Y a-t-il un risque accru de récidive après traitement ?
Oui, le risque de récidive est élevé, nécessitant un suivi régulier après traitement.
RécidiveSuivi médicalCarcinome corticosurrénalien
#5
Le carcinome corticosurrénalien peut-il affecter la qualité de vie ?
Oui, les symptômes et les traitements peuvent significativement impacter la qualité de vie.
Qualité de vieSymptômesCarcinome corticosurrénalien
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque du carcinome corticosurrénalien ?
Les antécédents familiaux, certaines maladies génétiques et l'obésité sont des facteurs de risque.
Facteurs de risqueObésitéCarcinome corticosurrénalien
#2
Les maladies génétiques augmentent-elles le risque ?
Oui, des syndromes comme le syndrome de Li-Fraumeni augmentent le risque de ce cancer.
Syndrome de Li-FraumeniGénétiqueCarcinome corticosurrénalien
#3
L'âge est-il un facteur de risque ?
Oui, le carcinome corticosurrénalien est plus fréquent chez les adultes jeunes à moyens.
ÂgeCarcinome corticosurrénalienFacteurs de risque
#4
Le sexe influence-t-il le risque de ce cancer ?
Les femmes sont légèrement plus susceptibles de développer ce cancer que les hommes.
SexeCarcinome corticosurrénalienFacteurs de risque
#5
Le stress a-t-il un impact sur le risque de carcinome ?
Bien que le stress soit un facteur de santé, son lien direct avec ce cancer n'est pas établi.
StressSantéCarcinome corticosurrénalien
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Carcinome corticosurrénalien : Questions médicales les plus fréquentes",
"headline": "Carcinome corticosurrénalien : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Carcinome corticosurrénalien : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-04",
"dateModified": "2025-03-31",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Carcinome corticosurrénalien"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Tumeurs corticosurrénaliennes",
"url": "https://questionsmedicales.fr/mesh/D000306",
"about": {
"@type": "MedicalCondition",
"name": "Tumeurs corticosurrénaliennes",
"code": {
"@type": "MedicalCode",
"code": "D000306",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "C19.344.078.265"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Carcinome corticosurrénalien",
"alternateName": "Adrenocortical Carcinoma",
"code": {
"@type": "MedicalCode",
"code": "D018268",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Martin Fassnacht",
"url": "https://questionsmedicales.fr/author/Martin%20Fassnacht",
"affiliation": {
"@type": "Organization",
"name": "Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Mainfranken, University of Würzburg, Würzburg, Germany; Central Laboratory, University Hospital Würzburg, Würzburg, Germany."
}
},
{
"@type": "Person",
"name": "Constanze Hantel",
"url": "https://questionsmedicales.fr/author/Constanze%20Hantel",
"affiliation": {
"@type": "Organization",
"name": "Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Germany."
}
},
{
"@type": "Person",
"name": "Katja Kiseljak-Vassiliades",
"url": "https://questionsmedicales.fr/author/Katja%20Kiseljak-Vassiliades",
"affiliation": {
"@type": "Organization",
"name": ""
}
},
{
"@type": "Person",
"name": "Sandra Sigala",
"url": "https://questionsmedicales.fr/author/Sandra%20Sigala",
"affiliation": {
"@type": "Organization",
"name": "Department of Molecular & Translational Medicine, Section of Pharmacology, University of Brescia, 25123 Brescia, Italy."
