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Acides aminés, peptides et protéines
Protéines
Protéines du sang
Immunoprotéines
Protéines du système du complément
Complément C3
Complément C3b
Complément C3c
Complément C3c : Questions médicales fréquentes
Termes MeSH sélectionnés :
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"description": "Comment mesurer le complément C3c ?\nQuels tests sont associés au C3c ?\nQuand évaluer le C3c ?\nLe C3c est-il un marqueur de maladie ?\nQuel rôle joue le C3c dans le diagnostic ?",
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"@type": "Question",
"name": "Comment mesurer le complément C3c ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le complément C3c est mesuré par un test sanguin spécifique en laboratoire."
}
},
{
"@type": "Question",
"name": "Quels tests sont associés au C3c ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de C3c sont souvent associés à des dosages de C3 et C4."
}
},
{
"@type": "Question",
"name": "Quand évaluer le C3c ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le C3c est évalué lors de suspicion de maladies auto-immunes ou inflammatoires."
}
},
{
"@type": "Question",
"name": "Le C3c est-il un marqueur de maladie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux de C3c peuvent indiquer des pathologies sous-jacentes."
}
},
{
"@type": "Question",
"name": "Quel rôle joue le C3c dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le C3c aide à évaluer l'activité du système du complément dans diverses conditions."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à un faible C3c ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un faible C3c peut entraîner des infections fréquentes et des inflammations."
}
},
{
"@type": "Question",
"name": "Un C3c élevé indique-t-il des symptômes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un C3c élevé peut être associé à des symptômes d'inflammation ou d'infection."
}
},
{
"@type": "Question",
"name": "Le C3c affecte-t-il la fatigue ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent contribuer à la fatigue liée à l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques au C3c ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, le C3c n'a pas de symptômes spécifiques, mais reflète l'état immunitaire."
}
},
{
"@type": "Question",
"name": "Le C3c est-il lié à des douleurs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés de C3c peuvent être associés à des douleurs inflammatoires."
}
},
{
"@type": "Question",
"name": "Comment prévenir les anomalies du C3c ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Maintenir un mode de vie sain et gérer les maladies chroniques aide à prévenir les anomalies."
}
},
{
"@type": "Question",
"name": "Le vaccin influence-t-il le C3c ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les vaccins peuvent stimuler le système immunitaire, influençant potentiellement le C3c."
}
},
{
"@type": "Question",
"name": "Y a-t-il des habitudes à éviter ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter le tabagisme et une mauvaise alimentation peut aider à maintenir un C3c normal."
}
},
{
"@type": "Question",
"name": "Le stress affecte-t-il le C3c ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut perturber le système immunitaire et affecter le C3c."
}
},
{
"@type": "Question",
"name": "Des examens réguliers sont-ils nécessaires ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter des anomalies du C3c tôt."
}
},
{
"@type": "Question",
"name": "Comment traiter un faible C3c ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement dépend de la cause sous-jacente, souvent par immunothérapie."
}
},
{
"@type": "Question",
"name": "Des médicaments affectent-ils le C3c ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments immunosuppresseurs peuvent réduire les niveaux de C3c."
}
},
{
"@type": "Question",
"name": "Le C3c nécessite-t-il un suivi ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est recommandé pour surveiller les niveaux de C3c."
}
},
{
"@type": "Question",
"name": "Peut-on augmenter le C3c naturellement ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent soutenir le système immunitaire."
}
},
{
"@type": "Question",
"name": "Les transfusions affectent-elles le C3c ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les transfusions peuvent influencer les niveaux de C3c en fonction des composants."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec un C3c bas ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un C3c bas peut entraîner des infections récurrentes et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Un C3c élevé cause-t-il des complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un C3c élevé peut être lié à des complications inflammatoires et des maladies chroniques."
}
},
{
"@type": "Question",
"name": "Le C3c affecte-t-il la guérison des blessures ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux anormaux de C3c peuvent retarder la guérison en perturbant l'inflammation."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de thrombose liés au C3c ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des niveaux élevés de C3c peuvent être associés à un risque accru de thrombose."
}
},
{
"@type": "Question",
"name": "Le C3c influence-t-il les maladies cardiovasculaires ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des niveaux anormaux de C3c peuvent être liés à un risque accru de maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de C3c anormal ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les maladies auto-immunes, infections chroniques et certains médicaments augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le C3c ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter les niveaux de C3c, souvent en raison de changements immunitaires."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans le C3c ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des différences hormonales peuvent influencer les niveaux de C3c entre les sexes."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le C3c ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent affecter le C3c."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils le C3c ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies immunitaires peuvent augmenter le risque de C3c anormal."
