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"description": "Comment la mitomycine est-elle administrée ?\nQuels tests sont nécessaires avant traitement ?\nLa mitomycine est-elle utilisée pour tous les cancers ?\nQuels marqueurs tumoraux sont surveillés ?\nY a-t-il des contre-indications au traitement ?",
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"headline": "Symptômes sur Mitomycine",
"description": "Quels sont les effets secondaires courants ?\nLa mitomycine cause-t-elle des douleurs ?\nQuels symptômes indiquent une réaction allergique ?\nPeut-elle affecter le système immunitaire ?\nQuels signes de toxicité doivent alerter ?",
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"headline": "Prévention sur Mitomycine",
"description": "Comment minimiser les effets secondaires ?\nDes vaccinations sont-elles nécessaires ?\nComment éviter les infections pendant le traitement ?\nY a-t-il des recommandations alimentaires ?\nComment gérer le stress pendant le traitement ?",
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"description": "La mitomycine est-elle utilisée seule ?\nQuelle est la durée du traitement ?\nComment surveiller l'efficacité du traitement ?\nQuels soins de soutien sont recommandés ?\nY a-t-il des interactions médicamenteuses ?",
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"description": "Qui est à risque d'effets secondaires ?\nLes antécédents de cancer augmentent-ils le risque ?\nLe tabagisme influence-t-il le traitement ?\nY a-t-il des facteurs génétiques à considérer ?\nL'âge influence-t-il la tolérance au traitement ?",
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"@type": "Question",
"name": "Comment la mitomycine est-elle administrée ?",
"position": 1,
"acceptedAnswer": {
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"text": "La mitomycine est généralement administrée par injection intraveineuse ou intravésicale."
}
},
{
"@type": "Question",
"name": "Quels tests sont nécessaires avant traitement ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins et des examens d'imagerie sont souvent requis pour évaluer la santé du patient."
}
},
{
"@type": "Question",
"name": "La mitomycine est-elle utilisée pour tous les cancers ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, elle est principalement utilisée pour des cancers spécifiques comme le cancer de la vessie."
}
},
{
"@type": "Question",
"name": "Quels marqueurs tumoraux sont surveillés ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les marqueurs comme le CA 19-9 peuvent être surveillés selon le type de cancer traité."
}
},
{
"@type": "Question",
"name": "Y a-t-il des contre-indications au traitement ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents d'allergies ou de maladies rénales peuvent être des contre-indications."
}
},
{
"@type": "Question",
"name": "Quels sont les effets secondaires courants ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires incluent nausées, vomissements, et fatigue."
}
},
{
"@type": "Question",
"name": "La mitomycine cause-t-elle des douleurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut provoquer des douleurs abdominales ou des douleurs au site d'injection."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une réaction allergique ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des démangeaisons, éruptions cutanées ou difficultés respiratoires peuvent indiquer une allergie."
}
},
{
"@type": "Question",
"name": "Peut-elle affecter le système immunitaire ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la mitomycine peut réduire les globules blancs, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Quels signes de toxicité doivent alerter ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des saignements inhabituels ou des ecchymoses peuvent indiquer une toxicité."
}
},
{
"@type": "Question",
"name": "Comment minimiser les effets secondaires ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hydratation et des médicaments antiémétiques peuvent aider à réduire les effets secondaires."
}
},
{
"@type": "Question",
"name": "Des vaccinations sont-elles nécessaires ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des vaccinations peuvent être recommandées pour prévenir les infections pendant le traitement."
}
},
{
"@type": "Question",
"name": "Comment éviter les infections pendant le traitement ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter les foules et pratiquer une bonne hygiène peut aider à prévenir les infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il des recommandations alimentaires ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et riche en nutriments est recommandée pour soutenir le traitement."
}
},
{
"@type": "Question",
"name": "Comment gérer le stress pendant le traitement ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des techniques de relaxation et le soutien psychologique peuvent aider à gérer le stress."
}
},
{
"@type": "Question",
"name": "La mitomycine est-elle utilisée seule ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut être utilisée seule ou en combinaison avec d'autres agents chimiothérapeutiques."
}
},
{
"@type": "Question",
"name": "Quelle est la durée du traitement ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La durée varie selon le type de cancer, mais elle est souvent administrée sur plusieurs cycles."