}
},
{
"@type": "Person",
"name": "Jaydira Del Rivero",
"url": "https://questionsmedicales.fr/author/Jaydira%20Del%20Rivero",
"affiliation": {
"@type": "Organization",
"name": "Developmental Therapeutics Branch, Rare Tumor Initiative, Center for Cancer Research, National Cancer Institute, Bethesda, MD, United States."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "The Antineoplastic Effect of Carboplatin Is Potentiated by Combination with Pitavastatin or Metformin in a Chemoresistant High-Grade Serous Carcinoma Cell Line.",
"datePublished": "2022-12-21",
"url": "https://questionsmedicales.fr/article/36613537",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.3390/ijms24010097"
}
},
{
"@type": "ScholarlyArticle",
"name": "Promotion of tumor progression induced by continuous low-dose administration of antineoplastic agent gemcitabine or gemcitabine combined with cisplatin.",
"datePublished": "2022-07-21",
"url": "https://questionsmedicales.fr/article/35870618",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.lfs.2022.120826"
}
},
{
"@type": "ScholarlyArticle",
"name": "Drug independence and the curability of cancer by combination chemotherapy.",
"datePublished": "2022-07-14",
"url": "https://questionsmedicales.fr/article/35842290",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.trecan.2022.06.009"
}
},
{
"@type": "ScholarlyArticle",
"name": "Daratumumab and antineoplastic therapy versus antineoplastic therapy only for adults with newly diagnosed multiple myeloma ineligible for transplant.",
"datePublished": "2024-05-02",
"url": "https://questionsmedicales.fr/article/38695605",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/14651858.CD013595.pub2"
}
},
{
"@type": "ScholarlyArticle",
"name": "Neoadjuvant Arterial Embolization Chemotherapy Combined PD-1 Inhibitor for Locally Advanced Rectal Cancer (NECI Study): a protocol for a phase II study.",
"datePublished": "2023-03-13",
"url": "https://questionsmedicales.fr/article/36914193",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1136/bmjopen-2022-069401"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Maladies endocriniennes",
"item": "https://questionsmedicales.fr/mesh/D004700"
},
{
"@type": "ListItem",
"position": 3,
"name": "Tumeurs des glandes endocrines",
"item": "https://questionsmedicales.fr/mesh/D004701"
},
{
"@type": "ListItem",
"position": 4,
"name": "Tumeurs de la surrénale",
"item": "https://questionsmedicales.fr/mesh/D000310"
},
{
"@type": "ListItem",
"position": 5,
"name": "Tumeurs corticosurrénaliennes",
"item": "https://questionsmedicales.fr/mesh/D000306"
},
{
"@type": "ListItem",
"position": 6,
"name": "Carcinome corticosurrénalien",
"item": "https://questionsmedicales.fr/mesh/D018268"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Carcinome corticosurrénalien - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Carcinome corticosurrénalien",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-04-30",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Carcinome corticosurrénalien",
"description": "Comment diagnostique-t-on un carcinome corticosurrénalien ?\nQuels tests hormonaux sont utilisés pour le diagnostic ?\nQuelle imagerie est la plus courante pour ce cancer ?\nLe diagnostic peut-il être confirmé par une biopsie ?\nQuels signes cliniques peuvent indiquer un carcinome corticosurrénalien ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Carcinome corticosurrénalien",
"description": "Quels sont les symptômes courants du carcinome corticosurrénalien ?\nLe carcinome corticosurrénalien cause-t-il des problèmes hormonaux ?\nComment le carcinome corticosurrénalien affecte-t-il le métabolisme ?\nY a-t-il des symptômes spécifiques chez les femmes ?\nLe carcinome corticosurrénalien peut-il causer des douleurs ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Carcinome corticosurrénalien",
"description": "Peut-on prévenir le carcinome corticosurrénalien ?\nQuels facteurs de risque sont associés à ce cancer ?\nLe mode de vie influence-t-il le risque de ce cancer ?\nLes examens réguliers aident-ils à la détection précoce ?\nY a-t-il des vaccins pour prévenir ce cancer ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Carcinome corticosurrénalien",
"description": "Quels sont les traitements principaux pour ce cancer ?\nLa chirurgie est-elle toujours possible ?\nQuand la chimiothérapie est-elle recommandée ?\nLa radiothérapie est-elle efficace pour ce type de cancer ?\nY a-t-il des traitements ciblés disponibles ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Carcinome corticosurrénalien",
"description": "Quelles sont les complications possibles du carcinome corticosurrénalien ?\nLe carcinome peut-il entraîner des problèmes cardiovasculaires ?\nComment les déséquilibres hormonaux affectent-ils la santé ?\nY a-t-il un risque accru de récidive après traitement ?\nLe carcinome corticosurrénalien peut-il affecter la qualité de vie ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Carcinome corticosurrénalien",
"description": "Quels sont les principaux facteurs de risque du carcinome corticosurrénalien ?\nLes maladies génétiques augmentent-elles le risque ?\nL'âge est-il un facteur de risque ?\nLe sexe influence-t-il le risque de ce cancer ?\nLe stress a-t-il un impact sur le risque de carcinome ?",
"url": "https://questionsmedicales.fr/mesh/D018268?mesh_terms=Antineoplastic+Combined+Chemotherapy+Protocols#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostique-t-on un carcinome corticosurrénalien ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur l'imagerie, les tests hormonaux et la biopsie."
