",
"name": "Le C3c est-il un marqueur de maladie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux de C3c peuvent indiquer des pathologies sous-jacentes."
}
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{
"@type": "Question",
"name": "Quel rôle joue le C3c dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
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"text": "Le C3c aide à évaluer l'activité du système du complément dans diverses conditions."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés à un faible C3c ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un faible C3c peut entraîner des infections fréquentes et des inflammations."
}
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{
"@type": "Question",
"name": "Un C3c élevé indique-t-il des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un C3c élevé peut être associé à des symptômes d'inflammation ou d'infection."
}
},
{
"@type": "Question",
"name": "Le C3c affecte-t-il la fatigue ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent contribuer à la fatigue liée à l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques au C3c ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le C3c n'a pas de symptômes spécifiques, mais reflète l'état immunitaire."
}
},
{
"@type": "Question",
"name": "Le C3c est-il lié à des douleurs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés de C3c peuvent être associés à des douleurs inflammatoires."
}
},
{
"@type": "Question",
"name": "Comment prévenir les anomalies du C3c ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain et gérer les maladies chroniques aide à prévenir les anomalies."
}
},
{
"@type": "Question",
"name": "Le vaccin influence-t-il le C3c ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccins peuvent stimuler le système immunitaire, influençant potentiellement le C3c."
}
},
{
"@type": "Question",
"name": "Y a-t-il des habitudes à éviter ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter le tabagisme et une mauvaise alimentation peut aider à maintenir un C3c normal."
}
},
{
"@type": "Question",
"name": "Le stress affecte-t-il le C3c ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber le système immunitaire et affecter le C3c."
}
},
{
"@type": "Question",
"name": "Des examens réguliers sont-ils nécessaires ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter des anomalies du C3c tôt."
}
},
{
"@type": "Question",
"name": "Comment traiter un faible C3c ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement dépend de la cause sous-jacente, souvent par immunothérapie."
}
},
{
"@type": "Question",
"name": "Des médicaments affectent-ils le C3c ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments immunosuppresseurs peuvent réduire les niveaux de C3c."
}
},
{
"@type": "Question",
"name": "Le C3c nécessite-t-il un suivi ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est recommandé pour surveiller les niveaux de C3c."
}
},
{
"@type": "Question",
"name": "Peut-on augmenter le C3c naturellement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent soutenir le système immunitaire."
}
},
{
"@type": "Question",
"name": "Les transfusions affectent-elles le C3c ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les transfusions peuvent influencer les niveaux de C3c en fonction des composants."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec un C3c bas ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un C3c bas peut entraîner des infections récurrentes et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Un C3c élevé cause-t-il des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un C3c élevé peut être lié à des complications inflammatoires et des maladies chroniques."
}
},
{
"@type": "Question",
"name": "Le C3c affecte-t-il la guérison des blessures ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent retarder la guérison en perturbant l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de thrombose liés au C3c ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés de C3c peuvent être associés à un risque accru de thrombose."
}
},
{
"@type": "Question",
"name": "Le C3c influence-t-il les maladies cardiovasculaires ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux de C3c peuvent être liés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de C3c anormal ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies auto-immunes, infections chroniques et certains médicaments augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le C3c ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter les niveaux de C3c, souvent en raison de changements immunitaires."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le C3c ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des différences hormonales peuvent influencer les niveaux de C3c entre les sexes."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le C3c ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter le C3c."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le C3c ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de C3c anormal."
}
}
]
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The classical pathway of the complement system is activated by the binding of C1q in the C1 complex to the target activator, including immune complexes. Factor H is regarded as the key downregulatory ...
Bacterial and mitochondrial DNA, sharing an evolutionary origin, act as danger-associated molecular patterns in infectious and sterile inflammation. They both contain immunomodulatory CpG motifs. Inte...
The role of the human immune system in pathologic responses to chemicals including nanomaterials was identified as a gap in current hazard assessments. However, the complexity of the human immune syst...
We treated commercially available pooled sera (PS) from healthy males, individual sera from healthy donors and from patients suffering from cancer, immunodeficiency and allergies with small molecules ...
The level of complement activation in PS differed significantly from responses of individual donors (p < 0.01). Only seven out of 32 investigated sera from healthy donors responded similarly to the po...
Our studies demonstrate that the use of pooled serum can lead to an over- or under-estimation of immunological response in particular for individuals with pre-existing pathologies. This is of high rel...
Atypical hemolytic uremic syndrome (aHUS) is a rare kidney disease caused by dysregulation of the complement alternative pathway. The complement dysregulation specifically leads to damage to the glome...
Endothelial cells were incubated with human test sera and stained with an anti-C5b-9 antibody to visualize and quantify complement depositions on the cells with immunofluorescence microscopy....
First, we showed that zymosan-activated sera resulted in increased endothelial C5b-9 depositions compared to normal human serum (NHS). The levels of C5b-9 depositions were similar between conditionall...
In conclusion, we demonstrate a robust and reliable model to adequately measure C5b-9-based complement deposition on human control and patient ciGMVECs. This model can be used to study the pathophysio...
Patients in the intensive care unit (ICU) often straddle the divide between life and death. Understanding the complex underlying pathomechanisms relevant to such situations may help intensivists selec...
The complement system which is part of the innate immune response against invading pathogens represents a powerful mechanism for killing of infected cells. Utilizing direct complement recruitment for ...
Cancer-related inflammation plays a central role in the establishment of tumor-promoting mechanisms. Tumor-associated myeloid cells, which engage in complex interactions with cancer cells, as well as ...
Patients with severe thrombocytopenia due to bone marrow failure and after chemotherapy are still treated with platelet transfusions. Platelet concentrates (PC) are associated with a high incidence of...
Single donor apheresis platelet concentrates (SDA PCs) were produced in a regional setting of the French Blood Establishment. After transfusion samples were collected from PC and possible AR in patien...
A total of 56 PC were included in the study. 30 PC induced no AR, and 26 induced AR (Febrile non-hemolytic transfusion reaction n = 16; Atypical Allergic Transfusion Reactions n = 11; hemodynamic inst...
In this study, we observed an association between HMGB1 and CAP and the incidence of AR. Furthermore, we demonstrated that both HMGB1 and complement activation were correlated to platelet activation....
Anti-platelet factor 4 (PF4)/heparin immune complexes that cause heparin-induced thrombocytopenia (HIT) activate complement via the classical pathway. Previous studies have shown that the alternative ...
These studies sought to examine the contributions of the alternative pathway to complement activation by HIT antibodies....
Using IgG monoclonal (KKO) and/or patient-derived HIT antibodies, we compared the effects of classical pathway (BBK32 and C1-esterase inhibitor [C1-INH]), alternative pathway (anti-factor B [fB] or fa...
Classical pathway inhibitors BBK32 and C1-INH and the combined classical/alternative pathway inhibitor sCR1 prevented KKO/HIT immune complex-induced complement activation, including release of C3 and ...
Collectively, these findings suggest the alternative pathway contributes little in support of complement activation by HIT immune complexes. Additional in vitro and in vivo studies are required to exa...
Increasing evidence suggests that activation of the complement system plays a key role in the pathogenesis and disease severity of Coronavirus disease 2019 (COVID-19). We used a systematic approach to...