}
}
]
}
]
}
We aimed to compare the clinical and laboratory characteristics of patients with SLE according to the weighted complement status of the EULAR/ACR criteria and investigate whether different weighting o...
Patients diagnosed with juvenile onset SLE who fulfilled the 2019 EULAR/ACR classification criteria were retrospectively analyzed....
Among 43 patients included, hypocomplementemia was observed in 37 (86%), mostly with a low level of both complement C3 (C3) and complement C4 (C4) (53.5%). In patients with low levels of both C3 and C...
Observation of more frequent clinical and serological activity with higher total scores from the EULAR/ACR classification criteria supported the higher scoring of patients with low C3 and C4 in the we...
Increased expression of the complement component 4A (C4A) gene is associated with a greater lifetime risk of schizophrenia. In the brain, C4A is involved in synaptic pruning; yet, it remains unclear t...
While C4A GREx is not related to childhood psychotic experiences, cognition, or global measures of brain structure, it is associated with a localized reduction in regional surface area (SA) of the ent...
Our results suggest neurodevelopmental effects of C4A on childhood medial temporal lobe structure, which may serve as a biomarker for schizophrenia risk prior to symptom onset....
Proteolytic cascades comprise several important physiological systems, including a primary arm of innate immunity called the complement cascade. To safeguard against complement-mediated attack, the et...
The objective of this study was to analyze complement activation in antiphospholipid antibody (aPL)-positive patients without other systemic autoimmune rheumatic diseases, using C3/C4 and cell-bound c...
Complete genetic deficiency of the complement component C2 is a strong risk factor for monogenic systemic lupus erythematosus (SLE), but whether heterozygous C2 deficiency adds to the risk of SLE or p...
The presence of the common 28-bp C2 deletion rs9332736 and C4 copy number variation was examined in Scandinavian patients who had received a diagnosis of SLE (n = 958) or primary SS (n = 911) and in 2...
Heterozygous C2 deficiency-when present in combination with a low C4A copy number-substantially increased the risk of SLE (odds ratio [OR] 10.2 [95% confidence interval (95% CI) 3.5-37.0]) and the ris...
We demonstrate that a genetic pattern involving partial deficiencies of C2 and C4A in the classical complement pathway is a strong risk factor for SLE and for primary SS. Our results emphasize the cen...
Complement system plays an important role in the pathogenesis of idiopathic membranous nephropathy (IMN), however, the relationship between serum complement 4 (C4) and kidney disease progression in IM...
The retrospective cohort assessed 1,254 participants with biopsy-proven IMN from three centers in Xi 'an, Shaanxi Province, China. Baseline serum C4 levels were measured at renal biopsy. The associati...
A total of 328 patients with IMN and nephrotic proteinuria were eligible, and 11.3% (37/328) of them attained the renal function progression events after a median follow-up of 51 months (37-59 months)...
Among patients with IMN and nephrotic proteinuria, serum C4 at renal biopsy is an independent predictor for kidney disease progression regardless of other confounders....
Schizophrenia is a severe mental illness and a major risk factor for suicide, with approximately 50% of schizophrenia patients attempting and 10% dying from suicide. Although genetic components play a...
Complex brain disorders like schizophrenia may have multifactorial origins related to mis-timed heritable and environmental factors interacting during neurodevelopment. Infections, inflammation, and a...
To explore the prevalence and clinical significance of low complement levels in patients with catastrophic antiphospholipid syndrome (CAPS)....
We reviewed data from the "CAPS Registry" on C3 and/or C4 complement plasma protein levels during acute CAPS episodes. Patients were classified into those with low and normal complement levels. Data o...
The "CAPS Registry" includes 566 patients with a total of 578 episodes of CAPS. Data on complement plasma protein levels was available in 73 episodes from the same number of patients. Low levels of C3...
In our study, low levels of C3 and C4 plasma proteins are detected in 58% episodes of CAPS, which were not associated with clinical presentation including TMA features, aPL triple positivity, or morta...
The aim of this study was to assess whether complement proteins C3 and C4 are produced by immortalized human conjunctival epithelial (HCjE) cells....
Supernatants and cell lysates from undifferentiated and differentiated HCjE cells were assayed for C3 and C4 by enzyme-linked immunosorbent assay. To measure complement protein function, supernatants ...
C3 was upregulated in supernatants from differentiated HCjE cells compared with undifferentiated HCjE cells (556.55 ± 91.75 vs. 56.95 ± 12.09 ng/mL, P <0.001). C4 was also increased in supernatants bu...
HCjE cells produce C3 and C4 in sufficient quantities to support the formation of sC5b-9, confirming their biological activity and suggesting that HCjE cells likely produce all complement proteins C1 ...