}
},
{
"@type": "Question",
"name": "Quels tests hormonaux sont utilisés pour le diagnostic ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "On mesure les niveaux de cortisol, d'aldostérone et d'androgènes dans le sang."
}
},
{
"@type": "Question",
"name": "Quelle imagerie est la plus courante pour ce cancer ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "La tomodensitométrie (TDM) est souvent utilisée pour visualiser la tumeur."
}
},
{
"@type": "Question",
"name": "Le diagnostic peut-il être confirmé par une biopsie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une biopsie permet de confirmer la présence de cellules cancéreuses."
}
},
{
"@type": "Question",
"name": "Quels signes cliniques peuvent indiquer un carcinome corticosurrénalien ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes comme l'hypertension, la perte de poids et des changements hormonaux peuvent apparaître."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants du carcinome corticosurrénalien ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent fatigue, hypertension, prise de poids et changements d'humeur."
}
},
{
"@type": "Question",
"name": "Le carcinome corticosurrénalien cause-t-il des problèmes hormonaux ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il peut entraîner un excès de cortisol, provoquant le syndrome de Cushing."
}
},
{
"@type": "Question",
"name": "Comment le carcinome corticosurrénalien affecte-t-il le métabolisme ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il peut provoquer une résistance à l'insuline et des troubles métaboliques."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes spécifiques chez les femmes ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les femmes peuvent présenter des signes d'hyperandrogénie, comme l'hirsutisme."
}
},
{
"@type": "Question",
"name": "Le carcinome corticosurrénalien peut-il causer des douleurs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs abdominales ou lombaires peuvent survenir en raison de la tumeur."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir le carcinome corticosurrénalien ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique, mais un suivi médical régulier est conseillé."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés à ce cancer ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux et certaines maladies génétiques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque de ce cancer ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut réduire le risque de nombreux cancers, y compris celui-ci."
}
},
{
"@type": "Question",
"name": "Les examens réguliers aident-ils à la détection précoce ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des examens réguliers peuvent aider à détecter des anomalies précoces."
}
},
{
"@type": "Question",
"name": "Y a-t-il des vaccins pour prévenir ce cancer ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Actuellement, il n'existe pas de vaccins spécifiques pour prévenir le carcinome corticosurrénalien."
}
},
{
"@type": "Question",
"name": "Quels sont les traitements principaux pour ce cancer ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le traitement inclut la chirurgie, la chimiothérapie et la radiothérapie."
}
},
{
"@type": "Question",
"name": "La chirurgie est-elle toujours possible ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chirurgie est souvent la première option, mais dépend de l'étendue de la maladie."
}
},
{
"@type": "Question",
"name": "Quand la chimiothérapie est-elle recommandée ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle est souvent utilisée pour les cas avancés ou inopérables du carcinome."
}
},
{
"@type": "Question",
"name": "La radiothérapie est-elle efficace pour ce type de cancer ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Elle peut être utilisée pour réduire la taille de la tumeur ou traiter les métastases."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements ciblés disponibles ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements ciblés sont en cours d'étude, mais ne sont pas encore standardisés."
}
},
{
"@type": "Question",
"name": "Quelles sont les complications possibles du carcinome corticosurrénalien ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent la propagation à d'autres organes et des déséquilibres hormonaux."
}
},
{
"@type": "Question",
"name": "Le carcinome peut-il entraîner des problèmes cardiovasculaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'hypertension et d'autres problèmes cardiovasculaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Comment les déséquilibres hormonaux affectent-ils la santé ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent provoquer des troubles métaboliques, des changements d'humeur et des problèmes de fertilité."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de récidive après traitement ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de récidive est élevé, nécessitant un suivi régulier après traitement."
}
},
{
"@type": "Question",
"name": "Le carcinome corticosurrénalien peut-il affecter la qualité de vie ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes et les traitements peuvent significativement impacter la qualité de vie."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque du carcinome corticosurrénalien ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antécédents familiaux, certaines maladies génétiques et l'obésité sont des facteurs de risque."