}
},
{
"@type": "Question",
"name": "Comment surveiller l'efficacité du traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens d'imagerie et des tests sanguins réguliers sont utilisés pour évaluer l'efficacité."
}
},
{
"@type": "Question",
"name": "Quels soins de soutien sont recommandés ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des soins de soutien comme la gestion de la douleur et des conseils nutritionnels sont recommandés."
}
},
{
"@type": "Question",
"name": "Y a-t-il des interactions médicamenteuses ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la mitomycine peut interagir avec d'autres médicaments, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications peuvent inclure des infections, des saignements et des problèmes rénaux."
}
},
{
"@type": "Question",
"name": "La mitomycine peut-elle causer des cancers secondaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'utilisation de mitomycine peut augmenter le risque de cancers secondaires à long terme."
}
},
{
"@type": "Question",
"name": "Comment gérer une toxicité sévère ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une hospitalisation et un traitement symptomatique peuvent être nécessaires en cas de toxicité sévère."
}
},
{
"@type": "Question",
"name": "Quels tests pour surveiller les complications ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests sanguins réguliers et des examens d'imagerie sont nécessaires pour surveiller les complications."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets à long terme ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets à long terme peuvent inclure des problèmes pulmonaires ou rénaux, nécessitant un suivi."
}
},
{
"@type": "Question",
"name": "Qui est à risque d'effets secondaires ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les personnes âgées et celles avec des antécédents médicaux complexes sont plus à risque."
}
},
{
"@type": "Question",
"name": "Les antécédents de cancer augmentent-ils le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents de cancer peuvent augmenter le risque d'effets secondaires lors du traitement."
}
},
{
"@type": "Question",
"name": "Le tabagisme influence-t-il le traitement ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut affecter l'efficacité du traitement et augmenter les risques d'effets secondaires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des facteurs génétiques à considérer ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines variations génétiques peuvent influencer la réponse au traitement par mitomycine."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il la tolérance au traitement ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les patients plus âgés peuvent avoir une tolérance réduite aux effets de la mitomycine."
}
}
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We compared computed tomography (CT) images and holograms (HG) to assess the number of arteries of the lung lobes undergoing lobectomy and assessed easiness in interpretation by radiologists and thora...
Patients scheduled for lobectomy for lung cancer were prospectively included and underwent CT for staging. A patient-specific three-dimensional model was generated and visualized in an augmented reali...
Fifty-two patients were prospectively included. The two doctors detected the same number of arteries in 44/52 images (85%) and in 51/52 holograms (98%). The mean difference between the number of arter...
Augmented reality by holograms is an effective tool for preoperative vascular anatomy assessment of lungs, especially when evaluating the upper lobes, more prone to anatomical variations....
ClinicalTrials.gov, NCT04227444 RELEVANCE STATEMENT: Preoperative evaluation of the lung lobe arteries through augmented reality may help the thoracic surgeons to carefully plan a lobectomy, thus cont...
• Preoperative assessment of the lung arteries may help surgical planning. • Lung artery detection by augmented reality was more accurate than that by CT images, particularly for the upper lobes. • Th...
This study aimed to propose reference standards for cardiorespiratory fitness (CRF) for Brazil from a pooled analysis and to compare peak oxygen uptake (V˙ o2peak ) in Brazilian, United States (US), a...
Reference values for treadmill V˙ o2peak in three different Brazilian regions were assessed from previous publications. We analyzed available samples to assess possible differences, generate weighted ...
Brazilian reference values had a lower V˙ o2peak value for the Northeast region and a higher V˙ o2peak value for the Southeast region for all sex and age groups. International comparisons with the Bra...
This study provides new CRF reference standards for Brazil. After pooling data from three Brazilian regions, a comparison revealed notable differences between regions, evidencing a negative gradient f...
Pertussis surveillance remains essential in Canada, but ascertainment bias limits the accuracy of surveillance data. Introducing other sources to improve detection has highlighted the importance of va...
We used a stratified strategy to sample the reference standard from a primary care electronic medical record cohort. We incorporated abstractor notes into definite, possible, ruled-out, and no mention...
We abstracted eight hundred records from the cohort of 404,922. There were 208 (26%) definite and 261 (32.6%) possible prevalent pertussis cases. Classifications demonstrated a wide variety of case se...