}
},
{
"@type": "Question",
"name": "Les maladies génétiques augmentent-elles le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des syndromes comme le syndrome de Li-Fraumeni augmentent le risque de ce cancer."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le carcinome corticosurrénalien est plus fréquent chez les adultes jeunes à moyens."
}
},
{
"@type": "Question",
"name": "Le sexe influence-t-il le risque de ce cancer ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les femmes sont légèrement plus susceptibles de développer ce cancer que les hommes."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur le risque de carcinome ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Bien que le stress soit un facteur de santé, son lien direct avec ce cancer n'est pas établi."
}
}
]
}
]
}
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Mainfranken, University of Würzburg, Würzburg, Germany; Central Laboratory, University Hospital Würzburg, Würzburg, Germany.
Publications dans "Carcinome corticosurrénalien" :
Klinik für Endokrinologie, Diabetologie und Klinische Ernährung, Universitätsspital Zürich, Zurich, Switzerland; Medizinische Klinik und Poliklinik III, University Hospital Carl Gustav Carus Dresden, Germany.
Publications dans "Carcinome corticosurrénalien" :
Department of Endocrine Neoplasia and Hormonal Disorders, University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Unit 1461, Houston, TX, 77030, USA. mahabra@mdanderson.org.
Publications dans "Carcinome corticosurrénalien" :
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany; Comprehensive Cancer Mainfranken, University of Würzburg, Würzburg, Germany; Central Laboratory, University Hospital Würzburg, Würzburg, Germany.
Publications dans "Carcinome corticosurrénalien" :
Medical Oncology Unit, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health, University of Brescia, ASST Spedali Civili of Brescia, 25123 Brescia, Italy.
Publications dans "Carcinome corticosurrénalien" :
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany. Electronic address: Altieri_B@ukw.de.
Publications dans "Carcinome corticosurrénalien" :
Division of Endocrinology and Diabetes, Department of Internal Medicine I, University Hospital, University of Würzburg, Würzburg, Germany; Institute of Metabolism and System Research, University of Birmingham, Birmingham, UK.
Publications dans "Carcinome corticosurrénalien" :
Instituto de Investigação e Inovação em Saúde (I3S), Universidade do Porto, Porto, Portugal.
Institute of Molecular Pathology and Immunology of the University of Porto (IPATIMUP), Porto, Portugal.
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal.
Publications dans "Carcinome corticosurrénalien" :
Endocrine, Cardiovascular & Metabolic Research, Department of Anatomy, Multidisciplinary Unit for Biomedical Research (UMIB), Instituto de Ciências Biomédicas Abel Salazar, University of Porto (ICBAS/UP), Porto, Portugal.
Publications dans "Carcinome corticosurrénalien" :
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Publications dans "Carcinome corticosurrénalien" :
Centre for Endocrinology, William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
Publications dans "Carcinome corticosurrénalien" :
The combination of Carboplatin with Paclitaxel is the mainstay treatment for high-grade serous carcinoma; however, many patients with advanced disease undergo relapse due to chemoresistance. Drug repu...
This study observes a previously neglected pharmacological phenomenon and investigates its mechanism of that the continuous low-dose administration of some antineoplastic agents in certain dose ranges...
There are indications that certain antineoplastic agents at low dosages may exhibit abnormal pharmacological actions, such as promoting tumor growth. However, the phenomenon still needs to be further ...
Gemcitabine (GEM) and cisplatin (CDDP) were employed as representative antineoplastic agents to observe effects of continuous low-dose chemotherapy with GEM or GEM combined with CDDP (GEM+CDDP) on tum...
The results showed that tumor formation and growth were both significantly promoted by GEM or GEM+CDDP at as low as half of the metronomic dosages, which were accompanied by enhancements of angiogenes...
These findings indicate that, the continuous low-dose administration of GEM and GEM+CDDP can promote tumorigenesis and tumor progression in vivo by inhibiting apoptosis, mobilizing BMDCs, and promotin...
Combination chemotherapy can cure certain leukemias and lymphomas, but most solid cancers are only curable at early stages. We review quantitative principles that explain the benefits of combining ind...
Multiple myeloma (MM) is a haematological malignancy that is characterised by proliferation of malignant plasma cells in the bone marrow. For adults ineligible to receive high-dose chemotherapy and au...
To determine the benefits and harms of daratumumab in addition to antineoplastic therapy compared to antineoplastic therapy only for adults with newly diagnosed MM who are ineligible for transplant....
We searched the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE, Embase, EU Clinical Trials Register, ClinicalTrials.gov, WHO ICTRP, and conference proceedings from 2010 to September...
We included randomised controlled trials that compared treatment with daratumumab added to antineoplastic therapy versus the same antineoplastic therapy alone in adult participants with a confirmed di...
Two review authors independently screened the results of the search strategies for eligibility. We documented the process of study selection in a flowchart as recommended by the PRISMA statement. We e...
We included four open-label, two-armed randomised controlled trials (34 publications) involving a total of 1783 participants. The ALCYONE, MAIA, and OCTANS trials were multicentre trials conducted wor...
Overall analysis of four studies showed a potential benefit for daratumumab in terms of overall survival and progression-free survival and a slight potential benefit in quality of life. Participants t...
The NICHE trial showed remarkable results of neoadjuvant immunotherapy in colorectal cancer patients with mismatch repair (MMR) deficiency (dMMR). However, rectal cancer patients with dMMR accounted f...
First, recruited patients will receive neoadjuvant arterial embolisation chemotherapy (NAEC) with oxaliplatin 85 mg/m...
The Human Research Ethics Committee of the Fourth Affiliated Hospital of Zhejiang University School of Medicine approved this study protocol. The results will be published in peer-reviewed journals an...
NCT05420584....
Although 80% of patients with metastatic colorectal cancer (CRC) experience liver metastases, only 10-25% undergo resection at the time of diagnosis. Even in initially unresectable conditions, if appr...
This is a single-center, randomized, open-label phase II trial (NCT05103020). Patients with untreated CRC, who have liver-only metastases and for whom liver resection is potentially possible but deeme...
This is the first randomized controlled trial to investigate the efficacy of HAI oxaliplatin in combination with sys-CT plus targeted therapy as first-line treatment from the initial diagnosis in pati...
ClinicalTrials.gov, (NCT05103020). Trial registration date: November 2, 2021....
Short-course radiotherapy (SCRT) with systemic therapy has the potential to further improve the long-term efficacy in patients with locally advanced rectal cancer (LARC). To maximise the benefits of n...
Fifty treatment-naïve patients with operable LARC (T3-4 and/or N+) will be recruited. Patients will be synchronously treated with capecitabine plus oxaliplatin (CAPOX) chemotherapy, tislelizumab and p...
The study protocol was approved by the Ethics Committee of Xiehe Affiliated Hospital of Fujian Medical University (XAHFMU) (No. 2021YF025-01). Results from our study will be disseminated in internatio...
NCT05176964....
Venetoclax is frequently used as salvage treatment in pediatric, adolescent, and young adult (AYA) patients with advanced hematologic malignancies. However, more data are needed from real-world studie...
We retrospectively reviewed the medical records of all patients diagnosed with hematologic malignancies less than 30 years of age treated with venetoclax outside of clinical trials at the University o...
We identified 13 patients (acute myeloid leukemia, n = 8; B-acute lymphoblastic leukemia, n = 3; myelodysplastic syndrome, n = 2) aged 4 months to 27 years. A median of 3 prior lines of therapy weregi...
Venetoclax in combination with hypomethylating agents or cytotoxic chemotherapy was effective in a subset of pediatric/AYA patients with advanced hematologic malignancies, but multiple severe infectio...
The limitations associated with cancer monotherapy including dose dependent toxicity and drug resistance can be addressed by combination chemotherapy. The combination of antineoplastic agents improves...
Neoadjuvant chemotherapy (nCT) or neoadjuvant chemoradiotherapy followed by surgery has been recommended as standard treatment in patients with locally advanced esophageal cancer (LAEC). But the risk ...
In this retrospective study, patients with resectable esophageal cancer who received surgery after nICT (n=26, 40%) or nCT alone (n=39, 60%) were included. The patients were classified as nICT or nCT ...
Three (11.5%) of the 26 patients achieved pathological complete remission (pCR) in the nICT group, and four (10.3%) of the 39 patients achieved pCR in the nCT group, respectively (P=1.000). Six (23.1%...
Neoadjuvant PD-1 blockade combined with chemotherapy was not superior to chemotherapy alone for patients with resectable locally advanced esophageal carcinoma. However, more studies with long-term fol...