When conducting validation studies for pertussis and other low prevalence diseases, this stratified sampling strategy can be used to develop a reference standard using limited resources. This approach...
Routine tissue-specific reference genes are often used in expression studies, but target genes are not taken into account. Using the relative RT-qPCR approach, we evaluated the expression of three tar...
Standardized results for laboratory tests are particularly important when their interpretation depends on fixed medical practice guidelines or common reference intervals. The medical laboratory commun...
The participants agreed that prioritization of measurands for standardization should be based on their impact on medical decisions in a clinical pathway. Ensuring that matrix-based CRMs are globally a...
A standardization initiative requires collaboration and planning among all interested stakeholders. Global collaboration should be further developed for prioritization of measurands for standardizatio...
In this community effort, we compare measurements between 34 laboratories from 19 countries, utilizing mixtures of labelled authentic synthetic standards, to quantify by mass spectrometry four clinica...
Normative standards for key cardiopulmonary exercise (CPX) test variables, including peak circulatory power (CircP), are needed to guide the interpretation of clinical exercise responses in individual...
This study aimed to establish age- and sex-specific reference standards for peak CircP derived from a healthy cohort from the Fitness Registry and the Importance of Exercise: A National Database (FRIE...
CPX test data from apparently healthy males and females from eight FRIEND United States exercise laboratories were considered. Inclusion criteria included ages 20-79 yr and a maximal, symptom-limited ...
A total of 6736 CPX tests (47% treadmill, 53% female) were included in the analysis. Overall, CircP was higher in males, higher on tests conducted on a treadmill, and decreased with age. Sex, exercise...
These results establish reference standards for CircP, a potentially important prognostic indicator of cardiovascular health. Future research exploring the role of percentiles and percent-predicted va...
Pharmacovigilance using real-world data (RWD), such as multicenter electronic health records (EHRs), yields massively parallel adverse drug reaction (ADR) signals. However, proper validation of comput...
This study aimed to develop a reference standard for ADR (RS-ADR) to streamline the systematic detection, assessment, and understanding of almost all drug-ADR associations suggested by RWD analyses....
We integrated well-known reference sets for drug-ADR pairs, including Side Effect Resource, Observational Medical Outcomes Partnership, and EU-ADR. We created a pharmacovigilance dictionary using cont...
The RS-ADR consisted of 1344 drugs, 4485 ADRs, and 6,027,840 drug-ADR pairs with positive and negative consensus votes as pharmacovigilance reference sets. After the curation of the initial version of...
RS-ADRs enriched with the pharmacovigilance dictionary, ADR knowledge, and real-world evidence from EHRs may streamline the systematic detection, evaluation, and causality assessment of computationall...
Peak rating of perceived exertion (RPE) is measured during clinical cardiopulmonary exercise testing (CPX) and is commonly used as a subjective indicator of maximal effort. However, no study to date h...
This study aimed to determine reference standards for peak RPE when using the 6-20 Borg scale for both treadmill and cycle tests....
The analysis included 9551 tests (8821 treadmill, 730 cycle ergometer) from 13 laboratories within the Fitness Registry and Importance of Exercise National Database (FRIEND). Using data from tests con...
There were statistically significant differences in RPE between age groups whether the test was performed on a treadmill or cycle ergometer ( P < 0.05). However, the mean and median RPE for each sex, ...
This report provides the first normative reference standards for peak RPE in both male and female individuals performing CPX on a treadmill or cycle ergometer. Furthermore, these reference standards h...
In 2018, we published the MONARCSi algorithmic decision support tool showing high inter-rater agreement, moderate sensitivity, and high specificity compared with drug-event pairs (DEPs) previously rev...
This paper describes the development of an independent reference standard (i.e., reference comparator) using a sample of DEPs evaluated by Roche subject matter experts (SMEs) and subsequent performanc...
Roche collected a random sample of 131 DEPs evaluated by an external vendor using the MONARCSi prototype during 2020, and collectively referred to as the VMON (Vendor using the MONARCSi system for med...
Binary comparison of the aggregate results showed substantial agreement (Gwet kappa = 0.81) between the VMON and reference standard CAUSMET assessments. Bayesian latent class modeling showed that both...
Analysis of causality results from the assessments by independent internal SMEs using MONARCSi shows there is no obvious difference in performance between the aggregate CAUSMET and VMON assessments ba...
